Alcohol and drug research最新文献_第4页

Comparative effects of ethanol and other depressant drugs on membrane order in rat synaptosomes using ESR spectroscopy. 用ESR光谱比较乙醇和其他抑制剂对大鼠突触体膜序的影响。

Alcohol and drug research Pub Date : 1987-01-01

B J Logan, R Laverty

引用次数: 0

The effects of N-allylnormetazocine on electric shock titration in squirrel monkeys. n -烯丙基去甲他唑嗪对松鼠猴电击滴定的影响。

Alcohol and drug research Pub Date : 1987-01-01

B L Slifer, L A Dykstra

{"title":"The effects of N-allylnormetazocine on electric shock titration in squirrel monkeys.","authors":"B L Slifer, L A Dykstra","doi":"","DOIUrl":"","url":null,"abstract":"The effects of the stereoisomers of the prototypic sigma agonist N-allylnormetazocine were evaluated in squirrel monkeys trained to respond on an electric shock titration schedule. The monkeys responded on a fixed-ratio schedule to decrease the level of shock delivered to their tails. The effects of the isomers were compared to the effects of phencyclidine and morphine administered alone and also in combination with a rate-suppressing dose of morphine. Morphine increased the level at which shock was maintained without decreasing rates of responding in the presence of shock. Both the (+)-isomer and PCP produced increases in the levels at which the monkeys maintained the shock, but only in some animals. The (-)-isomer of N-allylnormetazocine resulted in either decreases or no effect on the level at which the monkeys maintained the shock. The isomers were equipotent in decreasing response rates. When tested in combination with morphine, only the (-)-isomer antagonized the shock-level increasing effects of morphine. Thus, the isomers had similar effects on response rates but the (+)-isomer, like PCP, was more effective in increasing the level at which the monkeys maintained electric shock, while only the (-)-isomer was effective as a morphine antagonist. These results suggest analgesic-like effects for the (+)-isomer of N-allylnormetazocine and substantiate the opiate-antagonist properties of the (-)-isomer.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"7 4","pages":"217-24"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14162960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of long-term ethanol consumption on the rat ventricle. 长期饮用乙醇对大鼠心室的影响。

Alcohol and drug research Pub Date : 1987-01-01

P Posner, S P Baker, R G Carpentier, W W Hennemann

引用次数: 0

The response of rat brain protein synthesis to ethanol and sodium barbital. 乙醇和巴比妥钠对大鼠脑蛋白合成的影响。

Alcohol and drug research Pub Date : 1987-01-01

S Tewari, S A Greenberg, K Do, P A Grey

{"title":"The response of rat brain protein synthesis to ethanol and sodium barbital.","authors":"S Tewari, S A Greenberg, K Do, P A Grey","doi":"","DOIUrl":"","url":null,"abstract":"Central nervous system (CNS) depressants such as ethanol and barbiturates under acute or chronic conditions can induce changes in rat brain protein synthesis. While these data demonstrate the individual effects of drugs on protein synthesis, the response of brain protein synthesis to alcohol-drug interactions is not known. The goal of the present study was to determine the individual and combined effects of ethanol and sodium barbital on brain protein synthesis and gain an understanding of the mechanisms by which these alterations in protein synthesis are produced. Specifically, the in vivo and in vitro effects of sodium barbital (one class of barbiturates which is not metabolized by the hepatic tissue) were examined on brain protein synthesis in rats made physically dependent upon ethanol. Using cell free brain polysomal systems isolated from \"Control,\" \"Ethanol\" and 24 h \"Ethanol Withdrawn\" rats, data show that sodium barbital, when intubated intragastrically, inhibited the time dependent incorporation of 14(C) leucine into protein by all three groups of ribosomes. Under these conditions, the \"Ethanol Withdrawn\" group displayed the largest inhibition of the 14(C) leucine incorporation into protein when compared to the \"Control\" and \"Ethanol\" groups. In addition, sodium barbital when added at various concentrations in vitro to the incubation medium inhibited the incorporation of 14(C) leucine into protein by \"Control\" and \"Ethanol\" polysomes. The inhibitory effects were also obtained following preincubation of ribosomes in the presence of barbital but not cycloheximide. Data suggest that brain protein synthesis, specifically brain polysomes, through interaction with ethanol or barbital are involved in the functional development of tolerance. These interactions may occur through proteins or polypeptide chains or alterations in messenger RNA components associated with the ribosomal units.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"7 4","pages":"243-58"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14944668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demonstration of a threshold concentration for ethanol at the time of regaining the righting response in long-sleep and short-sleep mice. 长睡眠和短睡眠小鼠恢复恢复反应时乙醇阈值浓度的证明。

