Tropenmedizin und Parasitologie最新文献_第7页

Long-term treatment of onchocerciasis patients from the Liberian rain-forest with low doses of diethylcarbamazine citrate after complete nodulectomy. 利比里亚雨林盘尾丝虫病患者在完全结节切除术后低剂量的柠檬酸二乙基卡马嗪的长期治疗。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

E J Albiez

引用次数: 0

Pleomorphism in trypomastigotes of Trypanosoma cruzi from blood and cell culture. 克氏锥虫血液和细胞培养的锥乳突体的多形性。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

S Urdaneta-Morales

引用次数: 0

Comparative efficacy of some benzimidazoles and amoscanate (Go.9333) against experimental filarial infections. 一些苯并咪唑和阿莫昔酸(Go.9333)对实验性丝虫病感染的比较疗效。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

A B Reddy, U R Rao, R Chandrashekar, R Shrivastava, D Subrahmanyam

{"title":"Comparative efficacy of some benzimidazoles and amoscanate (Go.9333) against experimental filarial infections.","authors":"A B Reddy, U R Rao, R Chandrashekar, R Shrivastava, D Subrahmanyam","doi":"","DOIUrl":"","url":null,"abstract":"The comparative efficacy of mebendazole, fenbendazole, oxibendazole, oxfendazole, albendazole, flubendazole and micronized amoscanate (particle size 5-8 micron) against Litomosoides carinii and Brugia pahangi infections in Mastomys natalensis was studied on administration of the compounds per os (150 mg/kg/day for 5 days) and subcutaneous (100 mg/kg/day for 5 days) routes. It was found that benzimidazoles when given by the oral route had no effect on adults of L. carinii and B. pahangi. With most of these compounds there was a rise in microfilariae before registering a fall to varying degrees in the peripheral circulation. There was a gradual but effective reduction of microfilariae of L. carinii in animals treated orally with mebendazole (99%), flubendazole (95%) and oxfendazole (85%). No such effect was seen against B. pahangi microfilariae. On subcutaneous administration, all the benzimidazoles with the exception of fenbendazole exhibited marked macrofilaricidal activity against L. carinii. Such activity was not seen with oxibendazole, oxfendazole and fenbendazole against adults of B. pahangi. Amoscanate exhibited superiority over the benzimidazoles in that the compound eliminated microfilariae and adult worms of both L. carinii and B. pahangi species when given by oral and subcutaneous routes.","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 4","pages":"259-62"},"PeriodicalIF":0.0,"publicationDate":"1983-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17720783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serological and immunological investigations in patients with gross splenomegaly from the Gabon. 加蓬脾肿大患者的血清学和免疫学调查。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

P Kern, J Knobloch, G Riethmüller, M Dietrich

{"title":"Serological and immunological investigations in patients with gross splenomegaly from the Gabon.","authors":"P Kern, J Knobloch, G Riethmüller, M Dietrich","doi":"","DOIUrl":"","url":null,"abstract":"Serological investigations (immunoglobulin, haptoglobin, cryoglobulin, and antibody determination against Plasmodium falciparum and P. malariae antigens) were performed in 64 adults of the Albert-Schweitzer-Hospital, Lambarene, Gabon. The patients were referred consecutively for ultrasound examination of the upper abdominal tract. 31 patients had clinically and sonographically an enlarged spleen, whereas 34 had a normal-sized spleen. 18 patients were regarded as having a gross splenomegaly without an obvious underlying cause (tropical splenomegaly (TSS]. No significant differences were seen between the patient groups with regard to immunoglobulin M or antiplasmodial antibody concentration. Thus, a causal association of splenomegaly with chronic malaria infections could not be established. The haptoglobin levels were significantly (P less than 0.01) reduced in patients with splenomegaly. Peripheral T-lymphocyte subsets as defined by monoclonal antibodies showed in all 4 cases with gross splenomegaly examined distinct abnormalities. Tropical splenomegaly is thought to encompass a variety of diseases, most of them presenting an intermediate stage of reactive to autonome disorders of the lymphatic system.","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 4","pages":"253-8"},"PeriodicalIF":0.0,"publicationDate":"1983-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17663399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-step Plasmodium falciparum cultivation--application to in-vitro drug testing. 恶性疟原虫一步培养——在体外药物检测中的应用。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

P Druilhe, D Mazier, O Brandicourt, M Gentilini

引用次数: 0

[Entamoeba histolytica: I. Mechanism of cytotoxic activity]. [溶组织内阿米巴:1 .细胞毒活性的机制]。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

