Virchows Archiv. A, Pathological anatomy and histology最新文献_第7页

The ultrastructure of human fibrosing alveolitis. 人纤维化肺泡炎的超微结构。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429611

J J Coalson

{"title":"The ultrastructure of human fibrosing alveolitis.","authors":"J J Coalson","doi":"10.1007/BF00429611","DOIUrl":"https://doi.org/10.1007/BF00429611","url":null,"abstract":"This report describes the ultrastructural findings in 37 patients who underwent open lung biopsy which yielded diagnoses of fibrosing alveolitis. A spectrum of lesions are categorized for the capillary endothelium and its basement membrane, the interstitial space and its fibrocellular components, and the alveolar epithelium and its basement membrane. The findings typify the different pulmonary cellular reactions to injury. Evidence for cellular regeneration and death in both epithelial and endothelial cell populations include atypical epithelial cell proliferation, capillary basement membrane multilamination, decrease in capillary lumen size and prominent pericytic ensheathment of pulmonary capillaries. Within the interstitium of the lung, proliferation of collagen and elastic fibers are documented, but in addition, abundant myofibroblasts and smooth muscle cells are present. No ultrastructural evidence of immune complex deposition was found in this study. The morphologic findings of fibrosing alveolitis further support the widespread concept that the lung responds to various injuries in a similar manner and undergoes a common reparative response regardless of etiology.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"395 2","pages":"181-99"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00429611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18095396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Hepatic ultrastructure in leprechaunism. Hepatic ultrastructural evidence suggesting a syndrome with defective hepatic glucose release. 小妖精的肝脏超微结构。肝脏超微结构证据提示肝脏葡萄糖释放缺陷综合征。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00442383

S I Roth, H K Schedewie, D M Bier, H H Conaway, J Olefsky, A Rubenstein, M J Elders

{"title":"Hepatic ultrastructure in leprechaunism. Hepatic ultrastructural evidence suggesting a syndrome with defective hepatic glucose release.","authors":"S I Roth, H K Schedewie, D M Bier, H H Conaway, J Olefsky, A Rubenstein, M J Elders","doi":"10.1007/BF00442383","DOIUrl":"https://doi.org/10.1007/BF00442383","url":null,"abstract":"Leprechaunism is a congenital syndrome with characteristic habitus and facies, with fasting hypoglycemia and hyperinsulinism. In response to a glucose challenge there is prolonged severe hyperglycemia with an increased hyperinsulinemia. Our studies on such a patient showed a normal response of the serum glucose to glucagon stimulation in the fed state but no response in the postabsorptive state. Ultrastructural studies on the hepatocytes demonstrated that a lack of hepatic glycogen was not responsible for the biochemical features, since there was abundant normal beta-glycogen in both the fed and fasting state, the granules being smaller in the fasted state. We speculate that carbohydrate intolerance in leprechaunism may be due to a relative insulin resistance of cell receptors in the fed state. Reactive hyperinsulinemia persisting into the postabsorptive phase appears to antagonize the usual glycogenolytic response to glucagon during fasting, resulting in hypoglycemia despite the presence of large hepatic glycogen stores.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 2","pages":"121-30"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00442383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18192701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mesangial alterations in steroid-responsive minimal change nephrotic syndrome. 类固醇反应性肾病综合征的系膜改变。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00442389

J Fydryk, R Waldherr, G Mall, K Schärer

{"title":"Mesangial alterations in steroid-responsive minimal change nephrotic syndrome.","authors":"J Fydryk, R Waldherr, G Mall, K Schärer","doi":"10.1007/BF00442389","DOIUrl":"https://doi.org/10.1007/BF00442389","url":null,"abstract":"Renal biopsies from 25 children with steroid-sensitive minimal change nephrotic syndrome were evaluated retrospectively to determine whether there is any relation between the morphological changes and the frequency of relapses. Biopsy material was examined by light-, immunofluorescence-, and electron microscopy, and by morphometric methods. The patients were divided in a group of 15 children with frequent relapses (FR) and another group of 10 children with an absence of, or only infrequent, relapses (NR/IR). Semiquantitative evaluation of biopsy specimens disclosed no significant differences between groups, but morphometric measurements performed on toluidine stained semi-thin sections showed a significant increase of mesangial nuclei in FR compared with NR/IR (P less than 0.01). Furthermore, the mean area of mesangial nuclei was decreased and the relative frequency of smaller nuclear profiles was higher in patients with FR compared to NR/IR (p less than 0.01). These findings suggest mesangial cell activation in FR which may be related to a longer course of the disease prior to renal biopsy (mean 4.0 years in FR vs. 1.4 years in NR/IR). In our opinion, morphometric assessment of discrete mesangial alterations is a promising method for exploring clinicopathological correlations in minimal change nephrotic syndrome.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 2","pages":"193-202"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00442389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18192704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cytoplasmic inclusions in lymphocytes of chronic lymphocytic leukaemia. A report of 10 cases. 慢性淋巴细胞白血病淋巴细胞中的细胞质包涵体。报告10例病例。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429615

