AJP Reports最新文献

{"title":"Living Near Wildfires and the Risk of Fetal Congenital Heart Defects: Evaluating Critical Windows of Vulnerability.","authors":"Bo Y Park, Kriti Vedhanayagam, Jared Ortiz-Luis, Rupa Basu, Ciprian P Gheorghe, Shravya Govindappagari, Ray Abinader, Ruofan Yao","doi":"10.1055/a-2528-3588","DOIUrl":"10.1055/a-2528-3588","url":null,"abstract":"<p><p><b>Background</b>  Wildfires produce air pollutants that have been associated with complications during pregnancy. This study examined the association between wildfire exposure before and during pregnancy and the odds of congenital heart defect (CHD) in the offspring. <b>Methods</b>  This retrospective cohort study used the California Linked Birth File and the Forestry and Fire Protection data between 2007 and 2010. Patients living within 15 miles of wildfire during pregnancy were considered exposed. Multivariate logistic regression models were used to estimate the association between wildfire exposure by these various exposure metrics and atrial septal defect (ASD) or ventricular septal defect (VSD) types of CHD compared to pregnancies without wildfire exposure. <b>Results</b>  Compared to births without wildfire exposure, those with first-, second-, and third-trimester exposure were associated with a higher risk of ASD with a first-trimester adjusted odds ratio (aOR) of 1.11 (95% confidence interval (CI): 1.04-1.18), second-trimester aOR of 1.12 (95% CI: 1.07-1.18), and third-trimester aOR of 1.08 (95% CI: 1.02-1.14). Wildfire exposure during the critical window of fetal heart development (weeks 3-8) was associated with aOR of 1.12 (95% CI: 1.02-1.23). <b>Conclusion</b>  Wildfire exposure during pregnancy appears to increase the risk of developing ASD. <b>Key points</b> Wildfire exposure during critical periods in pregnancy are associated with congenital cardiac malformation.Pre-pregnancy exposure to wildfire is not associated with increased risk of congenital cardiac malformation.Pregnant individuals should avoid wildfire exposure.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 1","pages":"e18-e24"},"PeriodicalIF":0.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\" <i>Trying to Grab Pieces of Hope</i> \" <i>:</i> Exploring the Experiences of Black and Hispanic Parents following a Congenital Heart Disease Diagnosis.","authors":"Sharla Rent, Kwai Tei Candy Chan Poon, Meredith Sooy-Mossey, Mary Frances Weeks, James C Roberts, Dakota Douglas, Sarah Ellestad, Monica E Lemmon, Kevin Hill, McAllister Windom","doi":"10.1055/a-2504-1813","DOIUrl":"https://doi.org/10.1055/a-2504-1813","url":null,"abstract":"<p><p><b>Objective</b>  Congenital heart disease (CHD) is an important contributor to pediatric morbidity and mortality. Unfortunately, disparities in the diagnosis and treatment of CHD exist across racial and ethnic groups. The objective of this study was to share the experiences of Hispanic and Black families with CHD to better understand their needs. <b>Study Design</b>  This was a descriptive qualitative study involving two 2-part focus groups, one conducted in English and one in Spanish, consisting of parents of infants with CHD. Focus groups were audio recorded, transcribed, and analyzed via a conventional content analysis approach. <b>Results</b>  Six family members participated, representing a range of cardiac diagnoses. Two participants cited their identity as non-Hispanic Black and four as Hispanic. Three organizing themes emerged related to (1) communication, (2) psychosocial needs and processing, and (3) practical challenges associated with having a child with CHD. Together, these organizing themes supported a singular global theme: structural and socioemotional gaps in care exist for families of infants with CHD that need to be met in order to optimize care for patients and families. <b>Conclusion</b>  Societal and systems-level factors, including structural inequities, contribute to the care gaps experienced by racial and ethnic minority families of children with CHD. <b>Key Points</b> Poor communication around CHD diagnosis impairs provider-patient trust.Language barriers hinder accurate communication about CHD diagnosis and treatment.Parents of children with CHD have unmet mental health needs.Perinatal providers should champion health equity for CHD patients and their families.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 1","pages":"e6-e17"},"PeriodicalIF":0.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Prolonged Antenatal Intravenous Immunoglobulin Treatment in Preventing Gestational Alloimmune Liver Disease-A Case Series with Literature Review.","authors":"Eena Sunya Lin, Faraz Afridi, Sukrita Sheshu Mysore, Thomas Presenza, Alla Kushnir, Rafat Ahmed","doi":"10.1055/a-2496-8690","DOIUrl":"https://doi.org/10.1055/a-2496-8690","url":null,"abstract":"<p><p><b>Background</b>  Gestational alloimmune liver disease (GALD) is characterized by maternal IgG-directed fetal hepatocyte damage and can lead to severe liver failure and fetal or infant death. Moreover, GALD is associated with a near 90% risk of recurrence in subsequent pregnancies. <b>Case</b>  We present a case of a newborn patient delivered to a 32-year-old G2P1000 mother who received prolonged antenatal intravenous immunoglobulin (IVIG) treatment during the current pregnancy due to the neonatal death of the first child from GALD-related liver failure. Postnatal testing, including a liver magnetic resonance imaging (MRI) and buccal biopsy of this newborn, showed normal morphology of the liver without any abnormal iron deposition. Additional laboratory testing showed a lack of any liver injury. <b>Conclusion</b>  This case supports the use of antenatal IVIG immunotherapy to prevent the recurrence of GALD in subsequent pregnancies. <b>Key Points</b> GALD can lead to severe fetal liver injury.GALD is highly recurrent in subsequent pregnancies.Prophylactic IVIG may prevent GALD recurrence.