Leigh J Sowerby, T Wayne Matthews, Moussa Khalil, Harold Lau
{"title":"Primary large cell neuroendocrine carcinoma of the submandibular gland: unique presentation and surprising treatment response.","authors":"Leigh J Sowerby, T Wayne Matthews, Moussa Khalil, Harold Lau","doi":"10.2310/7070.2007.e007","DOIUrl":"https://doi.org/10.2310/7070.2007.e007","url":null,"abstract":"","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4","pages":"E65-9"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27581079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Oktem, Osman Yazicilar, M. G. Güvenç, M. Toprak, H. Uzun, S. Aydin, E. Uslu
{"title":"Urinary N-acetyl-beta-D-glucosaminidase levels in patients with laryngeal squamous cell carcinoma.","authors":"F. Oktem, Osman Yazicilar, M. G. Güvenç, M. Toprak, H. Uzun, S. Aydin, E. Uslu","doi":"10.2310/7070.2007.0028","DOIUrl":"https://doi.org/10.2310/7070.2007.0028","url":null,"abstract":"OBJECTIVE\u0000Tumour markers play an important role in the diagnosis of cancer and the early detection of recurrences during follow-up. This study aimed to assess the clinical value of measuring urinary N-acetyl-beta-d-glucosaminidase (U-NAG) levels in patients with laryngeal squamous cell carcinoma.\u0000\u0000\u0000DESIGN\u0000Prospective, controlled study.\u0000\u0000\u0000SETTING\u0000Tertiary university hospital.\u0000\u0000\u0000PATIENTS AND METHODS\u0000Our study included 21 patients with primary laryngeal squamous cell carcinoma and 17 cases with recurrent laryngeal squamous cell carcinoma. U-NAG levels of patients with tumours at different stages were compared with a control group of 19 healthy individuals with no known cancer.\u0000\u0000\u0000MAIN OUTCOME MEASURES\u0000Patients' age, TNM stage, blood urea, glucose, alanine aminotransferase (ALT), and U-NAG.\u0000\u0000\u0000RESULTS\u0000A statistically significant difference was found between U-NAG levels of patients with a primary tumour (preoperative period) and the control group (one-way analysis of variance, p = .00; Dunnett's t-test, p = .00). In the postoperative period, the observed trend was that of a significant decrease among primary cases (paired t-test, p = .00). U-NAG levels of patients with a recurrent tumour and patients with a primary tumour (preoperative period) were not significantly different (Tukey honest significant difference test, p = .841). There was no statistically significant difference for blood urea (t = -1.95, p = .064), glucose (t = -1.84, p = .074), or ALT (t = -1.79, p = .080). No significant relationship was found between the TNM stage and preoperative U-NAG levels (p > .05).\u0000\u0000\u0000CONCLUSIONS\u0000These results suggest that U-NAG might be used in the diagnosis of laryngeal carcinoma and the early detection of recurrences during follow-up. Further investigations are warranted to clarify the prognostic significance of U-NAG levels.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4 1","pages":"233-9"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68603192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charalambos E Skoulakis, Chariton E Papadakis, Andreas G Manios, Panagiotis D Moshotzopoulos, Evaggelos A Theos, Dimitris E Valagiannis
{"title":"Tonsilloplasty in children with obstructive symptoms.","authors":"Charalambos E Skoulakis, Chariton E Papadakis, Andreas G Manios, Panagiotis D Moshotzopoulos, Evaggelos A Theos, Dimitris E Valagiannis","doi":"10.2310/7070.2007.0030","DOIUrl":"https://doi.org/10.2310/7070.2007.0030","url":null,"abstract":"<p><strong>Objective: </strong>Obstructive symptoms, caused by tonsillar hypertrophy, have been attracting increasing interest, and tonsillectomy is often performed as a result of this indication. This study was undertaken to investigate the effect of the different surgical techniques, tonsilloplasty and tonsillectomy, on clinical symptoms in children with obstructive symptoms owing to tonsillar hypertrophy.</p><p><strong>Methods: </strong>Thirty children, 3 to 12 years old, were included; 15 of them underwent tonsilloplasty and 15 tonsillectomy. Tonsilloplasty was performed with a knife or scissors, and the trauma was closed with two or three sutures. The tonsillar capsule and about 15 to 20% of tonsillar tissue remain as a barrier to prevent exposure of the pharyngeal muscles. All children were operated on under the same anesthesia and followed the same postoperative scheme for analgesia.