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News from CROI 2022 - caveats using antiretrovirals as HIV prophylaxis. 来自CROI 2022的新闻-使用抗逆转录病毒药物作为艾滋病毒预防的警告。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-05-11 DOI: 10.24875/aidsrev.m22000049
P. Barreiro, V. Soriano
{"title":"News from CROI 2022 - caveats using antiretrovirals as HIV prophylaxis.","authors":"P. Barreiro, V. Soriano","doi":"10.24875/aidsrev.m22000049","DOIUrl":"https://doi.org/10.24875/aidsrev.m22000049","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45038053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research progress on HIV-1 immune escape mechanisms. HIV-1免疫逃逸机制研究进展。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-05-03 DOI: 10.24875/AIDSRev.21000068
Yuanxi Meng, Ji-Xin Zhong, Yanhan Lv, Wei Zou
{"title":"Research progress on HIV-1 immune escape mechanisms.","authors":"Yuanxi Meng, Ji-Xin Zhong, Yanhan Lv, Wei Zou","doi":"10.24875/AIDSRev.21000068","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000068","url":null,"abstract":"Although highly active antiretroviral therapy has transformed HIV-1 infection into a manageable chronic disease, the development of an effective vaccine is still an important and challengeable research field of HIV-1 treatment. The challenge arises from an enormous diversity of HIV-1 strains and their rapid evolution ahead of effective immune responses. HIV-1 evasion from host immunity contributes to viral spread and pathogenesis, thus understanding the mechanisms of HIV-1 immune evasion is important. In this review, we summarized our present knowledge on the mechanisms how HIV-1 escapes immune responses. Such knowledge will help with the design of effective vaccines capable of inducing immune control of HIV-1.","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47879572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Unexplained hepatitis in children after lifting COVID-19 pandemic restrictions. 解除新冠肺炎疫情限制后儿童出现不明原因肝炎。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-27 DOI: 10.24875/AIDSRev.M22000050
P. Barreiro
{"title":"Unexplained hepatitis in children after lifting COVID-19 pandemic restrictions.","authors":"P. Barreiro","doi":"10.24875/AIDSRev.M22000050","DOIUrl":"https://doi.org/10.24875/AIDSRev.M22000050","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41955331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Malignancies in people living with HIV. 艾滋病毒感染者的恶性肿瘤。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000057
Qiqiang Zhou, Wei Li, Lingbo Xia, Ruixiang Zou, Xinping Chen, Wei Zou
{"title":"Malignancies in people living with HIV.","authors":"Qiqiang Zhou,&nbsp;Wei Li,&nbsp;Lingbo Xia,&nbsp;Ruixiang Zou,&nbsp;Xinping Chen,&nbsp;Wei Zou","doi":"10.24875/AIDSRev.21000057","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000057","url":null,"abstract":"<p><p>Almost 40 years have passed since the first case of what is known as AIDS was documented. In these 40 years, AIDS has always been a research challenge and hot spot. Researchers and scientists have made tremendous progress in basic and clinical research on HIV. In particular, the widespread use of antiretroviral therapy (ART) has made it less of a deadly disease today and more of a manageable one. In the post- ART era when ART can significantly improve the immunity of people living with HIV (PLWH) and extend their life, the incidence of non-AIDS-defined cancers is greatly increased. Factors related to immunosuppression do not seem to explain this problem sufficiently. This suggests that besides immunosuppression, there are other mechanisms that may also contribute to the increased incidence of cancer in PLWH. Here, we summarized and discussed four possible mechanisms for the increased incidence of cancers in PLWH: immunosuppression, oncogenic viral infection, chronic infection, inflammatory damage, and the direct impact of HIV.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"69-78"},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40316406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Determinants of natural HIV-1 control. HIV-1自然控制的决定因素。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000048
Ana Moyano, Thumbi Ndung'u, Jaclyn K. Mann
{"title":"Determinants of natural HIV-1 control.","authors":"Ana Moyano,&nbsp;Thumbi Ndung'u,&nbsp;Jaclyn K. Mann","doi":"10.24875/AIDSRev.21000048","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000048","url":null,"abstract":"<p><p>HIV-1 infection usually progresses to AIDS within 10 years in antiretroviral therapy untreated individuals, but there is a group of infected individuals, known as controllers, who maintain low plasma HIV-1 RNA levels and normal CD4+ T-cell counts for many years. Evidence suggests that the mechanisms of viral control in these individuals are heterogeneous. In this review, we highlight the viral and host factors, particularly host immunological and immunogenetic factors that are associated with controller status. Despite the broad heterogeneity within controllers, there is compelling evidence that cytotoxic CD8+ T lymphocyte responses act as the main driver of control in the majority of these individuals, especially in those with protective HLA-I alleles. Further investigation of controllers without protective HLA-I alleles is required as it seems that this subset exhibits more durable control of HIV-1 disease progression. Understanding the immune defense mechanisms in controllers provides hope for harnessing these responses in the general population, either for protective or therapeutic vaccines or to achieve a functional cure in infected individuals.