The Journal of otolaryngology最新文献_第2页

Brachytherapy in the retreatment of patients with new primary head and neck cancer. 近距离放疗在新发原发性头颈癌患者再治疗中的应用。

The Journal of otolaryngology Pub Date : 2007-12-01

Laval Grimard, André Lamothe, Bernd Esche, Johanna N Spaans

{"title":"Brachytherapy in the retreatment of patients with new primary head and neck cancer.","authors":"Laval Grimard, André Lamothe, Bernd Esche, Johanna N Spaans","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Re-treatment for cure of the Head and Neck (H&N) region is therapeutically challenging. In this review we explore the long-term results of Ir(192) low-dose-rate (LDR) brachytherapy in the select subgroup of patients treated for a new H&N malignancy.Methods & material: Thirteen patients received brachytherapy between 1987-2004 for a new primary H&N cancer, six of whom had been retreated previously. Brachytherapy was given as a monotherapy in eight patients and delivered adjuvantly in five patients. Three of the thirteen patients had advanced disease at the time of diagnosis.Main outcome measures: In addition to the known prognostic factors of stage and site, intent of brachytherapy and prior re-treatment status were assessed for their influence on local control (LC) and overall survival (OS).Results: Local control differed by disease stage of the new primary tumor. With a median follow-up of 50 months, mean progression-free survival was 50.2 months [95%CI = 30.1-70.4] and the 2-year rate of LC was 58%. Adjuvant brachytherapy following surgery resulted in poor LC and OS due to advanced disease at diagnosis. Prior retreatment did not appear to affect LC or OS. OS at 2 and 5 years was 69% and 38%, respectively. There were no cases of grade III toxicity.Conclusions: LDR Brachytherapy for a new primary H&N cancer is a well-tolerated retreatment alternative that results in good local control. Our results suggest that the best chance for long-term survival remains in the routine follow-up and early diagnosis of the new H&N malignancy.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6","pages":"327-35"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27115448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic acinic cell carcinoma presenting as a recurrent pituitary adenoma. 转移性腺泡细胞癌表现为复发性垂体腺瘤。

The Journal of otolaryngology Pub Date : 2007-12-01

Tim Thomason, Lance E Oxford, Yadranko Ducic

引用次数: 0

Intravagal ectopic parathyroid presenting as vocal cord paralysis: case report and review of the literature. 静脉内异位甲状旁腺表现为声带麻痹:病例报告及文献回顾。

The Journal of otolaryngology Pub Date : 2007-12-01

George M Yousef, Nebojsa Denic, Jasbir Wadhwa, Soornahalli A Chandracanth, Thomas Smith, Ford Elms, Eleftherios P Diamandis

引用次数: 0

Management of advanced nodal disease following chemoradiation for head and neck squamous cell carcinoma: role of magnetic resonance imaging. 头颈部鳞状细胞癌放化疗后晚期淋巴结疾病的处理:磁共振成像的作用。

The Journal of otolaryngology Pub Date : 2007-12-01

Doris Lin, Christine M Glastonbury, Olga Rafaelian, David W Eisele, Steven J Wang

{"title":"Management of advanced nodal disease following chemoradiation for head and neck squamous cell carcinoma: role of magnetic resonance imaging.","authors":"Doris Lin, Christine M Glastonbury, Olga Rafaelian, David W Eisele, Steven J Wang","doi":"","DOIUrl":"","url":null,"abstract":"Background: The purpose of this study was to determine the role of magnetic resonance imaging (MRI) to predict persistent nodal disease in head and neck cancer treated with chemoradiation.Methods: Retrospective chart review of 38 patients with head and neck cancer and N2/N3 neck disease who were treated with chemoradiation and who had an MRI 6 to 8 weeks following treatment.Results: Sixteen patients had MRI findings suggestive of persistent nodal disease and were managed with neck dissections, three of whom had a persistent tumour. All of these patients have remained disease free in the neck (average follow-up 15 months). Among 22 patients without evidence of nodal disease on post-treatment MRI, 2 patients have had recurrence in the neck (average follow-up 26 months).Conclusions: Concomitant chemoradiation is effective for the treatment of advanced nodal disease in selected patients. Patients without MRI evidence of persistent nodal disease following chemoradiation who were observed had a low incidence (9%) of eventual neck recurrence, whereas those with evidence of persistent nodes on MRI had a 19% likelihood of residual pathologic neck disease. The optimal strategy for the evaluation of the neck following chemoradiation requires further investigation.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6","pages":"350-6"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27115451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kimura disease: an unusual cause of cervical lymphadenopathy with salivary gland involvement. 木村病:一种不寻常的颈部淋巴结病，累及唾液腺。

