Alcohol最新文献

{"title":"The decrease in alcohol consumption and suicide rate during the COVID-19 pandemic and their association","authors":"","doi":"10.1016/j.alcohol.2024.03.012","DOIUrl":"10.1016/j.alcohol.2024.03.012","url":null,"abstract":"<div><p>Despite the considerable change in alcohol consumption during the COVID-19 pandemic, the impact of the pandemic on the suicide rate in terms of alcohol consumption was not studied. This study was performed to examine whether the change in the suicide rate during the COVID-19 pandemic was related to alcohol consumption and whether the relation was specific to suicides when compared to mortality due to other causes. We performed a comparative interrupted time series (CITS) analysis for the suicide rate of people aged 19 to 60 with three comparison groups (the suicide rate of people aged 19 and under, the cancer death rate of people aged 19 to 60, and alcohol-induced death rates). The suicide rate of people aged 19 to 60 and alcohol consumption per capita, along with alcohol-induced death rates, continued to decrease during the pandemic in 2020 and 2021, while the suicide rate of people aged 19 and under and the cancer death rate showed increases. In the comparative interrupted time series model, alcohol consumption had an increasing effect on the adult suicide rate compared to comparison groups when time trends and changes associated with COVID-19 were adjusted. This study shows that the decrease in the adult suicide rate in Korea during the pandemic was associated with the decrease in alcohol use among the adult population. Considering that means restriction is the most effective way of controlling suicide and that alcohol can be the most potent and final trigger for suicide, the decrease in suicides during the pandemic and its association with alcohol consumption should be understood as a call for further efforts to decrease alcohol consumption.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 27-32"},"PeriodicalIF":2.5,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0741832924000570/pdfft?md5=85b9370259cd92c572bea6ac34bc38b0&pid=1-s2.0-S0741832924000570-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of moderate ethanol exposure on risk factors for cardiovascular disease and colorectal cancer in adult Wistar rats","authors":"Anna J. Kwon ,&nbsp;Lani Morales ,&nbsp;Louise Chatagnier ,&nbsp;Jacqueline Quigley ,&nbsp;Jeremy Pascua ,&nbsp;Natalie Pinkowski ,&nbsp;Susan M. Brasser ,&nbsp;Mee Young Hong","doi":"10.1016/j.alcohol.2024.03.010","DOIUrl":"10.1016/j.alcohol.2024.03.010","url":null,"abstract":"<div><p>While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (<em>n</em> = 12/group) for 13 weeks. Blood samples were collected to analyze levels of albumin, glucose, adiponectin, lipids, oxidized low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (apoA1), C-reactive protein (CRP), high-mobility group box 1 protein (HMGB-1), tumor necrosis factor-alpha (TNF-α), thyroxine, thyroid-stimulating hormone, 8-oxo-2′-deoxyguanosine (8-oxo-dG), liver function enzymes, and antioxidant capacity. Colonic gene expression related to colon carcinogenesis was also assessed. Ethanol-treated rats were found to have significantly higher HDL-C and apoA1 levels compared to controls. Moderate alcohol consumption led to significantly lower CRP levels and a trend for decrease in HMGB-1, TNF-α, and 8-oxo-dG levels. In the ethanol-exposed group, colonic gene expression of superoxide dismutase was upregulated while aldehyde dehydrogenase 2 showed a trend for increase compared to the control group. These results indicate that adopting a moderate approach to alcohol consumption could potentially improve health biomarkers related to CVD and CRC by increasing HDL-C levels and antioxidant activity and reducing DNA damage and inflammatory activity.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"117 ","pages":"Pages 55-63"},"PeriodicalIF":2.3,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0741832924000557/pdfft?md5=98bcd4027bad79b0581061da9b5718d8&pid=1-s2.0-S0741832924000557-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol: Epigenome alteration and inter/transgenerational effect","authors":"Nazila Heidari ,&nbsp;Arman Hajikarim-Hamedani ,&nbsp;Amirhossein Heidari ,&nbsp;Yekta Ghane ,&nbsp;Ghorbangol Ashabi ,&nbsp;Mohammad-Reza Zarrindast ,&nbsp;Mitra-Sadat Sadat-Shirazi","doi":"10.1016/j.alcohol.2024.03.008","DOIUrl":"10.1016/j.alcohol.2024.03.008","url":null,"abstract":"<div><p>While DNA serves as the fundamental genetic blueprint for an organism, it is not a static entity. Gene expression, the process by which genetic information is utilized to create functional products like proteins, can be modulated by a diverse range of environmental factors. Epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, play a pivotal role in mediating the intricate interplay between the environment and gene expression. Intriguingly, alterations in the epigenome have the potential to be inherited across generations. Alcohol use disorder (AUD) poses significant health issues worldwide. Alcohol has the capability to induce changes in the epigenome, which can be inherited by offspring, thus impacting them even in the absence of direct alcohol exposure. This review delves into the impact of alcohol on the epigenome, examining