发布求助
文献互助 智能选刊 最新文献

American Journal of Psychiatry最新文献

筛选
英文 中文
Commentary on Perinatal Mental Health. 围产期心理健康评论。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.20231024
Nada L Stotland
{"title":"Commentary on Perinatal Mental Health.","authors":"Nada L Stotland","doi":"10.1176/appi.ajp.20231024","DOIUrl":"https://doi.org/10.1176/appi.ajp.20231024","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"658"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Annual Meeting: President-Elect Address. 2024 年年会：当选主席致辞
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.24181005
Ramaswamy Viswanathan
{"title":"2024 Annual Meeting: President-Elect Address.","authors":"Ramaswamy Viswanathan","doi":"10.1176/appi.ajp.24181005","DOIUrl":"https://doi.org/10.1176/appi.ajp.24181005","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"586-587"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Medical Records to Investigate the Genetics of Treatment-Resistant Depression Across Health Care Systems. 利用医疗记录调查跨医疗系统的抗药性抑郁症遗传学。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.20240377
Renato Polimanti
{"title":"Using Medical Records to Investigate the Genetics of Treatment-Resistant Depression Across Health Care Systems.","authors":"Renato Polimanti","doi":"10.1176/appi.ajp.20240377","DOIUrl":"https://doi.org/10.1176/appi.ajp.20240377","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"569-571"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits. 耐药性抑郁症的全基因组关联研究：与代谢特征共享的生物学。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI: 10.1176/appi.ajp.20230247
JooEun Kang, Victor M Castro, Michael Ripperger, Sanan Venkatesh, David Burstein, Richard Karlsson Linnér, Daniel B Rocha, Yirui Hu, Drew Wilimitis, Theodore Morley, Lide Han, Rachel Youngjung Kim, Yen-Chen Anne Feng, Tian Ge, Stephan Heckers, Georgios Voloudakis, Christopher Chabris, Panos Roussos, Thomas H McCoy, Colin G Walsh, Roy H Perlis, Douglas M Ruderfer
{"title":"Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits.","authors":"JooEun Kang, Victor M Castro, Michael Ripperger, Sanan Venkatesh, David Burstein, Richard Karlsson Linnér, Daniel B Rocha, Yirui Hu, Drew Wilimitis, Theodore Morley, Lide Han, Rachel Youngjung Kim, Yen-Chen Anne Feng, Tian Ge, Stephan Heckers, Georgios Voloudakis, Christopher Chabris, Panos Roussos, Thomas H McCoy, Colin G Walsh, Roy H Perlis, Douglas M Ruderfer","doi":"10.1176/appi.ajp.20230247","DOIUrl":"10.1176/appi.ajp.20230247","url":null,"abstract":"<p><strong>Objective: </strong>Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability estimated at 8% when compared with non-treatment-resistant MDD, no replicated genetic loci have been identified, and the genetic architecture of TRD remains unclear. A key barrier to this work has been the paucity of adequately powered cohorts for investigation, largely because of the challenge in prospectively investigating this phenotype. The objective of this study was to perform a well-powered genetic study of TRD.</p><p><strong>Methods: </strong>Using receipt of electroconvulsive therapy (ECT) as a surrogate for TRD, the authors applied standard machine learning methods to electronic health record data to derive predicted probabilities of receiving ECT. These probabilities were then applied as a quantitative trait in a genome-wide association study of 154,433 genotyped patients across four large biobanks.</p><p><strong>Results: </strong>Heritability estimates ranged from 2% to 4.2%, and significant genetic overlap was observed with cognition, attention deficit hyperactivity disorder, schizophrenia, alcohol and smoking traits, and body mass index. Two genome-wide significant loci were identified, both previously implicated in metabolic traits, suggesting shared biology and potential pharmacological implications.</p><p><strong>Conclusions: </strong>This work provides support for the utility of estimation of disease probability for genomic investigation and provides insights into the genetic architecture and biology of TRD.</p>","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":" ","pages":"608-619"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Polygenic Scores and Phenotypic Data to Understand Psychiatric Outcomes. 整合多基因评分和表型数据以了解精神病结果。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.20240398
Katie Scott, Martin Alda
