Age and ageing最新文献

{"title":"Older people’s rehabilitation and recovery. Get up, stand up for geriatric rehabilitation","authors":"Wilco Achterberg, Adam L Gordon, Eléonore F van Dam van Isselt","doi":"10.1093/ageing/afaf199","DOIUrl":"https://doi.org/10.1093/ageing/afaf199","url":null,"abstract":"Effective health care for older people depends on a network of interconnected services across a variety of different settings that are all well developed, organised and financed. Preventive care, long term care, palliative care, and acute care in both hospital and community settings all play important, mutually dependent roles. Rehabilitation is important for patients in each of these contexts—it can play a role in recovery after acute or subacute health problems such as a hip fracture, stroke and pneumonia. This collection draws attention to the subject and, by sharing the state-of-the-art to date, to stimulate scholars all over the world to do research in this field and submit their work to Age and Ageing. This commentary accompanies this collection which explores the scientific output in this field as published in Age and Ageing over the last years.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"27 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of long-term glycemic variability with longitudinal motor and nonmotor progression in patients with Parkinson’s disease: an 8-year follow-up","authors":"Ryul Kim, Nyeonju Kang, Kyeongho Byun, Kiwon Park, Jin-Sun Jun, Beomseok Jeon","doi":"10.1093/ageing/afaf220","DOIUrl":"https://doi.org/10.1093/ageing/afaf220","url":null,"abstract":"Background Although recent evidence suggests that glycemic variability (GV) has a negative impact on neurodegeneration, its role in Parkinson’s disease (PD) remains unclear. Objective To explore the association between long-term GV and longitudinal motor and nonmotor progression in patients with PD and to uncover the disease-specific and nonspecific mechanisms underlying this association. Methods We used data obtained from the Parkinson’s Progression Markers Initiative cohort. Three hundred seventy-seven patients with early untreated PD underwent annual motor and nonmotor assessments covering neuropsychiatric, sleep-related, and autonomic symptoms for up to 8 years of follow-up. Dopamine transporter (DAT) imaging results and cerebrospinal fluid (CSF) marker levels, including α-synuclein, β-amyloid 1–42, total tau, phosphorylated tau181, and neurofilament light chain (NfL) were collected at baseline and for up to 6 years of follow-up. We defined GV as the intra-individual visit-to-visit variability in annual fasting blood glucose levels. Results With respect to motor symptoms, a greater GV was associated with a greater increase in postural instability/gait difficulty scores (P = .001) and a greater risk of developing freezing of gait (P = .002). With respect to nonmotor symptoms, higher GV was associated with a steeper decrease in Montreal Cognitive Assessment (P < .001) and semantic fluency test (P = .002) scores and a greater increase in Geriatric Depression Scale scores (P = .001). With respect to DAT imaging and CSF biomarkers, increased GV was associated with a greater increase in CSF NfL levels (P = .001) but not with other biomarker changes. Conclusion Our findings suggest that increased GV is related to unfavourable motor and nonmotor outcomes in patients with PD. However, we did not identify the specific mechanisms underlying these GV-related effects, despite its association with more severe neurodegeneration.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimal clinically important difference and substantial clinical benefits for single- and dual-task timed up and go test following motor-cognitive training in Parkinson’s disease","authors":"Ghorban Taghizadeh, Negin Eissazade, Seyed-Mohammad Fereshtehnejad, Parvaneh Taghavi Azar Sharabiani, Mohsen Shati, Seyede Salehe Mortazavi, Sayed Amir Hasan Habibi, Maryam SalemiJuybari, Maryam Mehdizadeh","doi":"10.1093/ageing/afaf241","DOIUrl":"https://doi.org/10.1093/ageing/afaf241","url":null,"abstract":"Objective To establish substantial clinical benefits (SCB) and minimal clinically important differences (MCIDs) for both the single-task and dual-task timed up and go (TUG) tests in people with Parkinson’s disease (PwPD). Design Prospective pre–post intervention study evaluating the effects of combined motor–cognitive training. Setting Rehabilitation centers. Participants