</p><p><strong>Results: </strong>All of the children were cured of their breathing obstruction. In the tonsilloplasty group, the tonsillar remnants healed completely within 1 week. The postoperative pain recorded was significantly less than in the tonsillectomy group. No major side effects occurred. The mean time used for the surgery was the same, and no postoperative bleeding was seen in both groups. The intraoperative bleeding observed was small in both groups, although significantly smaller for the tonsilloplasty group.</p><p><strong>Conclusions: </strong>Tonsilloplasty is a less traumatic and much less painful surgical method, and children recover more quickly. The results with respect to breathing obstruction are almost the same for both methods at the 1-year follow-up. It seems to be the most suitable method for children with tonsillar hypertrophy and obstructive symptoms.</p>","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4","pages":"240-6"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27051037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paule Dupuis, Louis Guertin, Marie-Stéphane Rainville, Dominique-Louise Prud'homme, François Lavigne
{"title":"Montreal's experience with Cyranose heat and moisture exchanger use in 15 laryngectomized patients.","authors":"Paule Dupuis, Louis Guertin, Marie-Stéphane Rainville, Dominique-Louise Prud'homme, François Lavigne","doi":"10.2310/7010.2007.0036","DOIUrl":"https://doi.org/10.2310/7010.2007.0036","url":null,"abstract":"<p><strong>Objective: </strong>Evaluate the effects of the improvement of filtration, heating and humidification of inspired air with Cyranose heat and moisture exchanger (HME) on voice quality, breathing, and secretion handling in laryngectomized patients.</p><p><strong>Design: </strong>Prospective study.</p><p><strong>Setting: </strong>Fifteen laryngectomized patients, mean age 68, ages ranging from 50 to 91 years.</p><p><strong>Methods: </strong>Information was given to patients through video and brochures. Patients were selected if they had minimal understanding, permanent decanulization, no tumour progression or bronchopulmonary infections, and received no recent radiation therapy treatment. They were given the prosthesis and a starter kit. They were then evaluated by a speech pathologist with a structured questionnaire after one week, one month, and three months.</p><p><strong>Main outcome measures: </strong>The outcomes measured were comfort, breathing, secretions, and ease of use of the prosthesis as well as its effect on voice. Impressions of patients on humidification, filtration, and heating of inspired air were also recorded.</p><p><strong>Results: </strong>At conclusion of trial, 75% of patients wore the prosthesis on a daily basis and they all found it easy to use. All patients who completed the trial found breathing and handling of secretions easier as they thought humidification and filtration of air had improved. Quality of voice improved for 50% while remaining unchanged for 37%. The positive effect of the prosthesis progressed throughout the trial. Seven patients dropped out of the trial, mainly because of adhesive-related issues.</p><p><strong>Conclusion: </strong>Laryngectomized patients from the Montreal area could benefit from Cyranose artificial nose following an adaptation period during our cold winter.</p>","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4","pages":"208-12"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7010.2007.0036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27053370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Behçet's disease on hearing thresholds and transient evoked otoacoustic emissions.","authors":"Nuray Bayar Muluk, Ahu Birol","doi":"10.2310/7010.2007.0043","DOIUrl":"https://doi.org/10.2310/7010.2007.0043","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this prospective study was to investigate hearing loss in patients with Behçet disease (BD).</p><p><strong>Methods: </strong>The study group consisted of 20 patients (8 males, 12 females) with BD and 40 ears. The control group consisted of 20 healthy patients without BD (8 males, 12 females) and 40 ears. All subjects were evaluated by an otolaryngologic examination, pure-tone and high-frequency audiometry, and transient evoked otoacoustic emissions (TEOAEs).