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Envisioning hepatitis delta cure without functional hepatitis B cure. 设想没有功能性乙型肝炎治疗的丁型肝炎治疗。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-12-28 DOI: 10.24875/AIDSRev.M22000056
Vicente Soriano, Carmen de Mendoza, Pablo Barreiro
{"title":"Envisioning hepatitis delta cure without functional hepatitis B cure.","authors":"Vicente Soriano, Carmen de Mendoza, Pablo Barreiro","doi":"10.24875/AIDSRev.M22000056","DOIUrl":"https://doi.org/10.24875/AIDSRev.M22000056","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 4","pages":"200"},"PeriodicalIF":2.2,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10474117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversy around SARS-CoV-2 Reinfections. 关于SARS-CoV-2再感染的争议。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-12-28 DOI: 10.24875/AIDSRev.M22000058
Pablo Barreiro
{"title":"Controversy around SARS-CoV-2 Reinfections.","authors":"Pablo Barreiro","doi":"10.24875/AIDSRev.M22000058","DOIUrl":"https://doi.org/10.24875/AIDSRev.M22000058","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 4","pages":"199"},"PeriodicalIF":2.2,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10474116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcopenia in people living with HIV. A review. 艾滋病毒感染者的肌肉减少症。复习一下。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-12-28 DOI: 10.24875/AIDSRev.22000010
Paola Conde-Higuera, José J Garduño-García, Alfonso J Cruz-Jentoft, Gloria G Peña-Ordónez, Gabriel G Huitrón-Bravo
{"title":"Sarcopenia in people living with HIV. A review.","authors":"Paola Conde-Higuera,&nbsp;José J Garduño-García,&nbsp;Alfonso J Cruz-Jentoft,&nbsp;Gloria G Peña-Ordónez,&nbsp;Gabriel G Huitrón-Bravo","doi":"10.24875/AIDSRev.22000010","DOIUrl":"https://doi.org/10.24875/AIDSRev.22000010","url":null,"abstract":"<p><p>The aim of this review is to know the current status of sarcopenia in people living with acquired immunodeficiency virus, as well as predictors, prevalence, and associated factors. Searches were done in PubMed, Scielo, and ScienceDirect databases (January 2010 to August 2021), using predefined search terms. Prevalence, intervention, and meta-analysis studies investigating sarcopenia or muscle mass and function in people living with Human immunodeficiency virus (PLHIV) were selected. We identified reports of high prevalence and increased risk for sarcopenia due to factors such as prolonged exposure to antiretroviral drugs, lack of physical activity, central obesity, drug use, and other sociodemographic factors, as well as disease duration. HIV should be considered a risk factor for sarcopenia, and evaluation of sarcopenia should be included as part of the comprehensive medical care of PLHIV. Forceful actions are required to prevent muscle weakness, especially in stages before old age with actions aimed at preserving strength and function.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 4","pages":"166-172"},"PeriodicalIF":2.2,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10476116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between cytokine storm and SARS-CoV-2 infection's worsening. 细胞因子风暴与SARS-CoV-2感染恶化的关系
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-10-25 DOI: 10.24875/AIDSRev.21000070
Baya Guermouche, Majda Dali-Sahi, Nouria Dennouni-Medjati, Youssouf Kachekouche, Hafida Merzouk
{"title":"Relationship between cytokine storm and SARS-CoV-2 infection's worsening.","authors":"Baya Guermouche,&nbsp;Majda Dali-Sahi,&nbsp;Nouria Dennouni-Medjati,&nbsp;Youssouf Kachekouche,&nbsp;Hafida Merzouk","doi":"10.24875/AIDSRev.21000070","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000070","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 3","pages":"115-121"},"PeriodicalIF":2.2,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39762465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A cure for HIV on the horizon. 治愈艾滋病毒的方法即将问世。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-05-11 DOI: 10.24875/aidsrev.m22000048
A. Treviño, V. Soriano
{"title":"A cure for HIV on the horizon.","authors":"A. Treviño, V. Soriano","doi":"10.24875/aidsrev.m22000048","DOIUrl":"https://doi.org/10.24875/aidsrev.m22000048","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45821355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
News from CROI 2022 - caveats using antiretrovirals as HIV prophylaxis. 来自CROI 2022的新闻-使用抗逆转录病毒药物作为艾滋病毒预防的警告。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-05-11 DOI: 10.24875/aidsrev.m22000049
P. Barreiro, V. Soriano
{"title":"News from CROI 2022 - caveats using antiretrovirals as HIV prophylaxis.","authors":"P. Barreiro, V. Soriano","doi":"10.24875/aidsrev.m22000049","DOIUrl":"https://doi.org/10.24875/aidsrev.m22000049","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45038053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research progress on HIV-1 immune escape mechanisms. HIV-1免疫逃逸机制研究进展。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-05-03 DOI: 10.24875/AIDSRev.21000068
Yuanxi Meng, Ji-Xin Zhong, Yanhan Lv, Wei Zou