The Journal of otolaryngology Pub Date : 2007-12-01

J R Bapuraj, Rohit Kochhar, R Nijhawan, Niranjan Khandelwal, Kushaljit Singh Sodhi, Sudha Suri

引用次数: 0

Sentinel lymph node biopsy in squamous cell carcinoma of the head and neck: where we stand now, and where we are going. 头颈部鳞状细胞癌前哨淋巴结活检:我们现在所处的位置，以及我们的发展方向。

The Journal of otolaryngology Pub Date : 2007-12-01

Valérie Côté, Karen Kost, Richard J Payne, Michael P Hier

{"title":"Sentinel lymph node biopsy in squamous cell carcinoma of the head and neck: where we stand now, and where we are going.","authors":"Valérie Côté, Karen Kost, Richard J Payne, Michael P Hier","doi":"","DOIUrl":"","url":null,"abstract":"Background and objectives: This review was performed to evaluate the existing literature on sentinel lymph node biopsy (SLNB) for early-stage oral and oropharyngeal head and neck squamous cell carcinoma (HNSCC) in clinically negative (N0) necks.Methods: A Medline search identified 43 pertinent published trials and reviews in the English-language literature from 1990 to 2005.Results: Recent studies consistently show high sensitivities > 93% for T1 and T2 HNSCC. SLNB has the potential to replace neck dissection in those patients. Data on T3 and T4 tumours are not as promising, although research is currently under way to determine the true metastasis detection rate. Appropriate technique is crucial for the complete detection of the sentinel nodes. For HNSCC sentinel lymphadenectomy, many studies have advocated the use of a colloid tracer and gamma probe detector, as well as the harvesting of a total of three nodes as a good standard technique.Conclusions: American multicentre trials are currently under way gathering crucial data on this technique. It is very likely that SLNB will become indicated for T1 and T2 oral cavity squamous cell carcinoma with N0 necks, and it is possible that the indication will extend to all early-stage HNSCCs. However, more research will be necessary for advanced head and neck cancers.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6","pages":"344-9"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27115450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasogastric tube syndrome. 鼻胃管综合征。

The Journal of otolaryngology Pub Date : 2007-12-01

Valérie Julie Brousseau, Karen M Kost

引用次数: 0

Vestibular compensation after unilateral labyrinthectomy: normal versus cerebellar dysfunctional mice. 单侧迷路切除后的前庭代偿:正常小鼠与小脑功能障碍小鼠。