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 1","pages":"e1-e5"},"PeriodicalIF":0.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Fetal Neural Tube Defect; Iniencephaly Clausus.","authors":"Bantayehu Nega Arega, Sintayehu Debas Endalew, Daniel Miskir Hailu","doi":"10.1055/a-2496-2417","DOIUrl":"10.1055/a-2496-2417","url":null,"abstract":"<p><p><b>Introduction</b>  Iniencephaly is an extremely rare type of neural tube defect characterized by the fusion of the cervical and cervicothoracic vertebrae. This condition results in acute retroflexion of the head, a short neck, significant lordosis of the cervical spine, and an upturned facial appearance. This condition typically results in poor fetal outcomes, with many cases ending in stillbirth or neonatal death. <b>Case summary</b>  Here, we present a case of iniencephaly diagnosed during intrapartum ultrasound in a 34-year-old gravida 5 woman referred from a health center to a primary hospital due to preterm premature rupture of membrane and labor. The fetus died intrapartum a few minutes before delivery. <b>Conclusion</b>  Iniencephaly remains a rare but critical condition that poses significant challenges for prenatal diagnosis and management. This case underscores the importance of early and accurate imaging in the detection of such severe anomalies, which can provide essential information for clinical decision-making and counseling.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e281-e283"},"PeriodicalIF":0.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Milk-Derived Fortifier to Reduce Hospital-Acquired Malnutrition in Uncomplicated Gastroschisis: A Case Report.","authors":"Anna Strle, Sarah M Reyes, Megan Schmidt, Mary Frances Lynch","doi":"10.1055/a-2490-3521","DOIUrl":"10.1055/a-2490-3521","url":null,"abstract":"<p><p>Gastroschisis is one of the most common congenital gastrointestinal disorders, occurring in about one in 1,953 infants born each year in the United States. Infants with gastroschisis rely on total parenteral nutrition (TPN) preoperatively, and due to intestinal function and dysmotility issues, continue to face feeding challenges postclosure, including feeding intolerance and increased risk of necrotizing enterocolitis (NEC). Postclosure, human milk-feeding is preferred over infant formula because of its associated reduced risk of feeding intolerance and NEC. However, unfortified human milk often falls short of meeting the increased metabolic demands of these postsurgical infants in the first few weeks of life, leading to hospital-acquired malnutrition (undernutrition) as TPN is weaned. We hypothesized that fortifying maternal milk with human milk-based fortifiers would mitigate the risk of hospital-acquired malnutrition while providing the tolerance benefits of an exclusive human milk diet, specifically by meeting the increased energy and protein demands of the immediate postsurgical infant as parenteral nutrition is weaned. The case report describes our unit's use of a human milk-based fortifier in an infant with uncomplicated gastroschisis and its positive effect on the patient's growth. Further research is warranted to assess the use of human milk-derived fortifiers to prevent hospital-acquired malnutrition after gastrointestinal surgery.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e275-e280"},"PeriodicalIF":0.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: The Collection and Application of Autologous Amniotic Fluid to Cesarean Delivery Closure.","authors":"Chad A Grotegut, Kristin E Weaver, Lena Fried, Sarah K Dotters-Katz, Jennifer B Gilner","doi":"10.1055/s-0044-1801260","DOIUrl":"10.1055/s-0044-1801260","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1055/a-2445-7954.].</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e274"},"PeriodicalIF":0.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report.","authors":"Trassanee Chatmethakul, Amy H Stanford, Danielle R Rios, Adrianne R Bischoff, Theresa Czech, Patrick J McNamara","doi":"10.1055/a-2447-8662","DOIUrl":"10.1055/a-2447-8662","url":null,"abstract":"<p><p>Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular dysfunction coinciding with the initiation of lacosamide.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e270-e273"},"PeriodicalIF":0.