The Journal of otolaryngology最新文献_第6页

Urinary N-acetyl-beta-D-glucosaminidase levels in patients with laryngeal squamous cell carcinoma. 喉鳞状细胞癌患者尿n -乙酰- β - d -氨基葡萄糖酶水平。

The Journal of otolaryngology Pub Date : 2007-08-01

Fatih Oktem, Osman Yazicilar, M Güven Güvenç, Murat Toprak, Hafize Uzun, Seval Aydin, Ezel Uslu

{"title":"Urinary N-acetyl-beta-D-glucosaminidase levels in patients with laryngeal squamous cell carcinoma.","authors":"Fatih Oktem, Osman Yazicilar, M Güven Güvenç, Murat Toprak, Hafize Uzun, Seval Aydin, Ezel Uslu","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Tumour markers play an important role in the diagnosis of cancer and the early detection of recurrences during follow-up. This study aimed to assess the clinical value of measuring urinary N-acetyl-beta-d-glucosaminidase (U-NAG) levels in patients with laryngeal squamous cell carcinoma.Design: Prospective, controlled study.Setting: Tertiary university hospital.Patients and methods: Our study included 21 patients with primary laryngeal squamous cell carcinoma and 17 cases with recurrent laryngeal squamous cell carcinoma. U-NAG levels of patients with tumours at different stages were compared with a control group of 19 healthy individuals with no known cancer.Main outcome measures: Patients' age, TNM stage, blood urea, glucose, alanine aminotransferase (ALT), and U-NAG.Results: A statistically significant difference was found between U-NAG levels of patients with a primary tumour (preoperative period) and the control group (one-way analysis of variance, p = .00; Dunnett's t-test, p = .00). In the postoperative period, the observed trend was that of a significant decrease among primary cases (paired t-test, p = .00). U-NAG levels of patients with a recurrent tumour and patients with a primary tumour (preoperative period) were not significantly different (Tukey honest significant difference test, p = .841). There was no statistically significant difference for blood urea (t = -1.95, p = .064), glucose (t = -1.84, p = .074), or ALT (t = -1.79, p = .080). No significant relationship was found between the TNM stage and preoperative U-NAG levels (p > .05).Conclusions: These results suggest that U-NAG might be used in the diagnosis of laryngeal carcinoma and the early detection of recurrences during follow-up. Further investigations are warranted to clarify the prognostic significance of U-NAG levels.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4","pages":"233-9"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27053376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic surgical treatment of pleomorphic adenoma of the inferior nasal turbinate. 下鼻甲多形性腺瘤的内镜手术治疗。

The Journal of otolaryngology Pub Date : 2007-06-01 DOI: 10.2310/7070.2006.0146

Giuseppe Mercante, Filippo Di Lella, Domenico Corradi, Guido Rindi, Gabriele Oretti, Teore Ferri

引用次数: 2

Contamination of post-endoscopic sinus surgery sinus cavities with Pasteurella multocida. 内窥镜鼻窦手术后窦腔多杀性巴氏杆菌污染。

The Journal of otolaryngology Pub Date : 2007-06-01 DOI: 10.2310/7070.2007.e0003

Simon Dufresne, Martin Desrosiers

引用次数: 3

Unusual congenital laryngeal web in an 11-year-old child. 11岁儿童不寻常的先天性喉网。

The Journal of otolaryngology Pub Date : 2007-06-01 DOI: 10.2310/7070.2007.e0004

Ivana Aras, Sinisa Stevanović, Mirko Ivkić, Katarina Pavisić Dokoza, Tomislav Baudoin, Livije Kalogjera

引用次数: 0

Clavipectoral osteomyocutaneous free flap in oromandibular reconstruction. 锁骨骨肌皮游离皮瓣在口腔颌面部重建中的应用。

The Journal of otolaryngology Pub Date : 2007-06-01 DOI: 10.2310/7070.2007.0023

H. Seikaly, A. Moshaver, J. Chau, J. Harris, K. Calhoun

{"title":"Clavipectoral osteomyocutaneous free flap in oromandibular reconstruction.","authors":"H. Seikaly, A. Moshaver, J. Chau, J. Harris, K. Calhoun","doi":"10.2310/7070.2007.0023","DOIUrl":"https://doi.org/10.2310/7070.2007.0023","url":null,"abstract":"INTRODUCTION\u0000Mandibular reconstruction continues to challenge most head and neck reconstructive surgeons despite the tremendous advances in surgical and fixation techniques. We recently described the clavipectoral osteocutaneous flap for mandibular reconstruction. This flap encompasses the clavicle and the clavicular head of the pectoralis major with overlying skin.\u0000\u0000\u0000OBJECTIVES\u0000The purpose of this article is to report our prospective clinical experience with the use of clavipectoral osteocutaneous flap in the reconstruction of oromandibular defects.\u0000\u0000\u0000STUDY DESIGN\u0000Prospective case series.\u0000\u0000\u0000METHODS\u0000Five patients with significant mandibular defects underwent reconstruction using the newly described clavipectoral flap. All patients had shoulder range of motion testing preoperatively and at 3 and 6 months postoperatively. Panorex and bone scans were obtained on the seventh postoperative day.\u0000\u0000\u0000RESULTS\u0000All five flaps survived. The transferred clavicles demonstrated good vascularity on the postoperative bone scans. The shoulder morbidity was minimal, with all patients resuming their preoperative level of activity.\u0000\u0000\u0000CONCLUSIONS\u0000The clavipectoral flap has bone and soft tissue components that are especially suited for composite mandibular defects, but it should be used as a second-line flap owing to the short pedicle and the regular need for vein grafts.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3 1","pages":"186-90"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68603123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Non-nutritive swallowing and respiration coordination among states of alertness in adult sheep. 成年羊警觉状态下非营养性吞咽和呼吸协调。

