The Journal of otolaryngology最新文献

The Journal of otolaryngology Pub Date : 2020-02-08 DOI: 10.32388/chwcbx

引用次数: 0

Sneezing. 打喷嚏。

The Journal of otolaryngology Pub Date : 2020-02-07 DOI: 10.1093/nq/s1-v.137.572h

A. Leung, W. Robson

引用次数: 2

Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins. 长非编码 RNA FosDT 通过与 REST 相关染色质修饰蛋白相互作用促进缺血性脑损伤

The Journal of otolaryngology Pub Date : 2015-12-16 DOI: 10.1523/JNEUROSCI.2943-15.2015

Suresh L Mehta, TaeHee Kim, Raghu Vemuganti

{"title":"Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins.","authors":"Suresh L Mehta, TaeHee Kim, Raghu Vemuganti","doi":"10.1523/JNEUROSCI.2943-15.2015","DOIUrl":"10.1523/JNEUROSCI.2943-15.2015","url":null,"abstract":"Ischemia induces extensive temporal changes in cerebral transcriptome that influences the neurologic outcome after stroke. In addition to protein-coding RNAs, many classes of noncoding RNAs, including long noncoding RNAs (LncRNAs), also undergo changes in the poststroke brain. We currently evaluated the functional significance of an LncRNA called Fos downstream transcript (FosDT) that is cogenic with Fos gene. Following transient middle cerebral artery occlusion (MCAO) in adult rats, expression of FosDT and Fos was induced. FosDT knockdown significantly ameliorated the postischemic motor deficits and reduced the infarct volume. Focal ischemia also increased FosDT binding to chromatin-modifying proteins (CMPs) Sin3a and coREST (corepressors of the transcription factor REST). Furthermore, FosDT knockdown derepressed REST-downstream genes GRIA2, NFκB2, and GRIN1 in the postischemic brain. Thus, FosDT induction and its interactions with REST-associated CMPs, and the resulting regulation of REST-downstream genes might modulate ischemic brain damage. LncRNAs, such as FosDT, can be therapeutically targeted to minimize poststroke brain damage.Significance statement: Mammalian brain is abundantly enriched with long noncoding RNAs (LncRNAs). Functional roles of LncRNAs in normal and pathological states are not yet understood. This study identified that LncRNA FosDT induced after transient focal ischemia modulates poststroke behavioral deficits and brain damage. These effects of FosDT in part are due to its interactions with chromatin-modifying proteins Sin3a and coREST (corepressors of the transcription factor REST) and subsequent derepression of REST-downstream genes GRIA2, NFκB2, and GRIN1. Therefore, LncRNA-mediated epigenetic remodeling could determine stroke outcome.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"30 5 1","pages":"16443-9"},"PeriodicalIF":0.0,"publicationDate":"2015-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90579325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of vascular endothelial growth factor in the pathogenesis of nasal polyps. 血管内皮生长因子在鼻息肉发病中的作用。