One hundred fifteen PwPD, with a mean age of 61.33 ± 13.01 years. Interventions Dual-task motor-cognitive training. Main outcome measures Time taken to complete the single-task and dual-task TUG tests, recorded both before and after the intervention. MCIDs were calculated using the anchor-based and distribution-based methods. SCB was assessed using the receiver operating characteristic (ROC) curve analysis. Results The anchor-based MCIDs for the single-task and dual-task TUG tests ranged from −0.71 to −1.27, and − 0.82 to −1.81, respectively. The distribution-based MCIDs for the single-task and dual-task TUG tests ranged from −1.07 to −1.14, and − 1.65 to −1.98, respectively. The SCB for both the single-task and dual-task TUG tests was determined to be less than −2.04. Conclusion This investigation provides critical insights into interpreting changes in functional mobility in PwPD, facilitating informed clinical interventions and enhancing research planning initiatives.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"26 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best practice summary of dementia care guidelines based on the Competence Onion Model.","authors":"Jinfeng Zhu, Xirong Hu, Yuanyuan Song, Bo Zhang, Jing Wang","doi":"10.1093/ageing/afaf251","DOIUrl":"https://doi.org/10.1093/ageing/afaf251","url":null,"abstract":"<p><strong>Background: </strong>The study addresses the growing challenge of ensuring high-quality dementia care, particularly in light of increasing numbers of people with dementia and the complex needs associated with dementia. It identifies a gap in existing dementia care guidelines, especially the lack of integration across the various competencies required by nursing professionals.</p><p><strong>Objective: </strong>To search, evaluate and integrate the best available evidence on dementia care content from relevant guidelines.</p><p><strong>Design: </strong>This study has been registered and approved, following the reporting standard established by the Fudan University Center for Evidence-based Nursing, under registration number ES20246923 (http://ebn.nursing.fudan.edu.cn/home).</p><p><strong>Methods: </strong>Systematic searches were conducted for dementia care guidelines, and the Appraisal of Guidelines for Research and Evaluation (AGREE II) tool was used to assess the quality of the guidelines. This evidence summary adheres to the reporting specifications established by the Fudan University Center for Evidence-based Nursing, which are based on the methodological framework developed by the Joanna Briggs Institute (JBI). These specifications encompass problem identification, literature retrieval, screening, evaluation, evidence summary and grading, as well as the formulation of practical recommendations.</p><p><strong>Results: </strong>Based on the inclusion and exclusion criteria, a total of 28 guidelines were included. Evidence was extracted according to the Competence Onion Model, focusing on five key areas: dementia-friendly environment, knowledge, skill, attitude and behaviour, traits and motive. A total of 140 pieces of best evidence were identified.</p><p><strong>Conclusion: </strong>This study summarises the best evidence on dementia care content guidelines, providing relevant evidence-based support for clinical practice.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communicative practices used by health and social care professionals, older adults and informal carers during advance care planning conversations: systematic review of qualitative evidence and narrative synthesis.","authors":"Emily Spencer, Sarah Griffiths, Pushpa Nair, Katie Flanagan, Greta Rait, Fiona Stevenson, Nathan Davies","doi":"10.1093/ageing/afaf253","DOIUrl":"https://doi.org/10.1093/ageing/afaf253","url":null,"abstract":"<p><strong>Background: </strong>While advance care planning (ACP) is linked with clinical and psychosocial benefits for older adults and their informal carers, uptake is low. Inadequate communication skills amongst clinicians has been identified as a key barrier to effective ACP. While existing literature reviews have focussed on hypothetical preferences, barriers and facilitators, none have examined direct experience of ACP communication with this population. The aim of this review was to identify and synthesise qualitative evidence regarding the communicative practices used to support older adults, informal carers and health and social care professionals (HSCPs) have ACP conversations.