Age and ageing最新文献

{"title":"Examining the association between toilet access and major depression among older adults in India: a cross-sectional analysis of the Longitudinal Aging Study in India from 2017 to 2018.","authors":"Anoop Jain,Helen O Pitchik,Rockli Kim,S V Subramanian,M Maria Glymour","doi":"10.1093/ageing/afaf170","DOIUrl":"https://doi.org/10.1093/ageing/afaf170","url":null,"abstract":"Inadequate access to toilets, which often results in open defecation, could be a risk factor for depression among India's older and ageing population. Using cross-sectional data from the Longitudinal Aging Study in India from 2017 to 2018, we assessed associations between the lack of a toilet and major depression among 64 082 women and men above the age of 45. In our adjusted multilevel model, we found no association between the lack of a household toilet and the risk of major depression (OR = 0.94, 95% CI: 0.79 to 1.11). We also found no association when we stratified by respondent's sex or age. Finally, we did not find any consistent association between toilet access and major depression across India's states and Union Territories. Despite our results, it is possible that inadequate access to sanitation is associated with acute feelings of anxiety, stress and shame-as has been shown in previous studies-but that this is not associated with major depression. Therefore, more research is required to examine associations between toilet access and other more proximal mental health outcomes.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"184 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101 years).","authors":"Ben Kirk, Stephanie L Harrison, Jesse Zanker, Andrew J Burghardt, Eric Orwoll, Peggy M Cawthon, Gustavo Duque","doi":"10.1093/ageing/afaf189","DOIUrl":"10.1093/ageing/afaf189","url":null,"abstract":"<p><strong>Background: </strong>Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable across the life cycle.</p><p><strong>Objective: </strong>To examine whether there is an interconnection between bone density and muscle mass on all-cause mortality in older men.</p><p><strong>Design: </strong>Prospective cohort study.</p><p><strong>Setting: </strong>The Osteoporotic Fractures in Men study, an multicenter longitudinal study across six US sites.</p><p><strong>Participants: </strong>Exposures measured at baseline visit (2014-2016) included bone density by dual-energy X-ray absorptiometry (hip, g/cm2); muscle mass by creatine dilution stable isotope (whole body, kg); bone strength by high-resolution computed tomography (tibia, newtons); and muscle volume by high-resolution computed tomography (calf, mm3). Covariates measured at baseline visit (2014-2016) included demographics and lifestyle factors as well as medical conditions.</p><p><strong>Main outcome measure: </strong>All-cause mortality by death certificates and International Classification of Diseases-Ninth Revision codes measured from 2014 to 2016 through August 2024. Data analysis was performed during December 2024. Cox hazards models were used to model the relationship between the exposures and outcomes, unadjusted and adjusted for covariates.</p><p><strong>Results: </strong>A total of 1388 men with a mean age of 84.2 ± 4.1 years (77-101 years, 91.6% white) were followed for 6.58 ± 2.61 years. A total of 663 (47.8%) men died. In unadjusted analyses using continuous exposures, interaction terms were significant between bone and muscle variables for all-cause mortality (P < 0.001 to 0.039). In men with low muscle mass or low muscle volume (≤50th percentile), each SD decrease in bone density increased all-cause mortality by a respective 19% (HR = 1.19 95% CI 1.07-1.34) and 29% (HR = 1.29 95% CI 1.11-1.49) in multivariable-adjusted models. Likewise, in men with low muscle mass or low muscle volume (≤50th percentile), each SD decrease in bone strength increased all-cause mortality by a respective 19% (HR = 1.19 95% CI 1.06-1.33) and 29% (HR = 1.29 95% CI 1.12-1.48) in multivariable-adjusted models.</p><p><strong>Conclusions: </strong>We found consistent evidence for a combined association of bone and muscle health on all-cause mortality. Randomised controlled trials are now needed to confirm if increasing or preserving bone and muscle mass in old age reduces mortality risk.