E Ralfkiaer, K Hou-Jensen, C Geisler, T Plesner, A Henschel, M M Hansen

{"title":"Cytoplasmic inclusions in lymphocytes of chronic lymphocytic leukaemia. A report of 10 cases.","authors":"E Ralfkiaer, K Hou-Jensen, C Geisler, T Plesner, A Henschel, M M Hansen","doi":"10.1007/BF00429615","DOIUrl":"https://doi.org/10.1007/BF00429615","url":null,"abstract":"Peripheral blood from 90 CLL patients was examined by light-and electron-microscopy for the occurrence of crystalline inclusions in lymphocytes. Inclusions were demonstrated in 10 patients (11%). In these patients the inclusions were present in 5-45% of peripheral blood lymphocytes. In the light microscope the inclusions appeared as rectangular, unstained structures in May-Grünewald Giemsa and PAS stains. In the electron microscope the inclusions appeared as intracytoplasmic, completely partially membrane-bound bodies, which were often associated with dilated profiles of rough endoplasmic reticulum. The ultrastructure of the inclusions was granular. In immunofluorescence staining the inclusions were found to contain immunoglobulin of the same type and class as the surface membrane-bound immunoglobulin of the neoplastic lymphocytes, most frequently IgM-lambda. The lymphocytes of one case with kappa light chains at the cell surface membrane contained inclusions of the same ultrastructural morphology as those of the other cases with lambda light chains. The presence of inclusions was not associated with any specific clinical or prognostic features. the inclusions persisted during antileukaemic therapy. Their formation may be related to a dysfunction in the synthesis of surface membrane-bound immunoglobulins.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"395 2","pages":"227-36"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00429615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17347913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages. 肿瘤细胞的滞留和外渗。连续切片在连续阶段的电子显微镜研究

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00428501

E A Machado, D A Gerard, J R Mitchell, B B Lozzio, C B Lozzio

{"title":"Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages.","authors":"E A Machado, D A Gerard, J R Mitchell, B B Lozzio, C B Lozzio","doi":"10.1007/BF00428501","DOIUrl":"https://doi.org/10.1007/BF00428501","url":null,"abstract":"The morphological aspects of the arrest and extravasation of malignant cells of human origin (K-562 cell line) in the lungs of athymic (nude) and asplenic-athymic (lasat) mice were studied by electron microscopy examination of serial sections. The specimens were obtained at sequential stages after the sc inoculation into newborn mice of 10(7) malignant cells. K-562 cells (10(5)) were also injected iv into control groups of nude and lasat mice to assess the influence of the route of inoculation on the in vivo behavior of K-562 cells. Our results demonstrated that K-562 cells were arrested and proliferated within the pulmonary capillaries without the participation of platelets or fibrin. The neoplastic cells extravasated by attrition and penetration of the endothelium (rather than by diapedesis) and continued to proliferate in the interstitial tissue of the lung, developing into neoplastic nodules. Following iv injection, K-562 cells induced the formation of platelet-tumor cell aggregates within the pulmonary capillaries. However, under these conditions, the neoplastic cells did not adhere to the endothelium nor did they proliferate or extravasate. These aggregates were flushed out by the circulation, restoring the permeability of the capillaries.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"396 1","pages":"73-89"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00428501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18140007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Clinicopathologic correlations in congestive cardiomyopathy. A study on endomyocardial biopsies. 充血性心肌病的临床病理相关性。心内膜肌活检的研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430894