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 2","pages":"51-58"},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39815820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Risk factors associated with pulmonary arterial hypertension among HIV-infected adults: A meta-analysis and systematic review. hiv感染成人肺动脉高压相关的危险因素:荟萃分析和系统评价
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.21000056
Ying Liu, Junyan Han, Bei Li, Jing Xiao, Leidan Zhang, Hongxin Zhao
{"title":"Risk factors associated with pulmonary arterial hypertension among HIV-infected adults: A meta-analysis and systematic review.","authors":"Ying Liu,&nbsp;Junyan Han,&nbsp;Bei Li,&nbsp;Jing Xiao,&nbsp;Leidan Zhang,&nbsp;Hongxin Zhao","doi":"10.24875/AIDSRev.21000056","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000056","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) occurs more frequently in patients with HIV infection than in general population. The predictive value of HIV-related factors and traditional cardiovascular factors with PAH is inconsistent across studies. The objective is to determine the roles of HIV-related risk factors and traditional cardiovascular risk factors in the development of PAH in adults with HIV. We searched Pubmed/Medline, Embase, Web of Science, and Google Scholar to identify studies published between January 1, 2000 and February 23, 2021 on risk factors associated with PAH among people living with HIV (PLWH). Ten studies were included for final analysis. PLWH with PAH had higher mean age (weighted mean difference [WMD] = 2.27, 95% confidence interval [CI] 0.31 ~ 4.24), and lower mean CD4 cell count (WMD = -95.8, 95% CI -153.41 ~ -38.2). Meanwhile, they were more likely to have detectable viral load (odds ratio [OR] = 1.36, 95% CI 1.16 ~ 1.60), to accompany arterial hypertension (OR = 2.02, 95% CI 1.51 ~ 2.71) and less likely to receive antiretroviral therapy (ART) (OR = 0.84, 95% CI 0.72 ~ 0.99). Besides, more intravenous drug users were observed in HIV-infected adults with PAH (OR = 2.25, 95% CI 1.51 ~ 3.33). HIV infection itself and ART impact PAH in two opposite ways. Traditional cardiovascular factors such as arterial hypertension, and older age are also important to the development of PAH. Screening HIV-related factors and traditional cardiovascular factors may help to target and manage patients at risk.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 2","pages":"59-68"},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39694670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International outbreak of monkeypox in men having sex with men. 猴痘在男男性行为者中的国际暴发。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-04-01 DOI: 10.24875/AIDSRev.M22000051
Vicente Soriano, Octavio Corral
{"title":"International outbreak of monkeypox in men having sex with men.","authors":"Vicente Soriano, Octavio Corral","doi":"10.24875/AIDSRev.M22000051","DOIUrl":"10.24875/AIDSRev.M22000051","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"1 1","pages":"101-103"},"PeriodicalIF":2.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41821990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
A greater virulent HIV-1 subtype B variant has circulated in The Netherlands since the 1990's. 自20世纪90年代以来,一种毒性更强的HIV-1 B亚型变体在荷兰流行。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.M22000047
A. Treviño, V. Soriano
{"title":"A greater virulent HIV-1 subtype B variant has circulated in The Netherlands since the 1990's.","authors":"A. Treviño, V. Soriano","doi":"10.24875/AIDSRev.M22000047","DOIUrl":"https://doi.org/10.24875/AIDSRev.M22000047","url":null,"abstract":"","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":"24 1 1","pages":"50"},"PeriodicalIF":2.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45011303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prevalence of HIV-infected Patients with Virological Suppression but a CD4+ T-cell Count of ≤ 200 Cells/mm3 after Highly Active Antiretroviral Therapy Initiation: A Meta-analysis. 高活性抗逆转录病毒治疗开始后,病毒学抑制但CD4+ t细胞计数≤200细胞/mm3的hiv感染患者的患病率:一项荟萃分析
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.21000011
Zhihui Wu, Chunling Yang, Yuqing Ma, Yueyuan Wang, Zhenkui Zhang, Zhibin Liu, Pengyu Li, Huijun Guo, Yantao Jin
