AIDS reviews最新文献_第7页

Risk factors and mortality outcomes of COVID-19 in people living with HIV: a systematic review and meta-analysis. 艾滋病毒感染者中 COVID-19 的风险因素和死亡结果：系统回顾和荟萃分析。

IF 2.2 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.23000017

Mahmoud Kandeel

{"title":"Risk factors and mortality outcomes of COVID-19 in people living with HIV: a systematic review and meta-analysis.","authors":"Mahmoud Kandeel","doi":"10.24875/AIDSRev.23000017","DOIUrl":"10.24875/AIDSRev.23000017","url":null,"abstract":"This study was performed to reveal the risk factors associated with mortality in people living with HIV (PLHIV) who were diagnosed with COVID-19. Studies reporting deaths among PLHIV and infected with SARS-CoV-2 were investigated. After protocol setup and registration, the extracted sources were categorized and assessed for quality. This study examined ten articles with a total of 46,136 patients. Patients aged ≥ 60 years (hazard ratio [HR] = 2.22; 95% CI: 1.617, 3.050; p < 0.001), male (HR = 1.668; 95% CI: 1.179, 2.361; p = 0.004), and people with diabetes (risk ratio [RR] = 3.34; 95% CI: 1.45, 7.68; p = 0.005) were at higher risk of death. Adherence to antiretroviral therapy (ART) reduced mortality risk (RR = 0.90; 95% CI: 0.83, 0.98; p = 0.02). Patients in the survival groups showed a statistically significant lower mean of C-reactive protein (mean difference = 114.08; 95% -74.05, 154.10; p < 0.001). Deceased patients showed higher mean levels of interleukin-6 (IL-6). Chronic respiratory disorders, hypertension, oxygen requirement, admission to an intensive care unit, D-dimer levels, and HIV viral load < 50 copies RNA/mL before admission did not show statistically significant differences between the deceased and survival groups. ART therapy reduced mortality risk (RR = 0.90; 95% 0.83, 0.98; p = 0.02). Identifying PLHIV at higher mortality risk could improve the outcomes of COVID-19 by stratifying these patients to the most effective treatment in a timely fashion.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 1","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually transmitted infections keep rising up. 性传播感染持续上升。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSREV.M24000077

Vicente Soriano, Ana Treviño

引用次数: 0

Adherence to antiretroviral therapy among HIV-1 patients from sub-Saharan Africa: a systematic review. 撒哈拉以南非洲地区 HIV-1 患者坚持抗逆转录病毒疗法的情况：系统综述。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.24000004

Pedro R S Almeida, Carlos A C Rafael, Victor Pimentel, Ana B Abecasis, Cruz S Sebastião, Joana de Morais

{"title":"Adherence to antiretroviral therapy among HIV-1 patients from sub-Saharan Africa: a systematic review.","authors":"Pedro R S Almeida, Carlos A C Rafael, Victor Pimentel, Ana B Abecasis, Cruz S Sebastião, Joana de Morais","doi":"10.24875/AIDSRev.24000004","DOIUrl":"https://doi.org/10.24875/AIDSRev.24000004","url":null,"abstract":"More than two decades after introducing antiretroviral therapy (ART), several challenges still prevail in keeping well people living with HIV, even with \"Test and Treat\" and/or \"Rapid Start of ART\" initiatives, as well as the scale-up of ART worldwide to promote access and adherence to treatment. This review examined articles on ART adherence in Africa between 2016 and 2023, published in English and indexed in PubMed. A total of 16 articles out of 2415 were eligible and included for analyses. Overall, good ART adherence rates in sub-Saharan African (SSA) regions ranged from 43% to 84%. Rates in the center of the SSA region ranged from 58% to 80%, in the north from 50% to 83%, in the south from 77% to 84%, in the west from 43% to 60%, and in the east from 69% to 73%. Most African countries use self-reporting to assess treatment adherence, which is frequently unreliable. The main factors with negative influence on ART adherence were comorbidities, lack of motivation, socioeconomic difficulties, or side effects. Conclusion: Adherence to ART is a good indicator for controlling the spread of HIV in a given region. It is important to overcome the barriers that make it difficult to comply with ART and reinforce the factors that facilitate access to medication.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 3","pages":"102-110"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico drug repurposing approach to predict most effective HAART for HIV drug resistance variants prevalent in the Indian HIV-positive population. 针对印度 HIV 阳性人群中普遍存在的 HIV 抗药性变体，预测最有效 HAART 的硅学药物再利用方法。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.24000010

