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Current opinion in neurology and neurosurgery最新文献

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The roles of heat shock proteins and immediate early genes in central nervous system normal function and pathology. 热休克蛋白和直接早期基因在中枢神经系统正常功能和病理中的作用。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
M Chopp
{"title":"The roles of heat shock proteins and immediate early genes in central nervous system normal function and pathology.","authors":"M Chopp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The expression and transcription of heat shock proteins and immediate early genes in the central nervous system are greatly affected by disease and injury. However, the participation of these genes in both normal and pathophysiologic function is uncertain. Experiments performed this past year shed light on the possible roles of heat shock proteins and immediate early genes in neurologic tissue.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"6-10"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular genetics of neurodegenerative diseases. 神经退行性疾病的分子遗传学。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
A D Roses
{"title":"Molecular genetics of neurodegenerative diseases.","authors":"A D Roses","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent progress in human neurogenetics has led to the discovery of new modes of inheritance and disease expression, including 1) stably inherited duplications in Charcot-Marie-Tooth disease type 1a, 2) dynamic mutations in fragile X syndrome and myotonic dystrophy, and 3) identical mutations with different phenotypes in fatal familial insomnia and Creutzfeldt-Jakob disease. The mechanisms by which known mutations of the amyloid precursor protein lead to early-onset Alzheimer's disease remain unexplained, despite hundreds of recent studies of beta-amyloid.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"34-9"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The economic approach to the stroke work-up. 中风治疗的经济方法。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
M E Shriver, L D Prockop
{"title":"The economic approach to the stroke work-up.","authors":"M E Shriver,&nbsp;L D Prockop","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stroke is the leading cause of morbidity in the United States and the expenditure for stroke aftercare, including lost wages, is astronomical. Reduction of risk factors and use of the most accurate diagnostic technology allows for intervention prior to catastrophic neurologic deficit. The most advantageous combination of diagnostic testing with regard to risk-benefit has been debated, but it is generally agreed that the cost of even the most sophisticated stroke work-up is far less than that of stroke aftercare.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"74-7"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19412976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is stroke rehabilitation worthwhile? 中风康复值得吗?
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
D T Wade
{"title":"Is stroke rehabilitation worthwhile?","authors":"D T Wade","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rehabilitation is an educational problem-solving process that focuses on disability and aims to minimize the patient's disability and distress and the stress on family members. There is established evidence that rehabilitation helps individual patients, and now there is good evidence that applying rehabilitation policies generally improves outcome in groups of patients. Moreover, well-organized specialist rehabilitation is efficient because total resources are reduced.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"78-82"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19412977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glial biology and disorders. 神经胶质生物学和疾病。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
N Baumann, A Baron-Van Evercooren, C Jacque, B Zalc
{"title":"Glial biology and disorders.","authors":"N Baumann,&nbsp;A Baron-Van Evercooren,&nbsp;C Jacque,&nbsp;B Zalc","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Much work has been devoted this year to the localization and mode of expression of growth factors and cytokines. Although it is not possible to extrapolate directly from in vitro to in vivo conditions, the plasticity of glial cells seems to be very influenced by growth factors. Astrocytes in vivo do not express many growth factors during normal conditions, but a pathologic event can lift these restrictions. Cytokines and their receptors have been localized on neuronal or glial cell types. The programmed cell death, well identified in neurons, seems to occur also in oligodendrocytes and may be influenced by survival factors. In the adult brain, glial progenitors are present and may be a potential source to generate myelinating oligodendrocytes for myelin repair. In the peripheral nervous system, axonal-Schwann cell signaling may function in both directions during development. Some animal neurologic mutants are models for human diseases; one of them, the Trembler mouse, has effectively led to the genetic characterization of Charcot-Marie-Tooth disease type 1a. As for myelin destruction, the relationship between demyelination and inflammation is still not very clear.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiplatelet and anticoagulant therapy. 抗血小板和抗凝治疗。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
S Bower, P Sandercock
{"title":"Antiplatelet and anticoagulant therapy.","authors":"S Bower,&nbsp;P Sandercock","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antiplatelet therapy is clearly indicated for long-term secondary prevention after transient ischemic attack and ischemic stroke. In stroke-free patients with atrial fibrillation, oral anticoagulants reduce the risk of stroke, and antiplatelet agents may be a lower risk alternative. For the early treatment of the acute phase of ischemic stroke, the role of antiplatelet and anticoagulant therapy is unclear, but is being evaluated in large clinical trials.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"55-9"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropsychology, dementia, and aging. 神经心理学，痴呆和衰老。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
{"title":"Neuropsychology, dementia, and aging.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"142-62"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular dementia: a concept in flux. 血管性痴呆:一个不断变化的概念。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
B Bendixen
{"title":"Vascular dementia: a concept in flux.","authors":"B Bendixen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vascular dementia describes global cognitive decline attributed to the cumulative effects of ischemic vascular disease. Discrete and multiple cognitive skills, including memory, are successively lost as a result of focal cerebrovascular insults. Our understanding of vascular dementia has evolved over time, in part through our ability to neuroradiologically image changes in patients, and also through our increased understanding of the neuropsychologic organization of the brain. This paper reviews the development of our present understanding of vascular dementia, examines the status of \"leukoaraiosis,\" pointing out current areas of controversy, and discusses clinical management.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"107-12"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ion channels and disorders of excitation in skeletal muscle. 骨骼肌离子通道与兴奋障碍。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
R L Barchi
{"title":"Ion channels and disorders of excitation in skeletal muscle.","authors":"R L Barchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For skeletal muscle to contract normally, signals from the neuromuscular junction must be conveyed to the contractile proteins by action potentials that spread across the surface membrane and into the T-tubular system. Hyperexcitability in the surface membrane can lead to unwanted and persistent contraction, while reduced excitability can cause weakness or paralysis. Many of the human muscle diseases that are associated with abnormalities of membrane excitability have been linked to defects in the function of membrane ion channels. Using molecular biologic tools, these abnormal channels can be identified and their molecular defects defined. Advances in these areas now provide the basis for a rational, mechanistic approach to the classification and treatment of these disorders of membrane excitation.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"40-7"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18682081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgery, angioplasty, and interventional neuroradiology. 外科，血管成形术，介入神经放射学。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
M M Brown
{"title":"Surgery, angioplasty, and interventional neuroradiology.","authors":"M M Brown","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article discusses recent advances in the treatment of three cerebrovascular conditions, namely carotid stenosis, cerebral aneurysm, and arteriovenous malformation. In all three the aim of treatment is to prevent stroke, and in all three, recent advances in interventional neuroradiology are supplementing traditional surgical techniques. The benefits of endarterectomy for severe symptomatic carotid stenosis have been clearly demonstrated by recent trials, and early case series suggest that percutaneous transluminal angioplasty may provide an alternative treatment. Recent advances in the management of cerebral aneurysm include new treatments for cerebral vasospasm and the use of endovascular occlusion to treat inoperable aneurysms. Endovascular embolization for arteriovenous malformations also looks promising, but more randomized trials are required to establish the benefit of these interventional procedures.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"66-73"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19412975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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