Acta paediatrica Japonica : Overseas edition最新文献

Effectiveness and safety of intravenous amiodarone in drug-resistant tachyarrhythmias of children. 静脉注射胺碘酮治疗儿童耐药速性心律失常的有效性和安全性。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb01992.x

A Celiker, N Ceviz, S Ozme

引用次数: 41

Primary changes in liver damage by aspirin in rats. 阿司匹林对大鼠肝损伤的原发性改变。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb01996.x

T Tomoda, T Kurashige, Y Hayashi, H Enzan

引用次数: 9

Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis. 与局灶性肾小球硬化相关的促肾上腺皮质激素和加压素的周期性排出。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb01998.x

W Yokoyama, M Fujieda, T Okada, H Maeda, M Ushida, Y Machida, K Naruse, A Maeda, H Wakiguchi, T Kurashige

引用次数: 1

Photosensitive fits elicited by TV animation: an electroencephalographic study. 电视动画引起的光敏痉挛:一项脑电图研究。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb02005.x

H Enoki, T Akiyama, J Hattori, E Oka

{"title":"Photosensitive fits elicited by TV animation: an electroencephalographic study.","authors":"H Enoki, T Akiyama, J Hattori, E Oka","doi":"10.1111/j.1442-200x.1998.tb02005.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb02005.x","url":null,"abstract":"Background: We carried out a clinical and electroencephalographic (EEG) study to reveal the pathophysiology of acute symptoms elicited by a TV animation program.Methods: Clinical data and EEG were obtained from 20 patients ranging in age from 6 to 30 years. A pattern presentation and an intermittent photic stimulation were performed.Results: Of 20 patients, 13 had a convulsion and seven had other symptoms, mainly nausea and/or vomiting. A photoparoxysmal response (PPR) was confirmed in 12 of 13 patients (92.3%) who had a convulsion. Only one of seven patients (14.3%) without a convulsion showed a PPR. The incidence of PPR was significantly higher in patients with convulsion than those without convulsion. There were no significant differences in the family history of convulsion, gender, parameters associated with TV watching and basic EEG between the two groups. All patients with PPR had a convulsion or consciousness disturbance.Conclusion: Acute symptoms, such as convulsion and impairment of consciousness, are supposed to be based on photosensitivity.","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 6","pages":"626-30"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb02005.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20799797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Pocket Monster incident and low luminance visual stimuli: special reference to deep red flicker stimulation. 口袋怪物事件和低亮度视觉刺激:特别参考深红色闪烁刺激。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb02006.x

T Takahashi, Y Tsukahara

{"title":"Pocket Monster incident and low luminance visual stimuli: special reference to deep red flicker stimulation.","authors":"T Takahashi, Y Tsukahara","doi":"10.1111/j.1442-200x.1998.tb02006.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb02006.x","url":null,"abstract":"On the evening of 16 December 1997 approximately 700 people around the nation (mostly children) were rushed to hospitals and treated for seizure symptoms. The youngsters had been watching the vastly popular TV animated cartoon series Pocket Monsters (Pokemon). We designated those individuals as a main group, who presumably had simultaneous occurrence of visually induced seizures. Follow-up studies revealed that 5-10.4% of Pokemon viewers had various minor symptoms not requiring hospital treatment. We designated those as a subgroup. Due to an official report regarding the problematic TV scene as a low luminance, 12 Hz alternating red/blue stimulus, we attempted an accounting of the Pokemon incident, with regard to the main group in particular, on the basis of electroencephalographic activation by use of low luminance 15 Hz deep red flicker stimulation. In order to explain the entire Pokemon incident, including symptoms experienced by individuals of the subgroup, we considered the possibility that some healthy youngsters may have latent photosensitivity and we thought that such a sensitivity might be disclosed by use of low luminance deep red flicker stimulation which is more provocative of photoparoxysmal response than ordinary high luminance stroboscopic intermittent photic stimulation. For prevention of visually induced seizures by TV viewing, we stress that care should be taken to test not only red flicker but also flickering geometric pattern stimuli.","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 6","pages":"631-7"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb02006.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20799798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

