Virchows Archiv. A, Pathological anatomy and histology最新文献

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Morphometry and cytodiagnosis of breast lesions. 乳腺病变的形态学和细胞诊断。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00428497
M E Boon, P A Trott, H van Kaam, P J Kurver, A Leach, J P Baak
{"title":"Morphometry and cytodiagnosis of breast lesions.","authors":"M E Boon,&nbsp;P A Trott,&nbsp;H van Kaam,&nbsp;P J Kurver,&nbsp;A Leach,&nbsp;J P Baak","doi":"10.1007/BF00428497","DOIUrl":"https://doi.org/10.1007/BF00428497","url":null,"abstract":"<p><p>Cells aspirated from breast lesions and smeared on slides were subjected to computer assisted morphometric analysis. Three groups of cases were studied. The first were those collected from patients with known benign and malignant lesions. The second group were 143 unselected consecutive aspirates from breast lesions and the third, a group with a needle aspirate cytodiagnosis \"suspicious of malignancy\". The analysis showed the malignant cells to have larger nuclei with more anisokaryosis and more variation in the nuclear cytoplasmic ratios when compared with benign cells. When this form of semiautomatic analysis was applied to the \"suspicious\" group the accuracy of cytodiagnosis was improved.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"396 1","pages":"9-18"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00428497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18140008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Elastofibroma. A correlated light and electron microscopic study. Elastofibroma。相关的光学和电子显微镜研究。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00431236
L G Kindblom, S S Spicer
{"title":"Elastofibroma. A correlated light and electron microscopic study.","authors":"L G Kindblom,&nbsp;S S Spicer","doi":"10.1007/BF00431236","DOIUrl":"https://doi.org/10.1007/BF00431236","url":null,"abstract":"<p><p>Four cases of elastofibroma located in the subscapular region of 3 men aged 66, 74, and 83 years, and a woman 70 years old are reported. A correlated light and electron microscopic study including ultrastructural examination of Verhoeff's iron-hematoxylin (VIH)-stained sections was performed. Light microscopically, the elastofibromas were characterized by connective tissue built up by collagen fibers and sclerotic masses mingled with numerous fibers and globules of elastin material. In one micron thick Epon sections these elastin fibers often revealed a central axis surrounded by a mantle composed of periodic segments giving them a necklace-like appearance. The ultrastructural findings of these elastin structures, stained with VIH, and the appearance of the stroma cells and their relation to the elastin indicate that elastofibroma is a non-neoplastic reactive lesion in which elastin material is synthesized by the stromal cells and predominantly laid down around preexisting elastic fibers.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"396 2","pages":"127-40"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00431236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17939426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Distribution of epithelial membrane antigen in benign and malignant lesions of the salivary glands. 涎腺良、恶性病变上皮膜抗原的分布。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00442392
B A Gusterson, R B Lucas, M G Ormerod
{"title":"Distribution of epithelial membrane antigen in benign and malignant lesions of the salivary glands.","authors":"B A Gusterson,&nbsp;R B Lucas,&nbsp;M G Ormerod","doi":"10.1007/BF00442392","DOIUrl":"https://doi.org/10.1007/BF00442392","url":null,"abstract":"<p><p>An antiserum against epithelial membrane antigen has been used to stain a variety of lesions arising in the salivary glands. In normal major and minor glands staining was localised to the ductal systems. There was no evidence of myoepithelial cell staining. The mucous elements of the submandibular and sublingual glands were negative, but in the mucous elements of the minor glands there was focal cytoplasmic positivity. There was no cytoplasmic staining of serous elements in major or minor salivary glands. In pleomorphic adenomas the luminal membrane of ductal elements was strongly positive, with focal cytoplasmic positivity in some myxoid areas. In mucoepidermoid tumours both adjacent cell membranes and cytoplasm were strongly positive. The ductal structure of adenoid cystic carcinomas were clearly delineated while the pseudoducts produced by enclosed areas of stroma were negative. All mesenchymally derived tumours were negative and a tumour previously considered as a chondroma was strongly positive. The results are discussed in relation to phenotypic heterogeneity and the histogenesis of salivary gland tumours.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 2","pages":"227-33"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00442392","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17356972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Hepatocellular carcinoma in an urbanised black community. A changing pattern. 城市化黑人社区的肝细胞癌。不断变化的模式。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429353
A C Paterson, C Isaacson