G Mall, F Schwarz, H Derks

引用次数: 11

Adenoma of the human pituitary producing growth hormone and thyrotropin. A histologic, immunocytologic and fine-structural study. 人脑垂体的腺瘤，产生生长激素和促甲状腺激素。组织学、免疫细胞学和精细结构研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443484

K Kovacs, E Horvath, C Ezrin, M H Weiss

{"title":"Adenoma of the human pituitary producing growth hormone and thyrotropin. A histologic, immunocytologic and fine-structural study.","authors":"K Kovacs, E Horvath, C Ezrin, M H Weiss","doi":"10.1007/BF00443484","DOIUrl":"https://doi.org/10.1007/BF00443484","url":null,"abstract":"A pituitary adenoma removed by surgery from a 22-year-old man was studied by histology, immunocytology, transmission electron microscopy and immunoelectron microscopy. Clinically, the patient had acromegaly and euthyroidism with elevated blood GH concentrations. Blood TSH and T4 levels were within the normal range. Histologically, the adenoma was chromophobic and exhibited no PAS, lead hematoxylin, aldehyde thionin or Grimelius silver positivity. By the immunoperoxidase technique GH, beta-TSH and alpha-subunit but no PRL, ACTH, alpha-endorphin, beta-FSH or beta-LH were demonstrated in the adenoma cells. Electron microscopy revealed adenoma cells which were similar to TSH cells and showed no resemblance to GH cells of nontumorous pituitaries or GH-secreting tumors. Immunoelectron microscopy demonstrated GH and beta-TSH in the secretory granules. It is concluded that pituitary adenomas composed of TSH-like cells may secret GH, resulting in acromegaly. Production of GH by adenomatous TSH cells cannot be explained on the basis of the one cell- one hormone theory. The question is raised whether bihormonal or multihormonal clones, capable of synthesizing more than one hormone, exist in the human pituitary. These cells are apparently dormant under normal conditions, but in the course of neoplastic transformation may undergo functional dedifferentiation and acquire the ability to produce two or more different hormones.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":" ","pages":"59-68"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00443484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35256349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Squamous metaplasia following necrosis of the adenohypophysis and of a chromophobe adenoma of the pituitary. 垂体腺垂体和嫌色腺瘤坏死后的鳞状化生。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443485

J J Kepes, J Sayler, R Hiszczynskyj

引用次数: 3

A case of angioimmunoblastic lymphadenopathy with involvement of the nervous system. 血管免疫母细胞性淋巴结病累及神经系统1例。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443489

R Schober

引用次数: 0

Sparsely granulated prolactin cell adenomas of the pituitary gland. Correlation of ultrastructure with plasma hormone level. 脑垂体的稀疏颗粒状泌乳素细胞腺瘤。超微结构与血浆激素水平的相关性。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00431239

K P Dingemans, J Assies, N Jansen, P C Diegenbach

{"title":"Sparsely granulated prolactin cell adenomas of the pituitary gland. Correlation of ultrastructure with plasma hormone level.","authors":"K P Dingemans, J Assies, N Jansen, P C Diegenbach","doi":"10.1007/BF00431239","DOIUrl":"https://doi.org/10.1007/BF00431239","url":null,"abstract":"The possible relationship between the preoperative plasma prolactin levels of patients having a sparsely granulated prolactin cell adenoma of the pituitary gland and the morphology of the tumors was studied by means of quantitative electron microscopy. To this end, a number of ultrastructural variables were chosen which are generally regarded to be indicative of cellular activity and which could be determined in a quantitative or semiquantitative way. These variables were determined in 19 adenomas from 17 patients and plotted against the corresponding prolactin levels. It appeared that marked endocrine activity was associated with a small number of granules per cell, a high frequency of exocytosis, and a marked development of the rough endoplasmic reticulum. Granule size and development of Golgi apparatus and lysosomes were not at all, or only poorly correlated with the plasma hormone levels. Finally, the number of mitochondria per cell showed a totally unexpected inverse correlation with endocrine activity. Due to the close mutual correlation existing between several of the variables investigated, combining them in a multivariate analysis did not significantly improve the correlation with the hormone level.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"396 2","pages":"167-86"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00431239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17864710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1