how its effects vary based on factors such as the age of exposure (adolescence or adulthood), the duration of exposure (chronic or acute), and the specific sample collected (brain, blood, or sperm). The literature underscores that alcohol exposure can elicit diverse effects on the epigenome during different life stages. Furthermore, compelling evidence from human and animal studies demonstrates that alcohol induces alterations in epigenome content, affecting both the brain and blood. Notably, rodent studies suggest that these epigenetic changes can result in lasting phenotype alterations that extend across at least two generations. In conclusion, the comprehensive literature analysis supports the notion that alcohol exposure induces lasting epigenetic alterations, influencing the behavior and health of future generations. This knowledge emphasizes the significance of addressing the potential transgenerational effects of alcohol and highlights the importance of preventive measures to minimize the adverse impact on offspring.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"117 ","pages":"Pages 27-41"},"PeriodicalIF":2.3,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol consumption questionnaire: Scale development in a sample of Mexican American young adults and association with ADH7","authors":"","doi":"10.1016/j.alcohol.2024.03.006","DOIUrl":"10.1016/j.alcohol.2024.03.006","url":null,"abstract":"<div><h3>Background</h3><p>To understand why some individuals who develop alcohol use disorders (AUD) first begin to drink heavily, a number of scales have been developed that index aspects of alcohol craving and restraint from drinking. We developed a new measure called the Alcohol Consumption Questionnaire (ACQ), based in part on items modified from scales used to index binge eating, because there are data to suggest that binge eating and binge drinking may share common antecedents. We present an initial validity study using data from a sample of Mexican Americans.</p></div><div><h3>Methods</h3><p>Data were from 699 Mexican American young adults in San Diego County, CA. A subsample (n = 60) had short-term test-retest data. Factor analysis and reliability assessment guided item reduction. Item response theory (IRT) analyses quantified item severity and identified questions with differential item functioning (DIF). Logistic regression assessed associations of mean scale scores with AUD, adjusting for key demographics, alcohol expectancies and subjective response to alcohol. We also examined associations with a protective genetic variant downstream from the alcohol dehydrogenase 7 (ADH7) gene.</p></div><div><h3>Results</h3><p>The scale was reduced from 20 to 14 questions, which can be summarized by a single overall score (Cronbach's alpha = 0.896) or by two sub-scores (Consumption: 12 items, Cronbach's alpha = 0.896; Enjoyment: 2 items, Cronbach's alpha = 0.780). Test-retest reliability was very high (0.80–0.98) in this sample. The overall ACQ score and each subdomain score were strongly associated with AUD (ORs = 5.95 mild; 11.41 moderate; 48.56 severe) and family history of AUD. Respondents with the protective genetic variant had significantly lower overall ACQ scores (p &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>The ACQ is a novel measure of alcohol consumption with strong relationships with both the AUD phenotype and ADH7 gene variants in a sample of Mexican American young adults.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"120 ","pages":"Pages 119-131"},"PeriodicalIF":2.5,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical incision pain induced an increase in alcohol consumption in mice","authors":"Sofia Ghani ,&nbsp;Yasmin Alkhlaif ,&nbsp;Jared Mann ,&nbsp;Lauren Moncayo ,&nbsp;Esad Ulker ,&nbsp;Martial Caillaud ,&nbsp;Mitali Barik ,&nbsp;Joseph W. Ditre ,&nbsp;Michael F. Miles ,&nbsp;M. Imad Damaj","doi":"10.1016/j.alcohol.2024.03.005","DOIUrl":"10.1016/j.alcohol.2024.03.005","url":null,"abstract":"<div><h3>Introduction</h3><p>Large population-based studies have suggested a link between increased alcohol use and reduced pain. In addition, these studies suggest that higher levels of pain intensity are associated with an increase in alcohol consumption and rates of hazardous drinking which potentiates the risk of developing alcohol use disorders (AUD). The mechanisms and determinants of the alcohol–pain interaction can be studied in preclinical studies.</p></div><div><h3>Methods</h3><p>The overall goal of this study is to use animal models to explore the impact of acute postoperative pain on alcohol intake. To achieve this, we characterized the timeline and levels of alcohol intake and preference in mice after laparotomy in the 2-bottle choice paradigm.</p></div><div><h3>Results</h3><p>Our results show that laparotomy surgery increased alcohol intake and preference in male mice but not females in the 2-bottle choice and 3-bottle choice assays. In addition, ketoprofen administration blocked the increase in alcohol consumption in male mice after laparotomy. We also found that changes in alcohol initial sensitivity and acute functional tolerance, using loss of righting reflex (LORR) response, occur after surgery in mice.</p></div><div><h3>Conclusion</h3><p>Taken together, these findings suggests that sex, pain and alcohol sensitivity-related factors may modulate the relationship between alcohol consumption and pain.