Virchows Archiv. A, Pathological anatomy and histology最新文献_第4页

Heterogeneous pituitary adenomas. A light microscopic, immunohistochemical and electron microscopic study. 异质性垂体腺瘤。光镜，免疫组织化学和电镜研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430667

D Martinez, D Barthe

{"title":"Heterogeneous pituitary adenomas. A light microscopic, immunohistochemical and electron microscopic study.","authors":"D Martinez, D Barthe","doi":"10.1007/BF00430667","DOIUrl":"https://doi.org/10.1007/BF00430667","url":null,"abstract":"The combined use of several histological procedures (i.e. conventional light microscopy, immunohistochemistry and electron microscopy) among 45 unselected pituitary adenomas demonstrated the existence of 9 tumors (20%) containing several identifiable adenohypophyseal cell types. The cellular associations were between 2 or 3 identifiable cell types. Mammosomatotrophic tumors were the most frequent but not the only mixed type (somatomammocorticotrophic, somatocorticotrophic tumors were also found). The cellular components varied in size but the cells appeared randomly distributed in the tumours. In all the adenomas there was an unidentified cell component (no reactivity with antisera used) varying from sparse to numerous elements. On adjacent sections the adenomatous cells reacted with a single specific antiserum, but in two cases the immunohistochemistry on contiguous paraffin embedded sections did not confirm this with certainty. These results confirm those of others and a new term is proposed to designate these tumors: heterogeneous pituitary adenomas. According to the nature and the proportions of the cell components the heterogeneous adenomas were subdivided into two groups: a group A which comprised adenomas formed by a major identifiable cellular type associated with one or two other less frequent cell types, and a group B formed by a predominant unidentifiable (no reactivity with immunochemical stainings) cell type associated with one or two other identified cell types. The present morphofunctional classifications of pituitary adenomas should be modified to include homogeneous adenomas with a single cell type and heterogeneous adenomas with several cell types.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"394 3","pages":"221-33"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00430667","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18089298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Veno-occlusive disease of the liver in patients receiving immunosuppressive therapy. 接受免疫抑制治疗的患者的肝脏静脉闭塞性疾病。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429351

H Weitz, J M Gokel, K Loeschke, K Possinger, M Eder

引用次数: 19

Immunological transmission of glomerulosclerotic changes in KK-mice with spontaneous diabetes. 1. Transplantation of spleen cells. 自发性糖尿病kk小鼠肾小球硬化改变的免疫传递。1. 脾细胞移植。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00428500

H Wehner, I König

{"title":"Immunological transmission of glomerulosclerotic changes in KK-mice with spontaneous diabetes. 1. Transplantation of spleen cells.","authors":"H Wehner, I König","doi":"10.1007/BF00428500","DOIUrl":"https://doi.org/10.1007/BF00428500","url":null,"abstract":"To investigate whether glomerulosclerotic changes can be transmitted by spleen cells, two-month-old diabetic KK-mice received a spleen homogenate transplanted subcutaneously. the donors were two-year-old diabetic KK-mice. Control animals received physiological saline. Kidneys and pancreas were removed four or ten months after the transplantation. Apart from histological and partly immunohistological studies the kidneys (glomeruli) were also evaluated morphometrically on a blind basis. Blood sugar levels were determined together with serum insulin concentrations in some animals. Marked widening of the mesangium and an increase in mesangial cells was found in the transplanted animals four months after the transplantation when compared with the control animals, a finding that was confirmed by morphometric studies. All transplanted animals exhibited a lymphoplasmocytic periductulitis and some showed insulitis in the pancreas. Degranulation of beta-cells was observed in some animals. Serum insulin was significantly reduced one month after the transplantation and blood sugar levels in the transplanted animals were continuously higher after three month than the values in the control animals. The investigations show that transplantation of spleen cells induces progression of diabetic glomerulosclerotic renal alterations and also causes periductulitis and in isolated cases insulitis.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"396 1","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00428500","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17803313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrapulmonary mesotheliomas: their identification by tissue culture. 肺内间皮瘤的组织培养鉴定。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429358

E Alvarez-Fernandez, J Escalona-Zapata

引用次数: 8

Primary adrenocortical nodular dysplasia with Cushing's syndrome and cardiac myxomas. A peculiar familial disease. 原发性肾上腺皮质结节性发育不良伴库欣综合征和心脏黏液瘤。一种特殊的家族性疾病。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00442388