</p><p><strong>Methods: </strong>A systematic review of qualitative evidence and narrative synthesis were undertaken. Five electronic databases (Medline, CINAHL, Emcare, Embase, PsychInfo) were systematically searched from inception to August 2024 for eligible studies reporting on features of ACP communication between HSCPs, older adults and informal carers. Quality appraisal was completed, with thematic analysis used to synthesise findings from eligible studies.</p><p><strong>Findings: </strong>From 6348 titles identified, 264 full texts were assessed for eligibility. Twenty-eight articles reporting on 25 studies were included in the narrative synthesis. Four analytical themes were generated: (i) Introducing a delicate topic; (ii) Participation within the care triad; (iii) Professional influence in decision-making; (iv) Patient perspectives on planning and care.</p><p><strong>Conclusions: </strong>ACP conversations would benefit from improved, personalised information provision to support informed decision-making, with clear, compassionate communication facilitated by continuity of care. Future research should further examine the role of informal carers, nonverbal communication, and take a broader view of ACP as an interactional process.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote assessment of physical function in older people: feasibility, safety and agreement with in-person administration.","authors":"Kimberley S van Schooten, Daniel Steffens, Adam Engeler, Meg Letton, Alicia Brown, Amy Perram, Lillian Miles, Michelle Ngo, Kim Delbaere","doi":"10.1093/ageing/afaf266","DOIUrl":"10.1093/ageing/afaf266","url":null,"abstract":"<p><strong>Background: </strong>Physical function is a key health indicator in older people. Interchangeable remote and in-person assessments could improve monitoring flexibility.</p><p><strong>Objective: </strong>To evaluate feasibility, safety and agreement between remote home and in-person laboratory physical function assessments in community-living older people.</p><p><strong>Methods: </strong>Thirty-seven people aged 60+ completed remote and in-person assessments of the five-times Sit-to-Stand (5STS), Timed Up-and-Go (TUG), standing balance test, 4 m Walk and Short Physical Performance Battery (SPPB) in counter-balanced order, two days apart. Feasibility was assessed as technological and environmental barriers, safety as adverse events, and agreement using intraclass correlation coefficients (ICCs) and smallest detectable differences (SDD), and based on kappa using clinical cutpoints (κ).</p><p><strong>Results: </strong>All participants completed the remote assessments without adverse events; 8% experienced minor connectivity issues. In-person performance was better for 5STS, TUG, 4 m Walk and standing balance; SPPB scores were comparable. Agreement was good for 5STS, TUG and standing balance (ICCs: 0.89 [95% confidence interval: 0.79-0.94], 0.85 [0.54-0.94], 0.77 [0.59-0.88], respectively)) and moderate for 4 m Walk and SPPB (ICCs: 0.64 [0.19-0.84] and 0.68 [0.46-0.82], respectively). SDD values for 5STS, TUG and SPPB fell within clinically acceptable ranges; categorical agreement was substantial (κ: 0.65, 0.77 and 0.65, respectively).</p><p><strong>Conclusions: </strong>Remote 5STS and TUG assessments showed good agreement, supporting their use with existing cut-points. Differences between settings in standing balance and walking speed (affecting SPPB) suggest caution in interpretation. Telehealth offers a feasible, safe option for monitoring physical function, though protocol refinements are needed for walking speed and standing balance.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pre-existing frailty on all-cause mortality in stroke survivors: a systematic review and dose-response meta-analysis.","authors":"Shouqi Wang, Jie Tan, Kaiyan Song, Qi Zhang, Wenhong Yang, Ying Wu","doi":"10.1093/ageing/afaf273","DOIUrl":"10.1093/ageing/afaf273","url":null,"abstract":"<p><strong>Background: </strong>The association between pre-existing frailty and increased mortality in stroke survivors remains unclear, with prior studies reporting inconsistent findings. This meta-analysis aimed to evaluate the impact of pre-stroke frailty on all-cause mortality in this population.