Priya Kalsi, Priya Jain, Gitanjali Goyal, Himanshu Sharma

{"title":"In silico drug repurposing approach to predict most effective HAART for HIV drug resistance variants prevalent in the Indian HIV-positive population.","authors":"Priya Kalsi, Priya Jain, Gitanjali Goyal, Himanshu Sharma","doi":"10.24875/AIDSRev.24000010","DOIUrl":"10.24875/AIDSRev.24000010","url":null,"abstract":"HIV epidemics still exist as a major global public health burden, especially in middle- and low-income countries. Given the lack of approved vaccines, antiretroviral therapy (ART) remains the primary approach to reduce the mortality and morbidity linked to this disease. Effective treatment for HIV-1 requires the simultaneous administration of multiple drugs. However, the virus can show resistance to antiretroviral drugs, resulting in treatment failure. Therefore, this study focused on assessing the prevalence of mutations within the Indian HIV-positive population. After assessing the data, we intended to identify the most effective highly active ART (HAART) regimens for individuals with drug-resistant variants. Furthermore, our analysis revealed a spectrum of HIV mutations, with varying effects on protein stability. The significance of this analysis lies in its potential to optimize HAART selection for HIV-positive individuals by accounting for both prevalence and stability-altering mutations. By considering mutation effects on protein stability, we can modify treatment regimens, increasing the likelihood of therapy success and diminishing the risk of resistance. Moreover, this study contributes to the broader field of drug repurposing, offering insights into the rational design of antiretroviral therapies.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 3","pages":"93-101"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The risk for pandemic avian influenza. 禽流感大流行的风险。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.M25000078

Vicente Soriano

引用次数: 0

HIV-1 resistance and virological failure to treatment with the integrase inhibitors bictegravir, cabotegravir, and dolutegravir: a systematic literature review. 整合酶抑制剂比特拉韦、卡博替拉韦和多罗替拉韦治疗的HIV-1耐药性和病毒学失败：系统性文献综述。

IF 1.9 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.24000011

Jos柩 L Blanco-Arévalo, Miguel García-Deltoro, Miguel Torralba, Manuel Vélez-Díaz-Pallarés, Antonio Castro, Darío Rubio-Rodríguez, Carlos Rubio-Terrés

{"title":"HIV-1 resistance and virological failure to treatment with the integrase inhibitors bictegravir, cabotegravir, and dolutegravir: a systematic literature review.","authors":"Jos柩 L Blanco-Arévalo, Miguel García-Deltoro, Miguel Torralba, Manuel Vélez-Díaz-Pallarés, Antonio Castro, Darío Rubio-Rodríguez, Carlos Rubio-Terrés","doi":"10.24875/AIDSRev.24000011","DOIUrl":"https://doi.org/10.24875/AIDSRev.24000011","url":null,"abstract":"We describe and analyze resistance-associated mutations (RM) and virological failures (VF) on antiretroviral therapy using the latest approved integrase inhibitors (INIs) dolutegravir (DTG), bictegravir (BIC), and cabotegravir (CAB), together with their companion drugs in fixed-dose formulations: BIC/emtricitabine/tenofovir; CAB/rilpivirine; DTG/abacavir/lamivudine; DTG/emtricitabine/tenofovir; and DTG/lamivudine. Systematic literature searches were conducted in PubMed and other electronic databases for clinical studies published between January 2010 and May 2023, according to preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA), which analyzed VFs and RMs of INIs. Fifty clinical studies were included in the synthesis. VF in antiretroviral treatment (ART)-naïve patients occurred in 0.7-4.0%, 0.6-1.4%, and 0.6-9.0% of patients treated with DTG, BIC, and CAB, respectively. VF was reported in patients with previous ART in 0-8.1%, 0-2.0%, and 0.4-2.3% of those treated with DTG, BIC, and CAB, respectively. RMs were detected in ART-naïve patients in only one study with DTG (0.3%), none of the studies with BIC, and three of the studies with CAB (0.1-5.4%). In ART-experienced patients, RMs were detected in 0-1.9% of DTG-treated patients. No cases of RM were detected in the 11 BIC studies reviewed. In the case of CAB, RMs were detected in eight studies, ranging from 0.3% to 1.9% of patients. In conclusion, RM rates in the studies reviewed were generally low using the latest INIs. This review identified BIC as the INI with the lowest number of observed VF and lack of RM.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"26 2","pages":"67-79"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HTLV in Sweden. 瑞典的 HTLV。