The Journal of otolaryngology Pub Date : 2007-12-01

Nuray Bayar Muluk, Pinar Atasoy, Osman Kürşat Arikan, Can Koc

{"title":"Role of vascular endothelial growth factor in the pathogenesis of nasal polyps.","authors":"Nuray Bayar Muluk, Pinar Atasoy, Osman Kürşat Arikan, Can Koc","doi":"","DOIUrl":"","url":null,"abstract":"Objective: This study was aimed at determining the expression of vascular endothelial growth factor (VEGF) in nasal polyps by immunohistochemical technique.Methods: The study group consisted of 25 adult patients with nasal polyps who underwent functional endoscopic sinus surgery. Polyp tissues were taken from the maxillary and ethmoid sinuseses and the nasal cavity. The control group consisted of three adult patients without nasal polyps who underwent septoplasty operation. Their inferior turbinate biopsies were taken with written approval. VEGF positivity was scored by the Vascular Endothelial Growth Factor Positivity Index (VEGF-PI) in the subepithelial (VEGF-PI-SE) and deep (VEGF-PI-Deep) layers of the mucosa on a 0 to 3 scale, and the percentage of inflammatory cells per 100 cells was found.Results: VEGF expression was identified as cytoplasmic staining in the vascular endothelium and inflammatory cells. In each of four groups (maxillary and ethmoid sinuses, nasal cavity, and control), no significant difference was present between VEGF-PI-SE and VEGF-PI-Deep scores. For the VEGF-PI-SE and VEGF-PI-Deep groups, nasal cavity scores were significantly higher. For plasma cell count, the nasal cavity value was significantly higher. As the plasma cell count increased, VEGF-PI-SE and VEGF-PI-Deep scores were also increased in all four groups.Conclusion: In the nasal cavity, VEGF expression is observed more, causing angiogenesis and an increase in the vascular permeability. In the paranasal sinuses, lower VEGF-PI results may show that contact inhibition reduces VEGF expression and thus the polyp growth rate.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6","pages":"357-66"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27115452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal multidisciplinary surgical approach for the treatment of pituitary tumours. 多模式多学科手术入路治疗垂体肿瘤。

The Journal of otolaryngology Pub Date : 2007-12-01

Peter M Abou-Jaoude, Anthony G Zeitouni, Labib Soualmi, Richard Leblanc

{"title":"Multimodal multidisciplinary surgical approach for the treatment of pituitary tumours.","authors":"Peter M Abou-Jaoude, Anthony G Zeitouni, Labib Soualmi, Richard Leblanc","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: The surgical management of pituitary tumours is being impacted by the development of two key technologies: image guidance and endoscopy. This study sought to assess their impact.Methods: Retrospective review of all patients referred to the Skull Base Clinic of the McGill University Health Centre since 2000. Patients were operated on in a multidisciplinary context using a multimodal approach combining endoscopy and microscopy. Imaging during the surgery was initially supported by both three-dimensional neuronavigation and traditional C-arm fluoroscopy.Results: Seventy-five patients were referred to the multidisciplinary clinic, for a total of 41 surgeries. Neuronavigation was used in all cases. C-arm fluoroscopy was not found to improve our surgeries and was removed from our protocol. Endoscopy was found to be advantageous as it allowed improved visualization. It also permitted identifying surrounding structures in the lateral wall of the sphenoid sinus, next to the tumour, and \"around corners.\" Moreover, it encouraged multidisciplinary co-operation as it allowed neurosurgeons and otolaryngologists to follow progress during the case. Nevertheless, the microscope continued to play a role as it facilitated a bimanual technique, stable magnification, and a three-dimensional view. Morbidities in our case series appeared to be minimal.Conclusion: Both endoscopy and the microscope were found to have a role in our surgeries. We consider these technologies to be complementary. C-arm fluoroscopy was rendered obsolete by the neuronavigation unit. A multidisciplinary, multimodal approach maximizes the benefits of these new technologies and permits the best surgical result.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6","pages":"322-6"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27115534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wait times in the diagnosis and treatment of head and neck cancer: comparison between wait times in 1995 and 2005--a prospective study. 头颈癌诊断和治疗的等待时间:1995年和2005年等待时间的比较——一项前瞻性研究。

