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Current opinion in neurology and neurosurgery最新文献

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Neurobiology of schizophrenia. 精神分裂症的神经生物学。
Current opinion in neurology and neurosurgery Pub Date : 1993-02-01
S S Wolf, T M Hyde, D R Weinberger
{"title":"Neurobiology of schizophrenia.","authors":"S S Wolf,&nbsp;T M Hyde,&nbsp;D R Weinberger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Schizophrenia is the most prevalent of the major psychoses, but the underlying neurobiology of this debilitating disorder remains mysterious. Recent developments in molecular biology, neuroanatomic pathology, neurochemistry, and functional imaging suggest that a number of factors converge to produce schizophrenia. Specifically, an early neurodevelopmental \"lesion,\" possibly within the mesial temporal lobe, may contribute to later temporolimbic-prefrontal dysfunction as the nervous system matures. Genetic factors appear to facilitate liability to schizophrenia, and dopaminergic and possibly other neurotransmitter systems may mediate clinical expression of the illness through newly recognized receptor subtypes.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"6 1","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19412978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infections of the central nervous system. 中枢神经系统的感染。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
M Takahashi
{"title":"Infections of the central nervous system.","authors":"M Takahashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several discussions of the neuroimaging of inflammatory diseases with emphasis on computerized tomography (CT) and magnetic resonance imaging (MRI) findings and on rare diseases, such as sparganosis, neuroborreliosis and various types of encephalitis, have been published during the past year. Infectious processes in immunosuppressed patients have been described by many authors, especially in the field of acquired immune deficiency syndrome (AIDS). The importance of gadolinium-diethylenetriamine-penta-acetic acid (Gd-DTPA) in MRI for delineation, and differential diagnosis of the inflammatory processes has been considered. Newly introduced techniques such as technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) single photon emission CT (SPECT) and proton spectroscopy have made the early detection of diseases possible.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"849-53"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12637271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lewy body disease. 路易体病。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
L A Hansen, D Galasko
{"title":"Lewy body disease.","authors":"L A Hansen,&nbsp;D Galasko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Subsumed under the rubric of Lewy body disease are idiopathic Parkinson's disease (PD), pure diffuse Lewy body disease (DLBD), and, most commonly, combined brainstem and neocortical Lewy bodies with Alzheimer's disease (AD) pathology in a relatively early developmental stage. Clinical correlates are dementia with psychiatric and subcortical features plus mild extrapyramidal signs (EPS).</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"889-94"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12637198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracranial pressure measurement/cranial vault mechanics: clinical and experimental observations. 颅内压测量/颅拱顶力学:临床和实验观察。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
A Y Razumovsky, D F Hanley
{"title":"Intracranial pressure measurement/cranial vault mechanics: clinical and experimental observations.","authors":"A Y Razumovsky,&nbsp;D F Hanley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The absolute value of intracranial pressure (ICP) should be considered in conjunction with evaluation of a patient's clinical condition. In addition, other aspects of cranial vault mechanics may be important in multiple disease states. Among the important physiological measures of cranial vault sufficiency are hydrodynamic interaction between brain tissue, blood and cerebrospinal fluid (CSF)--volume-pressure relation, CSF dynamics--CSF outflow resistance, CSF production rate, sagittal sinus pressure, and appearance of ICP waves. Clinical and experimental studies brought together in this review provide an insight into the dynamics of ICP and the cranial vault.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"818-25"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12637267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome evaluation in acute neurological injury. 急性神经损伤的预后评价。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
J C Torner
{"title":"Outcome evaluation in acute neurological injury.","authors":"J C Torner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To evaluate outcome one must define the outcome and those factors that contribute to it. Recent advances in measurement of brain injury by radiology, evoked potentials and electroencephalogram (EEG), cerebral blood flow (CBF) and cerebral metabolism have demonstrated differential prognosis. Outcome from coma has also been expanded to include cognitive and neurobehavioral measures as well as functional assessments.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"831-9"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12637269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural transplantation: problems and prospects for therapeutic application. 神经移植:问题及治疗应用前景。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
J D Sinden, S N Patel, H Hodges
{"title":"Neural transplantation: problems and prospects for therapeutic application.","authors":"J D Sinden,&nbsp;S N Patel,&nbsp;H Hodges","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Successful demonstrations of behavioural recovery in a variety of lesion and mutant animal models have encouraged the application of neural transplantation to the alleviation of neurodegenerative disease. Apart from the continuing shortage of foetal tissue, the major problems to be resolved for successful application of neural transplantation to humans are: first, immune rejection of allograft tissue and its pathological consequences to both graft and host tissue; and second, the establishment of normal and extensive graft-host connectivity. Recent developments in transplant research are beginning successfully to apply a number of strategies to resolve these problems.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"902-8"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12533494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic neuropathology. 动态神经病理学。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
{"title":"Dynamic neuropathology.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"968-94"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12533495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human prion diseases. 人类朊病毒疾病。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
M S Palmer, J Collinge
{"title":"Human prion diseases.","authors":"M S Palmer,&nbsp;J Collinge","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The past year has seen considerable advances in our understanding of the prion diseases, and there is increasing acceptance that the transmissible agent in these diseases may be an abnormal isoform of a normal host encoded protein. Molecular genetic studies have led to a new appreciation of the phenotypic spectrum of the prion diseases as the inherited forms of these conditions can now be diagnosed by a direct gene test. The conundrum of how a disease can be both inherited and transmissible is beginning to make sense.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"895-901"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12637199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial encephalomyopathies. 线粒体encephalomyopathies。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
B Eymard, J J Hauw
{"title":"Mitochondrial encephalomyopathies.","authors":"B Eymard,&nbsp;J J Hauw","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular genetic studies are now bringing a new classification and new insights into already recognized mitochondrial encephalomyopathies. There are, however, numerous reports on an overlap pattern between mitochondriopathies. In addition, the link between the defect in oxidative phosphorylation (OXPHOS) in the brain and the specific neuropathological pattern is unclear. A better knowledge of nuclear mutations in mitochondriopathies and of the interactions between nuclear and mitochondrial genomes will probably allow new developments.</p>","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"909-16"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12637200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging. 神经影像。
Current opinion in neurology and neurosurgery Pub Date : 1992-12-01
{"title":"Neuroimaging.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77089,"journal":{"name":"Current opinion in neurology and neurosurgery","volume":"5 6","pages":"949-68"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12637203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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