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Thyroid Storm Triggered by Partial Hydatidiform Mole: A Rare and Life-Threatening Complication. 由部分葡萄胎引发的甲状腺风暴:一种罕见且危及生命的并发症。
IF 0.8
AJP Reports Pub Date : 2025-06-18 eCollection Date: 2025-04-01 DOI: 10.1055/a-2626-9145
Hailey Cox, Maggie Wong, Jena Preszler, Nikolina Docheva, Nauman Khurshid
{"title":"Thyroid Storm Triggered by Partial Hydatidiform Mole: A Rare and Life-Threatening Complication.","authors":"Hailey Cox, Maggie Wong, Jena Preszler, Nikolina Docheva, Nauman Khurshid","doi":"10.1055/a-2626-9145","DOIUrl":"10.1055/a-2626-9145","url":null,"abstract":"<p><p>A 26-year-old woman, gravida 1 para 0 at 14 weeks' 1-day gestation, presented with vaginal spotting and systemic symptoms, including palpitations, shortness of breath, heat intolerance, nausea, and vomiting for 2 weeks. Workup revealed maternal tachycardia, severe-range blood pressure, elevated beta human chorionic gonadotropin of 2,442,400 mIU/mL, suppressed thyroid stimulating hormone, and elevated T4, consistent with thyroid storm with possible preeclampsia with severe features. 1 A transvaginal ultrasound suggested a partial molar pregnancy; this was later confirmed by surgical pathology. This case highlights the rare yet serious complications of hydatidiform mole, in particular, a partial molar pregnancy, including thyroid storm and superimposed preeclampsia, emphasizing the importance of management at a tertiary care center with a multidisciplinary team to optimize maternal outcomes. 2 3.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e94-e97"},"PeriodicalIF":0.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal Cytomegalovirus Associated Intraventricular Hemorrhage: A Rare Prenatal Complication. 胎儿巨细胞病毒相关脑室内出血:一种罕见的产前并发症。
IF 0.8
AJP Reports Pub Date : 2025-06-11 eCollection Date: 2025-04-01 DOI: 10.1055/a-2619-2338
Vincent D Tang, Jennifer Heibig, Joanne N Quiñones Rivera, Albert P Sarno, Meredith Rochon
{"title":"Fetal Cytomegalovirus Associated Intraventricular Hemorrhage: A Rare Prenatal Complication.","authors":"Vincent D Tang, Jennifer Heibig, Joanne N Quiñones Rivera, Albert P Sarno, Meredith Rochon","doi":"10.1055/a-2619-2338","DOIUrl":"10.1055/a-2619-2338","url":null,"abstract":"<p><p>Intraventricular hemorrhage (IVH) is an uncommon manifestation of congenital cytomegalovirus (CMV) infection. We report a case of primary CMV infection associated with preterm labor as well as fetal anemia, thrombocytopenia, and IVH. The finding of unexplained IVH on ultrasound provided an indication for testing of congenital infection. Our case indicates the need for detailed sonographic imaging in pregnancies complicated by preterm labor, as the integration of ultrasound diagnosis can significantly impact management and improve perinatal outcomes.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e89-e93"},"PeriodicalIF":0.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectangular-Shaped Hemostatic Sutures in the Management of Second-Trimester Placenta Accreta Spectrum Disorders at Tu Du Hospital, Vietnam: A Retrospective Descriptive Study. 矩形止血缝合线在越南杜杜医院治疗妊娠中期胎盘增生谱系障碍中的应用:一项回顾性描述性研究。
IF 0.8
AJP Reports Pub Date : 2025-06-10 eCollection Date: 2025-04-01 DOI: 10.1055/a-2608-0990
Van Hoang Bui, Hien Thi Nguyen, Le Quyen Nguyen, Phuong Thao Thi Truong, Phuong Thao Nguyen, Lam Phuong Thi Hoang, Phuc Nhon Nguyen
{"title":"Rectangular-Shaped Hemostatic Sutures in the Management of Second-Trimester Placenta Accreta Spectrum Disorders at Tu Du Hospital, Vietnam: A Retrospective Descriptive Study.","authors":"Van Hoang Bui, Hien Thi Nguyen, Le Quyen Nguyen, Phuong Thao Thi Truong, Phuong Thao Nguyen, Lam Phuong Thi Hoang, Phuc Nhon Nguyen","doi":"10.1055/a-2608-0990","DOIUrl":"10.1055/a-2608-0990","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to delineate the surgical outcomes of rectangular-shaped sutures in PAS surgery.