Virchows Archiv. A, Pathological anatomy and histology最新文献_第10页

Unusual pulmonary vascular lesions after intravenous injections of microcrystalline cellulose. A complication of pentazocine tablet abuse. 静脉注射微晶纤维素后肺血管异常病变。戊唑嗪片滥用的并发症。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429613

T B Zeltner, U Nussbaumer, O Rudin, A Zimmermann

引用次数: 14

The nephronophthisis complex. A clinicopathologic study in children. 肾病复合体。儿童临床病理研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430668

R Waldherr, T Lennert, H P Weber, H J Födisch, K Schärer

引用次数: 57

Primary sarcoma of the gallbladder. A light and electronmicroscopical study. 原发性胆囊肉瘤。光学和电子显微镜研究

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00428502

R Willén, H Willén

引用次数: 19

Microvasculature of human colorectal epithelial tumors. An electron microscopic study. 人结肠上皮肿瘤的微血管。电子显微镜研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00442384

W Wang, M Campiche

{"title":"Microvasculature of human colorectal epithelial tumors. An electron microscopic study.","authors":"W Wang, M Campiche","doi":"10.1007/BF00442384","DOIUrl":"https://doi.org/10.1007/BF00442384","url":null,"abstract":"The ultrastructure of the microvasculature in human colorectal adenomas and carcinomas was studied, and compared with that of normal tissue. Blood vessels in adenomas were generally of normal structure, whereas carcinoma vessels displayed a variety of structural alterations. Endothelial proliferation was frequently observed in all the eleven carcinomas examined, which confirms the reports of new vessel formation in experimental malignant tumors. The presence of fenestrations in obviously abnormal endothelium was tentatively attributed to hypoxia, vascular regression or immaturity of the cells, in spite of the fact that normal capillaries in colonic mucosa are fenestrated. Some vessels showed multilayered basement membranes, various types of activated cells containing numerous lysosomal granules, and thickened perivascular tissue. These features may be a vascular response to repeated damage or a manifestation of vascular remodelling. Dilated thin-walled vessels, which were usually found at the periphery of carcinomas, were identified as venules. Small vessels located between the closely apposed carcinoma tubules were not obviously abnormal. They were nevertheless considered to be tumor-induced vessels which had undergone differentiation. The differences in vascular morphology between adenomas and carcinomas were considered to be due to their different growth patterns, growth rates and degrees of maturity.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 2","pages":"131-47"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00442384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17356970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Pathology of a new toxic syndrome caused by ingestion of adulterated oil in Spain. 一个新的病理中毒综合征引起的摄入掺假油在西班牙。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00496569

F J Martinez-Tello, J J Navas-Palacios, J R Ricoy, R Gil-Martín, J M Conde-Zurita, F Colina-Ruiz Delgado, I Tellez, A Cabello, S Madero-García

{"title":"Pathology of a new toxic syndrome caused by ingestion of adulterated oil in Spain.","authors":"F J Martinez-Tello, J J Navas-Palacios, J R Ricoy, R Gil-Martín, J M Conde-Zurita, F Colina-Ruiz Delgado, I Tellez, A Cabello, S Madero-García","doi":"10.1007/BF00496569","DOIUrl":"https://doi.org/10.1007/BF00496569","url":null,"abstract":"The Toxic Syndrome (TS) caused by ingestion of adulterated rapeseed oil in Spain is a new disease of multisystemic character whose aetiology and pathogenesis remains unknown. The most prominent pathological feature is a peculiar non-necrotizing vasculitis, that affects mainly the intima and involves vessels of every type and size in practically every organ. The TS begins with an acute clinical picture with pleuropneumopathy, fever, headaches, exanthems and eosinophilia. In these early clinical phases the main pathological findings were observed in the lungs and consisted of intense pulmonary interstitial oedema with scanty inflammatory mononuclear infiltrates. Ultrastructural study revealed hydropic degeneration of pneumocytes types I and II with desquamation of type I. The patients in this phase died of respiratory failure, later deaths were due to thromboembolic complications. Later still the patients developed a neuromuscular syndrome, sclerodermiform skin lesions and severe weight loss and died predominantly of infectious complications and respiratory failure. The anatomopathological picture in the peripheral nerves was that of inflammatory neuropathy with a lymphocytic perineuritis that led to perineural fibrosis with secondary axonal degeneration. The muscle presented an interstitial inflammatory myopathy at first followed by a neurogenic muscular atrophy. The skin lesions in the late phases consisted in dermal or dermal and subdermal fibrosclerosis, with vasculitis of the small arteries in the lower dermis. The salivary glands and pancreas showed vasculitis and interstitial inflammation which progressed to interstitial fibrosis and parenchymal atrophy.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 3","pages":"261-85"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00496569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18174230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

The cardiomyopathy of Wilson's disease. Myocardial alterations in nine cases. 威尔逊氏病的心肌病。9例心肌改变。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00496571