{"title":"Research progress on HIV-1 immune escape mechanisms.","authors":"Yuanxi Meng, Ji-Xin Zhong, Yanhan Lv, Wei Zou","doi":"10.24875/AIDSRev.21000068","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000068","url":null,"abstract":"Although highly active antiretroviral therapy has transformed HIV-1 infection into a manageable chronic disease, the development of an effective vaccine is still an important and challengeable research field of HIV-1 treatment. The challenge arises from an enormous diversity of HIV-1 strains and their rapid evolution ahead of effective immune responses. HIV-1 evasion from host immunity contributes to viral spread and pathogenesis, thus understanding the mechanisms of HIV-1 immune evasion is important. In this review, we summarized our present knowledge on the mechanisms how HIV-1 escapes immune responses. Such knowledge will help with the design of effective vaccines capable of inducing immune control of HIV-1.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47879572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Unexplained hepatitis in children after lifting COVID-19 pandemic restrictions. 解除新冠肺炎疫情限制后儿童出现不明原因肝炎。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-27 DOI: 10.24875/AIDSRev.M22000050
P. Barreiro
{"title":"Unexplained hepatitis in children after lifting COVID-19 pandemic restrictions.","authors":"P. Barreiro","doi":"10.24875/AIDSRev.M22000050","DOIUrl":"https://doi.org/10.24875/AIDSRev.M22000050","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41955331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Risk factors associated with pulmonary arterial hypertension among HIV-infected adults: A meta-analysis and systematic review. hiv感染成人肺动脉高压相关的危险因素:荟萃分析和系统评价
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000056
Ying Liu, Junyan Han, Bei Li, Jing Xiao, Leidan Zhang, Hongxin Zhao
{"title":"Risk factors associated with pulmonary arterial hypertension among HIV-infected adults: A meta-analysis and systematic review.","authors":"Ying Liu,&nbsp;Junyan Han,&nbsp;Bei Li,&nbsp;Jing Xiao,&nbsp;Leidan Zhang,&nbsp;Hongxin Zhao","doi":"10.24875/AIDSRev.21000056","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000056","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) occurs more frequently in patients with HIV infection than in general population. The predictive value of HIV-related factors and traditional cardiovascular factors with PAH is inconsistent across studies. The objective is to determine the roles of HIV-related risk factors and traditional cardiovascular risk factors in the development of PAH in adults with HIV. We searched Pubmed/Medline, Embase, Web of Science, and Google Scholar to identify studies published between January 1, 2000 and February 23, 2021 on risk factors associated with PAH among people living with HIV (PLWH). Ten studies were included for final analysis. PLWH with PAH had higher mean age (weighted mean difference [WMD] = 2.27, 95% confidence interval [CI] 0.31 ~ 4.24), and lower mean CD4 cell count (WMD = -95.8, 95% CI -153.41 ~ -38.2). Meanwhile, they were more likely to have detectable viral load (odds ratio [OR] = 1.36, 95% CI 1.16 ~ 1.60), to accompany arterial hypertension (OR = 2.02, 95% CI 1.51 ~ 2.71) and less likely to receive antiretroviral therapy (ART) (OR = 0.84, 95% CI 0.72 ~ 0.99). Besides, more intravenous drug users were observed in HIV-infected adults with PAH (OR = 2.25, 95% CI 1.51 ~ 3.33). HIV infection itself and ART impact PAH in two opposite ways. Traditional cardiovascular factors such as arterial hypertension, and older age are also important to the development of PAH. Screening HIV-related factors and traditional cardiovascular factors may help to target and manage patients at risk.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 2","pages":"59-68"},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39694670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of natural HIV-1 control. HIV-1自然控制的决定因素。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000048
Ana Moyano, Thumbi Ndung'u, Jaclyn K. Mann
{"title":"Determinants of natural HIV-1 control.","authors":"Ana Moyano,&nbsp;Thumbi Ndung'u,&nbsp;Jaclyn K. Mann","doi":"10.24875/AIDSRev.21000048","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000048","url":null,"abstract":"<p><p>HIV-1 infection usually progresses to AIDS within 10 years in antiretroviral therapy untreated individuals, but there is a group of infected individuals, known as controllers, who maintain low plasma HIV-1 RNA levels and normal CD4+ T-cell counts for many years. Evidence suggests that the mechanisms of viral control in these individuals are heterogeneous. In this review, we highlight the viral and host factors, particularly host immunological and immunogenetic factors that are associated with controller status. Despite the broad heterogeneity within controllers, there is compelling evidence that cytotoxic CD8+ T lymphocyte responses act as the main driver of control in the majority of these individuals, especially in those with protective HLA-I alleles. Further investigation of controllers without protective HLA-I alleles is required as it seems that this subset exhibits more durable control of HIV-1 disease progression. Understanding the immune defense mechanisms in controllers provides hope for harnessing these responses in the general population, either for protective or therapeutic vaccines or to achieve a functional cure in infected individuals.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 2","pages":"51-58"},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39815820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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