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The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report). 产前产后静脉注射免疫球蛋白对新生儿血色素沉着症严重程度的影响:两兄弟的故事(病例报告)。
IF 0.9
AJP Reports Pub Date : 2021-04-01 Epub Date: 2021-06-30 DOI: 10.1055/s-0041-1731311
Veronica Mugarab-Samedi, Michelle D Ryan, Essa Hamdan Al Awad, Adel Elsharkawy
{"title":"The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report).","authors":"Veronica Mugarab-Samedi,&nbsp;Michelle D Ryan,&nbsp;Essa Hamdan Al Awad,&nbsp;Adel Elsharkawy","doi":"10.1055/s-0041-1731311","DOIUrl":"https://doi.org/10.1055/s-0041-1731311","url":null,"abstract":"<p><p><b>Background</b>  Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment. <b>Case Presentation</b>  We present two cases of NH from the same family to illustrate the role of antenatal treatment with IVIG in alleviation and possible prevention of this serious morbidity. <b>Conclusion</b>  A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure, and avoid the need for liver transplantation.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e102-e104"},"PeriodicalIF":0.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1731311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39149945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Kagami-Ogata Syndrome: Case Series and Review of Literature. 神绪综合征:个案系列及文献回顾。
IF 0.9
AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727287
Rishika P Sakaria, Roya Mostafavi, Stephen Miller, Jewell C Ward, Eniko K Pivnick, Ajay J Talati
{"title":"Kagami-Ogata Syndrome: Case Series and Review of Literature.","authors":"Rishika P Sakaria,&nbsp;Roya Mostafavi,&nbsp;Stephen Miller,&nbsp;Jewell C Ward,&nbsp;Eniko K Pivnick,&nbsp;Ajay J Talati","doi":"10.1055/s-0041-1727287","DOIUrl":"https://doi.org/10.1055/s-0041-1727287","url":null,"abstract":"<p><p>Kagami-Ogata syndrome (KOS) (OMIM #608149) is a genetic imprinting disorder affecting chromosome 14 that results in a characteristic phenotype consisting of typical facial features, skeletal abnormalities including rib abnormalities described as \"coat hanger ribs,\" respiratory distress, abdominal wall defects, polyhydramnios, and developmental delay. First identified by Wang et al in 1991, over 80 cases of KOS have been reported in the literature. KOS, however, continues to remain a rare and potentially underdiagnosed disorder. In this report, we describe two unrelated male infants with differing initial presentations who were both found to have the characteristic \"coat hanger\" rib appearance on chest X-ray, raising suspicion for KOS. Molecular testing confirmed KOS in each case. In addition to these new cases, we reviewed the existing cases reported in literature. Presence of polyhydramnios, small thorax, curved ribs, and abdominal wall defects must alert the perinatologist toward the possibility of KOS to facilitate appropriate molecular testing. The overall prognosis of KOS remains poor. Early diagnosis allows for counseling by a multidisciplinary team and enables parents to make informed decisions regarding both pregnancy management and postnatal care.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e65-e75"},"PeriodicalIF":0.9,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1727287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Severe Consumptive Coagulopathy in an Extremely-Low-Birth-Weight Infant with Intra-Abdominal Umbilical Vein Varix: A Case Report. 严重消耗性凝血功能障碍的极低出生体重婴儿腹腔内脐静脉曲张:1例报告。
IF 0.9
AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727288
Mitsuhiro Haga, Kanako Itoh, Tsuguhiro Horikoshi, Fumihiko Namba, Kazuhiko Kabe
{"title":"Severe Consumptive Coagulopathy in an Extremely-Low-Birth-Weight Infant with Intra-Abdominal Umbilical Vein Varix: A Case Report.","authors":"Mitsuhiro Haga,&nbsp;Kanako Itoh,&nbsp;Tsuguhiro Horikoshi,&nbsp;Fumihiko Namba,&nbsp;Kazuhiko Kabe","doi":"10.1055/s-0041-1727288","DOIUrl":"https://doi.org/10.1055/s-0041-1727288","url":null,"abstract":"<p><p>Recent studies have shown favorable outcomes for intra-abdominal umbilical vein varices (IUVVs) in term neonates who have no other complications. Little is known, however, about the prognosis of IUVVs in preterm neonates. We encountered a case of IUVV in an extremely low-birth-weight infant who developed severe consumptive coagulopathy after birth. The patient's coagulation test normalized as the varix spontaneously obstructed. Although life-threatening hemorrhagic complications were avoided, a cerebellum hemorrhage was found in the brain magnetic resonance imaging at the term-equivalent age. In a literature survey, coagulopathy was reported in 4 out of 15 infants with IUVVs born before 34 weeks of gestation, including our present case. Preterm infants with IUVVs may develop coagulopathy because of the prematurity of their coagulation-fibrinolysis systems. Attention should be given to the coagulation status of preterm neonates with IUVVs.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e76-e79"},"PeriodicalIF":0.9,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1727288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neonatal Rupture of the Spleen: Successful Treatment with Splenic Artery Embolization. 新生儿脾破裂:脾动脉栓塞成功治疗。