<b>Materials and Methods</b> This retrospective study was conducted between January 2018 and December 2022 at Tu Du Hospital in Vietnam. The study reviewed all PAS cases below 22 weeks of gestational age (GA) that underwent cesarean delivery with rectangular-shaped hemostatic sutures. All the pregnancy characteristics, surgical features, and postoperative outcomes were described.</p><p><strong>Results: </strong>Among thirteen pregnant women with PAS, GA from 13 to 17 weeks of GA occupied 11/13 cases. PAS was classified as accreta ( <i>n</i>  = 1), increta ( <i>n</i>  = 1), increta-percreta ( <i>n</i>  = 2), percreta ( <i>n</i>  = 4), and percreta invasive to other organs ( <i>n</i>  = 5). The estimated blood loss was 761.54 ± 614.12 (150-2,100 mL). Intraoperative blood loss between 500 and 1,500 mL accounted for 46.15%. The surgical duration time was 180.77 ± 32.07 (130-260 minutes). Postoperative duration time was 5.85 ± 2.08 (4-12 days). During the postpartum course, one case was reported with postpartum hemorrhage, acute renal dysfunction, and postoperative infection, respectively. Out of 13 PAS cases, 12 cases were successfully managed with conservative surgery.</p><p><strong>Conclusion: </strong>Surgical management of PAS disorders using rectangular-shaped hemostatic sutures could be acceptable. The technical suture is simple, safe, and cost-effective.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e79-e88"},"PeriodicalIF":0.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12151718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management and Outcomes of Congenital Atrioventricular Block in Neonates: A 6-Year Experience at a Tunisian Tertiary Center. 新生儿先天性房室传导阻滞的处理和结果:突尼斯三级中心6年的经验。
IF 0.8
AJP Reports Pub Date : 2025-06-09 eCollection Date: 2025-04-01 DOI: 10.1055/a-2616-5273
Rim B Aziza, Sameh Hajji, Khaoula Samaali, Hajer Chourou, Wafa B Ammar, Neila B Aba, Khaled Neji, Samia Kacem
{"title":"Management and Outcomes of Congenital Atrioventricular Block in Neonates: A 6-Year Experience at a Tunisian Tertiary Center.","authors":"Rim B Aziza, Sameh Hajji, Khaoula Samaali, Hajer Chourou, Wafa B Ammar, Neila B Aba, Khaled Neji, Samia Kacem","doi":"10.1055/a-2616-5273","DOIUrl":"10.1055/a-2616-5273","url":null,"abstract":"<p><strong>Background: </strong>Congenital atrioventricular block (CAVB) is a rare and serious condition often associated with maternal autoimmune diseases or congenital heart defects. This study aims to evaluate the clinical presentation, management, and outcomes of neonates diagnosed with CAVB.</p><p><strong>Methods: </strong>We conducted a retrospective study from January 2018 to December 2024, including eight neonates diagnosed with CAVB. Data on demographics, clinical features, treatment, and follow-up were analyzed.</p><p><strong>Results: </strong>All cases were prenatally diagnosed between 20 and 25 weeks of gestation, with positive anti-SSA/SSB antibodies in five cases. Management included cesarean delivery, Holter ECG monitoring, and pacemaker implantation for four patients. One case resulted in intrauterine fetal death, and two patients died in the neonatal period. Survivors had successful pacemaker implantation with an average follow-up of 18 months.</p><p><strong>Conclusion: </strong>Early prenatal detection and timely management of CAVB are crucial. Pacemaker implantation significantly improves survival, though challenges such as resource limitations and the lack of long-term follow-up data remain. Future studies should address these gaps to optimize care for CAVB patients.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e73-e78"},"PeriodicalIF":0.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Application Value of Early Amplitude-Integrated Electroencephalogram in a Newborn with Nonketotic Hyperglycinemia: A Rare Case Report. 早期振幅综合脑电图在新生儿非酮症性高血糖症中的应用价值:1例罕见报告。
IF 0.8
AJP Reports Pub Date : 2025-05-27 eCollection Date: 2025-04-01 DOI: 10.1055/a-2595-5740
Enting Ma, Wei Li, Hong Gao, Shifeng Ma, Qianwen Chai, Li Wei, Jing Wang