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"117 ","pages":"Pages 1-9"},"PeriodicalIF":2.3,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The trends and incidence of alcohol-associated hepatitis hospitalizations from 2016–2020 and the impact of the COVID-19 pandemic","authors":"Megan B. Ghai ,&nbsp;Pooja Rangan ,&nbsp;Naim Alkhouri ,&nbsp;Jessica Mellinger ,&nbsp;Karn Wijarnpreecha","doi":"10.1016/j.alcohol.2024.03.003","DOIUrl":"10.1016/j.alcohol.2024.03.003","url":null,"abstract":"<div><h3>Introduction</h3><div>The impact of the COVID-19 pandemic on hospitalizations for alcohol-associated hepatitis (AH) is poorly understood. Here we explore AH trends from 2016 to 2020 and evaluate demographic disparities including sex and race.</div></div><div><h3>Methods</h3><div>A retrospective analysis of the 2016–2020 Healthcare Cost and Utilization Project National Inpatient Sample was performed to assess temporal trends in hospitalizations for AH. The 2020 dataset was evaluated to compare AH hospitalizations between those with and without an additional diagnosis of COVID-19.</div></div><div><h3>Results</h3><div>Included were 607 140 weighted inpatient AH discharges per 145,055,152 all-cause discharges from 2016 to 2020. AH hospitalizations increased at a rate of 23.4 hospitalizations per 100 000 all-cause discharges per year between 2016 and 2019 and increased to 113 hospitalizations per 100 000 all-cause discharges in 2020. Mortality was higher in females despite lower rates of hospitalization than males. The adjusted odds of hospitalization for AH in 2020 were higher than in 2016–2019 (aOR = 1.28, <em>p</em> &lt; 0.001). The Hispanic population had greater odds of hospitalization with AH and COVID-19 compared to other races (aOR = 2.71, <em>p</em> &lt; 0.001).</div></div><div><h3>Discussion</h3><div>Increased efforts toward primary prevention of excessive alcohol use and greater social support for those with alcohol use disorder are needed. More research is required to elucidate the racial disparities among the Hispanic population with AH and COVID-19.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 177-184"},"PeriodicalIF":2.5,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140069003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with alcohol abuse have higher risks of complications after coronary artery bypass grafting: A population-based study of National Inpatient Sample from 2015 to 2020","authors":"","doi":"10.1016/j.alcohol.2024.03.002","DOIUrl":"10.1016/j.alcohol.2024.03.002","url":null,"abstract":"<div><h3>Background</h3><p>Alcohol abuse (AA) has s high prevalence, affecting 10 to 15 million Americans. While AA was demonstrated to negatively impact cardiovascular health, limited evidence from existing studies presents conflicting findings regarding the effects of AA on coronary artery bypass grafting (CABG) outcomes. This study aimed to compare the in-hospital outcomes after CABG between AA and non-AA patients.</p></div><div><h3>Methods</h3><p>Patients who underwent CABG were identified in National Inpatient Sample from Q4 2015–2020. Exclusion criteria included age&lt;18 years and concomitant procedures. A 1:3 propensity-score matching was used to address differences in demographics, socioeconomic status, primary payer status, hospital characteristics, comorbidities, and transfer/admission status between AA and non-AA patients. In-hospital outcomes after CABG were examined.</p></div><div><h3>Results</h3><p>There were 5694 (3.39%) AA patients who underwent CABG. After matching, 17,315 from 162,488 non-AA patients were matched to all AA patients. AA and non-AA patients had comparable mortality (1.64% vs 1.55%, p = 0.67) and MACE (2.46% vs 2.56%, p = 0.73). However, AA patients had higher cardiogenic shock (8.31% vs 7.43%, p = 0.03), mechanical ventilation (11.51% vs 7.96%, p &lt; 0.01), hemorrhage/hematoma (57.49% vs 54.75%, p &lt; 0.01), superficial (0.99% vs 0.61%, p &lt; 0.01) and deep wound complications (0.37% vs 0.18%, p = 0.02), reopen surgery for bleeding control (0.92% vs 0.63%, p = 0.03), transfer out (21.00% vs 16.38%, p &lt; 0.01), longer time from admission to operation (p &lt; 0.01), longer length of stay (p &lt; 0.01), and higher hospital charge (p &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>While AA was not found to be linked with in-hospital mortality or MACE after CABG, it was independently associated with postoperative complications. These findings could enhance preoperative risk stratification for AA patients and inform postoperative management following CABG.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"120 ","pages":"Pages 51-57"},"PeriodicalIF":2.5,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol use disorder and muscle weakness: Original study of the effect of vitamin D supplementation in ambulatory participants with alcohol use disorder","authors":"","doi":"10.1016/j.alcohol.2024.03.001","DOIUrl":"10.1016/j.alcohol.2024.03.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic alcohol-related myopathy presents with proximal muscle weakness. We studied the effect of vitamin D supplementation on muscle weakness in adults with alcohol use disorder.