Alcohol and drug research最新文献_第9页

Place-aversion conditioned by phencyclidine in rats: development of tolerance and pharmacologic antagonism. 苯环利定引起的大鼠场所厌恶:耐受性和药理学拮抗的发展。

Alcohol and drug research Pub Date : 1985-01-01

E T Iwamoto

{"title":"Place-aversion conditioned by phencyclidine in rats: development of tolerance and pharmacologic antagonism.","authors":"E T Iwamoto","doi":"","DOIUrl":"","url":null,"abstract":"The pharmacologic properties of phencyclidine were assessed in adult, male rats using a three-chambered, place-conditioning apparatus. Phencyclidine hydrochloride (PCP), at doses of 0.5 to 4 mg/kg, produced a dose-related place-aversion after three drug/environment pairings. During the place-conditioning procedure, 4 mg/kg of PCP significantly increased spontaneous locomotor activity compared to saline-control. Tolerance to PCP-induced place-aversion developed after four daily administrations of 4 mg/kg of PCP. d-Butaclamol, 0.4 mg/kg, given 1 min before each of the three conditioning-doses of PCP decreased the development of the place-aversion induced by PCP. 1-Butaclamol was without significant effect. Spiroperidol, 0.06 mg/kg, completely blocked the development of PCP place-aversion. Spiroperidol and the stereoisomers of butaclamol did not have significant place-conditioning activity when administered alone in the place-conditioning paradigm. The data suggest that PCP induces place-aversion in rats in the place-conditioning model, and that tolerance to this effect develops within 4 days. Furthermore, since d-butaclamol or spiroperidol, but not 1-butaclamol, antagonized this effect of PCP, PCP-induced place-aversion may be mediated in part by a dopaminergic mechanism.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13566454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity of phencyclidine and ethanol in combination. 苯环利定与乙醇联用的毒性。

Alcohol and drug research Pub Date : 1985-01-01

B L Brunet, R J Reiffenstein, T Williams, L Wong

{"title":"Toxicity of phencyclidine and ethanol in combination.","authors":"B L Brunet, R J Reiffenstein, T Williams, L Wong","doi":"","DOIUrl":"","url":null,"abstract":"The role of ethanol in phencyclidine-related death and loss of motor co-ordination was studied in male ICR albino mice. LD50s, and ED50s for loss of righting reflex, and for the \"rotarod\" test were determined for each drug in the presence of various doses of the other. Isobolograms (plots of equieffective dose combinations) of these LD50s and ED50s showed that low doses of ethanol reduced the LD50 of phencyclidine (PCP) by about 20%, while higher doses (1-3 g/kg) of ethanol were without further effect. In contrast to effects on lethality, there was synergism (potentiation) of loss of motor co-ordination. Doses of ethanol above 1 g/kg reduced the ED50 of PCP for loss of righting from about 60 mg/kg to 1-3 mg/kg. Similarly, low doses of PCP (less than 40 mg/kg) reduced the ED50 of ethanol from 3 g/kg to 1 g/kg. There was a slight but consistent synergism between the drugs in the rotarod test over the range of effective doses (0.25-2.0mg/kg PCP and 0.1-1.2 g/kg ethanol). It is concluded that consumption of ethanol does not greatly increase the risk of death from PCP overdose; however the severe adverse effects on motor co-ordination of moderate doses of PCP together with moderate doses of ethanol are greatly potentiated by doses of the other drug. It is estimated that commonly used doses could result in total loss of motor ability, which could explain the prevalence of accidental deaths (especially drowning) when PCP and ethanol have been consumed together.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14950513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythrocyte aldehyde dehydrogenase and clinical chemical markers of alcohol abuse and alcoholism. 红细胞醛脱氢酶与酒精滥用和酒精中毒的临床化学标志物。

Alcohol and drug research Pub Date : 1985-01-01

J F Towell, W F Townsend, J H Kalbfleisch, R I Wang, C J Zablocki

引用次数: 0

Salsolinol in the urine of nonalcoholic individuals after long-term moderate drinking. 长期适度饮酒后非酒精个体尿液中的沙索林醇。

Alcohol and drug research Pub Date : 1985-01-01

K Matsubara, A Akane, C Maseda, S Takahashi, Y Fukui

引用次数: 0

On the use of nuclear magnetic resonance spectroscopy (NMR) to study the mechanism(s) of ethanol action. 利用核磁共振波谱(NMR)研究乙醇作用机理。

Alcohol and drug research Pub Date : 1985-01-01

G Kreishman, C Graham-Brittain, H Schueler, R Hitzemann