</p><p><strong>Results: </strong>Sensorineural hearing loss (SNHL) was present in 25% of the ears on pure-tone audiometry and 60% of the ears on high-frequency audiometry in the study group. In the study group, at pure-tone and high-frequency audiometry, hearing thresholds were significantly higher than in the control group. For TEOAE values, in the BD group, each of the 1.0 to 4.0 kHz percent and amplitude values was significantly lower than in the control group. It was found that as age increased, hearing thresholds increased and TEOAEs decreased. As the disease duration got longer, hearing thresholds continued to increase and otoacoustic emissions at 3.0 kHz decreased. In males, hearing thresholds increased more whereas emissions decreased more than in females.</p><p><strong>Conclusion: </strong>Since SNHL is not infrequent in BD patients, patients may be evaluated regularly by pure-tone and high-frequency audiometry and TEOAEs. It may be possible to detect cochlear pathologies earlier than audiometric tests by TEOAEs.</p>","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4","pages":"220-6"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7010.2007.0043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27053374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evan J Propst, Susan Blaser, Stephanie Holowka, Peter K Lewin, Derek Armstrong, Blake C Papsin
{"title":"Dilated endolymphatic fossae in a 2800-year-old Egyptian mummy.","authors":"Evan J Propst, Susan Blaser, Stephanie Holowka, Peter K Lewin, Derek Armstrong, Blake C Papsin","doi":"10.2310/7070.2005.0163","DOIUrl":"https://doi.org/10.2310/7070.2005.0163","url":null,"abstract":"","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4","pages":"E45-7"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27581583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel A Lopez-Gonzalez, Ana M Santiago, Francisco Esteban-Ortega
{"title":"Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway.","authors":"Miguel A Lopez-Gonzalez, Ana M Santiago, Francisco Esteban-Ortega","doi":"10.2310/7070.2007.0018","DOIUrl":"https://doi.org/10.2310/7070.2007.0018","url":null,"abstract":"<p><strong>Objectives: </strong>Sulpiride and melatonin decrease dopamine activity. Sulpiride, a D2 antagonist of dopamine receptors, and melatonin, a pineal substance with antidopaminergic action, are administered to tinnitus patients to decrease tinnitus perception.</p><p><strong>Design: </strong>A prospective, randomized, double-blinded, placebo-controlled study was done.</p><p><strong>Setting: </strong>General otorhinolaryngologic consultation for 2002-2004 in Seville, Spain.</p><p><strong>Methods: </strong>One hundred twenty patients consulted for subjective tinnitus. They were included randomly in four groups of 30. One group took sulpiride (50 mg/8 h) alone, the second group took melatonin (3 mg/24 h), the third group took the same doses of sulpiride (50 mg/8 h) plus melatonin (3 mg/24 h), and the fourth group took placebo (lactose 50 mg/8 h), all for 1 month. Ninety-nine patients completed the study.</p><p><strong>Main outcome measures: </strong>Clinical history, tonal audiometry, tympanometry, and tinnitometry were done at the beginning and end of the study. Subjective grading of tinnitus perception and a visual analogue scale (0-10) were done for evaluation of results.</p><p><strong>Results: </strong>Based on the subjective grading, tinnitus perception diminished by 56% in patients treated with sulpiride, by 40% in patients treated with melatonin, by 81% in patients treated with sulpiride plus melatonin, and by 22% in patients treated with placebo. Based on the visual analogue scale, tinnitus perception diminished from 7.7 to 6.3 in patients treated with sulpiride, to 6.5 in those treated with melatonin, to 4.8 in patients treated with sulpiride plus melatonin, and to 7.0 in those treated with placebo.</p><p><strong>Conclusions: </strong>Sulpiride and melatonin reduce tinnitus perception, decreasing dopamine activity. The tinnitus auditolimbic dopaminergic pathway has broad therapeutic implications.</p>","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 4","pages":"213-9"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27053372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}