AIDS reviews最新文献_第7页

HIV and aging, biological mechanisms, and therapies: What do we know? 艾滋病毒与衰老，生物机制和治疗:我们知道什么?

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-01-01 DOI: 10.24875/AIDSRev.21000085

Tomás M Grosso, José Alcamí, José R Arribas, Marta Martín, Irini Sereti, Philip Tarr, Pedro Cahn, Bonaventura Clotet, Omar Sued, Eugenia Negredo

{"title":"HIV and aging, biological mechanisms, and therapies: What do we know?","authors":"Tomás M Grosso, José Alcamí, José R Arribas, Marta Martín, Irini Sereti, Philip Tarr, Pedro Cahn, Bonaventura Clotet, Omar Sued, Eugenia Negredo","doi":"10.24875/AIDSRev.21000085","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000085","url":null,"abstract":"Aging, a time-dependent loss of physiological function, and its drivers are turning into a significant topic of researchas the population's mean age increases. Epigenetic alterations, telomere shortening or dysfunction, mitogenic stress,oxidative stress, or accumulation of DNA damage can drive the cell to senescence a permanent cell cycle arrest sometimes associated with a secretory phenotype and inflammatory consequences in the surrounding tissue. The amount of senescent cellsgrows over time in older organisms and may induce tissue inflammation and threaten overall tissue homeostasis, favoring aging. Senolytic and senomorphic therapeuticsare an emerging approach to eliminate senescent cells or to block their secretoryphenotypes respectively. Given that people living with HIV suffer non-AIDS comorbidities in a higher prevalence than the general population, aging is accentuated among them. Inflammation biomarkers may be helpful to assess prognosis or act as surrogate endpoints for studies of strategies focused on reversal of HIV-associated accelerated aging. This review summarizes the latest findings in aging and its major drivers, under the light of HIV infection. Since the number of older PLWH is currently rising, it will be of great importance to address and treat their age-related conditions, as well as to better decipher their biological mechanisms.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"25 2","pages":"79-86"},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40639531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The role of nurses in the prevention of anal cancer in HIV-infected men having sex with men - a focus on papillomavirus vaccination and anal cytology screening. 护士在预防感染艾滋病毒的男男性行为者肛门癌中的作用——重点是乳头瘤病毒疫苗接种和肛门细胞学检查。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-01-01 DOI: 10.24875/AIDSRev.M22000053

Jèssica Muñoz-Rodríguez, Lucia Millán-Revilla

引用次数: 0

COVID-19 vaccination in people living with HIV: current data and perspectives. 艾滋病毒感染者COVID-19疫苗接种:当前数据和观点

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-01-01 DOI: 10.24875/AIDSRev.22000017

Roland Thomas, Jean Cyr Yombi

{"title":"COVID-19 vaccination in people living with HIV: current data and perspectives.","authors":"Roland Thomas, Jean Cyr Yombi","doi":"10.24875/AIDSRev.22000017","DOIUrl":"https://doi.org/10.24875/AIDSRev.22000017","url":null,"abstract":"There is no correlation between HIV per se and other risk factors for severe COVID-19 disease. Pivotal studies have shown that vaccination is one of the effective ways to prevent severe COVID-19 illness in the general population. Studies on people living with HIV (PLWH) are scarce. The majority of these studies with mRNA (BNT126b2 and mRNA-1273) and adenovirus vector (Ad26.COV2.2 and ChAdOx1) vaccines with a low number of patients included shows that PLWH on antiretroviral treatment and with CD4 count > 200/mm³ has a robust immune response. These vaccines are thus effective in preventing severe infection caused by severe acute respiratory syndrome coronavirus 2 in PLWH. However, PLWH with a CD4 count of < 200/mm³ and uncontrolled viral load (VL) seems to have a lower immune response. COVID-19 vaccines are safe in PLWH; adverse effects are mild or moderate, and their incidence is similar to non-HIV people (NHP). The CD4 count decreased significantly and transiently, and the VL rebounded insignificantly in a few patients. A complete vaccination including a third dose is, therefore, recommended. A booster dose with an mRNA vaccine is recommended in PLWH with an advanced stage of their disease.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 4","pages":"173-182"},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10831937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Less hepatic decompensation events but rising liver cancer in hepatitis B patients on long-term nucleos(t)ide therapy. 长期接受核苷治疗的乙型肝炎患者肝脏失代偿事件较少，但肝癌发生率上升。