S M Factor, S Cho, I Sternlieb, I H Scheinberg, S Goldfischer

{"title":"The cardiomyopathy of Wilson's disease. Myocardial alterations in nine cases.","authors":"S M Factor, S Cho, I Sternlieb, I H Scheinberg, S Goldfischer","doi":"10.1007/BF00496571","DOIUrl":"https://doi.org/10.1007/BF00496571","url":null,"abstract":"Though myocardial alterations are well recognized in haemochromatosis, little attention has been paid to the cardiac changes in Wilson's disease. To define the extent of myocardial degeneration in newly diagnosed or chronically treated Wilson's disease, we reviewed the autopsy findings in 9 cases with this condition. We compared our observations with those in 3 control cases, selected for comparable age and with liver disease having no known association with cardiac degeneration. Our results revealed cardiac hypertrophy in 5 out of 9 cases of Wilson's disease. There was evidence of interstitial and replacement fibrosis, intramyocardial small vessel sclerosis and focal inflammatory cell inflammation to a variable degree in all cases. One case had AV nodal degeneration, and a 15 year old boy had severe atherosclerosis of the left main coronary artery. Two patients died suddenly, presumably secondary to an arrhythmia; one of these patients had the most marked myocardial alterations. We could not correlate these changes specifically with the tissue levels of copper, treatment with D-penicillamine, or the presence of cirrhosis. We conclude that there are definite morphological abnormalities in the hearts of patients with Wilson's disease consistent with a cardiomyopathy. Though the myocardial changes were non-specific, the fact that 2 patients died suddenly, suggests the need for a prospective study of cardiac function in these patients in the future.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 3","pages":"301-11"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00496571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18174231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Intracellular keratins in normal and pathological bronchial mucosa. Immunocytochemical studies on biopsies and cell suspensions. 正常和病理支气管粘膜细胞内角蛋白。活组织检查和细胞悬液的免疫细胞化学研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443487

F Bejui-Thivolet, J Viac, J Thivolet, M Faure

{"title":"Intracellular keratins in normal and pathological bronchial mucosa. Immunocytochemical studies on biopsies and cell suspensions.","authors":"F Bejui-Thivolet, J Viac, J Thivolet, M Faure","doi":"10.1007/BF00443487","DOIUrl":"https://doi.org/10.1007/BF00443487","url":null,"abstract":"The distribution of intracellular keratins was investigated in normal bronchial epithelium and in several morphologically distinct forms of respiratory tract carcinomas. This study was performed with two different experimentally produced antisera against normal human stratum corneum keratin and against keratin protein of MW 67,000 dalton, using indirect immunofluorescence and immunoperoxidase methods on tissue sections and cell suspensions. In normal bronchial epithelium, the basal cells were strongly labelled by both antisera. The ciliated columnar cells appeared devoid of cytokeratins in tissue sections but were strongly labelled with both antisera in cell suspensions. The goblet cells remained negative in every case. In squamous metaplasia of the bronchus, all epithelial cells were unevenly stained with both antisera. Among tumours, only the squamous cell carcinomas were strongly labelled by both antisera. Primary lung adenocarcinoma appeared weakly positive, whereas metastatic lung carcinomas, undifferentiated lung carcinomas, oat cell tumours, carcinoid tumours were negative. The immunocytochemical determination of keratins appeared to be of value in the study of normal and abnormal epithelial differentiation, in the diagnosis of poorly differentiated carcinomas and in their distinction from metastatic tumours of the lung.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"395 1","pages":"87-98"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00443487","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17242142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

[Ultrastructure of endocardial lesions in the carcinoid syndrome (author's transl)]. [类癌综合征心内膜病变的超微结构(作者图1)]。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1981-01-01 DOI: 10.1007/BF00589793

H G Müller, R E Siebenmann

引用次数: 3

Neural differentiation in the OTT-6050 mouse teratoma. Production of a tumor fraction restricted to stem cells and neural cells after centrifugal elutriation. OTT-6050小鼠畸胎瘤的神经分化。离心洗脱后产生的肿瘤部分仅限于干细胞和神经细胞。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1981-01-01 DOI: 10.1007/BF02155666

S R VandenBerg, M Chatel, O M Griffiths, S J DeArmond, C Pappas, M M Herman

{"title":"Neural differentiation in the OTT-6050 mouse teratoma. Production of a tumor fraction restricted to stem cells and neural cells after centrifugal elutriation.","authors":"S R VandenBerg, M Chatel, O M Griffiths, S J DeArmond, C Pappas, M M Herman","doi":"10.1007/BF02155666","DOIUrl":"https://doi.org/10.1007/BF02155666","url":null,"abstract":"Dissociation and centrifugal elutriation procedures were applied to subcutaneous transplants of the OTT-6050 mouse teratoma line in order to enrich the neuroepithelial cells. One of the resultant cell fractions, designated IB-21, was then implanted beneath the renal capsule of syngeneic mice and rebanked every 3 to 6 weeks for a total of 58 passages over 5 years. Sequential passages resulted in a tumor restricted to stem cells and neural cells (neuroblasts and glial cells). The primitive neural cells lost the ability to form rosettes after the early transplants. Subcutaneous or intracerebral transplantation of these tumors evinced their capacity for further neuroepithelial differentiation, with the demonstration of astrocytes and occasional mature synapse-forming neurons. Conversion of the tumor to the ascitic form resulted in unorganized clusters of neoplastic cells in contrast to the highly structured embryoid bodies that are characteristic of the parent Ott-6050 line. The absence of non-neural cells in the IB-21 tumor fraction and its ability to demonstrate divergent neural differentiation suggest that a transplantable neural-determined cell population exists in the OTT-6050 mouse teratoma.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"392 3","pages":"281-94"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02155666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18283266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Neural differentiation in the OTT-6050 mouse teratoma. Production of a tumor fraction showing melanogenesis in neuroepithelial cells after centrifugal elutriation. OTT-6050小鼠畸胎瘤的神经分化。离心洗脱后显示神经上皮细胞中黑色素生成的肿瘤部分的产生。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1981-01-01 DOI: 10.1007/BF02155667

S R VandenBerg, J R Hess, M M Herman, S J DeArmond, M Halks-Miller, L J Rubinstein

引用次数: 10