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静脉注射胺碘酮治疗儿童耐药速性心律失常的有效性和安全性。

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-12-01 DOI:10.1111/j.1442-200x.1998.tb01992.x
A Celiker, N Ceviz, S Ozme
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引用次数: 41

摘要

背景:儿童静脉注射胺碘酮的经验有限。在这项研究中，我们的经验，静脉注射胺碘酮在儿童急性危及生命或慢性心动过速。方法和结果:12例患者，平均年龄3.4±3.1岁，范围9个月-10年(2例为不间断性室性心动过速，1例为异位性房性心动过速，2例为房室再入性心动过速(3次发作)，4例为术后或先天性结异位性心动过速，2例为慢速心动过速综合征，1例为房性心动过速)，共13次心动过速发作，静脉注射胺碘酮治疗。6例患者左心室收缩功能下降。在11例患者中，在静脉注射胺碘酮之前尝试了两种药物(范围1 - 4)的中位数，包括腺苷输注和5例直流心律转复，但均未成功。在所有发作中，胺碘酮的负荷剂量为5 mg/kg，输注时间超过1 h。有12次发作需要维持输注。10例(77%)胺碘酮被认为有效，1例(7.6%)部分有效(结性异位心动过速)，2例(15.4%)无效(病窦综合征、房性心动过速)。治疗效果中位时间为30小时(范围1-103小时)，平均有效维持剂量为10 +/- 4.7微克/千克每分钟(范围5-15微克/千克每分钟)。1例患者出现轻度低血压，3例患者出现蜂窝织炎，但均无需终止治疗。结论:静脉注射胺碘酮是一种安全有效的抗心律失常药物，可用于急性危及生命的慢性快速心律失常和左室收缩功能下降的儿童。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Effectiveness and safety of intravenous amiodarone in drug-resistant tachyarrhythmias of children.
Background: Experience with pediatric use of intravenous amiodarone is limited. In this study, our experiences with intravenous amiodarone in children with acute life‐threatening or chronic tachyarrhythmias are reviewed.
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Acta paediatrica Japonica : Overseas edition
Acta paediatrica Japonica : Overseas edition
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