AIDS reviews最新文献_第6页

Unexplained hepatitis in children after lifting COVID-19 pandemic restrictions. 解除新冠肺炎疫情限制后儿童出现不明原因肝炎。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-04-27 DOI: 10.24875/AIDSRev.M22000050

P. Barreiro

引用次数: 1

Malignancies in people living with HIV. 艾滋病毒感染者的恶性肿瘤。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000057

Qiqiang Zhou, Wei Li, Lingbo Xia, Ruixiang Zou, Xinping Chen, Wei Zou

引用次数: 2

Determinants of natural HIV-1 control. HIV-1自然控制的决定因素。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000048

Ana Moyano, Thumbi Ndung'u, Jaclyn K. Mann

引用次数: 2

Risk factors associated with pulmonary arterial hypertension among HIV-infected adults: A meta-analysis and systematic review. hiv感染成人肺动脉高压相关的危险因素:荟萃分析和系统评价

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000056

Ying Liu, Junyan Han, Bei Li, Jing Xiao, Leidan Zhang, Hongxin Zhao

{"title":"Risk factors associated with pulmonary arterial hypertension among HIV-infected adults: A meta-analysis and systematic review.","authors":"Ying Liu, Junyan Han, Bei Li, Jing Xiao, Leidan Zhang, Hongxin Zhao","doi":"10.24875/AIDSRev.21000056","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000056","url":null,"abstract":"Pulmonary arterial hypertension (PAH) occurs more frequently in patients with HIV infection than in general population. The predictive value of HIV-related factors and traditional cardiovascular factors with PAH is inconsistent across studies. The objective is to determine the roles of HIV-related risk factors and traditional cardiovascular risk factors in the development of PAH in adults with HIV. We searched Pubmed/Medline, Embase, Web of Science, and Google Scholar to identify studies published between January 1, 2000 and February 23, 2021 on risk factors associated with PAH among people living with HIV (PLWH). Ten studies were included for final analysis. PLWH with PAH had higher mean age (weighted mean difference [WMD] = 2.27, 95% confidence interval [CI] 0.31 ~ 4.24), and lower mean CD4 cell count (WMD = -95.8, 95% CI -153.41 ~ -38.2). Meanwhile, they were more likely to have detectable viral load (odds ratio [OR] = 1.36, 95% CI 1.16 ~ 1.60), to accompany arterial hypertension (OR = 2.02, 95% CI 1.51 ~ 2.71) and less likely to receive antiretroviral therapy (ART) (OR = 0.84, 95% CI 0.72 ~ 0.99). Besides, more intravenous drug users were observed in HIV-infected adults with PAH (OR = 2.25, 95% CI 1.51 ~ 3.33). HIV infection itself and ART impact PAH in two opposite ways. Traditional cardiovascular factors such as arterial hypertension, and older age are also important to the development of PAH. Screening HIV-related factors and traditional cardiovascular factors may help to target and manage patients at risk.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39694670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

International outbreak of monkeypox in men having sex with men. 猴痘在男男性行为者中的国际暴发。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.M22000051

Vicente Soriano, Octavio Corral

引用次数: 11

A greater virulent HIV-1 subtype B variant has circulated in The Netherlands since the 1990's. 自20世纪90年代以来，一种毒性更强的HIV-1 B亚型变体在荷兰流行。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.M22000047

A. Treviño, V. Soriano

引用次数: 0

The Prevalence of HIV-infected Patients with Virological Suppression but a CD4⁺ T-cell Count of ≤ 200 Cells/mm³ after Highly Active Antiretroviral Therapy Initiation: A Meta-analysis. 高活性抗逆转录病毒治疗开始后，病毒学抑制但CD4+ t细胞计数≤200细胞/mm3的hiv感染患者的患病率:一项荟萃分析

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.21000011

Zhihui Wu, Chunling Yang, Yuqing Ma, Yueyuan Wang, Zhenkui Zhang, Zhibin Liu, Pengyu Li, Huijun Guo, Yantao Jin