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 7","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in anticholinergic cognitive burden and risk of single and recurrent falls: population-based cohort study","authors":"Xiang Jiang Xu, Phyo Kyaw Myint, Man Chun Wong, Sumaiyah Mat, Shaun Wen Huey Lee, Saber Sami, Maw Pin Tan","doi":"10.1093/ageing/afaf177","DOIUrl":"https://doi.org/10.1093/ageing/afaf177","url":null,"abstract":"Background Medications with high anticholinergic cognitive burden (ACB) are associated with increased fall risk in older adults. However, the potential alteration of risk with changes in ACB over time has yet to be established. Objective To estimate the association between the changes in ACB with single and recurrent falls. Methods Data from European Investigation of Cancer-Norfolk (EPIC-Norfolk) study participants, aged 40 years and above, who attended the first (1HC:1993–98), second (2HC:1998–2000) and third (3HC: 2004–11) health checks were utilised. The main outcome was a single fall event or recurrent ($ge 2$) falls occurring during the 12 months preceding the time point of the 3HC. Results Data from 10 717 participants with a median, Interquartile range (IQR) age of 55.6 (13.1) years were included. Three thousand four hundred forty-five (32.2%) participants had an ACB of one or greater at baseline. Participants were classified into four groups: no (67.8%), late (21.1%), transient (6.8%) and continuous (4.3%). Late (OR 1.49, 95% CI 1.25–1.79), transient (1.66, 1.28–2.14) and continuous (1.67, 1.22–2.29) exposure were significantly associated with increased recurrent falls compared with no exposure. Mediation analysis revealed that gait speed (GS) contributed to 16.9% (CI: 9.4%–27.8%) of the increase in risk of recurrent falls associated with ACB. Discussion Anticholinergic medication use, in adults aged 40 years and above, was linked to recurrent falls at 14-year follow-up, regardless of whether introduction or cessation occurred during the follow-up. Future research should determine effective strategies for minimising the long-term risk of falls when starting anticholinergic medications, which could include GS as a risk-detection and monitoring tool.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"25 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectrical impedance analysis for sarcopenia: a systematic review and meta-analysis of diagnostic accuracy","authors":"Meng Luo, Zhaoyuan Duan, Yunpeng Li, Yamin Wang, Lulu Chen, Jing Gao, Mingli Wu, Yalei Sun, Lidian Chen, Xiaodong Feng","doi":"10.1093/ageing/afaf181","DOIUrl":"https://doi.org/10.1093/ageing/afaf181","url":null,"abstract":"Objective To evaluate the diagnostic performance of bioelectrical impedance analysis (BIA) for detecting sarcopenia across diverse populations. Methods We conducted a search of MEDLINE, Embase, and Web of Science up to 2 January 2024. Cross-sectional, retrospective, and prospective cohort studies evaluating BIA’s diagnostic performance for detecting sarcopenia across diverse populations were included. The pooled sensitivity, specificity, positive and negative likelihood ratios (positive likelihood ratio [PLR] and negative likelihood ratio [NLR]), diagnostic odds ratio (DOR), and the area under the curve of summary receiver operating characteristic (SROC-AUC) were calculated using bivariate random-effects models. For each outcome, 95% confidence intervals (CI) were reported. Results A total of 27 studies involving 6239 participants were included. The pooled sensitivity was 79% (95% CI, 75%–82%), and the pooled specificity was 72% (95% CI, 68%–75%). The pooled PLR was 2.8 (95% CI, 2.5–3.1), the pooled NLR was 0.29 (95% CI, 0.25–0.35), and the pooled DOR was 9 (95% CI, 7–12). The SROC-AUC was 0.82 (95% CI, 0.78–0.85). Sensitivity analysis confirmed the robustness of these results. Heterogeneity was observed, which was attributable to variations in clinical and methodological factors. Conclusions This systematic review indicates that BIA has moderate diagnostic accuracy and practical clinical utility as a screening tool for sarcopenia, particularly in primary care and community settings. Further research is warranted to develop standardised protocols and predictive models to enhance consistency and reliability across populations.