An infant with 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase/isomerase deficiency presenting with typical neonatal hepatitis syndrome: the first Japanese case. 3 -羟基- δ 5- c27 -类固醇脱氢酶/异构酶缺乏的婴儿表现为典型的新生儿肝炎综合征:日本首例病例。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb02007.x

S Terazawa, A Kimura, T Inoue, T Murai, T Kurosawa, A Takao

引用次数: 6

Juvenile chronic arthritis profile in Greek children. 希腊儿童的青少年慢性关节炎概况。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb01990.x

C Dracou, N Constantinidou, A Constantopoulos

{"title":"Juvenile chronic arthritis profile in Greek children.","authors":"C Dracou, N Constantinidou, A Constantopoulos","doi":"10.1111/j.1442-200x.1998.tb01990.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01990.x","url":null,"abstract":"Background: Juvenile chronic arthritis (JCA) is the commonest autoimmune rheumatic disease in childhood and presents different clinical subtypes. Juvenile chronic arthritis is considered to be of a polygenic nature and its genetic background is still under investigation. The clinical profile of JCA in the Greek population has not been studied completely. This study retrospectively analyzed the clinical and immunological features of JCA in Greek children presented between 1989 and 1994. Human leukocyte antigen (HLA)-positive or -negative associations in the different clinical subtypes were also detected. The findings of this study were correlated with those reported from other populations.Methods and results: Antinuclear antibodies (ANA) anti-ds DNA and anti-extractable nuclear antigen antibodies were estimated by immunofluorescent and ELISA assays. Human leukocyte antigen typing was performed by microlymphocytotoxicity, using immunobeads. The peak ages of JCA onset were between 2 and 5 years and also between 9 and 12 years. There was a high female predominance in pauciarticular and polyarticular groups. The most common disease was pauciarticular (58.7%) followed by systemic (25%) arthritis. The incidence of eye involvement was 12.5% and presented only in the pauciarticular group. Overall, ANA positivity was 53.7%, increasing to 90% in pauciarticular cases associated with chronic uveitis. In the early onset (EOPA) pauciarticular subtype, positive-HLA associations with alleles DR11 and DR8 were shown. In the late onset pauciarticular (LOPA) group only B27 allele was increased.Conclusions: The results of this retrospective study did not reveal major differences between JCA in Greek children compared with other Caucasian series.","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 6","pages":"558-63"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01990.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20799344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

A simple and efficient purification of transduced cells by using green fluorescent protein gene as a selection marker. 利用绿色荧光蛋白基因作为选择标记，简单高效地纯化转导细胞。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb01995.x

T Shimizu, K Ando, M Kimura, H Miyatake, S Inokuchi, I Takakura, M Migita, T Shimada, S Kato

{"title":"A simple and efficient purification of transduced cells by using green fluorescent protein gene as a selection marker.","authors":"T Shimizu, K Ando, M Kimura, H Miyatake, S Inokuchi, I Takakura, M Migita, T Shimada, S Kato","doi":"10.1111/j.1442-200x.1998.tb01995.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01995.x","url":null,"abstract":"Background: Simple and efficient method for the selection of transduced cells would greatly facilitate the clinical utilization of retrovirus vectors. We developed a therapeutic bicistronic retrovirus vector for Gaucher disease, MFG-GC-GFP, which contains the human glucocerebrosidase (GC) gene and the green fluorescent protein (GFP) gene of the jellyfish Aequorea victoria as a vital selection marker, and investigated its applicability as gene therapy for Gaucher disease.Methods and results: A packaging cell line, GP + envAM12, was transfected with MFG-GC-GFP and, thus, produced a high titer recombinant virus (1.0 x 10(6) c.f.u./mL) in the culture supernatant. The expression level of GFP was correlated with the virus production in cells. The recombinant virus infected skin fibroblasts from a Gaucher patient and a sorted fraction of the cells expressing GFP by flow cytometry exhibited almost a six-fold higher activity of GC than normal fibroblasts.Conclusions: These data indicate that MFG-GC-GFP enables the one-step purification of a transduced fraction of target cells and is, therefore, considered to be a useful therapeutic vector for the experimental gene therapy of Gaucher disease.","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 6","pages":"586-92"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01995.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20799349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hepatic damage in gluten sensitive enteropathy. 麸质敏感性肠病的肝损害。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb01997.x