M Schweizer-Cagianut, F Salomon, C E Hedinger

{"title":"Primary adrenocortical nodular dysplasia with Cushing's syndrome and cardiac myxomas. A peculiar familial disease.","authors":"M Schweizer-Cagianut, F Salomon, C E Hedinger","doi":"10.1007/BF00442388","DOIUrl":"https://doi.org/10.1007/BF00442388","url":null,"abstract":"In a family with 4 children, 2 had slowly developing Cushing's syndrome and were adrenalectomized between the ages of 18 and 28 years. As in other cases with familial Cushing's syndrome, primary adrenocortical nodular dysplasia, the so-called adrenocortical adenomatosis, was demonstrated. The brother, now 39 years old, is in good health. The sister, however, died at the age of 36 years. Autopsy revealed a cardiac myxoma of the left atrium. A cardiac myxoma had been found incidentally at autopsy of these two patients' oldest brother, a boy who died at the age of 4 years. Both siblings with Cushing's syndrome presented additional Peutz-Jegher-like hyperpigmentation and myxomatous tumours of the skin. Identical observations of familial adrenocortical nodular dysplasia, Cushing's syndrome and cardiac myxomas have not been reported to date. However, the familial occurrence of cardiac myxomas and adrenocortical dysplasia in combination with bilateral large cell calcifying Sertoli cell tumours of the testis has been published recently.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 2","pages":"183-92"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00442388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18192703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Morphological effects in pituitary tumours following radiotherapy. 垂体肿瘤放疗后的形态学影响。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443483

M Anniko, J Wersäll

{"title":"Morphological effects in pituitary tumours following radiotherapy.","authors":"M Anniko, J Wersäll","doi":"10.1007/BF00443483","DOIUrl":"https://doi.org/10.1007/BF00443483","url":null,"abstract":"Seven cases with different endocrinological types of pituitary tumours were subject to open surgery 6-25 years after fractionated and 2 months - 9 years after single dose irradiation. Two cases had been treated with both types of irradiation. Tumour tissue was analyzed at the light and electron microscopic levels. Hyalinization around blood vessels occurred independent of type of irradiation but required some time to develop. This was not found in one tumour analyzed 2 months after single dose treatment. Single dose treatment (30-70 Gy) caused extensive fibrosis and few surviving cells in the primary target area. Tumours treated with fractionated dose irradiation (26-45 Gy) showed a large number of tumour cells present 6-8 years after treatment. Many of these cells revealed morphological damage. The morphological findings of the presently available material may indicate that a single dose treatment causes rapid and extensive tumour damage at the site of the primary target but that surviving tumour cells are present outside this area. Fractionated irradiation results in an initial dysfunction with persistence of more or less structurally altered cells for several years.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":" ","pages":"45-58"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00443483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35256348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Lesions characteristic of infection or malignant tumor in Paleo-Eskimo skulls. An anatomical and radiological study of two specimens. 古爱斯基摩人头骨中具有感染或恶性肿瘤特征的病变。两个标本的解剖和放射学研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429350

R Lagier, C A Baud, G Arnaud, S Arnaud, R Menk

引用次数: 3

Papillary carcinoma of choroid plexus. Light and electron microscopic study. 脉络膜丛乳头状癌。光学和电子显微镜研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429356

N Nakashima, K Goto, J Takeuchi

引用次数: 4

J-chain-producing immunoblastic lymphoma in a case of Richter's syndrome. Immunohistochemical evidence for a gradual malignant transformation of a single B-cell clone and flow cytophotometric data. 里希特氏综合征一例产生j链的免疫母细胞淋巴瘤。单个b细胞克隆逐渐恶性转化的免疫组织化学证据和流式细胞光度测定数据。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00431242

P Möller, G E Feichter, D Fritze, D Haag, B Schüle

{"title":"J-chain-producing immunoblastic lymphoma in a case of Richter's syndrome. Immunohistochemical evidence for a gradual malignant transformation of a single B-cell clone and flow cytophotometric data.","authors":"P Möller, G E Feichter, D Fritze, D Haag, B Schüle","doi":"10.1007/BF00431242","DOIUrl":"https://doi.org/10.1007/BF00431242","url":null,"abstract":"A 66-year old male with Richter's syndrome died 52 month after diagnosis of chronic lymphocytic leukaemia (CLL). The clinical course was characterized by a marked IgM hypoglobulinaemia which paralleled a chronically relapsing Herpes simplex infection. Autopsy showed a large retroperitoneal and intraabdominal tumour mass and well defined supradiaphragmatic lymphomas. Histological examination revealed a composite tumour consisting of CLL B-cell type (B-CLL) and immunoblastic malignant lymphoma of B-cell type (B-IbL). The lymphocytes bear mu-chains on their surface and to a lesser extend within their cytoplasm, the obviously defective immunoblasts produce J chains exclusively. Flow cytophotometric data seem to indicate an identical diploid stem line of the two tumours. The majority of the cells are in G0/1 phase. The CLL rarely produces mitoses, however, the IbL has a mitotic rate of 7% and a considerable proportion (33%) of cells in the phase of DNA-synthesis. This is the fourth malignant lymphoma and the second immunoblastic lymphoma to be reported that produces J chain in the absence of immunoglobulin.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"396 2","pages":"213-24"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00431242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17864711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Development of malignant lymphoma in myoepithelial sialadenitis (Sjögren's syndrome). 肌上皮性涎腺炎(Sjögren综合征)中恶性淋巴瘤的发展。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443482

U Schmid, D Helbron, K Lennert

引用次数: 71