{"title":"The Prevalence of HIV-infected Patients with Virological Suppression but a CD4+ T-cell Count of ≤ 200 Cells/mm3 after Highly Active Antiretroviral Therapy Initiation: A Meta-analysis.","authors":"Zhihui Wu, Chunling Yang, Yuqing Ma, Yueyuan Wang, Zhenkui Zhang, Zhibin Liu, Pengyu Li, Huijun Guo, Yantao Jin","doi":"10.24875/AIDSRev.21000011","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000011","url":null,"abstract":"Highly active antiretroviral therapy (HAART) strongly inhibits HIV replication. However, many patients show suboptimal immune recovery (SIR), as defined by virological suppression (i.e. low viral load) with a CD4+ T-cell count of ≤ 200 cells/mm3, after HAART initiation. Here, we performed a systematic evaluation of the SIR prevalence among HIV-infected patients in cohort studies. We searched PubMed, Cochrane Library, Embase, CNKI, Wanfang database, and Chinese Biomedicine Database for cohort studies about HIV-infected participants whose CD4+ T-cell count was ≤ 200 cells/mm3 but still had virological suppression after HAART initiation. The SIR prevalence from each of those cohort studies was pooled into a random-effect meta-analysis. We obtained two kinds of pooled post-HARRT initiation SIR prevalence: one among participants with virological suppression (11 cohort studies involving 18,672 participants), and the other among all HIV-infected participants (seven cohort studies involving 12,063 participants). The pooled SIR prevalence among HIV-infected patients with virological suppression after HAART initiation was 43% (95% confidence interval [CI], 34-51%) at 6 months post-HAART initiation and 10% (95% CI, 5-18%) at 36 months post-HAART initiation; among all HIV-infected patients after HAART initiation, it was 17% (95% CI, 0-55%) and 5% (95% CI, 2-10%) at 6 and 36 months post-HAART initiation, respectively. The SIR prevalence among HIV-infected patients is high at 6 months post-HAART initiation, but its prevalence gradually reduces over time under continuous HAART. Thus, it is important to follow-up on variations in the CD4+ T-cell count and viral load.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39252451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Oral antivirals for the prevention and treatment of SARS-CoV-2 infection. 预防和治疗 SARS-CoV-2 感染的口服抗病毒药物。

IF 1.9 4区医学

AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.22000001

Vicente Soriano, Carmen de-Mendoza, Benson Edagwa, Ana Treviño, Pablo Barreiro, José V Fernandez-Montero, Howard E Gendelman

{"title":"Oral antivirals for the prevention and treatment of SARS-CoV-2 infection.","authors":"Vicente Soriano, Carmen de-Mendoza, Benson Edagwa, Ana Treviño, Pablo Barreiro, José V Fernandez-Montero, Howard E Gendelman","doi":"10.24875/AIDSRev.22000001","DOIUrl":"10.24875/AIDSRev.22000001","url":null,"abstract":"Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against severe COVID-19 disease manifestations and complications. However, waning immunity and emergence of vaccine escape mutants remains a growing threat. This is highlighted by the current surge of the omicron COVID-19 variant. Thus, there is a race to find treatment alternatives. We contend that oral small molecule antivirals that halt SARSCoV- 2 infection are essential. Compared to currently available monoclonal antibodies and remdesivir, where parenteral administration is required, oral antivirals offer treatments in an outpatient setting with dissemination available on a larger scale. In response to this need at 2021's end, regulatory agencies provided emergency use authorization for both molnupiravir and nirmatrelvir. These medicines act on the viral polymerase and protease, respectively. Each is given for 5 days and can reduce disease progression by 30% and 89%, respectively. The advent of additional oral antivirals, the assessment of combination therapies, the formulation of extended-release medications, and their benefit for both early treatment and prophylaxis will likely transform the landscape of the COVID-19 pandemic.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352153/pdf/nihms-1810140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39717477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mobile applications in HIV self-management: A systematic review of scientific literature. 移动应用在艾滋病毒自我管理:科学文献的系统回顾。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.21000025