IF 2.2 4区医学

AIDS reviews Pub Date : 2024-01-01 DOI: 10.24875/AIDSRev.24000002

Jan Vesterbacka, Anna-Karin Svensson, Piotr Nowak

引用次数: 0

Pre-exposure prophylaxis of non-HIV viral infections and the role of long-acting antivirals. 非艾滋病毒病毒感染的暴露前预防和长效抗病毒药物的作用。

IF 2.2 4区医学

AIDS reviews Pub Date : 2023-12-15 DOI: 10.24875/AIDSRev.M23000066

Vicente Soriano, Víctor Moreno-Torres, Carmen de Mendoza, José V Fernández-Montero, Ana Treviño, Octavio Corral, Fernando de Jesús, Pablo Barreiro

{"title":"Pre-exposure prophylaxis of non-HIV viral infections and the role of long-acting antivirals.","authors":"Vicente Soriano, Víctor Moreno-Torres, Carmen de Mendoza, José V Fernández-Montero, Ana Treviño, Octavio Corral, Fernando de Jesús, Pablo Barreiro","doi":"10.24875/AIDSRev.M23000066","DOIUrl":"10.24875/AIDSRev.M23000066","url":null,"abstract":"Viruses cause a large burden of human infectious diseases. During the past 50 years, antivirals have been developed to treat many pathogenic viruses, including herpesviruses, retroviruses, hepatitis viruses, and influenza. Besides being used as treatment, antivirals have shown efficacy for preventing certain viral infections. Following the success in the HIV field, a renewed interest has emerged on the use of antivirals as prophylaxis for other viruses. The development of formulations with extended half-life has pushed further this consideration in persons at risk for a wide range of viral infections. In this way, long-acting antivirals might behave as \"chemovaccines\" when classical vaccines do not exist, cannot be recommended, immune responses are suboptimal, escape mutants emerge, and/or immunity wanes. Five main caveats would temper its use, namely, selection of drug resistance, drug interactions, short- and long-term side effects, potential teratogenicity in women of child-bearing age, and high cost. Herein, we discuss the prospects for long-acting antivirals as prophylaxis of human viral infections other than HIV.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"162-172"},"PeriodicalIF":2.2,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138796864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HTLV European Research Network 2023: the silent pandemic of HTLV-1 infection. HTLV欧洲研究网络2023：HTLV-1感染的无声流行病。

IF 2.2 4区医学

AIDS reviews Pub Date : 2023-10-26 DOI: 10.24875/AIDSRev.M23000064

Carmen de Mendoza, Ana Treviño, Vicente Soriano

引用次数: 0

Mental health crisis in the youth and rebound in sexually transmitted infections. 青少年心理健康危机与性传播感染反弹

IF 2.2 4区医学

AIDS reviews Pub Date : 2023-07-31 DOI: 10.24875/AIDSRev.M23000062

Vicente Soriano, Joaquín González-Cabrera

引用次数: 0