The Journal of otolaryngology Pub Date : 2007-12-01 DOI: 10.2310/7070.2007.0050

M. Aleisa, A. Zeitouni, K. Cullen

{"title":"Vestibular compensation after unilateral labyrinthectomy: normal versus cerebellar dysfunctional mice.","authors":"M. Aleisa, A. Zeitouni, K. Cullen","doi":"10.2310/7070.2007.0050","DOIUrl":"https://doi.org/10.2310/7070.2007.0050","url":null,"abstract":"INTRODUCTION\u0000Loss of vestibular information from one labyrinth produces marked asymmetries of postural and ocular motor control, which resolve over time. Recent developments in mouse genetic engineering, which allow the generation of transgenic and knockout mutant mice, provide a unique opportunity to bridge the gap between the molecular mechanisms that underlie compensation and behaviour.\u0000\u0000\u0000METHOD\u0000We compared compensation following unilateral labyrinthectomy in wild-type mice and a cerebellar-dysfunctional mouse (the Lurcher mutant). The Lurcher mutant is characterized by a point mutation in the ionotropic glutamate receptor delta 2 subunit gene that results in loss of all Purkinje cells. To further investigate this question, we characterized vestibular compensation in a strain of mutant mice that completely lack cerebellar Purkinje cells.\u0000\u0000\u0000RESULTS\u0000Static signs resolved within 24 hours in wild-type mice but did not fully resolve in Lurcher mice. Dynamic signs were evaluated by the quantitative analysis of vestibulo-ocular (VOR) and vestibulocollic (VCR) reflexes. The VOR assessed at 0.5 Hz exhibited increasing gain from day 1 to day 5, reaching control levels by day 20 for the wild-type mice. In contrast, Lurcher mutant mice showed significantly less compensation over this same period. VOR compensation in the mutant mice was slightly more robust in response to high acceleration thrusts but again never reached control levels. Similarly, VCR gains showed limited compensation and remained subnormal in mutant mice.\u0000\u0000\u0000CONCLUSION\u0000Compensation for dynamic signs starts at day 5 after unilateral labyrinthectomy in normal mice. Cerebellar dysfunctional mutant mice do not compensate for static signs and show limited vestibular compensation for dynamic signs only. We conclude that other noncerebellar pathways for vestibular compensation exist, and our findings emphasize the need for these to be further explored.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"201 1","pages":"315-21"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68603524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Relapsing polychondritis: a case with subglottic stenosis and laryngotracheal reconstruction. 复发性多软骨炎伴声门下狭窄合并喉气管重建1例。

The Journal of otolaryngology Pub Date : 2007-12-01

Harun Cansiz, Süleyman Yilmaz, Cihan Duman

引用次数: 0

Vestibular compensation after unilateral labyrinthectomy: normal versus cerebellar dysfunctional mice. 单侧迷路切除后的前庭代偿:正常小鼠与小脑功能障碍小鼠。

The Journal of otolaryngology Pub Date : 2007-12-01

Mohammad Aleisa, Anthony G Zeitouni, Kathleen E Cullen

{"title":"Vestibular compensation after unilateral labyrinthectomy: normal versus cerebellar dysfunctional mice.","authors":"Mohammad Aleisa, Anthony G Zeitouni, Kathleen E Cullen","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Loss of vestibular information from one labyrinth produces marked asymmetries of postural and ocular motor control, which resolve over time. Recent developments in mouse genetic engineering, which allow the generation of transgenic and knockout mutant mice, provide a unique opportunity to bridge the gap between the molecular mechanisms that underlie compensation and behaviour.Method: We compared compensation following unilateral labyrinthectomy in wild-type mice and a cerebellar-dysfunctional mouse (the Lurcher mutant). The Lurcher mutant is characterized by a point mutation in the ionotropic glutamate receptor delta 2 subunit gene that results in loss of all Purkinje cells. To further investigate this question, we characterized vestibular compensation in a strain of mutant mice that completely lack cerebellar Purkinje cells.Results: Static signs resolved within 24 hours in wild-type mice but did not fully resolve in Lurcher mice. Dynamic signs were evaluated by the quantitative analysis of vestibulo-ocular (VOR) and vestibulocollic (VCR) reflexes. The VOR assessed at 0.5 Hz exhibited increasing gain from day 1 to day 5, reaching control levels by day 20 for the wild-type mice. In contrast, Lurcher mutant mice showed significantly less compensation over this same period. VOR compensation in the mutant mice was slightly more robust in response to high acceleration thrusts but again never reached control levels. Similarly, VCR gains showed limited compensation and remained subnormal in mutant mice.Conclusion: Compensation for dynamic signs starts at day 5 after unilateral labyrinthectomy in normal mice. Cerebellar dysfunctional mutant mice do not compensate for static signs and show limited vestibular compensation for dynamic signs only. We conclude that other noncerebellar pathways for vestibular compensation exist, and our findings emphasize the need for these to be further explored.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 6","pages":"315-21"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27115533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0