IF 2.2 4区医学

AIDS reviews Pub Date : 2022-01-01 DOI: 10.24875/AIDSRev.M22000055

Ana Treviño, Vicente Soriano

引用次数: 0

"Moving Fourth": Introduction of a practical toolkit for shared decision-making to facilitate healthy living beyond HIV viral suppression. "第四个行动":为共同决策引入实用工具包，以促进抑制艾滋病毒以外的健康生活。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-12-29 DOI: 10.24875/AIDSRev.20000130

Adrian Curran, Joop Arends, Thomas Buhk, Mario Cascio, Eugenio Teofilo, Guido van den Berk, Giovanni Guaraldi

{"title":"\"Moving Fourth\": Introduction of a practical toolkit for shared decision-making to facilitate healthy living beyond HIV viral suppression.","authors":"Adrian Curran, Joop Arends, Thomas Buhk, Mario Cascio, Eugenio Teofilo, Guido van den Berk, Giovanni Guaraldi","doi":"10.24875/AIDSRev.20000130","DOIUrl":"https://doi.org/10.24875/AIDSRev.20000130","url":null,"abstract":"An extension of the UNAIDS 90-90-90 target proposes >90% of people living with HIV (PLHIV) should have good health-related quality of life (HrQoL); however, limited guidance exists. The \"Health Goals for Me\" framework, an individualized approach to HIV care, provides a framework to assess HrQoL. We analyzed several patient-reported outcome measures (PROMs) to develop a practical toolkit to facilitate shared physician-patient decision-making. HrQoL subdomains, actionable in the clinical setting and measurable as PROMs, were selected. PROMs were collated through systematic literature searches, scored by the authors on usability, validation, and availability, after which practical recommendations were made. Nine subdomains were selected across physical, psychological, social, and environmental domains; 46 validated PROMs were identified. After pre-screening, from 39 evaluated PROMs, we recommended PROMs in the following subdomains: fatigue/energy loss, frailty/resilience, sleep disturbance, substance use, anxiety/depression, cognition, sexual function and desire, and stigma. Using this toolkit, healthcare professionals and PLHIV can collaborate and mutually agree on individual care objectives. Following the \"Health Goals for Me\" framework, appropriate care interventions can be implemented and reviewed in a continuous cycle. We discussed how eHealth interventions, which will have increasing importance in the post-COVID era, can facilitate improved HrQoL for PLHIV by utilizing toolkits such as the one described here. Implementation of this practical framework and the PROMs toolkit could provide a useful approach to assessing HrQoL in PLHIV and could enhance the physician's ability to gain valuable insights into the patient's daily life across a broad range of HrQoL issues.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 4","pages":"204-213"},"PeriodicalIF":2.2,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39053959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Safety of Antiretroviral Therapy in the Treatment of HIV/AIDS in Children: Systematic Review and Meta-analysis. 抗逆转录病毒治疗儿童HIV/AIDS的安全性:系统评价和荟萃分析。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-12-29 DOI: 10.24875/AIDSRev.200001071

Renata Szpak, Natália F Lombardi, Frederico A Dias, Helena H L Borba, Roberto Pontarolo, Astrid Wiens

{"title":"Safety of Antiretroviral Therapy in the Treatment of HIV/AIDS in Children: Systematic Review and Meta-analysis.","authors":"Renata Szpak, Natália F Lombardi, Frederico A Dias, Helena H L Borba, Roberto Pontarolo, Astrid Wiens","doi":"10.24875/AIDSRev.200001071","DOIUrl":"https://doi.org/10.24875/AIDSRev.200001071","url":null,"abstract":"The safety of using different antiretroviral therapies (ART) in pediatric HIV/AIDS patients is not well-established. Therefore, this study aimed to assess the safety of ART in children. A systematic review of randomized clinical trials (RCTs) was conducted to assess the safety of ART used by pediatric patients living with HIV/AIDS. The electronic search was conducted in PubMed and Scopus, in addition to a manual search. Studies were included if they assessed the safety of ART compared to placebo or another ART. Direct and indirect meta-analyses were conducted regarding safety outcomes. The systematic review included 21 RCTs. The studies included more than 5500 participants, and age ranged from 3 months to 18 years. The drugs evaluated were nucleoside reverse transcriptase inhibitors (NRTI); non-NRTI; and protease inhibitors. The predominant route of infection was vertical. Direct meta-analyses were performed for the outcomes sleep disorders, hepatobiliary disorders, respiratory disorders, hypertransaminasemia, neutropenia, hospitalization, and death. For these outcomes, no statistically significant differences were found. Indirect meta-analyses were performed for the outcomes anemia, gastrointestinal disorders, liver disorders, severe adverse events (AE), AE that led to changes in treatment, fever, and skin manifestations. However, no statistically significant differences were found for these outcomes. In this study, non-significant differences were detected in the safety of different ART used in pediatric individuals. The choice of appropriate therapy should be based on its efficacy and the individual characteristics of each patient.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 4","pages":"196-203"},"PeriodicalIF":2.2,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39057820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Magnetic Resonance Imaging Studies in Perinatally HIV-Infected Individuals. 围产期hiv感染者磁共振成像研究的系统综述

