Tropenmedizin und Parasitologie最新文献

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Chronic exposure of the eggs and adults of Biomphalaria glabrata (Say) to the molluscicide, nicotinanilide. 长时间暴露于杀软体剂烟酰胺的光藻卵和成虫。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
J Duncan, N Brown
{"title":"Chronic exposure of the eggs and adults of Biomphalaria glabrata (Say) to the molluscicide, nicotinanilide.","authors":"J Duncan,&nbsp;N Brown","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Some effects of chronic, low-dosage treatment of Biomphalaria glabrata eggs and adults with nicotinanilide, are reported. The susceptibility of eggs decreased with age. The development and hatching of 0-1 day old eggs could be prevented by continuous exposure to 0.0005-0.001 mg/l-1 whereas prehatch stages had a susceptibility similar to that of adult snails (0.1-0.2 mg/l-1). The possible use of slow-release formulations of nicotinanilide in the control of field populations of snails and schistosomiasis transmission is discussed.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"184-6"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17691419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onchocerciasis in Ecuador. I. Prevalence and distribution in the province of Esmeraldas. 厄瓜多尔的盘尾丝虫病。1 .在埃斯梅拉达斯省的流行和分布。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
R H Guderian, J Molea, D Swanson, R Proaño, R Carrillo, W L Swanson
{"title":"Onchocerciasis in Ecuador. I. Prevalence and distribution in the province of Esmeraldas.","authors":"R H Guderian,&nbsp;J Molea,&nbsp;D Swanson,&nbsp;R Proaño,&nbsp;R Carrillo,&nbsp;W L Swanson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the province of Esmeraldas in Ecuador, 11 endemic foci of onchocerciasis were identified. The major focus, located on Rio Cayapas, consisted of 65 contiguous positive communities with an average infection rate of 51.1%. A distance-dependent characteristic of the onchocerciasis infection suggested that the transmission was centered principally in the areas near the head-waters of the river. This area, inhabited primarily by the indigenous tribe, Chachi, with an infection rate of 85%, was considered an area of hyperendemicity. Towards the river's mouth, where the majority of the inhabitants were Blacks, the rate of infection was 7%. The endemic focus located on Rio Santiago, populated entirely by Blacks and consisting of 17 contiguous positive communities, had an average infection rate of 18.8%. Again, the highest rate of infection, 33%, occurred in the upper reaches of the river. Resulting from the transient and migratory activity of some microfilariae-positive persons, 9 other isolated foci were found dispersed throughout the province. The infection rate of each focus was distinct, reflecting geographical location and ethnic composition. All foci other than the interior regions of Rio Cayapas were areas of hypoendemicity.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"143-8"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17692629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onchocerciasis in Ecuador. II. Epidemiology of the endemic foci in the province of Esmeraldas. 厄瓜多尔的盘尾丝虫病。2埃斯梅拉达斯省地方性疫源地的流行病学。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
R H Guderian, D Swanson, R Carrillo, R Proaño, J Molea, W L Swanson
{"title":"Onchocerciasis in Ecuador. II. Epidemiology of the endemic foci in the province of Esmeraldas.","authors":"R H Guderian,&nbsp;D Swanson,&nbsp;R Carrillo,&nbsp;R Proaño,&nbsp;J Molea,&nbsp;W L Swanson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The epidemiology of infection was studied in all endemic foci of onchocerciasis in the province of Esmeraldas in Ecuador. The incidence of infection and the density of microfilariae in the skin, both greater in males than females, increased with age, reaching highest levels at 40-45 years in males and at 60 years and older in females. In the hyperendemic area males and females had the same rate of infection, but the microfilarial density in males exceeded that in females. In the hypoendemic areas males had a higher infection rate than females, but females registered a higher density of microfilariae in the skin. The incidence and location of the onchocercal nodules correlated closely with the density of microfilariae. Adults, aged 50-54 had the highest prevalence of onchocercal nodules, which occurred primarily in the thorax and pelvic regions. Children aged 0-14 years showed a low prevalence of nodules, the head region being the primary site. Of the two diagnostic methods used to detect the presence of microfilariae, most of the diagnoses (85.6%) were made by skin biopsies as compared to those made by the Mazzotti test (14.4%).</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"149-54"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17691415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of human serum resistant Trypanozoon from cattle in Nigeria. 尼日利亚牛中人类血清耐药锥虫的分离。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
R A Joshua, Y Magaji, Y S Kayit
