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Acta chemica Scandinavica (Copenhagen, Denmark : 1989)最新文献

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Friedländer synthesis of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Friedländer食品致癌物2-氨基-1-甲基-6-苯咪唑[4,5-b]吡啶的合成。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1995-05-01 DOI: 10.3891/acta.chem.scand.49-0361
S Lindström
{"title":"Friedländer synthesis of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.","authors":"S Lindström","doi":"10.3891/acta.chem.scand.49-0361","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.49-0361","url":null,"abstract":"<p><p>2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine has been prepared in 26% yield from 3-amino-2-phenylpropenal and creatinine which were heated with N,O-bis(trimethylsilyl)acetamide at 120 degrees C for 2 h. Under certain other conditions, the main product was a pyrimidine derivative.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"49 5","pages":"361-3"},"PeriodicalIF":0.0,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18766803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Incrustoporin, a new antibiotic from Incrustoporia carneola (Bres.) Ryv. (Basidiomycetes). 红曲霉毒素，一种新的抗生素。（担子菌门）。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1995-03-01 DOI: 10.3891/acta.chem.scand.49-0233
S Zapf, T Anke, O Sterner
{"title":"Incrustoporin, a new antibiotic from Incrustoporia carneola (Bres.) Ryv. (Basidiomycetes).","authors":"S Zapf,&nbsp;T Anke,&nbsp;O Sterner","doi":"10.3891/acta.chem.scand.49-0233","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.49-0233","url":null,"abstract":"","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"49 3","pages":"233-4"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18773901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Facile desulfurization of cyclic thioureas by hydrogen peroxide in acetic acid. 双氧水在乙酸中快速脱硫环硫脲的研究。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1995-03-01 DOI: 10.3891/acta.chem.scand.49-0225
S Grivas, E Ronne
{"title":"Facile desulfurization of cyclic thioureas by hydrogen peroxide in acetic acid.","authors":"S Grivas,&nbsp;E Ronne","doi":"10.3891/acta.chem.scand.49-0225","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.49-0225","url":null,"abstract":"<p><p>A simple, mild and synthetically useful method for the desulfurization of cyclic thioureas and related compounds, existing as thiol-thione tautomeric mixtures, by hydrogen peroxide in acetic acid is proposed. The effect of substituting different solvents for the acetic acid was investigated.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"49 3","pages":"225-9"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18773899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An alternative synthesis of the NMDA antagonist CGS 19755 via free radical carbamoylation of ethyl isonicotinate. 异烟酸乙酯自由基氨基化法合成NMDA拮抗剂CGS 19755。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1995-03-01 DOI: 10.3891/acta.chem.scand.49-0230
I Martin, J Anvelt, L Vares, I Kühn, A Claesson
{"title":"An alternative synthesis of the NMDA antagonist CGS 19755 via free radical carbamoylation of ethyl isonicotinate.","authors":"I Martin,&nbsp;J Anvelt,&nbsp;L Vares,&nbsp;I Kühn,&nbsp;A Claesson","doi":"10.3891/acta.chem.scand.49-0230","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.49-0230","url":null,"abstract":"<p><p>The NMDA antagonist CGS 19755 (cis-4-phosphonomethyl-2-piperidinecarboxylic acid) has been prepared by applying Minisci reaction conditions [formamide, hydrogen peroxide, iron(II) sulfate] to ethyl isonicotinate, reduction of the ester with sodium borohydride, alcoholysis of the 2-carboxamide, formation of 4-(diethylphosphonomethyl)-2-pyridinecarboxylate, hydrogenation of the pyridine nucleus, and acid hydrolysis. The overall, unoptimized yield was around 11%. The procedure employs cheap starting materials, is practical and avoids the use of toxic and hazardous cyanotrimethylsilane which is used in the published procedure.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"49 3","pages":"230-2"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18773900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Synthesis of 15N-labelled Leu-enkephalins. 15n标记亮氨酸脑啡肽的合成。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1995-02-01 DOI: 10.3891/acta.chem.scand.49-0149
F Degerbeck, B Fransson, L Grehn, U Ragnarsson
{"title":"Synthesis of 15N-labelled Leu-enkephalins.","authors":"F Degerbeck,&nbsp;B Fransson,&nbsp;L Grehn,&nbsp;U Ragnarsson","doi":"10.3891/acta.chem.scand.49-0149","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.49-0149","url":null,"abstract":"","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"49 2","pages":"149-51"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18697929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Purification and characterization of the bovine pituitary luteinizing hormone releasing hormone M(r) 60,000 binding protein. 牛垂体黄体生成素释放激素M(r) 60000结合蛋白的纯化与鉴定。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-12-01 DOI: 10.3891/acta.chem.scand.48-0994
J Christiansen, G Houen
{"title":"Purification and characterization of the bovine pituitary luteinizing hormone releasing hormone M(r) 60,000 binding protein.","authors":"J Christiansen,&nbsp;G Houen","doi":"10.3891/acta.chem.scand.48-0994","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0994","url":null,"abstract":"<p><p>Luteinizing hormone releasing hormone (LHRH) regulates the release of luteinizing hormone and follicle stimulating hormone from the pituitary. This process takes place through interaction with high affinity membrane receptors. In addition LHRH inhibits the growth of several cancer cell lines through the interaction with M(r) 60,000 LHRH receptors. Here we describe the purification to homogeneity of the M(r) 60,000 bovine pituitary LHRH binding protein in amounts allowing N-terminal sequencing and peptide mapping. The procedure describes solubilization of luteinizing hormone releasing hormone receptors from homogenized bovine pituitaries in an active form by using the detergent Triton X-114. The receptors were retained in the Triton X-114 phase during temperature-dependent phase separation. Preparative phase separations were performed directly on solubilized bovine pituitary extracts. SDS-PAGE of the purified LHRH receptor after LHRH-immobilized affinity chromatography showed the presence of a single band with M(r) 60,000. Partial sequencing of this band after trypsin digestion of gel pieces revealed unknown sequences with a possible homology to other receptors including some G-protein coupled receptors.