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Wiener klinische Wochenschrift. Supplementum最新文献

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Analyses of the pattern of therapeutic drug monitoring in a university hospital laboratory. Suitability and performance of the CEDIA assays. 某高校医院实验室治疗药物监测模式分析。CEDIA检测方法的适用性和性能。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
E Hänseler, S Bigler, N Wad
{"title":"Analyses of the pattern of therapeutic drug monitoring in a university hospital laboratory. Suitability and performance of the CEDIA assays.","authors":"E Hänseler,&nbsp;S Bigler,&nbsp;N Wad","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>New homogeneous enzyme immunoassays (CEDIA assays) for therapeutic drug monitoring were evaluated on Boehringer Mannheim/Hitachi 704. A fluorescence polarization immunoassay and HPLC were chosen as comparison methods. A good correlation of patient data was observed for both methods (slopes 1.033-1.167). Imprecision within-run and between-day as well as the recovery in control samples of an external quality control survey were excellent and comparable to the routine method. In order to optimize the use of the CEDIA assays also for parameters which are less frequently requested, a parameter-setting for the batch-analyzer COBAS Fara was worked out. Performance of the CEDIA assays on random access analyzers is discussed with regard to the background of a laboratory for clinical chemistry in a University Hospital.</p>","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"191 ","pages":"23-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12679263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
International Workshop on CEDIA Assays. Vienna, 1-3 September 1991. CEDIA检测国际研讨会。维也纳，1991年9月1日至3日。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
{"title":"International Workshop on CEDIA Assays. Vienna, 1-3 September 1991.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"191 ","pages":"3-87"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12527607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous digoxin-like immunoreactive factors (DLIF) as measured by the CEDIA digoxin assay and a fluorescence polarization immunoassay. 内源性地高辛样免疫反应因子(DLIF)通过CEDIA地高辛测定法和荧光偏振免疫测定法测定。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
H Schlebusch, J Jarausch, I Domke
{"title":"Endogenous digoxin-like immunoreactive factors (DLIF) as measured by the CEDIA digoxin assay and a fluorescence polarization immunoassay.","authors":"H Schlebusch,&nbsp;J Jarausch,&nbsp;I Domke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The sensitivity of a new homogeneous enzyme immunoassay for the determination of digoxin (CEDIA Digoxin assay) and a fluorescence polarization immunoassay (FPIA) to interference by digoxin-like immunoreactive factors (DLIF) was studied in sera from pregnant women, newborns, patients undergoing hemodialysis and patients with renal insufficiency, but without hemodialysis. None of the patients had been treated with digoxin or digitoxin. Cross-reactivity of DLIF in the CEDIA assay was generally lower than in the FPIA. Data on the distribution DLIF of values and method comparisons showed that sera of the four patient groups reacted in a completely different way in both assays, suggesting that the nature of DLIF in the four groups is not identical. Addition of digoxin to sera of patients not treated with this drug resulted in a reduction of the apparent DLIF concentration in the CEDIA assay and the FPIA. This shows that DLIF interference may be less pronounced in sera of patients undergoing digoxin therapy compared to untreated persons. Although the CEDIA assay is less sensitive to DLIF interference than the FPIA, further efforts are needed to reduce the extent of this interference.</p>","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"191 ","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12678491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical relevance of the determination of antiepileptic drugs in serum. 血清中抗癫痫药物测定的临床意义。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
W Fröscher
{"title":"Clinical relevance of the determination of antiepileptic drugs in serum.","authors":"W Fröscher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Opinions on the clinical relevance of the determination of antiepileptic drugs in serum are very divergent. Specially the value of routine determinations has not been clarified up to now. At present the determination of antiepileptic drugs is indicated in the following situations: resistance to therapy including suspected irregular intake, adjustment of the serum level into the therapeutic range to prevent under- or overdosage, suspected intoxication (particularly during combined therapy), dosage monitoring when changes in the dosage-serum level relationship might occur, combined therapy, dosage reduction in the absence of seizures, determination of a baseline level in patients with good anticonvulsant control, legal indications, therapy research.</p>","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"191 ","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12679261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Risk of HIV infection in the area of emergency medicine]. [急诊医学领域的HIV感染风险]。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
M Röggla, G Röggla
{"title":"[Risk of HIV infection in the area of emergency medicine].","authors":"M Röggla,&nbsp;G Röggla","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"194 ","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12462241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Emergency admission to the general hospital in Vienna--the first annual report]. [维也纳综合医院急诊入院————第一份年度报告]。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