The Journal of otolaryngology Pub Date : 2007-12-01

David Goldstein, Goran Jeremic, Jeffrey Werger, Jonathan Irish

{"title":"Wait times in the diagnosis and treatment of head and neck cancer: comparison between wait times in 1995 and 2005--a prospective study.","authors":"David Goldstein, Goran Jeremic, Jeffrey Werger, Jonathan Irish","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: There are limited studies documenting current wait times in the diagnosis and treatment of head and neck cancer. The objective of this study was to describe wait times along the health care pathway of head and neck cancer patients referred to an oncology centre in Ontario in 2005 and compare these times with those in a similar cohort of patients enrolled in 1995.Methods: A cross-sectional study investigating wait times in newly diagnosed patients with squamous cell carcinoma of the head and neck was undertaken at the Princess Margaret Hospital, Toronto, Ontario. Data were collected prospectively in 2005 and 1995. Patient interviewing and health care provider corroboration were employed for a sample size of 45 patients in 2005 and 40 patients in 1995.Results: Median wait times in 2005 were similar to those in 1995 for each time period, except for the time from consultation with the first tertiary specialist to treatment, which was statistically significantly shorter in 1995 (25 days) than in 2005 (37 days), p = .002. The median time from initial primary care practitioner seen to treatment (total professional delay) was not different from 1995 (126 days) to 2005 (115 days), p = .47. On univariate analysis, there were no statistically significant differences in wait times in each time period based on site (p = .226 and .321, respectively) and overall stage (p = .655 and .538, respectively).Conclusions: Wait times for head and neck cancer treatment from the time of initial consultation with an oncologist have increased from 1995 to 2005.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6","pages":"336-43"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27115449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary renal cell carcinoma of the head and neck. 头颈部继发性肾细胞癌。

The Journal of otolaryngology Pub Date : 2007-12-01

Michael G Brandt, Kevin M Higgins

引用次数: 0

Aggressive cemento-ossifying fibroma. 侵袭性骨水泥骨化纤维瘤。

The Journal of otolaryngology Pub Date : 2007-12-01

Metin Gungormus

引用次数: 0

Sialolithiasis with concurrent sialadenitis in an 18-year-old boy with triple A syndrome. 涎石症并发涎腺炎的18岁男孩与aaa综合征。

The Journal of otolaryngology Pub Date : 2007-12-01

Miroslav Dumić, Nevena Janjanin, Duska Markov-Glavas, Drago Prgomet, Natasa Rojnić Putarek

引用次数: 0

Management of advanced nodal disease following chemoradiation for head and neck squamous cell carcinoma: role of magnetic resonance imaging. 头颈部鳞状细胞癌放化疗后晚期淋巴结疾病的处理:磁共振成像的作用。

The Journal of otolaryngology Pub Date : 2007-12-01 DOI: 10.2310/7070.2007.0055

Doris Lin, C. Glastonbury, Olga Rafaelian, D. Eisele, Steven J. Wang

{"title":"Management of advanced nodal disease following chemoradiation for head and neck squamous cell carcinoma: role of magnetic resonance imaging.","authors":"Doris Lin, C. Glastonbury, Olga Rafaelian, D. Eisele, Steven J. Wang","doi":"10.2310/7070.2007.0055","DOIUrl":"https://doi.org/10.2310/7070.2007.0055","url":null,"abstract":"BACKGROUND\u0000The purpose of this study was to determine the role of magnetic resonance imaging (MRI) to predict persistent nodal disease in head and neck cancer treated with chemoradiation.\u0000\u0000\u0000METHODS\u0000Retrospective chart review of 38 patients with head and neck cancer and N2/N3 neck disease who were treated with chemoradiation and who had an MRI 6 to 8 weeks following treatment.\u0000\u0000\u0000RESULTS\u0000Sixteen patients had MRI findings suggestive of persistent nodal disease and were managed with neck dissections, three of whom had a persistent tumour. All of these patients have remained disease free in the neck (average follow-up 15 months). Among 22 patients without evidence of nodal disease on post-treatment MRI, 2 patients have had recurrence in the neck (average follow-up 26 months).\u0000\u0000\u0000CONCLUSIONS\u0000Concomitant chemoradiation is effective for the treatment of advanced nodal disease in selected patients. Patients without MRI evidence of persistent nodal disease following chemoradiation who were observed had a low incidence (9%) of eventual neck recurrence, whereas those with evidence of persistent nodes on MRI had a 19% likelihood of residual pathologic neck disease. The optimal strategy for the evaluation of the neck following chemoradiation requires further investigation.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6 1","pages":"350-6"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68603603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5