IF 0.9
AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727257
Jelle W Raats, Lievay van Dam, Pieter J van Doormaal, Marjoleine van Hengel-Jacobs, Hester Langeveld-Benders
{"title":"Neonatal Rupture of the Spleen: Successful Treatment with Splenic Artery Embolization.","authors":"Jelle W Raats,&nbsp;Lievay van Dam,&nbsp;Pieter J van Doormaal,&nbsp;Marjoleine van Hengel-Jacobs,&nbsp;Hester Langeveld-Benders","doi":"10.1055/s-0041-1727257","DOIUrl":"https://doi.org/10.1055/s-0041-1727257","url":null,"abstract":"<p><p>Neonatal intra-abdominal hemorrhage has been rarely reported in the literature. We report a case of splenic injury in a neonate, highlighting the importance of a high-index suspicion in early recognition of this rare and potentially fatal injury. We report the first case of a neonate who had a splenic rupture and underwent successful endovascular treatment.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e58-e60"},"PeriodicalIF":0.9,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1727257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Refractory Pulmonary Interstitial Emphysema in Extreme Premature Newborn. 极早产儿难治性肺间质性肺气肿。
IF 0.9
AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727261
Mahmoud Ali, Lea Mallett, Greg Miller
{"title":"Refractory Pulmonary Interstitial Emphysema in Extreme Premature Newborn.","authors":"Mahmoud Ali,&nbsp;Lea Mallett,&nbsp;Greg Miller","doi":"10.1055/s-0041-1727261","DOIUrl":"https://doi.org/10.1055/s-0041-1727261","url":null,"abstract":"<p><p>Pulmonary interstitial emphysema (PIE) occurs when air leaks into the pulmonary interstitium due to overdistension of distal airways, it occurs mainly in neonates with respiratory distress syndrome who need positive pressure ventilation but has also been reported in spontaneously breathing infants. Herein, we report on an extremely low birth weight infant with severe persistent PIE, while on invasive mechanical ventilation (high-frequency oscillatory ventilation, high-frequency jet ventilation, and neurally adjust ventilator assist) managed successfully with 2 weeks of selective right lung ventilation after failure of more conservative measures, including shorter periods of right mainstem intubation, before the prolonged trial that was successful.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e61-e64"},"PeriodicalIF":0.9,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1727261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pneumothorax in Neonates Born to COVID-19-Positive Mothers: Fact or Fortuity? covid -19阳性母亲所生新生儿气胸:事实还是偶然?
IF 0.9
AJP Reports Pub Date : 2021-01-01 Epub Date: 2021-03-23 DOI: 10.1055/s-0041-1726020
Ranjith Kamity, Amrita Nayak, Vikramaditya Dumpa
{"title":"Pneumothorax in Neonates Born to COVID-19-Positive Mothers: Fact or Fortuity?","authors":"Ranjith Kamity,&nbsp;Amrita Nayak,&nbsp;Vikramaditya Dumpa","doi":"10.1055/s-0041-1726020","DOIUrl":"https://doi.org/10.1055/s-0041-1726020","url":null,"abstract":"<p><p>Neonates born to mothers with coronavirus disease 2019 (COVID-19) have been largely asymptomatic based on initial reports. All neonates born to mothers with COVID-19 have tested negative for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in our institution (published data as of April 12, 2020). As novel presentations of COVID-19, such as multisystem inflammatory syndrome in children are being increasingly reported, we raise the possibility of increased incidence of pneumothorax in neonates born to SARS-CoV-2-positive mothers. Two recently described neonates with COVID-19 infection were noted to have pneumothoraces. We describe two SARS-CoV-2-negative neonates born to COVID-19-positive mothers at 38 and 33 weeks, respectively, admitted to our neonatal intensive care unit for respiratory distress and subsequently developed pneumothoraces. As diverse clinical presentations in various age groups are being described, it becomes difficult to differentiate the increased incidence of complications related to an underlying illness, from COVID-19-related illness. It remains to be seen if neonates with in utero exposure to SARS-CoV-2 have an elevated inflammatory response with pneumonitis and exaggerated lung disease, similar to adult COVID-19 patients, due to in utero exposure.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 1","pages":"e49-e53"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1726020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25517602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Risk of Early Birth among Women with a Urinary Tract Infection: A Retrospective Cohort Study. 尿路感染妇女早产的风险:一项回顾性队列研究