</div></div><div><h3>Method</h3><div>The study was a randomized controlled trial. Participants were community-dwelling adults with alcohol use disorder. Participants allocated to VIDIO, vitamin D intensive outreach, received bimonthly oral doses of 50,000–100,000 IU cholecalciferol for 12 months. Participants allocated to CAU, care as usual, received prescriptions of once-a-day tablets containing 800 IU cholecalciferol and 500 mg calcium carbonate. Data included demographic variables, laboratory tests, alcohol use, and rating scales of help-seeking and support. Main outcomes were the participants’ quadriceps maximum voluntary contractions (qMVC) and serum-25(OH)vitamin D concentrations, 25(OH)D.</div></div><div><h3>Results</h3><div>In 66 participants, sex ratio 50/16, mean age 51 years, alcohol use was a median of 52 [IQR 24–95] drinks per week. Baseline qMVC values were 77% (SD 29%) of reference values. Laboratory tests were available in 44/66 participants: baseline 25(OH)D concentrations were 39.4 (SD 23.7) nmol/L. Thirty-one participants with 25(OH)D concentrations &lt;50 nmol/L received either VIDIO or CAU and improved in qMVC, respectively, with a mean of 51 (<em>p</em> &lt; 0.05) and 62 N (no <em>p</em> value because of loss of follow-up) after one year of treatment. Vitamin D status increased with a mean of +56.1 and + 37.4 nmol/L, respectively, in VIDIO and CAU.</div></div><div><h3>Conclusion</h3><div>The qMVC values improved during vitamin supplementation in adults with vitamin D deficiency and alcohol use disorder. Despite higher 25(OH)D concentrations in VIDIO, in terms of muscle health no advice could be given in favor of one vitamin strategy over the other.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 169-176"},"PeriodicalIF":2.5,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A role for circuitry of the cortical amygdala in excessive alcohol drinking, withdrawal, and alcohol use disorder","authors":"","doi":"10.1016/j.alcohol.2024.02.008","DOIUrl":"10.1016/j.alcohol.2024.02.008","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) poses a significant public health challenge. Individuals with AUD engage in chronic and excessive alcohol consumption, leading to cycles of intoxication, withdrawal, and craving behaviors. This review explores the involvement of the cortical amygdala (CoA), a cortical brain region that has primarily been examined in relation to olfactory behavior, in the expression of alcohol dependence and excessive alcohol drinking. While extensive research has identified the involvement of numerous brain regions in AUD, the CoA has emerged as a relatively understudied yet promising candidate for future study. The CoA plays a vital role in rewarding and aversive signaling and olfactory-related behaviors and has recently been shown to be involved in alcohol-dependent drinking in mice. The CoA projects directly to brain regions that are critically important for AUD, such as the central amygdala, bed nucleus of the stria terminalis, and basolateral amygdala. These projections may convey key modulatory signaling that drives excessive alcohol drinking in alcohol-dependent subjects. This review summarizes existing knowledge on the structure and connectivity of the CoA and its potential involvement in AUD. Understanding the contribution of this region to excessive drinking behavior could offer novel insights into the etiology of AUD and potential therapeutic targets.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 151-159"},"PeriodicalIF":2.5,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study","authors":"","doi":"10.1016/j.alcohol.2024.02.010","DOIUrl":"10.1016/j.alcohol.2024.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol consumption is a significant public health concern in Korea, with many individuals engaging in risky drinking behaviors. This study aims to analyze the association between facial flushing responses and the progression of hypertension in Korean adults, stratified by gender, using a large-scale prospective cohort study.</div></div><div><h3>Methods</h3><div>This study included 39,868 participants (10,868 males and 29,000 females) from the health examinees cohort. Participants were divided into two groups according to their weekly drinking patterns (moderate and heavy) and facial flushing responses (non-flusher and flusher) for statistical analysis. A multivariate Cox proportional hazards regression model was used to calculate hazard ratios and 95% confidence intervals between flushing response after alcohol consumption and hypertension risk.</div></div><div><h3>Results</h3><div>In males, the flusher group with a moderate alcohol intake pattern had a decreased risk of incident hypertension compared with non-flushers. In females, the flusher group had relatively higher risk of pre-hypertension and hypertension compared to the non-flusher group.</div></div><div><h3>Conclusion</h3><div>The association between facial flushing and hypertension varies depending on the level of alcohol consumption and should be considered in relation to gender differences. Further research is needed to understand the relationship between facial flushing response and the risk of hypertension based on alcohol consumption levels.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 133-139"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}