Acta chemica Scandinavica (Copenhagen, Denmark : 1989)最新文献_第9页

Partial purification of a cyanobacterial membrane protein with amino terminal sequence similarity to the N-methylphenylalanine pilins. 氨基末端序列与n -甲基苯丙氨酸肽相似的一种蓝藻膜蛋白的部分纯化。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-07-01 DOI: 10.3891/acta.chem.scand.48-0578

B F Nore, M A Harrison, J N Keen, J F Allen

引用次数: 1

Stereoselectivity of Baker's yeast reduction of 2-propanones: influence of substituents. 贝克酵母还原2-丙酮的立体选择性:取代基的影响。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-06-01 DOI: 10.3891/acta.chem.scand.48-0506

V Waagen, V Partali, I Hollingsaeter, M S Huang, T Anthonsen

引用次数: 24

Synthesis and antiviral activity of three pyrazole analogues of distamycin A. 三种吡唑类双霉素A的合成及其抗病毒活性。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-06-01 DOI: 10.3891/acta.chem.scand.48-0498

L Ding, L Grehn, E De Clercq, G Andrei, R Snoeck, J Balzarini, B Fransson, U Ragnarsson

{"title":"Synthesis and antiviral activity of three pyrazole analogues of distamycin A.","authors":"L Ding, L Grehn, E De Clercq, G Andrei, R Snoeck, J Balzarini, B Fransson, U Ragnarsson","doi":"10.3891/acta.chem.scand.48-0498","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0498","url":null,"abstract":"The synthesis of three new monopyrazole analogues of the antiviral compound distamycin A is reported. Suitably protected 4-amino-1-methylpyrrole-2-carboxylic acid and 3-amino-1-methylpyrazole-5-carboxylic acid derivatives were chosen as starting materials. The construction of the trimeric polyamide framework was accomplished by assembly of the monomeric precursors under condensing conditions by analogy with our previous methodology, although with significant improvements in some pivotal steps. After chromatographic purification and spectroscopic characterisation, the analogues were assayed for antiviral activity. Compounds 7a-c inhibited vaccinia virus at a concentration similar to or lower than distamycin A and the related antibiotic netropsin. Analogues 7b and 7c exhibited an antiviral effect comparable to those of distamycin A and netropsin against HSV-1 and HSV-2, whereas their antiviral activity against several other viruses including HIV-1 and HIV-2 was somewhat lower. The cellular toxicity of 7a-c toward different host cell types proved to be of similar magnitude or lower than those of distamycin A and netropsin.","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 6","pages":"498-505"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19054833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequence-selective metal ion binding to DNA hexamers. 序列选择性金属离子与DNA六聚体结合。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-05-01 DOI: 10.3891/acta.chem.scand.48-0388

S Steinkopf, E Sletten

{"title":"Sequence-selective metal ion binding to DNA hexamers.","authors":"S Steinkopf, E Sletten","doi":"10.3891/acta.chem.scand.48-0388","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0388","url":null,"abstract":"Base-selective interaction between divalent metal ions and DNA oligomers has been studied by 1D and 2D NMR spectroscopy. Titration with paramagnetic metal ions induces selective line broadening of resonances from protons close to the binding site. Also the intensities of 2D NOESY cross-peaks involving paramagnetic affected protons will be quenched. Two hexamers, 5'-d(CGTACG)2 (I) and 5' (GCATGC)2 (II) have been titrated with Mn(II) ions. Manganese binds selectively to the terminal guanine, G1, in sequence II as manifested through pronounced paramagnetic line broadening and loss of intensities of NOESY cross-peaks involving G-H8 protons. The second guanine, G5, and the non-guanine residues are appreciably less affected. In sequence I both guanines, G2 and G6, are the targets for selective metal binding as judged from G-H8 line broadening. The extent of interaction is almost identical for the two G-residues and comparable to that observed for G1 in sequence II. The metal binding site in the duplexes is most likely nitrogen G-N7. Selective metal binding to oligonucleotides may be related to sequence-dependent variation in molecular electrostatic potentials (MEP) along the chain.","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 5","pages":"388-92"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19012618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Analogs of galanin (1-16) modified in positions 1-3 as ligands to rat hypothalamic galanin receptors. 甘丙氨酸(1-16)类似物在1-3位修饰为大鼠下丘脑甘丙氨酸受体的配体。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-05-01 DOI: 10.3891/acta.chem.scand.48-0434