{"title":"The Application Value of Early Amplitude-Integrated Electroencephalogram in a Newborn with Nonketotic Hyperglycinemia: A Rare Case Report.","authors":"Enting Ma, Wei Li, Hong Gao, Shifeng Ma, Qianwen Chai, Li Wei, Jing Wang","doi":"10.1055/a-2595-5740","DOIUrl":"10.1055/a-2595-5740","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the application value of amplitude-integrated electroencephalogram (aEEG) findings in a newborn with nonketotic hyperglycinemia (NKH).</p><p><strong>Study design: </strong>The clinical data of a neonatal patient with NKH were retrospectively analyzed. In this study, aEEG was first used to assess brain function in NKH due to <i>AMT</i> gene mutations in the Chinese mainland so far. The aEEG assessment was stratified according to its background pattern, sleep-wake cycle (SWC), and seizure activity, which gave more objective and systemic results.</p><p><strong>Results: </strong>Seizures and burst-suppression pattern were detected on the aEEG. The background belonged to discontinuous voltage, and showed discontinuity of cerebral activity in the form of the burst-suppression pattern. The classification of SWC in this record belonged to the \"No SWC\" category, which meant the child had severe brain damage. A typical neonatal single seizure was found. The seizure activity lasted approximately 30 seconds. However, clinical symptoms were not observed.</p><p><strong>Conclusion: </strong>Patients with NKH often exhibit complicated clinical phenotypes, and there is a lack of specific symptoms, especially the symptoms of encephalopathy are atypical. aEEG is helpful for the early diagnosis and treatment of seizures. It can help the doctor to carry out appropriate treatment in time. The application value of aEEG in patients with NKH was significant.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e67-e72"},"PeriodicalIF":0.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Enoxaparin Treatment in a Newborn with Cerebral Venous Sinus Thrombosis and Acute Cerebellar Hemorrhage. 早期依诺肝素治疗新生儿脑静脉窦血栓形成和急性小脑出血1例。
IF 0.8
AJP Reports Pub Date : 2025-04-21 eCollection Date: 2025-04-01 DOI: 10.1055/a-2566-3952
Margherita Velardi, Rita Luciano, Simonetta Costa, Mirta Corsello, Tommaso Verdolotti, Luca Massimi, Domenico M Romeo, Francesca Gallini, Giovanni Vento
{"title":"Early Enoxaparin Treatment in a Newborn with Cerebral Venous Sinus Thrombosis and Acute Cerebellar Hemorrhage.","authors":"Margherita Velardi, Rita Luciano, Simonetta Costa, Mirta Corsello, Tommaso Verdolotti, Luca Massimi, Domenico M Romeo, Francesca Gallini, Giovanni Vento","doi":"10.1055/a-2566-3952","DOIUrl":"https://doi.org/10.1055/a-2566-3952","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the management of anticoagulant therapy in neonates with cerebral sinus venous thrombosis (CSVT), focusing on potential benefits and risks.</p><p><strong>Study design: </strong>We report the case of a full-term neonate diagnosed with CSVT, highlighting the rationale for early anticoagulation with unfractionated heparin. A brief literature review supports our clinical decision-making, considering current evidence and expert consensus despite limited neonatal-specific guidelines.</p><p><strong>Results: </strong>Heparin therapy was started shortly after diagnosis, without hemorrhagic complications. Neuroimaging showed complete thrombus resolution. The neonate had a normal neurological examination at discharge. Follow-up confirmed overall good clinical condition and showed mild axial hypotonia and convergent strabismus suggestive of cortical visual impairment.</p><p><strong>Conclusion: </strong>Management of CSVT in neonates remains debated. While heparin may carry a risk of bleeding, delaying treatment can lead to thrombus progression. Our case supports the potential safety and efficacy of early heparin use in selected patients. Tailored, risk-based decisions may improve outcomes, though further studies are needed to establish standardized protocols.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e62-e66"},"PeriodicalIF":0.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal Aspiration of Fetal Ovarian Cysts: When to Intervene? A Case Report and Review of the Literature. 胎儿卵巢囊肿的产前抽吸:何时干预?一例病例报告及文献回顾。
