Alcohol and drug research最新文献_第7页

Development of tolerance to ethanol-induced tachycardia in rats. 大鼠对乙醇性心动过速耐受性的研究进展。

Alcohol and drug research Pub Date : 1985-01-01

L A Pohorecky, J T Peterson, J A Carpenter

引用次数: 0

Implications of changes in apomorphine-induced hypothermia after prenatal exposure to phenobarbital. 产前暴露于苯巴比妥后阿帕吗啡诱导的低温变化的意义。

Alcohol and drug research Pub Date : 1985-01-01

J Yanai

{"title":"Implications of changes in apomorphine-induced hypothermia after prenatal exposure to phenobarbital.","authors":"J Yanai","doi":"","DOIUrl":"","url":null,"abstract":"Pregnant mice were exposed to phenobarbital (PhB) on gestation days 9 to 18 (3 gm/kg milled food). Their offspring, who were exposed to the drug transplacentally (B offspring), were tested at an age of 50 days for apomorphine- (0.5, 1.0 and 2.0 mg/kg) induced hypothermia. At doses of 1.0 and 2.0 mg/kg, B offspring had less hypothermic response to apomorphine than controls (p less than 0.01); the effect was similar in both sexes. In order to acquire further understanding of the alterations in apomorphine hypothermia, mainly in relation to dopamine (DA) receptors, adult intact mice were exposed to haloperidol for 4 weeks (25 mg/kg milled food) in order to increase their DA receptor number, and their hypothermic response to apomorphine was tested 4 days post withdrawal. The treated animals had an increased DA receptor number, as was attested by a 23% increase in 3H-spiroperidol binding (P less than 0.01) and a 77% increase in apomorphine-induced climbing. However, their apomorphine-induced hypothermia did not differ from control. Therefore, there is no evidence as yet that alterations in apomorphine-induced hypothermia after prenatal exposure to PhB indicates changes in DA receptors, and the implications of this phenomenon still remain an open question.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"6 1","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15185423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophysiological effects of low dose alcohol on human subjects at high altitude. 低剂量酒精对高海拔人体电生理的影响。

Alcohol and drug research Pub Date : 1985-01-01

R Freedman, M C Waldo, L E Adler, N Baker, D Levin, R Deitrich

{"title":"Electrophysiological effects of low dose alcohol on human subjects at high altitude.","authors":"R Freedman, M C Waldo, L E Adler, N Baker, D Levin, R Deitrich","doi":"","DOIUrl":"","url":null,"abstract":"Low dose alcohol significantly altered auditory evoked potentials in normal human subjects. Effects of alcohol were studied on the P50 evoked potential wave following click stimulation, which was presented in a conditioning-testing paradigm. The conditioning-testing paradigm uses paired stimuli to demonstrate inhibitory sensory gating, measured as suppression of the amplitude of the second or \"test\" response following the first or \"conditioning\" response. Alcohol at blood levels under 0.1 g per dl caused significant decrement in the size of the P50 wave in the initial conditioning response and also decreased the suppression normally seen in the conditioning-testing paradigm. These data suggest that low doses of alcohol affect both the excitatory mechanisms responsible for the formation of the P50 wave in the conditioning response and the inhibitory mechanisms responsible for its suppression in the test response. Nine of the 17 subjects studied using this paradigm were recorded both at Denver, Colorado (5,280 feet above sea level) and on Mt. Evans (14,264 feet above sea level). Despite the commonly held belief that alcohol causes more intoxication at high altitudes there was no significant difference in the effects of alcohol on evoked potentials in these subjects at these two attitudes.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"6 4","pages":"289-97"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15203534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proceedings of the International Narcotics Research Conference. North Falmouth, Massachusetts, June 23-28, 1985. 国际麻醉品研究会议论文集。北法尔茅斯，马萨诸塞州，1985年6月23日至28日。

Alcohol and drug research Pub Date : 1985-01-01

引用次数: 0

Opioid physiology. 阿片样物质生理机能。

Alcohol and drug research Pub Date : 1985-01-01

R Dingledine

引用次数: 0

Place-conditioning properties of mu, kappa, and sigma opioid agonists. mu, kappa和sigma阿片激动剂的位置调节特性。

Alcohol and drug research Pub Date : 1985-01-01

E T Iwamoto

{"title":"Place-conditioning properties of mu, kappa, and sigma opioid agonists.","authors":"E T Iwamoto","doi":"","DOIUrl":"","url":null,"abstract":"The place-conditioning capacities of morphine, ketocyclazocine, ethylketocyclazocine, bremazocine, U 50488, d,1-N-allylnormetazocine (NAN), d-NAN, 1-NAN, and the effects of the opioid antagonists naloxone, WIN 44,441-3, and MR 2266BS were assessed in adult male rats using a three-chambered place-conditioning apparatus. Morphine, ketocyclazocine, ethylketocyclazocine, d,1-NAN, and 1-NAN at doses ranging from 0.25 to 4 mg/kg induced place-preferences for the compartment that was paired with drug administration during the conditioning process. One, 2, or 4 mg/kg of d-NAN had little effect. Naloxone, at doses of 1, 2, 4, and 10 mg/kg, conditioned strong place-aversions in rats; that is, on test day, rats spent significantly more time in the compartment that was not paired with drug-treatment. Bremazocine (0.05 to 4 mg/kg) and U 50488 (0.4 to 4 mg/kg) also conditioned significant, dose-related place-aversions. The results of the putative kappa opioid antagonists were mixed; MR 2266BS caused a dose-related place-aversion while the WIN 44,441-3 produced place-preference. Two mg/kg, but not 0.02 or 0.2 mg/kg, of naloxone administered prior to conditioning with 4 mg/kg of morphine, ethylketocyclazocine, and d,1-NAN, or 2 mg/kg of ketocyclazocine, resulted in place-aversions similar in magnitude to those found after naloxone-conditioning alone. Thus, the mu agonist morphine, the kappa agonists ketocyclazocine and ethylketocyclazocine, the sigma-agonist d,1-NAN, and the levo isomer of NAN all induce place-preferences in the rat according to the place-conditioning paradigm. In contrast, the kappa agonists bremazocine and U 50488, and the kappa antagonist MR 2266BS, induced place-avoiding responses. Since the development of place-preference after morphine, ketocyclazocine, ethylketocyclazocine, and d,1-NAN was antagonized by a kappa-receptor-antagonist dose of naloxone (2 mg/kg) and not by mu-receptor-antagonist doses, these data provide evidence that these particular mu, kappa, and sigma opioids may share a common underlying pharmacologic action.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"6 5","pages":"327-39"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14144042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular biological approaches. 分子生物学方法。

Alcohol and drug research Pub Date : 1985-01-01

J Schwartz

引用次数: 0

Ethanol-stress interaction on dopamine metabolism in the medial prefrontal cortex. 乙醇-应激相互作用对内侧前额皮质多巴胺代谢的影响。

Alcohol and drug research Pub Date : 1985-01-01

F Fadda, E Mosca, R Meloni, G L Gessa

引用次数: 0

GABAA receptors and opioid receptors as examples of multiple site receptor proteins. GABAA受体和阿片受体是多位点受体蛋白的例子。

Alcohol and drug research Pub Date : 1985-01-01

E Barnard