{"title":"Isolation of human serum resistant Trypanozoon from cattle in Nigeria.","authors":"R A Joshua,&nbsp;Y Magaji,&nbsp;Y S Kayit","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four trypanosome stocks of the subgenus Trypanozoon were isolated from a herd of cattle in the Jos Plateau of Nigerian during a study on the epizootiology of trypanosomiasis. One of the stocks was repeatedly highly resistant to normal human serum (Blood Incubation Infectivity Test), indicating potential human infectivity. These observations suggest that the domestic cattle might act as reservoir hosts for the causative agent of human trypanosomiasis.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"201-2"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17691421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune complexes in experimental alveolar hydatidosis. 实验性肺泡包虫病的免疫复合物。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
Z Ali-Khan, R Siboo
{"title":"Immune complexes in experimental alveolar hydatidosis.","authors":"Z Ali-Khan,&nbsp;R Siboo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Increasing amounts of immune complexes (IC) accumulated in the blood of C57BL/6J (H-2b) mice infected for 16 weeks with alveolar hydatid cysts. The circulating IC were detected both quantitatively (precipitation with 3.75% polyethylene glycol) and qualitatively (Raji cell binding assay) in the sera of hydatid-mice. The levels of serum IC roughly parallel the increase in weight of the larval cyst masses (LCM) and were inversely reacted to serum compliment activity; the latter was markedly reduced at 14 weeks postinfection. The solubilized serum IC was reacted with appropriate antisera in gel precipitation test; it consisted of E. multilocularis antigens, IgGl, IgG2b, IgM and C3. Mouse IgG, IgM, complement and hydatid antigens were also detected by the indirect immunofluorescent technique in kidney sections of hydatid-mice infected 14 weeks before. The role of IC is discussed with reference to immunodepression and growth of the LCM in hydatid mice.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"187-92"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17289663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma lipid changes in human malaria. 人疟疾患者血浆脂质变化。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
I C Onongbu, E C Onyeneke
{"title":"Plasma lipid changes in human malaria.","authors":"I C Onongbu,&nbsp;E C Onyeneke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lipid concentrations in human subjects during and after infection by Plasmodium falciparum were determined. The increase in the concentration of phospholipids and triglycerides during infection was statistically significant (p less than 0.01 for moderate infection and p less than 0.001 for severe infection) when compared with concentration after infection. The increases in these lipid levels were almost two-fold in moderate infection and three fold in severe infection. There was no significant change in the plasma cholesterol during and after infection.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"193-6"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17417091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomal enzyme in Mastomys natalensis during Dipetalonema viteae infection. 双盘线虫感染期间纳塔利乳突虫的溶酶体酶。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
A K Srivastava, D P Singh, R K Chatterjee, S Ghatak
{"title":"Lysosomal enzyme in Mastomys natalensis during Dipetalonema viteae infection.","authors":"A K Srivastava,&nbsp;D P Singh,&nbsp;R K Chatterjee,&nbsp;S Ghatak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Activities of certain acid hydrolases (viz. acid phosphatase, beta-glucosidase, beta-galactosidase, N-acetyl-beta-D-glucosaminidase and cathepsine) of post mitochondrial fraction of liver and spleen were studied during the course of Dipetalonema viteae infection in Mastomys natalensis. The values are significantly higher from prepatent to patent phase of infection as compared with normal animals. However, a decrease in the activity of hepatic acid phosphatase and N-acetyl-beta-D-glucosaminidase was noticed in latent phase of infection while a several fold increase in the activity of these enzymes was observed in splenic tissue when there were no detectable microfilariae (mf) in peripheral circulation. The results suggest that lysosomal acid hydrolases which constitute an important component of resistance may be activated by mf products through the sensitized cells of RE system.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"174-6"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17474844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of 75-seleno-methionine labelled Trypanosoma brucei to measure parasite replication in vivo. 使用75-硒-蛋氨酸标记的布鲁氏锥虫来测量寄生虫在体内的复制。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
J A MacAskill, P H Holmes