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"47 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating community services provision for older people living with severe frailty: implications from an England-wide survey","authors":"Richard Green, Sarah Combes, Jenny Harris, Caroline Nicholson","doi":"10.1093/ageing/afaf174","DOIUrl":"https://doi.org/10.1093/ageing/afaf174","url":null,"abstract":"Background Older people with severe frailty are nearing the end of life and require community services that span the care continuum, integrating older people’s care (e.g. physical function; rehabilitation) and palliative care (e.g. symptoms; what matters most to the person). Little is known about current community service provision to this population. Objective To characterise the scope of community service provision to older people with severe frailty in England. Methods A cross-sectional online survey design identifying common components and service configurations of community services providing care to older people with severe frailty in England. A self-selecting sample of multidisciplinary care providers from multi-agency community services working with older people with severe frailty with end-of-life care needs. Results Two hundred ninety-eight participants from 102 unique services across all English regions reported information on their service, including frailty and end-of-life assessment, service components, training, service costs and service development. Identification and assessment of frailty and end of life were routinely practiced, but approaches to identification varied. Organisations’ training and development were focussed on their own service provision with little focus on inter-organisational and cross-sectoral working. Conclusions Community care services responses were varied to this population’s diverse needs, which risks less coordinated practice and poorer care outcomes. Poorly integrated services can only partially meet the needs of older people with severe frailty. Further research is needed to address barriers to integration, including cross-sector collaboration, consistent use of appropriate assessment tools and service innovations driven by older people’s expressed needs.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"27 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the 4AT for assessing recovery from delirium in older hospital patients","authors":"Haruno McCartney, Erin Noble, Kali Thompson, Kseniia Fomina, Laura Mesia Guevara, Daniel H J Davis, Jonathan Evans, Susan D Shenkin, Graciela Muniz, Daisy Sandeman, Alasdair M J MacLullich, Zoë Tieges","doi":"10.1093/ageing/afaf166","DOIUrl":"https://doi.org/10.1093/ageing/afaf166","url":null,"abstract":"Background A crucial part of delirium care is assessing for recovery, yet there are no validated methods for this. The 4AT is a widely used delirium assessment tool, but its performance in assessing recovery remains unstudied. This study evaluated the 4AT’s performance in assessing recovery from delirium. Materials and methods In this prospective diagnostic accuracy study, older hospitalised patients (≥70 years) with reference standard delirium on enrolment were assessed 2–4 times over ≤9 days. Paired researchers independently conducted blinded assessments of (i) a reference standard (Diagnostic and Statistical Manual for Mental Disorders, 5th edition), including the Delirium Rating Scale-Revised-98 and neuropsychological tests and (ii) the 4AT (index test, score ≥ 4 positive) plus brief measures of distress and psychotic symptoms. Results A total of 120 people with delirium participated [median age 86.3, range 70–99, 67 (55.8%) female and 55 (45.8%) with dementia]. All of them completed the first two assessments, 103 (85.8%) completed three and 69 (57.5%) four. Reference standard delirium was present in 102/120 (85%), 72/103 (69.9%) and 53/69 (76.8%) cases at assessments two to four, respectively. In Receiver Operating Characteristic analyses, the 4AT’s sensitivity for detecting delirium was 0.95 (confidence interval 0.91–0.99), 0.96 (0.91–1) and 0.94 (0.88–1), and specificity was 0.67 (0.13–1), 0.88 (0.71–1) and 1 (1–1) at assessments two to four. In total 18 (15%) participants recovered from delirium. Distress was common in delirium and decreased with recovery. Conclusion The 4AT maintains diagnostic accuracy on repeated admissions and may effectively assess delirium recovery in acute hospital settings. Fewer patients than expected recovered within 9 days, suggesting more studies on the natural history of delirium in different settings would be informative.