{"title":"Hepatocellular carcinoma in an urbanised black community. A changing pattern.","authors":"A C Paterson,&nbsp;C Isaacson","doi":"10.1007/BF00429353","DOIUrl":"https://doi.org/10.1007/BF00429353","url":null,"abstract":"<p><p>Hepatocellular carcinoma has been extensively studied in Southern Africa, and particularly its relationship to hepatitis B virus infection. Most of this work involved rural Black populations. In this study the impact of urbanization on this relationship is investigated. The material is derived from the laboratory records at Baragwanath Hospital which serves the Black urban community of Soweto, Cases autopsied during the periods 1956-1960 and 1976-1980 have been examined with regard to age, sex, underlying cirrhosis and presence of HBsAg in the non-tumour liver. In addition, all biopsies from 1955 to 1980 have been analysed with respect to age and sex. There is evidence of a significant increase in overall average age and in the proportion of female cases, while the percentage of HBsAg positive cases has fallen. Possible causes for these findings are considered.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"395 3","pages":"273-8"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00429353","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17349725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Giant cell tumor bone. Enzyme histochemical, biochemical and tissue culture studies. 骨巨细胞瘤。酶组织化学,生化和组织培养研究。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429357
H Yoshida, M Akeho, T Yumoto
{"title":"Giant cell tumor bone. Enzyme histochemical, biochemical and tissue culture studies.","authors":"H Yoshida,&nbsp;M Akeho,&nbsp;T Yumoto","doi":"10.1007/BF00429357","DOIUrl":"https://doi.org/10.1007/BF00429357","url":null,"abstract":"<p><p>Three giant cell tumors of bone (2 benign and 1 malignant) were examined enzyme-histochemically, and a tissue culture study of the malignant case was performed. Multinucleated giant cells and mononuclear round cells had similar activities of ACPase and non-specific esterase with a diffuse strong reaction. ATPase and 5'-nucleotidase reactions were strongly positive in the cytoplasm of multinucleated giant cells, and were seen not only in the cytoplasm but also on the cell membrane of round cells. The proliferating spindle cells in the malignant case were faintly positive for ACPase and non-specific esterase and were less positive for ATPase and 5'-nucleotidase on the cell membrane. The multinucleated giant cells and mononuclear round cells resembled histiocytes in the activities of 4 hydrolytic enzymes, and the multinucleated giant cells had enzyme activities similar to those of osteoclasts from new-born rat skull. The malignant giant cell tumor and cells in its tissue culture showed ALPase activity preferentially on the cell membrane of the spindle cells, and rarely on round cells or multinucleated giant cells. ALPase was resistant to heat treatment and was found to be the type IV isoenzyme by diffusion electrophoresis. The origin of the giant cell tumor of bone and the significance of the ALPase activity are discussed.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"395 3","pages":"319-30"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00429357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17349727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 968
Primary malignant mixed mesodermal tumor of the gallbladder. Report of a case and critical review of diagnostic criteria. 胆囊原发性恶性混合中胚层肿瘤。病例报告和诊断标准的严格审查。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00431243
D Aldovini, F Piscioli, R Togni
{"title":"Primary malignant mixed mesodermal tumor of the gallbladder. Report of a case and critical review of diagnostic criteria.","authors":"D Aldovini,&nbsp;F Piscioli,&nbsp;R Togni","doi":"10.1007/BF00431243","DOIUrl":"https://doi.org/10.1007/BF00431243","url":null,"abstract":"<p><p>A rare case of primary malignant mixed mesodermal tumor of the gallbladder arising in a 75 year old woman is reported. The previously published cases of similar tumors were reviewed in order to outline the histological features and the histogenesis. In diagnosing a malignant mixed mesodermal tumor of the gallbladder it was imperative that we excluded malignant neoplasms with multiple histological patterns. The diffuse and close intermingling of the epithelial and mesenchymal component ruled out a collision tumor. The high mitotic rate, the typical reticulin pattern and the obviously malignant osteoblasts excluded a spindle cell carcinoma with osseous metaplasia. The authors conclude that this is the first case of malignant mixed mesodermal tumor with evident osteosarcomatous areas, described in the gallbladder.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"396 2","pages":"225-30"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00431243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17351527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Epithelioid granulomata in a nonossifying fibroma. The possible drug-induced mechanism. 非骨化性纤维瘤中的上皮样肉芽肿。可能的药物诱导机制。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430893
C Cozzutto, A Comelli