B Altuntaş, A Kansu, N Girgin

{"title":"Hepatic damage in gluten sensitive enteropathy.","authors":"B Altuntaş, A Kansu, N Girgin","doi":"10.1111/j.1442-200x.1998.tb01997.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01997.x","url":null,"abstract":"Background: Gluten sensitive enteropathy has been reported to occur concomitantly with liver abnormalities, such as primary biliary cirrhosis, chronic active hepatitis and primary sclerosing cholangitis.Methods: Duodenal biopsy was performed in nine children (all with short stature, five with chronic diarrhea and three with hepatosplenomegaly of unknown etiology) with a possible diagnosis of gluten sensitive enteropathy. All of the patients had different abnormalities in serum aminotransferase levels. With the help of laboratory investigations, viral, autoimmune, metabolic and toxic etiologies which cause hepatic damage were excluded. Liver biopsy was performed in five of these patients, two showing fibrosis and three nonspecific reactive changes. Gliadin antibodies were measured in six cases.Results: Intestinal mucosal histopathology was compatible with gluten sensitive enteropathy in all patients. While immunoglobulin (Ig) G gliadin antibodies were positive in all cases, only three cases were found to have positive IgA gliadin antibodies. After a gluten-free diet, levels of transaminases fell to normal within 3 months and remained so in seven of these patients. A second intestinal biopsy, which was performed after 1 year of gluten-free diet revealed normal intestinal mucosa in all patients.Conclusion: Gluten sensitive enteropathy should be considered when evaluating a child with elevated levels of serum transaminase and in cases with cryptogenic liver disease.","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 6","pages":"597-9"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01997.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20799789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Prognostic value of proliferating cell nuclear antigen immunostaining in pediatric rhabdomyosarcomas. 增殖细胞核抗原免疫染色对小儿横纹肌肉瘤的预后价值。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI: 10.1111/j.1442-200x.1998.tb01993.x

G Tokuç, O Doğan, I Ayan, R Kebudi, S Doğan, M Demiryont, H Camlica

{"title":"Prognostic value of proliferating cell nuclear antigen immunostaining in pediatric rhabdomyosarcomas.","authors":"G Tokuç, O Doğan, I Ayan, R Kebudi, S Doğan, M Demiryont, H Camlica","doi":"10.1111/j.1442-200x.1998.tb01993.x","DOIUrl":"https://doi.org/10.1111/j.1442-200x.1998.tb01993.x","url":null,"abstract":"Background: The levels of proliferating cell nuclear antigen (PCNA) are almost negligible in long-term quiescent cells and increase dramatically during the cell cycle. Recently, the monoclonal antibodies to PCNA have been used to demonstrate the proliferative component of paraffin-embedded tumor tissues. It has been shown to be available as a simple histological marker of proliferative activity and the PCNA labeling index has been correlated with the prognosis of several malignant neoplasms.Methods: Formalin fixed, paraffin embedded tissue specimens of 29 primary pediatric rhabdomyosarcomas were immunostained by using an anti-PCNA monoclonal antibody (DAKO PCNA PC10). The relationship between the PCNA index and prognosis, clinicopathological features and survival were assessed retrospectively.Results: The mean PCNA index for the whole series was 54%. There was no correlation between PCNA index and any of the clinicopathological characteristics. However, patients having tumors with a high (> 54%) PCNA index demonstrated significantly lower survival rates than tumors with a low (< 54%) PCNA index (P = 0.01). Moreover, there were significantly more patients with relapse or progressive disease in the high PCNA index group (P = 0.005).Conclusion: The PCNA labeling index can be a useful prognostic factor and a good indicator of recurrence and/or survival in patients with rhabdomyosarcoma.","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 6","pages":"573-9"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01993.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20799347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7