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Collection and Application of Autologous Amniotic Fluid to Cesarean Delivery Closure.","authors":"Chad A Grotegut, Kristin E Weaver, Lena Fried, Sarah K Dotters-Katz, Jennifer B Gilner","doi":"10.1055/a-2445-7954","DOIUrl":"10.1055/a-2445-7954","url":null,"abstract":"<p><p><b>Background</b>  Amniotic fluid and amnion membranes have been used in surgery specialties to improve wound healing and decrease surgical adhesion formation. <b>Objective</b>  The objective was to determine if amniotic fluid could be collected at cesarean delivery and then reapplied to the layers of the closure using the CeaLogic Specimen Collection and Ratio Applicator Kit. <b>Study Design</b>  Twenty pregnant individuals who met inclusion and exclusion criteria were enrolled. Amniotic fluid was collected at artificial rupture of the membranes using the collection kit. Autologous amniotic fluid was then transferred to the applicator kit, mixed with calcium chloride solution, and applied directly to each of the surgical repair layers during closure: closed hysterotomy incision, closed fascial incision, closed subcutaneous layer (if applicable), and closed skin. Subjects were then followed for six weeks. Photographs of the incision were taken immediately following surgery, one-week following surgery, and at the four-week postpartum visit. The Modified Hollander Cosmesis Score was used to assess wound appearance. <b>Results</b>  Twenty pregnant individuals who met inclusion and exclusion criteria were enrolled and all completed the study. The mean volume of amniotic fluid collected was 30 ± 19 mL. The median (IQR) Modified Hollander Cosmesis Score (Range 0-best, to 6-worst) at the one week and four-week postpartum visits was 0 (0,1) and 0 (0,2), respectively. There were no wound complications nor surgical site infections among the cohort. Further, there were no unscheduled visits for wound issues among any of the subjects. <b>Conclusion</b>  The CeaLogic Specimen Collection and Ratio Applicator Kits can be used to collect and reapply autologous amniotic fluid at the time of cesarean delivery. Future studies are needed to determine if the application of autologous amniotic fluid to cesarean delivery closure can improve cosmesis and wound healing, as well as decrease the risk for the development of intraabdominal adhesions.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e262-e269"},"PeriodicalIF":0.6,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced Liver Injury from Intravenous Immunoglobulin for Prevention of Recurrent Gestational Alloimmune Liver Disease: A Clinical Catch-22.","authors":"Jessica A Meyer, Jenna S Silverstein, Kristen M Thomas, Sara G Brubaker, Judith L Chervenak","doi":"10.1055/a-2444-7155","DOIUrl":"https://doi.org/10.1055/a-2444-7155","url":null,"abstract":"<p><p>Gestational alloimmune liver disease (GALD) is a rare autoimmune syndrome in which maternal antibodies lead to in utero fetal hepatocyte destruction, often presenting as neonatal liver failure and hemochromatosis. Antenatal intravenous immunoglobulin (IVIG) is generally accepted to be safe in pregnancy with demonstrable benefits for reducing GALD recurrence risk in subsequent pregnancies. Here we present a case of a 33-year-old woman with a prior neonatal demise due to GALD who received multiple prophylactic IVIG infusions in a subsequent twin pregnancy complicated by maternal jaundice and acute hepatitis. A liver biopsy demonstrated hepatocellular injury with bridging necrosis and cholestatic features consistent with drug-induced liver injury. This case demonstrates the importance of close clinical monitoring during IVIG therapy and the need for further research into alternative prophylaxis options for GALD. <b>Key Points</b> GALD is a rare antibody-mediated autoimmune syndrome with high recurrence risk.IVIG can be effective in reducing risk of GALD recurrence and fetal loss.Patient's receiving ongoing IVIG therapy should be closely monitored for developing adverse effects, including DILI.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e254-e258"},"PeriodicalIF":0.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroleptic Malignant Syndrome in a 10-Month-Old Ex-Preterm Infant with Delirium.","authors":"Gloria Akuamoah-Boateng, Kayla A Buttafuoco, Courtney C Sutton, Brian P Hackett","doi":"10.1055/a-2441-4217","DOIUrl":"https://doi.org/10.1055/a-2441-4217","url":null,"abstract":"<p><p>In recent times, atypical antipsychotics are increasingly being used in the neonatal intensive care unit (NICU) for the management of neonatal delirium. As the recognition of delirium in NICU infants increases, caution should be exercised with use of antipsychotics for management, given associated adverse effects. Neuroleptic malignant syndrome (NMS) is a rare adverse drug reaction associated with exposure to antipsychotics and other antidopaminergic medications. Most reported cases of NMS in pediatric patients have been in older children on antipsychotic medications. We present a case of a 10-month-old former preterm infant who developed clinical signs suggestive of NMS after exposure to olanzapine for treatment of delirium. Our case report details the clinical course of this infant, delves into the condition, and outlines some useful lessons for the clinician in the identification and management of this rare but life-threatening adverse effect. <b>Key Points</b> NMS is a rare side effect of antipsychotic medications.Hyperthermia with mental status changes could be due to NMS.Antipsychotics should be used cautiously in infants.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"14 4","pages":"e259-e261"},"PeriodicalIF":0.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}