{"title":"Epithelioid granulomata in a nonossifying fibroma. The possible drug-induced mechanism.","authors":"C Cozzutto,&nbsp;A Comelli","doi":"10.1007/BF00430893","DOIUrl":"https://doi.org/10.1007/BF00430893","url":null,"abstract":"<p><p>A 13-year-old boy affected by bursitis of the R knee and nonossifying fibroma of the distal metaphysis of the R femur, was treated in the weeks prior to surgical intervention with water-soluble aspirin tablets to relieve local pain. Unexpected epithelioid cell granulomata were observed inside the neoplastic fibrous stroma of the nonossifying fibroma. The coincidental appearance of a slight blood eosinophilia (7%) and perioral fixed drug eruption are clues that suggest that the histological bone findings may represent an expression of the hypersensitivity response elicited by aspirin. It cannot be ruled out that this unusual finding may be related to documented previous trauma, resulting in interstitial hemorrhages and subsequent reactive resorptive processes.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 1","pages":"61-6"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00430893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17280355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoelectron microscopic study of plasma protein pathways through the different segments of the rat intestinal vasculature. 免疫电镜研究血浆蛋白通过大鼠肠血管不同节段的途径。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429609
N Hinglais, J Grossetete, M Paing, J Bariety
{"title":"Immunoelectron microscopic study of plasma protein pathways through the different segments of the rat intestinal vasculature.","authors":"N Hinglais,&nbsp;J Grossetete,&nbsp;M Paing,&nbsp;J Bariety","doi":"10.1007/BF00429609","DOIUrl":"https://doi.org/10.1007/BF00429609","url":null,"abstract":"<p><p>Nineteen Brown-Norway (BN) rats received intravenous injections of sheep anti-peroxidase (HRP) antibodies. Four BN rats were immunized to HRP. The anti-HRP antibodies were used to trace permeability pathways of large physiological molecules across different vessels of the small intestine. This organ was chosen because of the possibility of convenient \"in situ\" fixation and for the diversity of vessel types it contains. It was shown that: 1) There were no obvious transendothelial pathways in arteries with an elastic lamina. 2) The antibodies readily crossed fenestrated capillaries through the fenestrae. 3) There were two possible pathways through muscle capillaries and pericytic venules, namely transcytoplasmic vesicular \"cactus-like\" channels and interendothelial junctions. 4) Interendothelial permeability was a possible factor in veins with an elastic lamina. 5) Lymphatics were readily permeable through intercellular junctions and cytoplasmic vesicles.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":" ","pages":"153-68"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00429609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40495523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Demonstration of alpha 1-antitrypsin in paraffin sections of hepatoma and cirrhosis. 肝癌和肝硬化石蜡切片显示α 1-抗胰蛋白酶。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00442386
L Nakopoulou, G Theodoropoulos, L Kotsis, N Papacharalampous
{"title":"Demonstration of alpha 1-antitrypsin in paraffin sections of hepatoma and cirrhosis.","authors":"L Nakopoulou,&nbsp;G Theodoropoulos,&nbsp;L Kotsis,&nbsp;N Papacharalampous","doi":"10.1007/BF00442386","DOIUrl":"https://doi.org/10.1007/BF00442386","url":null,"abstract":"<p><p>Alpha 1-antitrypsin has been examined in formalin-fixed, paraffin-embedded liver specimens from Greek patients with cirrhosis (35 cases) and hepatoma (55 cases) by peroxidase-antiperoxidase (PAP) method. Ring-like AAT globules were found in the non-neoplastic cells in 12% of the cases of hepatoma and in 11% of the cases of cirrhosis. Atypical globules were seen in neoplastic cells in 5.4% of the cases of hepatoma and in 17% of the cases of liver cirrhosis. A diffuse fine granular pattern of AAT distribution was present in 31% of the cases of hepatoma in the neoplastic cells and in 27% of those in the non-neoplastic cells. The relatively high incidence of ring-like AAT-globules, and of atypical globules in cases of hepatoma and cirrhosis is not in agreement with the extremely low gene frequency of Z allele in a Greek population of patients with cirrhosis and hepatoma. Thus, there is some doubt whether AAT-globules in the liver represent a histopathologic marker of genetically determined AAT deficiency. A relationship between AAT deposits and the degree of differentiation of hepatoma was noted in this series. AAT-positive cells were found in 55% of moderately differentiated, in 29% of highly differentiated and in 20% of poorly differentiated hepatomas.</p>","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 2","pages":"163-70"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00442386","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17356971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Angiomatoid malignant fibrous histiocytoma. Case report and electron microscopic findings. 血管瘤样恶性纤维组织细胞瘤。病例报告及电镜检查结果。
Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443488
H J Leu, M Makek
{"title":"Angiomatoid malignant fibrous histiocytoma. Case report and electron microscopic findings.","authors":"H J Leu,&nbsp;M Makek","doi":"10.1007/BF00443488","DOIUrl":"https://doi.org/10.1007/BF00443488","url":null,"abstract":"","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"395 1","pages":"99-107"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00443488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17343536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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