The Journal of otolaryngology Pub Date : 2007-06-01

Stéphane Roberge, Nathalie Samson, Stéphanie Dorion, Dominique Dorion, Jean-Paul Praud

{"title":"Non-nutritive swallowing and respiration coordination among states of alertness in adult sheep.","authors":"Stéphane Roberge, Nathalie Samson, Stéphanie Dorion, Dominique Dorion, Jean-Paul Praud","doi":"","DOIUrl":"","url":null,"abstract":"Swallowing is a powerful inhibitor of respiration. Its coordination with respiration is therefore crucial to avoid aspiration and apnea. The aim of this study was to determine the coordination between non-nutritive swallowing (NNS) and phases of the respiratory cycle, including the assessment of the effect of states of alertness in adult sheep. Six animals were surgically instrumented under general anesthesia to record electroencephalography, electro-oculography (state of alertness), diaphragmatic electromyography (EMG), nasal flow (respiration), esophageal EMG, and the thyroarytenoid muscle (NNS). Our results revealed that (1) the highest NNS frequency is observed in rapid eye movement (REM) sleep, especially for bursts of NNS; (2) while NNS begins mainly during inspiration in all states of alertness, REM sleep, however, is responsible for an increase in the proportion of NNS beginning in expiration; (3) the link between inspiration and NNS is not affected by rumination. In conclusion, the link between NNS and inspiration in adult sheep is similar to that of lambs but contrary to previous reports on NNS induced by water in humans. Whether these differences are related to interspecies differences or the experimental techniques clearly needs further studies on spontaneous NNS in humans.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"140-7"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26899682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma. 喉鳞癌微卫星不稳定的意义及机制。

The Journal of otolaryngology Pub Date : 2007-06-01

Huang Zhigang, Han Demin, Gao Han, Fan Erzhong, Chen Xiaohong, Xu Hongbo

{"title":"Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma.","authors":"Huang Zhigang, Han Demin, Gao Han, Fan Erzhong, Chen Xiaohong, Xu Hongbo","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the significance and mechanism of microsatellite instability (MSI) in laryngeal squamous cell carcinoma (LSCC).Methods: We investigated the expression frequency and clinical significance of MSI in 50 LSCC patients. The status of MSI was evaluated by using microdissection, polymerase chain reaction, single-strand length polymorphism, and silver staining. Five markers on chromosomes 1p, 3p, 5q, 9p, and 17p were used. Two of the six components of mismatch repair (MMR)-hMLH1 and hMSH2-were investigated by an immunohistochemical approach.Results: The informative case numbers of the five markers (D17S796, D3S3544, D5S656, D1S375, D9S162) were 44, 42, 45, 44, and 40 in all 50 cases, respectively. The incidence of MSI on D17S796 (TP53) was 20.5% (9 of 44), on D3S3544 (FHIT) was 14.3% (6 of 42), on D5S656 (APC) was 31.1% (14 of 45), on D1S375 (BCAR3) was 20.5% (9 of 44), and on D9S162 (CDKN2A) was 15.0% (6 of 40). Although there was no relationship between MSI status and age, gender, smoking history, tumour location, tumour differentiation, and T stage (p > .05), there was a strong relationship between MSI and relapse condition (p < .01). Also, MSI status correlated with MMR expression to some degree (p < .01). But it was common that negative and positive staining of MMR coexisted on the same slide.Conclusion: MSI and abnormal MMR may contribute to the carcinogenesis of a subset of LSCC. MSI may be a characteristic signal of tumour recurrence.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"168-74"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26899687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rounding of the inferior rectus muscle as an indication of orbital floor fracture with periorbital disruption. 下直肌变圆表明眶底骨折伴眶周破裂。