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 12","pages":"994-1000"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18863450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Human placental calreticulin: purification, characterization and association with other proteins. 人胎盘钙网蛋白:纯化、表征及与其它蛋白的结合。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-11-01 DOI: 10.3891/acta.chem.scand.48-0905
G Houen, C Koch
{"title":"Human placental calreticulin: purification, characterization and association with other proteins.","authors":"G Houen,&nbsp;C Koch","doi":"10.3891/acta.chem.scand.48-0905","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0905","url":null,"abstract":"<p><p>Calreticulin is an intracellular protein known to be involved in calcium binding, but is also known to appear as an autoantigen in certain autoimmune diseases. The cDNA sequence is known but the protein has not yet been well characterized at the amino acid level. Owing to the possible involvement of this protein in autoimmune disease and with the aim of making monoclonal antibodies for use in assay development and immunohistochemistry, we have purified calreticulin using human placental material. Amino acid analysis of the purified protein confirmed the cDNA-derived composition, and only one discrepancy between the cDNA-predicted sequence and the amino acid sequence was found by peptide mapping and microsequencing. The protein contains one disulfide bridge and has one free SH group and the protein is neither glycosylated nor phosphorylated. Affinity chromatography of a placental protein extract on a column with immobilized calreticulin showed the existence of at least six proteins interacting with calreticulin. Using the purified calreticulin in Western blots, two out of eight patients with autoimmune disease diagnosed as having anti DNA antibodies in their serum were found also to contain autoantibodies to calreticulin in their serum.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 11","pages":"905-11"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
The structure of a toroidal, neutral, homoleptic Ni(II) complex with a chelate dithiolate ligand, [Ni6(SCH2CH2CH2S)6]. 环状中性同感镍(II)配合物与螯合二硫酸盐配体的结构[Ni6(SCH2CH2CH2S)6]。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-11-01 DOI: 10.3891/acta.chem.scand.48-0929
J Sletten, J A Kovacs
{"title":"The structure of a toroidal, neutral, homoleptic Ni(II) complex with a chelate dithiolate ligand, [Ni6(SCH2CH2CH2S)6].","authors":"J Sletten,&nbsp;J A Kovacs","doi":"10.3891/acta.chem.scand.48-0929","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0929","url":null,"abstract":"","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 11","pages":"929-32"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18839337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Erythrocyte lipid extraction in alcohol-chloroform systems: a comparative study. 醇-氯仿系统中红细胞脂质提取的比较研究。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-09-01 DOI: 10.3891/acta.chem.scand.48-0753
W Q Wang, A Gustafson
{"title":"Erythrocyte lipid extraction in alcohol-chloroform systems: a comparative study.","authors":"W Q Wang,&nbsp;A Gustafson","doi":"10.3891/acta.chem.scand.48-0753","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0753","url":null,"abstract":"<p><p>Lipid extraction efficiency is variable when different methods are used on the same tissue. After a systematic comparison on erythrocytes, we found that this variability was due to several factors, such as the addition of alcohol and chloroform as a mixture, the use of repeated extractions or partition procedures after the extraction. Most important, however, was the uneven distribution of solvents and lipids in an apparently monophasic extraction system. This formation reduces lipid extraction and causes accumulation of lipids in the extract supernatant, which leads to an overestimation of the extracted lipid content. We recommend a one-step 18.75 volume of methanol-chloroform (1.5:1 v/v) method for lipid extraction from erythrocytes, with methanol added before chloroform. This method combines simplicity in the extraction procedure, complete extraction of cholesterol and total phospholipids, and reliability in the quantitation of the extracted lipids.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 9","pages":"753-8"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18942994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Pigment interferes with cholesterol analysis in erythrocyte lipid extracts: a procedure for removal. 红血球脂质提取物中色素干扰胆固醇分析:去除过程。
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) Pub Date : 1994-08-01 DOI: 10.3891/acta.chem.scand.48-0699
W Q Wang, A Gustafson
{"title":"Pigment interferes with cholesterol analysis in erythrocyte lipid extracts: a procedure for removal.","authors":"W Q Wang,&nbsp;A Gustafson","doi":"10.3891/acta.chem.scand.48-0699","DOIUrl":"https://doi.org/10.3891/acta.chem.scand.48-0699","url":null,"abstract":"<p><p>Removal of pigments from erythrocyte lipid extracts was achieved simply by adding isopropyl alcohol (2 ml) and silica gel H (0.05 g) to an aliquot of dried extract. This procedure is superior to other available methods because of its simplicity and high efficiency.</p>","PeriodicalId":76966,"journal":{"name":"Acta chemica Scandinavica (Copenhagen, Denmark : 1989)","volume":"48 8","pages":"699-700"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18916614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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