{"title":"Clinical neurophysiology, neuroimaging, and the surgical treatment of epilepsy.","authors":"J Engel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Improved neurodiagnostic tools for examining cerebral structure and function have greatly enhanced the safety and efficacy of surgical treatment for epilepsy, and markedly increased the number of candidates for these surgical interventions. The application of new developments in clinical neurophysiology, as well as recent advances in neuroimaging, for surgical therapy of medically refractory seizures are reviewed. Improvements in surgical results are documented and future directions are discussed.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 2","pages":"240-9"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19464868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alzheimer's disease: new developments for noninvasive detection of early cases.","authors":"L deToledo-Morrell, F Morrell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"113-8"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitochondrial disorders in muscle.","authors":"E A Schon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The successful analysis of mutations in mitochondrial DNA has been a major step forward in our understanding of a number of baffling clinical syndromes, and the application of new technology to analyze and study mitochondrial DNA mutations has led to new insights into the pathogenesis of these disorders. Moreover, the field of mitochondrial DNA diseases is now expanding beyond the limited purview of relatively rare disorders to encompass clinical phenotypes that may be much more frequent in the population.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Developmental language disorders: evidence for a basic processing deficit.","authors":"K C Anderson, C P Brown, P Tallal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although there is still some disagreement whether developmental reading and language disorders are neurologically based, recent research provides increasing evidence that these disorders may be due to both abnormal cerebral lateralization patterns and neurological pathology at the cellular level. Technological advances in the field of neuroscience have led to increasing knowledge about brain-behavior relationships, particularly in the area of higher cognitive functions. Hypotheses about the underlying causes of the functional deficits characterizing developmental language and reading disorders are now focusing on specific neurological processing mechanisms, the disruption of which may be at the heart of these disorders.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"98-106"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18682082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical neurochemistry.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"119-27"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treatment of acute cerebral infarction.","authors":"J Nader, J Bogousslavsky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review focuses on the recent advances in the management of acute ischemic stroke. We highlight the best current treatment, as proposed by different authors, as well as future lines of treatment.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"51-4"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strategies for preventing stroke.","authors":"M C Kanter, D G Sherman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The limited effectiveness of any therapy for acute stroke dictates that emphasis be placed on strategies for preventing stroke. The identification and management of risk factors is paramount. Modifiable risk factors include hypertension, smoking, hyperlipidemia, and diabetes. Patients with transient ischemic attacks or stroke are at risk for recurrent stroke and should be considered for antithrombotic therapy and carotid endarterectomy. Patients with nonvalvular atrial fibrillation should also be treated with antithrombotic therapy. The proper management of other cardiac, malignant, and hematologic disorders is important in preventing stroke in these high-risk patients.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"60-5"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19412974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disorders of memory in humans.","authors":"J D Gabrieli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Memory is composed of dissociable systems that accomplish different forms of learning and that are mediated by distinct neural networks. Knowledge about the psychological nature and neural basis of specific memory systems has come primarily from lesion analysis, but this year functional brain imaging has provided a new source of convergent evidence. Recent findings are reviewed that provide new information about a limbic-diencephalic system critical for learning new declarative information, a temporal lobe system that stores long-term semantic knowledge in a domain-specific fashion, an occipital system that subserves visuoperceptual implicit memory, and a fronto-thalamo-neostriatal system that mediates the executive component of working memory and that plays an important role in some forms of sensorimotor skill learning.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"93-7"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19412979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role and expression of neurotrophins and the trk family of tyrosine kinase receptors in neural growth and rescue after injury.","authors":"H Persson, C F Ibáñez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular cloning of genes for the neurotrophin family and the identification of their high-affinity receptors have recently contributed to our understanding of neurotrophic interactions in the vertebrate nervous system. From their primary sites of synthesis, novel neuronal populations that may be sensitive to the neurotrophins have been identified. Protective roles for these factors following epileptic, ischemic, and hypoglycemic insults have been inferred. Documented neurotrophic actions on basal forebrain cholinergic neurons and mesencephalic dopaminergic neurons imply future clinical applications for the treatment of dementia of both Alzheimer's and Parkinson's disease. Studies on structure-function relationships of the neurotrophins hold promises for the development of specific receptor agonists and antagonists with possible basic science and clinical applications.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"11-8"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cerebrovascular disease.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"127-42"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19411134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}