Friedländer synthesis of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

S Lindström
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引用次数: 6

Abstract

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine has been prepared in 26% yield from 3-amino-2-phenylpropenal and creatinine which were heated with N,O-bis(trimethylsilyl)acetamide at 120 degrees C for 2 h. Under certain other conditions, the main product was a pyrimidine derivative.

Friedländer食品致癌物2-氨基-1-甲基-6-苯咪唑[4,5-b]吡啶的合成。
以3-氨基-2-苯基原酸和肌酸酐为原料,用N, o-二(三甲基硅基)乙酰胺在120℃下加热2 h,以26%的收率制得2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶。在一定条件下,主要产物为嘧啶衍生物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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