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, Web of Science, Cochrane Library, CINAHL, PsycINFO, CNKI, Wanfang, VIP, and SinoMed databases up to November 12, 2024. Study selection and data extraction were independently performed by two investigators. Studies using validated frailty assessment tools and reporting adjusted hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were included.</p><p><strong>Results: </strong>Sixteen studies involving 55,897 patients met the inclusion criteria. The prevalence of frailty among stroke survivors ranged from 11.2% to 75.3%. Meta-analysis showed that pre-stroke frailty was significantly associated with increased all-cause mortality (pooled HR = 2.19, 95% CI: 1.44-3.34; pooled OR for continuous frailty scores = 1.26, 95% CI: 1.14-1.38). Dose-response analysis revealed a linear relationship, with each one-point increase in frailty score associated with a 6.4% higher risk of death (HR = 1.064, 95% CI: 1.031-1.098). Subgroup analyses indicated that the association was particularly strong in acute ischemic stroke populations (OR = 3.43, 95% CI: 1.81-6.51). The type of frailty assessment tool and study sample size were identified as potential sources of heterogeneity.</p><p><strong>Conclusion: </strong>Pre-stroke frailty independently predicts all-cause mortality in stroke survivors. Even mild increases in frailty burden are associated with worse outcomes, highlighting the clinical importance of incorporating frailty assessment into prognostic evaluation.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintaining independence at home after a fall: a process evaluation of the MAINTAIN multicomponent intervention for people living with dementia.","authors":"Leanne Greene, Louise M Allan, Alison Bingham, Ashima Sharma, Bethany Whale, Robert Barber, Christopher Fox, Victoria A Goodwin, Adam Lee Gordon, Abigail J Hall, Rowan H Harwood, Claire Hulme, Thomas Andrew Jackson, Rachel Litherland, Steve W Parry, Obi Ukoumunne, Sarah Morgan-Trimmer","doi":"10.1093/ageing/afaf245","DOIUrl":"10.1093/ageing/afaf245","url":null,"abstract":"<p><strong>Background: </strong>People with dementia who have a fall can experience both physical and psychological effects, often leading to diminished independence. Falls impose economic costs on the healthcare system. Despite elevated fall risks in dementia populations, evidence supporting effective home-based interventions remains limited.</p><p><strong>Methods: </strong>Multiple-methods process evaluation within a pilot cluster randomised controlled trial informed by a realist approach. Settings included six UK sites/clusters (three intervention, three control). Fidelity checks on routine data collection and fidelity observations of intervention sessions, multidisciplinary team meetings and supervision sessions were undertaken. Semi-structured interviews were conducted with people with dementia, caregivers and intervention therapists.</p><p><strong>Results: </strong>The MAINTAIN intervention demonstrated high fidelity in home assessments and intervention delivery, with participants receiving a mean of 15 of the 22 available sessions with a range of 5-25 sessions. Qualitative findings revealed that regular home visits increased engagement and motivation. Multidisciplinary team support enhanced therapists' confidence, particularly with complex cases. While most participants achieved their functional goals and reported improved confidence, challenges included geographical disparities in service delivery, carer burden and varying effectiveness of referral pathways. Therapists' attitudes towards advanced dementia influenced intervention delivery. The paired approach, involving both the person living with dementia and their carer, supported activity engagement but occasionally added extra responsibilities for caregivers.</p><p><strong>Conclusions: </strong>MAINTAIN was both feasible and acceptable. Future studies should consider standardising multidisciplinary support, incorporating targeted falls-related anxiety support and establishing sustainable post-intervention maintenance strategies. Protocol adaptations, such as video consultations, showed promise in addressing workforce constraints.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing a vigorous intermittent lifestyle physical activity intervention in adults transitioning to retirement: a pilot randomised controlled trial.","authors":"Bingyan Pang, Joanna C Moullin, Craig Thompson, Cecilie Thøgersen-Ntoumani, Emmanuel Stamatakis, Matthew Ahmadi, Joanne A McVeigh","doi":"10.1093/ageing/afaf244","DOIUrl":"10.1093/ageing/afaf244","url":null,"abstract":"<p><strong>Background: </strong>Vigorous intermittent lifestyle physical activity (VILPA; short bursts of vigorous-intensity activities in a person's daily life) could be an attractive and feasible option to increase physical activity (PA) in adults transitioning to retirement.