{"title":"The use of 75-seleno-methionine labelled Trypanosoma brucei to measure parasite replication in vivo.","authors":"J A MacAskill,&nbsp;P H Holmes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The suitability of 75-Se-labelled trypanosomes for the measurement of trypanosome replication rates in vivo was investigated. The principle used to estimate the doubling time of the circulating parasites was the decrease in specific activity of 10(-7) parasites and this was determined both for parasites contained in a whole blood sample and for parasites separated from the blood sample by DEAE-cellulose chromatography. When two stocks of T. brucei (TrEU 226, TrEU 667) were compared it was found that the parasitemic profiles of radio-labelled trypanosomes transfered into naive mice were essentially the same as those of unlabelled parasites of each stock. Furthermore it was found that in an acute infection (TrEU 226) there was a rapid and continuous fall in the specific activity implying a constant doubling time. However, in the more chronic relapsing infection (TrEU 667) a biphasic decrease in the specific activity occurred which although initially similar to that of the acute infection changed to a much slower rate of replication at the time of peak parasitemia. The results indicate that radiolabelled trypanosomes can be used to measure parasite replication rates in vivo, and may therefore be a valuable method for investigating the factors governing parasite growth in the circulation.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"197-200"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17691420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The fine structure of adult Onchocerca volvulus. V. The digestive tract and the reproductive system of the female worm. 成虫盘尾丝虫的精细结构。五、雌虫的消化道和生殖系统。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
M Franz, D W Büttner
{"title":"The fine structure of adult Onchocerca volvulus. V. The digestive tract and the reproductive system of the female worm.","authors":"M Franz,&nbsp;D W Büttner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The morphology of the oesophagus, the intestine, the ovary, the uterus, the vagina and some inclusions in the body cavity are described in worms of different ages. The oesophagus wall comprises mostly muscle fibrils and a few glandular regions located only in the posterior portion. In the lumen, some material was found. From the anterior to the posterior end, the lumen of the intestine is reduced. The plasm of the intestinal cells of older worms is filled with concentric spherules containing iron, which are absent in mature but not full-grown worms. The ovarial cells contain in their outer region some fibrils and in the inner region some dense bodies. The ring-muscles of the uterine wall run in clefts of the basal lamina. They usually have accumulated iron containing bodies. In the final portion of the uterus and in the vagina the muscles are very thick. A comparison of the general morphology of the midbody regions of young, not full-grown worms, one less than five years old worm and some worms at least five years old is given.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"155-61"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17691416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of in vitro culture conditions of Brugia pahangi four day old developing larvae for use in an antifilarial drug assay. 4日龄pahangi幼虫体外培养条件的改进及抗丝虫药物试验研究。
Tropenmedizin und Parasitologie Pub Date : 1983-09-01
J P Court, G M Lees
{"title":"Improvement of in vitro culture conditions of Brugia pahangi four day old developing larvae for use in an antifilarial drug assay.","authors":"J P Court,&nbsp;G M Lees","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four day old third stage larvae of Brugia pahangi were cultured in the presence of differing concentrations of early passage dog kidney cells and inactivated foetal calf serum. After a six day culture period worm length, number of moults and worm mortality were determined. Analysis of the length data demonstrated a significant interactive relationship between cell and serum concentration. The greatest increases in length were obtained using an initial cell density of dog kidney cells of 40 x 10(4) plus a serum concentration of 10%. (The surface area of all culture vessels was 2.0 cm2). In addition moulting occurred earlier and was more prolific with higher cell and serum concentrations. The response of larvae to antiparasitic agents in the presence or absence of a confluent dog kidney feeder layer was then compared to determine whether the inclusion of cells altered drug effects. From this it was found that the killing effects of flubendazole, albendazole, furazolidone, levamisole and nifurtimox at their minimum effective concentrations were delayed under biphasic culture conditions. It is suggested that this is an advantage and will improve the selectivity of the assay over and above an assay which does not include a cell feeder layer. In addition the improved growth rates obtained in cultures containing dog kidney cells should mean an increase in test sensitivity to agents capable of disrupting biosynthesis.</p>","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 3","pages":"162-8"},"PeriodicalIF":0.0,"publicationDate":"1983-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17691417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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