H Hudler, H Stemberger, O Scheiner, H Kollaritsch, G Wiedermann

{"title":"[Entamoeba histolytica: I. Mechanism of cytotoxic activity].","authors":"H Hudler, H Stemberger, O Scheiner, H Kollaritsch, G Wiedermann","doi":"","DOIUrl":"","url":null,"abstract":"Cytotoxic action against K562-tissue culture cells was investigated under various conditions with a Chromium-release-assay. When amoebae and target cells were centrifuged together, pathogenic strains of amoebae induced a very fast increase of target cell lysis (up to 50% of maximum lysis after 10 minutes). Only a minor degree of target cell lysis resulted, however, when amoebae and K562 cells were kept in suspension. When amoebae were eliminated selectively by addition of complement 10 minutes after starting the experiment, this fast increase of lysis could not be prevented. These observations suggest that the cytotoxic action might take place in two distinct phases. The first step (\"lethal hit\") seems to be temperature-independent, whereas a temperature of 37 degrees C is necessary for the second step to occur during which cytoplasmic material is released (chromium release). The presence of amoebae is not necessary for the second step. When amoebae together with and target cells are kept in suspension, amoebae lost their capability of setting the \"lethal hit\" with increasing time of coincubation. It seems, as if the \"lethal hit\" cannot be accomplished effectively under the conditions of suspension: cytotoxic substances released by the amoebae cannot be transferred to the target cells and are lost in the fluid phase. Thereby, the amoebae are depleted of such substances. Thus, a stable contact between amoebae and target cells for at least a few minutes seems to be necessary for the expression of cytotoxicity.","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 4","pages":"248-52"},"PeriodicalIF":0.0,"publicationDate":"1983-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17381866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental chemotherapy of Taenia saginata cysticercosis - a field trial. 猪带绦虫囊尾蚴病的实验性化疗-野外试验。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

M Walther, M S Bhogal

引用次数: 0

A simple classification of different types of trypanosomiasis occurring in four camel herds in selected areas of Kenya. 肯尼亚选定地区四个骆驼群中发生的不同类型锥虫病的简单分类。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

A J Wilson, H J Schwartz, R Dolan, W M Olahu

引用次数: 0

Topographical distribution of the cerebral lesions in mice infected with Plasmodium berghei. 伯氏疟原虫感染小鼠脑损伤的地理分布。

Tropenmedizin und Parasitologie Pub Date : 1983-12-01

T Polder, C Jerusalem, W Eling

{"title":"Topographical distribution of the cerebral lesions in mice infected with Plasmodium berghei.","authors":"T Polder, C Jerusalem, W Eling","doi":"","DOIUrl":"","url":null,"abstract":"In the mouse P. berghei malaria model systematic studies were carried out on the relationship between the type and the topographical distribution of the brain lesion in cerebral malaria. As previously stated for pernicious P. falciparum malaria in man, petechial haemorrhage was not the sole morphologic lesion. In addition to severe brain oedema, microthrombosis, sludging of mononuclear cells, arteriolar spasms, scattered disturbances of the microcirculation, and the occasional proliferation of gliocytes were the prevailing morphologic changes. Pronounced perivascular oedema with compression of capillaries and ischaemic demyelinisation were particular frequent in the nucleus caudatus putamen, while the adjacent regions (radiatio corporis callosi, claustrum, hippocampus, and fimbria hippocampi) were the sites of predilection of petechial haemorrhage. Arteriolar spasms were particularly frequent in branches of the posterior choroidal artery. The proliferation of gliocytes was practically restricted to the tubercula olfactoria and to the subependymal zone of the lateral wall of the lateral ventricle. The present results indicate a neurovascular component in the pathogenesis of cerebral malaria. The preponderance of a special histopathological lesion in a certain cerebral region may be the result of a particular sensitivity of cells of these areas to noxious events (pathoclisis), for instance hypoxia, and/or exaggeration of autoregulatory phenomena that exist between the cerebral parenchyma and the supplying vasculature.","PeriodicalId":76764,"journal":{"name":"Tropenmedizin und Parasitologie","volume":"34 4","pages":"235-43"},"PeriodicalIF":0.0,"publicationDate":"1983-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17424863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of schistosomiasis in Adwa, Ethiopia, using the plant molluscicide endod (Phytolacca dodecandra). 使用植物杀软体剂endd (Phytolacca dodecandra)防治埃塞俄比亚Adwa血吸虫病。

Tropenmedizin und Parasitologie Pub Date : 1983-09-01

P H Goll, A Lemma, J Duncan, B Mazengia

引用次数: 0