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"633 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patient-centered nutritional intervention with a new fortified high-protein high-energy paste: an observational study to assess nutritional intakes in hospitalized older adults","authors":"Marie Blanquet, Candy Guiguet-Auclair, Pauline Berland, Véronique Neves, Jocelyn Aubert, Sabine Combes, Jérôme Bruel, Laurent Gerbaud, Yves Boirie","doi":"10.1093/ageing/afaf179","DOIUrl":"https://doi.org/10.1093/ageing/afaf179","url":null,"abstract":"Background Protein-energy undernutrition in hospitalized older adults remains a major issue that warrants purposeful intervention. Objective To assess how a nutritional management process, using a fortified high-protein, high-energy paste, could help meet patient nutritional requirements. Methods An observational study was carried out between September 2021 and April 2022 in a community hospital’s multidisciplinary care unit (MCU) and geriatric rehabilitation unit (GRU). Hospital stays of patients aged 75 years or older were included. Intakes were recorded for each component of each lunchtime and evening meal throughout the hospital stay. Daily energy and protein intakes were compared to patient recommended requirements, i.e. 30 kcal/kg/day and 1.2 g/kg/day. Results Analysis included 403 hospital stays (296 in the MCU, 107 in the GRU). Energy recommended requirements were met in 23.3% of MCU stays and 31.8% of GRU stays. Daily energy intakes were lower than the recommended level in both units (P &amp;lt; 0.001): 25.2 ± 7.7 kcal/kg/day in the MCU and 27.0 ± 6.9 in the GRU. Protein recommended requirements were reached in 45.3% of MCU stays and 58.9% of GRU stays. Daily protein intakes were not significantly lower than the recommended level in both units: 1.17 ± 0.39 g/kg/day in the MCU (P = 0.10) and 1.26 ± 0.35 in GRU (P = 0.96). Conclusions The nutritional management process helped patients covering their protein requirements especially in the geriatric rehabilitation unit, but more efforts are still needed to reach energy requirements. Healthcare teams should be alert to the dependency in activities of daily living of patients.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"64 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between a Planetary Health Diet and changes in intrinsic capacity in older adults: the Seniors-ENRICA cohorts","authors":"Mercedes Gómez-Cao, María del Carmen Aznar de la Riera, Rosario Ortolá, Esther García-Esquinas, Verónica Cabanas-Sánchez, José R Banegas, Fernando Rodríguez-Artalejo, Mercedes Sotos-Prieto","doi":"10.1093/ageing/afaf175","DOIUrl":"https://doi.org/10.1093/ageing/afaf175","url":null,"abstract":"Background The Planetary Health Diet (PHD) benefits health and the environment. However, its impact on healthy ageing, estimated by intrinsic capacity (IC), remains unexplored. Objective To examine the association between adherence to a PHD Index (PHDI) and changes in IC in older adults. Methods Data were collected from 2519 adults aged ≥60y from the Seniors-ENRICA-1 (2012–15) and 3273 aged ≥65y from the Seniors-ENRICA-2 (2017–19) Spanish cohorts. Food consumption was collected with a dietary history, and the PHDI was based on 15 food groups. IC was measured across six domains: cognition, psychology, vitality, hearing, vision and locomotion (ranged: 0–18, lower score equals better IC). Adjusted multinomial logistic regressions were used, and data from both cohorts were pooled. Results Over a 2.6-year median follow-up, IC worsened for 32.0% of participants, improved for 27.7% and remained stable for 40.3%. Participants in the highest vs lowest tertile of adherence to the PHDI were more likely to improve vs worsen IC [relative risk ratio (RRR) 1.36; 95% confidence interval (95% CI) 1.05–1.77; P-trend = .021]. Higher PHDI scores were significantly associated with improvement vs worsening in the hearing domain (RRR 1.37; 95% CI 1.04–1.82; P-trend = .025). Higher adherence to PHDI’s recommendations regarding nuts (RRR 1.05; 95% CI 1.01–1.09) and starchy vegetables (RRR 1.09; 95% CI 1.01–1.17) were independently associated with improvement vs worsening IC. Conclusion In these older-adult cohorts, higher adherence to the PHDI was associated with improvement in overall IC and in its hearing domain. Adherence to nuts and starchy vegetables recommendations was particularly beneficial.