{"title":"Integrating Polygenic Scores and Phenotypic Data to Understand Psychiatric Outcomes.","authors":"Katie Scott, Martin Alda","doi":"10.1176/appi.ajp.20240398","DOIUrl":"https://doi.org/10.1176/appi.ajp.20240398","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"572-574"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Petros Levounis, M.D., M.A., 150th APA President, 2023-2024. Petros Levounis, M.D., M.A.，第 150 任 APA 主席，2023-2024 年。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.24181006
Katherine G Kennedy
{"title":"Petros Levounis, M.D., M.A., 150th APA President, 2023-2024.","authors":"Katherine G Kennedy","doi":"10.1176/appi.ajp.24181006","DOIUrl":"https://doi.org/10.1176/appi.ajp.24181006","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"590"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressants and Bipolar Disorder: The Plot Thickens. 抗抑郁药与躁狂症：情节愈加复杂。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.20240411
Natalie Gottlieb, Allan H Young
{"title":"Antidepressants and Bipolar Disorder: The Plot Thickens.","authors":"Natalie Gottlieb, Allan H Young","doi":"10.1176/appi.ajp.20240411","DOIUrl":"https://doi.org/10.1176/appi.ajp.20240411","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"575-577"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression. 评估双相抑郁症患者中抗抑郁药诱发躁狂症风险的全国性目标试验模拟。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.20230477
Christopher Rohde, Søren Dinesen Østergaard, Oskar Hougaard Jefsen
{"title":"A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression.","authors":"Christopher Rohde, Søren Dinesen Østergaard, Oskar Hougaard Jefsen","doi":"10.1176/appi.ajp.20230477","DOIUrl":"10.1176/appi.ajp.20230477","url":null,"abstract":"<p><strong>Objective: </strong>Antidepressants are commonly used to treat bipolar depression but may increase the risk of mania. The evidence from randomized controlled trials, however, is limited by short treatment durations, providing little evidence for the long-term risk of antidepressant-induced mania. The authors performed a target trial emulation to compare the risk of mania among individuals with bipolar depression treated or not treated with antidepressants over a 1-year period.</p><p><strong>Methods: </strong>The authors emulated a target trial using observational data from nationwide Danish health registers. The study included 979 individuals with bipolar depression recently discharged from a psychiatric ward. Of these, 358 individuals received antidepressant treatment, and 621 did not. The occurrence of mania and bipolar depression over the following year was ascertained, and the intention-to-treat effect of antidepressants was analyzed by using Cox proportional hazards regression with adjustment for baseline covariates to emulate randomized open-label treatment allocation.</p><p><strong>Results: </strong>The fully adjusted analyses revealed no statistically significant associations between treatment with an antidepressant and the risk of mania in the full sample (hazard rate ratio=1.08, 95% CI=0.72-1.61), in the subsample concomitantly treated with a mood-stabilizing agent (hazard rate ratio=1.16, 95% CI=0.63-2.13), and in the subsample not treated with a mood-stabilizing agent (hazard rate ratio=1.16, 95% CI=0.65-2.07). Secondary analyses revealed no statistically significant association between treatment with an antidepressant and bipolar depression recurrence.</p><p><strong>Conclusions: </strong>These findings suggest that the risk of antidepressant-induced mania is negligible and call for further studies to optimize treatment strategies for individuals with bipolar depression.</p>","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"630-638"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reports to the Membership. 向成员报告。
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.24181003
{"title":"Reports to the Membership.","authors":"","doi":"10.1176/appi.ajp.24181003","DOIUrl":"https://doi.org/10.1176/appi.ajp.24181003","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"660-686"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why Psychological Problems Presage Cardiometabolic Health Problems. 为什么心理问题会预示着心脏代谢健康问题？
IF 15.1 1区 医学
American Journal of Psychiatry Pub Date : 2024-07-01 DOI: 10.1176/appi.ajp.20240370
Benjamin B Lahey
{"title":"Why Psychological Problems Presage Cardiometabolic Health Problems.","authors":"Benjamin B Lahey","doi":"10.1176/appi.ajp.20240370","DOIUrl":"https://doi.org/10.1176/appi.ajp.20240370","url":null,"abstract":"","PeriodicalId":7656,"journal":{"name":"American Journal of Psychiatry","volume":"181 7","pages":"581-583"},"PeriodicalIF":15.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信