The Journal of otolaryngology Pub Date : 2007-06-01

Avik Banerjee, Corey C Moore, Raymond Tse, Damir Matic

{"title":"Rounding of the inferior rectus muscle as an indication of orbital floor fracture with periorbital disruption.","authors":"Avik Banerjee, Corey C Moore, Raymond Tse, Damir Matic","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To determine if rounding of the inferior rectus muscle on coronal computed tomographic (CT) scans predicts disruption of the periorbita in orbital floor fractures and therefore predicts delayed enophthalmos.Design: Cadaveric study with CT scan analysis.Setting: Cadaveric laboratory and CT scanner at a tertiary care hospital in London, Ontario.Methods: Each orbit of each cadaveric head was randomly assigned to have either intact or disrupted periorbita. Progressively larger orbital floor fractures were made and CT scans were taken before fractures and after each fracture to assess the shape of the inferior rectus muscle. Measurements were made of the length of the long and short axis of the inferior rectus muscle using CT analysis software. The short to long axis ratio was then compared.Main outcome measures: Change in the short to long axis ratio of the inferior rectus muscle and correlation of the ratio with intact and disrupted periorbita.Results: Orbital floor fractures measuring 1 x 1 cm show an increase in the short to long axis ratio (rounding) of the inferior rectus muscle only if the periorbita is disrupted. Orbital floor fractures measuring 2 x 2 cm show rounding of the inferior rectus muscle regardless of whether the periorbita is intact or disrupted; however, the degree of rounding is greater if the periorbita is disrupted.Conclusions: For small orbital floor fractures, rounding of the inferior rectus muscle predicts periorbital disruption. This may therefore represent an indication for early surgical repair to prevent delayed enophthalmos.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"175-80"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26899688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To "EE" or not to "EE". “EE”还是不“EE”。

The Journal of otolaryngology Pub Date : 2007-06-01 DOI: 10.2310/7070.2007.0019

M. Draper, B. Blagnys, D. Premachandra

{"title":"To \"EE\" or not to \"EE\".","authors":"M. Draper, B. Blagnys, D. Premachandra","doi":"10.2310/7070.2007.0019","DOIUrl":"https://doi.org/10.2310/7070.2007.0019","url":null,"abstract":"OBJECTIVE\u0000To assess whether /i:/ (\"ee\") is the best sound to use during indirect laryngoscopy to produce the optimal view of the larynx.\u0000\u0000\u0000DESIGN\u0000Prospective study.\u0000\u0000\u0000SETTING\u0000District general hospital otolaryngology outpatient clinic.\u0000\u0000\u0000PATIENTS\u0000Eighty-seven patients from a general otolaryngology clinic with no laryngeal or pharyngeal symptoms or pathology.\u0000\u0000\u0000MAIN OUTCOME MEASURES\u0000The views obtained during indirect laryngoscopy and vocalization of /i:/ (\"ee\"), /ei/ (\"ay\"), /[see text]/ (\"err\"), /a:/ (\"ah\"), and /eă/ (\"air\") were graded according to a laryngoscopy grading system.\u0000\u0000\u0000RESULTS\u0000The greatest number of adequate views of the larynx was achieved by using the sounds /i:/ and /[see text]/. There was no significant difference between /i:/ and /[see text]/ (p = .740), but there were significant differences between /i:/ and /ei/ (p = .019), /i:/ and /a:/ (p = .00000), and /i:/ and /eă/ (p = .00013).\u0000\u0000\u0000CONCLUSION\u0000For the optimal view of the larynx during indirect laryngoscopy, we recommend the use of the sounds /i:/ (\"ee\") and /[see text]/ (\"err\").","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3 1","pages":"191-95"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68602881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Clavipectoral osteomyocutaneous free flap in oromandibular reconstruction. 锁骨骨肌皮游离皮瓣在口腔颌面部重建中的应用。

The Journal of otolaryngology Pub Date : 2007-06-01

Hadi Seikaly, Ali Moshaver, Jason Chau, Jeffrey R Harris, Karen H Calhoun

{"title":"Clavipectoral osteomyocutaneous free flap in oromandibular reconstruction.","authors":"Hadi Seikaly, Ali Moshaver, Jason Chau, Jeffrey R Harris, Karen H Calhoun","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Mandibular reconstruction continues to challenge most head and neck reconstructive surgeons despite the tremendous advances in surgical and fixation techniques. We recently described the clavipectoral osteocutaneous flap for mandibular reconstruction. This flap encompasses the clavicle and the clavicular head of the pectoralis major with overlying skin.Objectives: The purpose of this article is to report our prospective clinical experience with the use of clavipectoral osteocutaneous flap in the reconstruction of oromandibular defects.Study design: Prospective case series.Methods: Five patients with significant mandibular defects underwent reconstruction using the newly described clavipectoral flap. All patients had shoulder range of motion testing preoperatively and at 3 and 6 months postoperatively. Panorex and bone scans were obtained on the seventh postoperative day.Results: All five flaps survived. The transferred clavicles demonstrated good vascularity on the postoperative bone scans. The shoulder morbidity was minimal, with all patients resuming their preoperative level of activity.Conclusions: The clavipectoral flap has bone and soft tissue components that are especially suited for composite mandibular defects, but it should be used as a second-line flap owing to the short pedicle and the regular need for vein grafts.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"186-90"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26899617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0