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"49 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New horizons in advancing lifestyle medicine for older adults utilizing a transdisciplinary approach: gaps and opportunities","authors":"Rebecca K F Lassell, Kevin Pritchard, Laura A Baehr, Mirnova E Ceïde, Sudeshna A Chatterjee, Cristina Colón-Semenza, Oshadi Jayakody, Sarah B Lieber, Julia V Loewenthal, Christopher L Mosher, Elena Myasoedova, Annalisa Na, Una Makris, Andrea Sherman, Anoop Sheshadri, Kamal Wagle, Mariana Wingood, Brian J Andonian","doi":"10.1093/ageing/afaf159","DOIUrl":"https://doi.org/10.1093/ageing/afaf159","url":null,"abstract":"Nearly half of premature deaths can be prevented with healthy lifestyle behaviours. However, most older adults do not adhere to established guidelines to promote a healthy lifestyle. We propose a tailored framework of lifestyle medicine that acknowledges the complex contexts and care needs of older adults. The proposed framework of lifestyle medicine for older adults integrates their lived experiences (e.g. social determinants of health, built environment), the 5 M framework of geriatric medicine (i.e. Mind, Mobility, Medications, Multicomplexity, Matters Most) and the six pillars of lifestyle medicine (i.e. nutrition/diet, physical activity/exercise, restorative sleep, stress management, avoidance of risky substances, positive social connections) through a novel transdisciplinary approach. Guided by the updated framework, key gaps and opportunities are presented to advance lifestyle medicine practice, research and policy with the goal of promoting sustained behaviour change and improving the healthspan of older adults.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"602 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should octogenarians and people aged 90 years and over be treated separately in studies of stroke? An evaluation of national audit data","authors":"Meabh Kelly, Joan McCormack, Olga Brych, Peter J Kelly, Tim Cassidy, Ronan Collins, Joseph A Harbison","doi":"10.1093/ageing/afaf164","DOIUrl":"https://doi.org/10.1093/ageing/afaf164","url":null,"abstract":"Introduction Population studies frequently use ≥80 years for defining ‘very old’ but as mean life expectancy frequently exceeds 80 years internationally, this may no longer be appropriate. Those ≥90 years now represent a significant proportion of stroke patients. We examined national data to examine the differences between those 80–89 years and those 90+ years. Methods Data from the Irish National Audit of Stroke (2017–22 inclusive), including demographic, admission and outcome data, including prestroke and discharge modified Rankin Scores (mRS), were analysed. Proportional data were analysed using Chi-square statistics. Results Data on 26 829 individual stroke events were analysed of which 7329 (27.3%) were in people 80–89 years; 52.8% were women. 1708 events occurred in people ≥90 (6.4%); 70.0% were women. 73.7% of those 80–89 years had mRS &amp;lt; 3 prestroke vs 51.3% of those ≥90 (P &amp;lt; .001). In hospital mortality for people ≥90 was higher (26.8% vs 17.4% P &amp;lt; .001) and they were less likely to have mRS &amp;lt; 3 at discharge (17.0% vs 35.8% P &amp;lt; .001). Proportion of haemorrhagic stroke was significantly lower in those ≥90 (15.3% vs 12.9% P = .015). Only one haemorrhage was reported amongst 31 people ≥100 years. The proportion of atrial fibrillation (AF) detected following stroke was not significantly different (≥90 years: 33.9%, 80–89 years, 32.4% P = .38). On logistic regression, nonrecovery to independence (mRS &amp;gt;2) in those ≥90 was associated with prestroke mRS, haemorrhagic stroke, AF and being thrombolysed. Conclusion There are differences in profiles and outcomes between the groups, and it is now more appropriate to consider them separately.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"58 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}