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-12-29 DOI: 10.24875/AIDSRev.20000088

Manuela Martín-Bejarano, Beatriz Ruiz-Saez, Ana Martinez-de-Aragón, Helena Melero, Berta Zamora, Norberto A Malpica, Jose T Ramos, Maria I Gonzalez-Tomé

{"title":"A Systematic Review of Magnetic Resonance Imaging Studies in Perinatally HIV-Infected Individuals.","authors":"Manuela Martín-Bejarano, Beatriz Ruiz-Saez, Ana Martinez-de-Aragón, Helena Melero, Berta Zamora, Norberto A Malpica, Jose T Ramos, Maria I Gonzalez-Tomé","doi":"10.24875/AIDSRev.20000088","DOIUrl":"https://doi.org/10.24875/AIDSRev.20000088","url":null,"abstract":"Over the past few years, neuroimaging studies have been performed in young adults with perinatally acquired HIV (PHIV) to study the impact of HIV infection on the central nervous system (CNS), but no recent review have been published. This review aims to identify brain areas where PHIV eems to have greater impact taking into account demographic, behavioral, and clinical characteristics in PHIV infected patients. For this purpose, PubMed and Medline searches were carried out which included studies from 2010 to April 2020. We performed a systematic review and included 26 articles using structural (brain morphometry and diffusion tensor imaging) and functional magnetic resonance imaging methods involving 1182 PHIV-infected participants. Ample evidence has been provided of HIV effects on underlying brain structure. However, information recorded in the studies is commonly incomplete and results sometimes contradictory. In addition to future improvements and dissemination of tools for the developing brain MRI processing and analysis, the inclusion of data related to HIV infection itself (including clinical and immunovirological characteristics as well as detailed information about antiretroviral treatment such as age at ART initiation) may be of vital importance to the better understanding of the impact of the disease on CNS.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"23 4","pages":"167-185"},"PeriodicalIF":2.2,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25491807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The opioid epidemic during the COVID-19 pandemic: Impact on HIV and HCV control. COVID-19大流行期间阿片类药物流行:对艾滋病毒和丙型肝炎病毒控制的影响

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-12-29 DOI: 10.24875/AIDSRev.M21000046

Ana Treviño, Vicente Soriano

引用次数: 0

Another patient has cured HIV infection. 另一名患者治愈了艾滋病毒感染。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-12-29 DOI: 10.24875/AIDSRev.M21000045

Carmen de Mendoza, Vicente Soriano

引用次数: 0

Nutritional assessment in the HIV-infected older population receiving antiretroviral therapy. 接受抗逆转录病毒治疗的老年艾滋病毒感染者的营养评估。

IF 2.2 4区医学

AIDS reviews Pub Date : 2021-12-22 DOI: 10.24875/AIDSRev.21000051

Tippawan Siritientong, Daylia Thet

{"title":"Nutritional assessment in the HIV-infected older population receiving antiretroviral therapy.","authors":"Tippawan Siritientong, Daylia Thet","doi":"10.24875/AIDSRev.21000051","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000051","url":null,"abstract":"Malnutrition is a pronounced public health issue which often seems underestimated in the older people living with HIV (PLWH) virus infection. PLWH are highly vulnerable to nutritional problems resulting from agingrelated deterioration, disease itself, and adverse effects of antiretroviral therapy (ART). The comprehensive nutritional assessments are necessary to perform routinely in this population to monitor and provide appropriate interventions to reduce comorbid conditions. In this review, we focus on the untoward impacts of malnutrition and nutritional assessments on the morbidity and mortality in the older PLWH. Some predictive factors of nutritional status in this group of patients are discussed. We propose the important components for nutrition assessment tool for older PLWH on ART. Highlighted issue is the need for developing uniform standardized tools for the early diagnosis of malnutrition in this population. Applications of the nutritional assessments, proper nutritional interventions, and regular monitoring of nutritional status in older PLWH liv-ing in every clinical setting may help the patients get better well-being.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 4","pages":"153-161"},"PeriodicalIF":2.2,"publicationDate":"2021-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10515587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0