IF 0.8
AJP Reports Pub Date : 2025-04-10 eCollection Date: 2025-04-01 DOI: 10.1055/a-2562-1898
Giulia Bonanni, Scott A Shainker, Eyal Krispin, Ryne A Didier, Terry L Buchmiller, Alireza A Shamshirsaz
{"title":"Prenatal Aspiration of Fetal Ovarian Cysts: When to Intervene? A Case Report and Review of the Literature.","authors":"Giulia Bonanni, Scott A Shainker, Eyal Krispin, Ryne A Didier, Terry L Buchmiller, Alireza A Shamshirsaz","doi":"10.1055/a-2562-1898","DOIUrl":"https://doi.org/10.1055/a-2562-1898","url":null,"abstract":"<p><p>Fetal adnexal cysts present unique challenges during pregnancy, requiring careful management strategies to mitigate risks throughout gestation and delivery. We present the case of a 35-year-old G4P2 patient, referred to our center for a large adnexal cyst confirmed by ultrasound (US) and fetal MRI, with a calculated volume of 210 mL. Given the cyst's size and the family's strong preference for vaginal delivery (VD), US-guided aspiration was performed at 35 <sup>6/7</sup> weeks, followed by an uncomplicated spontaneous VD at 37 <sup>2/7</sup> weeks. Two weeks postpartum, the ovarian cyst re-accumulated, requiring laparoscopic-assisted cystectomy in a torsed but viable left ovary. This case demonstrates the importance of individualized prenatal care, where clinical decisions balance parental preferences with medical risks. Maximizing the opportunity for vaginal birth was a top priority for the family, and the successful reduction of the cyst's size through percutaneous aspiration minimized the risk of abdominal dystocia and allowed for a safe VD. We review relevant literature, emphasizing the need for further research to refine fetal intervention criteria and improve outcomes for such cases.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e58-e61"},"PeriodicalIF":0.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Di-Cavitary Twin Pregnancy in Didelphys Uterus with Associated Renal Agenesis. 双子宫双腔妊娠伴肾发育不全。
IF 0.8
AJP Reports Pub Date : 2025-04-10 eCollection Date: 2025-04-01 DOI: 10.1055/a-2562-1607
Helen Woolcock Martinez, Noora Haghighi, Whitney A Booker
{"title":"Di-Cavitary Twin Pregnancy in Didelphys Uterus with Associated Renal Agenesis.","authors":"Helen Woolcock Martinez, Noora Haghighi, Whitney A Booker","doi":"10.1055/a-2562-1607","DOIUrl":"https://doi.org/10.1055/a-2562-1607","url":null,"abstract":"<p><strong>Introduction: </strong>A didelphys uterus is a rare Müllerian duct anomaly (MDA) caused by the incomplete fusion of the Müllerian ducts, leading to the formation of two distinct uterine cavities. The occurrence of simultaneous twin pregnancies, with each fetus developing in a separate horn of a didelphys uterus, is estimated at approximately 1 in 1,000,000 cases. This case report describes a rare instance of a spontaneous dichorionic diamniotic twin pregnancy, with one fetus in each horn of a didelphys uterus.</p><p><strong>Case description: </strong>This is the case of a 35-year-old woman with unilateral renal agenesis who presented with a spontaneous dichorionic diamniotic twin pregnancy, with one fetus in each uterine cavity. This patient's pregnancy complications included intrahepatic cholestasis of pregnancy and rising creatinine levels, leading to a planned cesarean delivery at 36 weeks. The delivery was complicated by intrapartum hemorrhage and the postpartum course was further complicated by sepsis and endometritis.</p><p><strong>Conclusion: </strong>This case highlights the complexity of managing a dichorionic diamniotic twin pregnancy in a didelphys uterus with concomitant congenital unilateral renal agenesis. It contributes to the understanding of optimal management strategies for MDA presentations and highlights the necessity for ongoing research into complications and long-term outcomes associated with such anomalies.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e53-e57"},"PeriodicalIF":0.8,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infant with Known Dandy-Walker Malformation and Poor Feeding Found to Have Additional Diagnosis. 婴儿有已知的丹迪步行者畸形和喂养不良被发现有额外的诊断。