A N Laggner
{"title":"[Emergency admission to the general hospital in Vienna--the first annual report].","authors":"A N Laggner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"194 ","pages":"3-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12462242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic aspects of therapeutic drug monitoring. 治疗药物监测的经济方面。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
J Feuerstein, R Thomae
{"title":"Economic aspects of therapeutic drug monitoring.","authors":"J Feuerstein,&nbsp;R Thomae","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the last two decades two major trends heavily influenced the situation of the clinical laboratories. Cost saving issues have become more and more significant and an exploding number of tests has to be performed by a limited number of technicians. The latter task is facilitated by the use of automated analyzers. The CEDIA assays for therapeutic drug monitoring (TDM) can be performed on Boehringer Mannheim/Hitachi systems used for routine clinical chemistry. This means that now it is possible to determine all parameters of clinical chemistry, proteins, and TDM without sample splitting on one analyzer, resulting in saving of manual workload and costs.</p>","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"191 ","pages":"85-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12678404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of the multicenter evaluation of the CEDIA Phenobarbital assay. CEDIA苯巴比妥测定的多中心评价结果。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
G Klein, W Collinsworth, A Courbe, O Diez, I Domke, E Hänseler, P Haux, R Kattermann, A Knoke, P Lehmann
{"title":"Results of the multicenter evaluation of the CEDIA Phenobarbital assay.","authors":"G Klein,&nbsp;W Collinsworth,&nbsp;A Courbe,&nbsp;O Diez,&nbsp;I Domke,&nbsp;E Hänseler,&nbsp;P Haux,&nbsp;R Kattermann,&nbsp;A Knoke,&nbsp;P Lehmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The CEDIA Phenobarbital assay has been evaluated in twelve clinical laboratories in Europe and U.S.A. on Boehringer Mannheim/Hitachi analysis systems. The evaluation focused on the analysis of imprecision and accuracy. Within-run and between-day coefficients of variations of the new assay were comparable to those of established routine methods. As demonstrated in an interlaboratory survey study with controls and human sera, results obtained in different laboratories showed a good agreement. The CEDIA Phenobarbital assay measured very accurately, as particularly confirmed by comparison with HPLC. It can be recommended as a reliable and practicable test for monitoring of phenobarbital on Boehringer Mannheim/Hitachi analyzers used in routine clinical chemistry.</p>","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"191 ","pages":"43-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12678487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of the multicenter evaluation of a novel homogeneous immunoassay for digoxin based on the cloned enzyme donor immunoassay technology. 基于克隆酶供体免疫分析技术的新型地高辛均相免疫分析的多中心评价结果。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
J Jarausch, W Collinsworth, Y Cano, G Hafner, E Hammer, H Malandain, L Pokieser, F L Redondo, H Schlebusch, A Taylor
{"title":"Results of the multicenter evaluation of a novel homogeneous immunoassay for digoxin based on the cloned enzyme donor immunoassay technology.","authors":"J Jarausch,&nbsp;W Collinsworth,&nbsp;Y Cano,&nbsp;G Hafner,&nbsp;E Hammer,&nbsp;H Malandain,&nbsp;L Pokieser,&nbsp;F L Redondo,&nbsp;H Schlebusch,&nbsp;A Taylor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new CEDIA assay for the measurement of digoxin in serum on random access analyzers was evaluated by twelve laboratories in Europe and the United States. Studies on the analytical range, reproducibility, calibration stability, recovery in controls, interlaboratory comparability, comparability with routine methods, and the effect of various interfering factors have been performed and the results are presented in this paper. The analytical performance was comparable to that of routine methods provided the manual pipetting step for pre-incubation was performed with accurate pipettes. A major advantage of the CEDIA Digoxin assay in terms of convenience is the simple two-point calibration procedure. Moreover, digoxin can be determined within 15 minutes after receiving the samples on random access analyzers like Boehringer Mannheim/Hitachi analysis systems. Thus, the CEDIA Digoxin assay represents an attractive alternative to the measurement of digoxin on dedicated immunochemical assay systems.</p>","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"191 ","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12678493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Current issues in chemotherapy of infectious diseases. Munich, Federal Republic of Germany, May 15-16, 1992. Abstracts]. 传染病化疗的现状1992年5月15日至16日，德意志联邦共和国慕尼黑。摘要]。
Wiener klinische Wochenschrift. Supplementum Pub Date : 1992-01-01
{"title":"[Current issues in chemotherapy of infectious diseases. Munich, Federal Republic of Germany, May 15-16, 1992. Abstracts].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76822,"journal":{"name":"Wiener klinische Wochenschrift. Supplementum","volume":"193 ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12530934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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