{"title":"The Prevalence of HIV-infected Patients with Virological Suppression but a CD4<sup>+</sup> T-cell Count of ≤ 200 Cells/mm<sup>3</sup> after Highly Active Antiretroviral Therapy Initiation: A Meta-analysis.","authors":"Zhihui Wu,&nbsp;Chunling Yang,&nbsp;Yuqing Ma,&nbsp;Yueyuan Wang,&nbsp;Zhenkui Zhang,&nbsp;Zhibin Liu,&nbsp;Pengyu Li,&nbsp;Huijun Guo,&nbsp;Yantao Jin","doi":"10.24875/AIDSRev.21000011","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000011","url":null,"abstract":"<p><p>Highly active antiretroviral therapy (HAART) strongly inhibits HIV replication. However, many patients show suboptimal immune recovery (SIR), as defined by virological suppression (i.e. low viral load) with a CD4<sup>+</sup> T-cell count of ≤ 200 cells/mm<sup>3</sup>, after HAART initiation. Here, we performed a systematic evaluation of the SIR prevalence among HIV-infected patients in cohort studies. We searched PubMed, Cochrane Library, Embase, CNKI, Wanfang database, and Chinese Biomedicine Database for cohort studies about HIV-infected participants whose CD4<sup>+</sup> T-cell count was ≤ 200 cells/mm<sup>3</sup> but still had virological suppression after HAART initiation. The SIR prevalence from each of those cohort studies was pooled into a random-effect meta-analysis. We obtained two kinds of pooled post-HARRT initiation SIR prevalence: one among participants with virological suppression (11 cohort studies involving 18,672 participants), and the other among all HIV-infected participants (seven cohort studies involving 12,063 participants). The pooled SIR prevalence among HIV-infected patients with virological suppression after HAART initiation was 43% (95% confidence interval [CI], 34-51%) at 6 months post-HAART initiation and 10% (95% CI, 5-18%) at 36 months post-HAART initiation; among all HIV-infected patients after HAART initiation, it was 17% (95% CI, 0-55%) and 5% (95% CI, 2-10%) at 6 and 36 months post-HAART initiation, respectively. The SIR prevalence among HIV-infected patients is high at 6 months post-HAART initiation, but its prevalence gradually reduces over time under continuous HAART. Thus, it is important to follow-up on variations in the CD4<sup>+</sup> T-cell count and viral load.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"16-23"},"PeriodicalIF":2.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39252451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Mobile applications in HIV self-management: A systematic review of scientific literature. 移动应用在艾滋病毒自我管理:科学文献的系统回顾。
IF 2.2 4区 医学
AIDS reviews Pub Date : 2022-03-01 DOI: 10.24875/AIDSRev.21000025
Esmaeil Mehraeen, SeyedAhmad SeyedAlinaghi, Zahra Pashaei, Pegah Mirzapour, Alireza Barzegary, Farzin Vahedi, Kowsar Qaderi, Marcarious M Tantuoyir, Zahra Nazeri, Amirali Karimi, Mohammad Mehrtak, Mohammad Heydari
{"title":"Mobile applications in HIV self-management: A systematic review of scientific literature.","authors":"Esmaeil Mehraeen,&nbsp;SeyedAhmad SeyedAlinaghi,&nbsp;Zahra Pashaei,&nbsp;Pegah Mirzapour,&nbsp;Alireza Barzegary,&nbsp;Farzin Vahedi,&nbsp;Kowsar Qaderi,&nbsp;Marcarious M Tantuoyir,&nbsp;Zahra Nazeri,&nbsp;Amirali Karimi,&nbsp;Mohammad Mehrtak,&nbsp;Mohammad Heydari","doi":"10.24875/AIDSRev.21000025","DOIUrl":"https://doi.org/10.24875/AIDSRev.21000025","url":null,"abstract":"<p><p>Self-management through mHealth by mobile apps creates new opportunities for people living with HIV (PLHIV) for integrated and accurate management. Our study focused on current evidence on HIV selfmanagement mobile applications to identify and assess their objective, infrastructure, and target populations. A systematic review was conducted on studies that use apps to improve self-management among HIV-positive patients, using PubMed, Scopus, Embase, Science direct, UpToDate, and Web of Science databases. The search was limited to English-written articles and published in the past 10 years. A search of Google Play for Android and App Store for iOS devices was performed to find the apps identified in the included articles. Concerning the aim of this study, the target populations of 17 identified HIV-apps were found to be mainly directed at PLHIV (n = 15). Furthermore, the objectives of 17 identified HIV-apps were found to self-care, self-monitoring, and self-management (n = 7), improve medication adherence (n = 5), prevention and treatment (n = 5), adherence to antiretroviral therapy (ART) (n = 4), Cognitive Behavioral Stress Management (n = 1), and support safer conception among HIV couples (n = 1). The operating system of most HIV-apps was Android (n = 15), one app for iOS and seven apps was both of them, and most apps were free (n = 19). The findings indicate that mHealth strategies for PLHIV have had a substantial positive effect on ART, drug adherence, prevention, and treatment, as well as social and behavioral problems affecting PLHIV. Even though the mHealth market needs to be regulated, it specifies that mHealth is relevant and should be used in the self-management, self-monitoring, and self-care of PLHIV.</p>","PeriodicalId":7685,"journal":{"name":"AIDS reviews","volume":" ","pages":"24-31"},"PeriodicalIF":2.2,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39834217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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