</p><p><strong>Design and setting: </strong>Two-arm pilot randomised controlled trial (RCT) to test the feasibility of the intervention and the plausibility of the intervention to increase PA in adults transitioning to retirement in Perth, Western Australia.</p><p><strong>Participants: </strong>Insufficiently physically active adults transitioning to retirement.</p><p><strong>Intervention: </strong>Twelve-week theory-based and evidence-informed VILPA intervention designed to increase PA in adults transitioning to retirement.</p><p><strong>Objectives and measurements: </strong>The feasibility of the pilot was determined by the projected sample size with actual sample size, drop-out rates and reporting rates. The feasibility, acceptability and appropriateness of the intervention were assessed using validated questionnaires. The intervention's plausibility to increase PA was assessed by accelerometer-measured PA, functional fitness test and general health questionnaire.</p><p><strong>Results: </strong>Eighty individuals expressed interest in participating in the trial; 42 (feasibility of recruitment = 52.5%) were recruited and 34 completed the trial (retention = 80%). The preliminary data indicated increases in both total PA and VILPA, with positive impacts in self-reported general health and functional fitness. Participants found the intervention acceptable and intended to continue participation in VILPA and accumulate PA after the intervention.</p><p><strong>Conclusions: </strong>The VILPA intervention appears to be feasible for promoting PA in ageing adults. The findings of this pilot RCT also support a larger trial to seek the effectiveness of VILPA in improving health outcomes in ageing adults.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of low-dose aspirin on reversing frailty status in older prefrail and frail adults: a secondary analysis of the ASPREE randomised clinical trial.","authors":"Ananta P Handono, Joanne Ryan, Fajar Setiawan, Sara E Espinoza, Aung Zaw Zaw Phyo, Chao Zhu, Mark R Nelson, Michael E Ernst, Suzanne G Orchard, Rory Wolfe, Robyn Woods, Peng Qiu, Zhen Zhou","doi":"10.1093/ageing/afaf271","DOIUrl":"10.1093/ageing/afaf271","url":null,"abstract":"<p><strong>Background: </strong>Chronic low-grade inflammation is hypothesised as a central driver of frailty. This study aims to evaluate whether low-dose aspirin can reverse frailty status among initially prefrail/frail older adults.</p><p><strong>Methods: </strong>This was a post hoc subgroup analysis of the Aspirin in Reducing Events in the Elderly (ASPREE), a randomised, placebo-controlled trial, involving community-dwelling adults aged ≥65 years. The median (Interquartile range) follow-up was 4.7 (3.6-5.7) years. We included participants who were prefrail or frail at baseline, with frailty assessed using two validated measures: the Fried Frailty Phenotype (FFP) and the Deficit-Accumulation Frailty Index (FI). Frailty reversal was defined as a transition to a less severe state (from frail to prefrail/nonfrail, prefrail to nonfrail). The discrete-time survival model was used for outcome analysis; linear mixed-effects models compared longitudinal frailty trajectories between the treatment arms.</p><p><strong>Results: </strong>Among 6595 and 8766 participants included in the FFP and FI analyses, respectively, there was no significant difference in frailty status reversal between aspirin and placebo groups (FFP-HR: 1.00, 95% CI: 0.92-1.07; FI-HR: 1.00, 95% CI: 0.94-1.07). No significant difference was found in the change of FFP counts (β = 0.014, SE = 0.007, P = .06) and FI score (β = 0.0004, SE = 0.004, P = .37) between the aspirin and placebo groups over time, suggesting that aspirin neither reversed nor worsened frailty severity. Subgroup analyses revealed no effect modification by frailty risk factors such as age, sex, race and medical history.</p><p><strong>Conclusion: </strong>Low-dose aspirin has no effect in reversing frailty among prefrail and frail individuals. The findings highlight the need to explore alternative anti-inflammatory medications for frailty management.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}