Alcohol and drug research Pub Date : 1987-01-01

A Smolen, T N Smolen

引用次数: 0

Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats. 酒精偏好与N/Nih异种饲养大鼠脑区域单胺含量的关系。

Alcohol and drug research Pub Date : 1987-01-01

J M Murphy, W J McBride, L Lumeng, T K Li

引用次数: 0

Toxicity of MDA (3,4-methylenedioxyamphetamine) considered for relevance to hazards of MDMA (Ecstasy) abuse. MDA(3,4-亚甲基二氧苯丙胺)的毒性被认为与MDMA(摇头丸)滥用的危害有关。

Alcohol and drug research Pub Date : 1987-01-01

W M Davis, H T Hatoum, I W Waters

引用次数: 0

Proglumide exhibits delta opioid agonist properties. 丙氨酰胺表现出阿片受体激动剂的特性。

Alcohol and drug research Pub Date : 1987-01-01

A Rezvani, K B Stokes, D L Rhoads, E L Way

{"title":"Proglumide exhibits delta opioid agonist properties.","authors":"A Rezvani, K B Stokes, D L Rhoads, E L Way","doi":"","DOIUrl":"","url":null,"abstract":"Recently, it was reported that proglumide, a cholecystokinin (CCK) antagonist, potentiates the analgetic effects of morphine and endogenous opioid peptides and reverses morphine tolerance by antagonizing the CCK system in the central nervous system of the rat. In order to provide additional insight into the mode of action of this agent, we assessed the effect of proglumide in the isolated guinea pig ileum and the mouse, rat and rabbit vas deferens. Furthermore, we studied the in vitro binding affinity of this substance to mouse brain synaptosomes. Our results show that proglumide inhibits, dose dependently, the electrically stimulated twitches in the mouse vas deferens and guinea pig ileum, but not in the rat or rabbit vas deferens. The inhibitory action of proglumide on the mouse vas deferens, but not on the guinea pig ileum, is antagonized by naloxone and by the selective delta-antagonist, ICI 174,864, in a competitive fashion. Other CCK antagonists were found to be devoid of such activity on the mouse vas deferens. In vitro binding studies showed that proglumide displaces D-ala-D-[leucine]5-enkephalin (DADLE), a delta agonist, but not ethylketocyclazocine (EKC), a preferentially selective kappa agonist. The effect of proglumide appeared to be elicited presynaptically since it did not alter the norepinephrine-induced contractions of the mouse vas deferens. Our results suggest that proglumide might exert its opiate-like effects by activation of delta-opioid receptors.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"7 3","pages":"135-46"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14162959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological profile of delta 9-THC carbamate. 氨基甲酸酯δ 9-四氢大麻酚的药理学特征。

Alcohol and drug research Pub Date : 1987-01-01

P J Little, N C Kaplan, B R Martin

引用次数: 0

Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats. 幽门结扎、低温约束应激、阿司匹林、吲哚美辛、利血平对吗啡依赖大鼠胃致孕作用的研究。

Alcohol and drug research Pub Date : 1987-01-01

N S Parmar, M Tariq, A M Ageel

{"title":"Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats.","authors":"N S Parmar, M Tariq, A M Ageel","doi":"","DOIUrl":"","url":null,"abstract":"The gastric mucosal damage induced by pylorus ligation for 6 h, hypothermic restraint stress, aspirin, indomethacin and reserpine was studied in morphine dependent rats. Morphine tolerance and dependence were produced by administering the gradually increasing concentrations of morphine sulphate in drinking water for 21-24 days. The tolerance and dependence produced by morphine were confirmed by a decreased analgesic response to morphine in the hot plate test and by producing a naloxone precipitated withdrawal syndrome respectively. The intensity of gastric mucosal damage induced by pylorus ligation, aspirin and indomethacin was significantly higher in morphine dependent rats than that observed in the naive animals. Studies on the gastric secretion did not reveal any significant change in the volume of gastric secretion, titrable acidity and gastric output of 6 h pylorus ligated rats. The average lesion scores in the reserpine treated and hypothermic restraint stressed rats were not significantly different from those obtained in the naive animals. Further studies are required to establish the exact mechanisms underlying these observations.","PeriodicalId":7671,"journal":{"name":"Alcohol and drug research","volume":"7 5-6","pages":"341-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14741387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0