C Rivera Baeza, K Kask, U Langel, T Bartfai, A Undén

{"title":"Analogs of galanin (1-16) modified in positions 1-3 as ligands to rat hypothalamic galanin receptors.","authors":"C Rivera Baeza, K Kask, U Langel, T Bartfai, A Undén","doi":"10.3891/acta.chem.scand.48-0434","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0434","url":null,"abstract":"Structure-activity relationship (SAR) studies have revealed that the first three residues of galanin (Gly1-Trp2-Thr3) are of critical importance for high-affinity binding to the galanin receptor. Furthermore degradation studies have shown that galanin is easily cleaved to yield inactive fragments in rat hypothalamus (t1/2 = 100 min). To obtain galanin receptor ligands with long-lasting biological activity the amino-terminus of galanin must be protected. We have therefore synthesized analogs of rat galanin(1-16) carrying modifications at the three amino-termini of galanin. All modifications of the peptide backbone flanking Trp2 as in the analogs [N-Me-Trp2]-galanin(1-16), [Tcc2]-galanin-(1-16), (Trp2-psi[CH2NH]-Thr3)-galanin-(1-16) produced a dramatic loss of affinity toward the galanin receptor. [N-Me-Thr3]-galanin(1-16) was the most active of the peptide backbone modified analogs (KD = 997 +/- 1 nM). Modifications of the indole ring in Trp2 ([For-Trp2]-galanin-(1-16), [Tcc2]-galanin-(1-16)) yielded analogs which, at concentrations up to 10 microM, did not displace [125I]galanin binding. N-Methylation of Gly1 by the introduction of sarcosine ([Sar1]-galanin(1-16)) did not significantly affect the ligand-binding properties of galanin(1-16) (KD = 8.7 +/- 0.1 nM).","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 5","pages":"434-8"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19012619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Synthesis of the 2"-hydroxy, 4"-deoxy and 4"-epi analogues of beta-D-GalNAc-(1-->3)-alpha-D-Gal-(1-->4)-beta-D-Gal, the terminal trisaccharide of globotetraose. 合成β -d - galnac -(1—>3)- α -d - gal -(1—>4)- β -d - gal末端三糖的2”-羟基、4”-脱氧和4”-外生类似物。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-04-01 DOI: 10.3891/acta.chem.scand.48-0356

U Nilsson, A Wendler, G Magnusson

引用次数: 0

Facile preparation of 1,6-anhydrohexoses using solvent effects and a catalytic amount of a Lewis acid. 利用溶剂效应和路易斯酸的催化量制备1,6-无氢己糖。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-03-01 DOI: 10.3891/acta.chem.scand.48-0228

P M Aberg, B Ernst

引用次数: 21

Malonofungin: an antifungal aminomalonic acid from Phaeoramularia fusimaculans. malonfungin:一种从镰刀菌中提取的抗真菌氨基丙酸。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-03-01 DOI: 10.3891/acta.chem.scand.48-0240

N Berova, J Breinholt, G W Jensen, A Kjaer, L C Lo, K Nakanishi, R I Nielsen, C E Olsen, C Pedersen, C E Stidsen

引用次数: 9

5'-Azido and 5'-fluoro alpha-nucleosides as analogues of AZT and FLT. 5'-叠氮和5'-氟核苷作为AZT和FLT的类似物。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-03-01 DOI: 10.3891/acta.chem.scand.48-0215

L Schmidt, E B Pedersen, C Nielsen

引用次数: 12

HPLC and NMR investigation of the serum amine oxidase catalyzed oxidation of polyamines. 血清胺氧化酶催化多胺氧化的HPLC和NMR研究。

Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-01-01 DOI: 10.3891/acta.chem.scand.48-0052

G Houen, K Bock, A L Jensen

引用次数: 34