IF 0.8
AJP Reports Pub Date : 2025-04-08 eCollection Date: 2025-04-01 DOI: 10.1055/a-2562-1814
Jacob Q Lin, April Cooke, Nick Townley
{"title":"Infant with Known Dandy-Walker Malformation and Poor Feeding Found to Have Additional Diagnosis.","authors":"Jacob Q Lin, April Cooke, Nick Townley","doi":"10.1055/a-2562-1814","DOIUrl":"https://doi.org/10.1055/a-2562-1814","url":null,"abstract":"<p><strong>Background: </strong>There are few reported cases of Dandy-Walker Malformation associated with Noonan syndrome (NS).</p><p><strong>Case presentation: </strong>We herein present a case of a late preterm infant with Dandy-Walker malformation (DWM) that underwent a workup for feeding difficulty and was found to have NS. This is one of the few reported cases of DWM with NS having a PTPN11 gene mutation.</p><p><strong>Conclusion: </strong>Overlapping clinical features may disguise diagnosis in infants with multiple pathologies.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e43-e46"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse Pregnancy Outcomes in Sjogren's Disease Compared to Controls: An Interdisciplinary Approach with Maternal-Fetal Medicine. 与对照组相比,干燥病的不良妊娠结局:母胎医学的跨学科方法。
IF 0.8
AJP Reports Pub Date : 2025-04-08 eCollection Date: 2025-04-01 DOI: 10.1055/a-2562-1643
Lauren Tesoriero, Jennifer Kidd, Julie Piccione, Peter Izmirly, Meredith Akerman, Steven Carsons, Patricia Rekawek, Julie Nusbaum
{"title":"Adverse Pregnancy Outcomes in Sjogren's Disease Compared to Controls: An Interdisciplinary Approach with Maternal-Fetal Medicine.","authors":"Lauren Tesoriero, Jennifer Kidd, Julie Piccione, Peter Izmirly, Meredith Akerman, Steven Carsons, Patricia Rekawek, Julie Nusbaum","doi":"10.1055/a-2562-1643","DOIUrl":"https://doi.org/10.1055/a-2562-1643","url":null,"abstract":"<p><strong>Objectives: </strong>Outside of the association of SS-A antibody with congenital heart block, little is known about adverse maternal and neonatal outcomes, in patients with Sjogren's disease (SjD). Our study involved collaboration with maternal-fetal medicine (MFM).</p><p><strong>Methods: </strong>A retrospective cohort study of pregnant patients: SjD patients were matched 1:3 with non-SjD controls. SjD patients were included by meeting the 2016 ACR/EULAR Criteria or by a rheumatologist diagnosis. Exclusion criteria were concurrent autoimmune disease or related antibodies. A composite of grouped outcomes was utilized and verified by MFM specialists. The primary outcome was adverse pregnancy outcome (APO) between the two groups. Statistical analysis was performed using a two-sample <i>t</i> -test and Fisher's exact test.</p><p><strong>Results: </strong>48 patients were included: 12 SjD patients and 36 controls. APO was significantly increased in SjD with one preterm birth, one fetal growth restriction, and one limb anomaly; non-SjD had one cardiac anomaly. There were no cases of CHB. SjD patients were more likely to be delivered by cesarean delivery.</p><p><strong>Conclusion: </strong>There was an increased risk of APO in SjD patients compared with controls. No significant difference in neonatal outcomes was found. We speculate that placental pathology may play a role in pathophysiology and future studies should be performed.</p><p><strong>Key points: </strong>There was an increased risk of APO in SjD patients compared with controls.No significant difference in neonatal outcomes was found.We speculate that placental pathology may play a role in pathophysiology, prompting future studies.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"15 2","pages":"e47-e52"},"PeriodicalIF":0.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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