Esmaeil Mehraeen, SeyedAhmad SeyedAlinaghi, Zahra Pashaei, Pegah Mirzapour, Alireza Barzegary, Farzin Vahedi, Kowsar Qaderi, Marcarious M Tantuoyir, Zahra Nazeri, Amirali Karimi, Mohammad Mehrtak, Mohammad Heydari

{"title":"Mobile applications in HIV self-management: A systematic review of scientific literature.","authors":"Esmaeil Mehraeen, SeyedAhmad SeyedAlinaghi, Zahra Pashaei, Pegah Mirzapour, Alireza Barzegary, Farzin Vahedi, Kowsar Qaderi, Marcarious M Tantuoyir, Zahra Nazeri, Amirali Karimi, Mohammad Mehrtak, Mohammad Heydari","doi":"10.24875/AIDSRev.21000025","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000025","url":null,"abstract":"Self-management through mHealth by mobile apps creates new opportunities for people living with HIV (PLHIV) for integrated and accurate management. Our study focused on current evidence on HIV selfmanagement mobile applications to identify and assess their objective, infrastructure, and target populations. A systematic review was conducted on studies that use apps to improve self-management among HIV-positive patients, using PubMed, Scopus, Embase, Science direct, UpToDate, and Web of Science databases. The search was limited to English-written articles and published in the past 10 years. A search of Google Play for Android and App Store for iOS devices was performed to find the apps identified in the included articles. Concerning the aim of this study, the target populations of 17 identified HIV-apps were found to be mainly directed at PLHIV (n = 15). Furthermore, the objectives of 17 identified HIV-apps were found to self-care, self-monitoring, and self-management (n = 7), improve medication adherence (n = 5), prevention and treatment (n = 5), adherence to antiretroviral therapy (ART) (n = 4), Cognitive Behavioral Stress Management (n = 1), and support safer conception among HIV couples (n = 1). The operating system of most HIV-apps was Android (n = 15), one app for iOS and seven apps was both of them, and most apps were free (n = 19). The findings indicate that mHealth strategies for PLHIV have had a substantial positive effect on ART, drug adherence, prevention, and treatment, as well as social and behavioral problems affecting PLHIV. Even though the mHealth market needs to be regulated, it specifies that mHealth is relevant and should be used in the self-management, self-monitoring, and self-care of PLHIV.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39834217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Sarcopenia in Persons Living with HIV under Antiretroviral Therapy: Literature Review. 接受抗逆转录病毒治疗的HIV感染者肌肉减少症:文献综述。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.21000018

Marcus V L Dos-Santos-Quaresma, Sandra M Lima-Ribeiro

{"title":"Sarcopenia in Persons Living with HIV under Antiretroviral Therapy: Literature Review.","authors":"Marcus V L Dos-Santos-Quaresma, Sandra M Lima-Ribeiro","doi":"10.24875/AIDSRev.21000018","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000018","url":null,"abstract":"The epidemiological profile of people living with HIV (PLWH) has expressively changed since the introduction of antiretroviral therapy (ART), from a high mortality rate to a profile similar to those living with chronic diseases. Despite the advances and effectiveness of ART, there are still various challenges to overcome, and we highlight the increased risk of sarcopenia in PLWH. This review study aims to (i) explore the pathophysiological background of sarcopenia in PLWH under the different existing ART and (ii) develop a mini-systematic review searching epidemiological studies investigating sarcopenia prevalence in PLWH. As our main findings: we established the risk of sarcopenia development, under a sequential path involving HIV, ART, immune activation, low-grade systemic inflammation, metabolic disorders, and changes in protein synthesis and breakdown in skeletal muscle tissue; some ART drugs, mainly reverse transcriptase inhibitors and protease inhibitors, contribute to critical metabolic changes, lowering the autophagy, increasing mitochondrial dysfunction and insulin resistance, which favor the development of inflammation and muscle protein breakdown. There is still insufficient data to discuss the effects of the new generation drugs, namely integrase inhibitors and fusion inhibitors, on skeletal muscle. More studies are needed to better clarify these relationships.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39057821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0