IF 0.9
AJP Reports Pub Date : 2021-01-01 Epub Date: 2021-01-13 DOI: 10.1055/s-0040-1721668
Rebecca J Baer, Nichole Nidey, Gretchen Bandoli, Brittany D Chambers, Christina D Chambers, Sky Feuer, Deborah Karasek, Scott P Oltman, Larry Rand, Kelli K Ryckman, Laura L Jelliffe-Pawlowski
{"title":"Risk of Early Birth among Women with a Urinary Tract Infection: A Retrospective Cohort Study.","authors":"Rebecca J Baer, Nichole Nidey, Gretchen Bandoli, Brittany D Chambers, Christina D Chambers, Sky Feuer, Deborah Karasek, Scott P Oltman, Larry Rand, Kelli K Ryckman, Laura L Jelliffe-Pawlowski","doi":"10.1055/s-0040-1721668","DOIUrl":"10.1055/s-0040-1721668","url":null,"abstract":"<p><p><b>Objective</b>  The aim of the study is to evaluate the risk of preterm birth (PTB, <37 weeks) and early term (37 and 38 weeks) birth among women with an emergency department (ED) visit or hospitalization with a urinary tract infection (UTI) by trimester of pregnancy. <b>Methods</b>  The primary sample was selected from births in California between 2011 and 2017. UTIs were identified from the ED or hospital discharge records. Risk of PTB, by subtype, and early term birth were evaluated by trimester of pregnancy and by type of visit using log-linear regression. Risk ratios were adjusted for maternal factors. Antibiotic usage was examined in a population of privately insured women from Iowa. <b>Results</b>  Women with a UTI during pregnancy were at elevated risk of a birth <32 weeks, 32 to 36 weeks, and 37 to 38 weeks (adjusted risk ratios [aRRs] 1.1-1.4). Of the women with a diagnostic code for multiple bacterial species, 28.8% had a PTB. A UTI diagnosis elevated risk of PTB regardless of antibiotic treatment (aRR 1.4 for treated, aRR 1.5 for untreated). <b>Conclusion</b>  UTIs are associated with early birth. This association is present regardless of the trimester of pregnancy, type of PTB, and antibiotic treatment.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 1","pages":"e5-e14"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1721668","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38855121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Association between Receipt of Intrapartum Magnesium Sulfate and Postpartum Hemorrhage. 产前服用硫酸镁与产后出血之间的关系。
IF 0.8
AJP Reports Pub Date : 2021-01-01 Epub Date: 2021-02-01 DOI: 10.1055/s-0040-1721671
Emily M S Miller, Allie Sakowicz, Elise Leger, Elizabeth Lange, Lynn M Yee
{"title":"Association between Receipt of Intrapartum Magnesium Sulfate and Postpartum Hemorrhage.","authors":"Emily M S Miller, Allie Sakowicz, Elise Leger, Elizabeth Lange, Lynn M Yee","doi":"10.1055/s-0040-1721671","DOIUrl":"10.1055/s-0040-1721671","url":null,"abstract":"<p><p><b>Objective</b>  The aim of the study is to investigate the association between intrapartum administration of magnesium sulfate in women with hypertensive disorders of pregnancy and postpartum hemorrhage. <b>Study Design</b>  This was a retrospective cohort study of women diagnosed with a hypertensive disorder of pregnancy who delivered singleton gestations >32 weeks at a single, large volume tertiary care center between January 2006 and February 2015. Women who received intrapartum magnesium sulfate for seizure prophylaxis were compared with women who did not receive intrapartum magnesium sulfate. The primary outcome was frequency of postpartum hemorrhage. Secondary outcomes included estimated blood loss, uterine atony, and transfusion of packed red blood cells. Bivariable analyses were used to compare the frequencies of each outcome. Multivariable logistic regression models examined the independent associations of magnesium sulfate with outcomes. <b>Results</b>  Of 2,970 women who met inclusion criteria, 1,072 (36%) received intrapartum magnesium sulfate. Women who received magnesium sulfate were more likely to be nulliparous, publicly insured, of minority race or ethnicity, earlier gestational age at delivery, and undergo labor induction. The frequency of postpartum hemorrhage was significantly higher among women who received magnesium sulfate compared with those who did not (12.4 vs. 9.3%, <i>p</i>  = 0.008), which persisted after controlling for potential confounders. Of secondary outcomes, there was no difference in estimated blood loss between women who did and did not receive magnesium sulfate (250 mL [interquartile range 250-750] vs. 250 mL [interquartile range 250-750], <i>p</i>  = 0.446). However, compared with women who did not receive magnesium sulfate, women who received magnesium sulfate had a greater frequency of uterine atony (8.9 vs 4.9%, <i>p</i>  < 0.001) and transfusion of packed red blood cells (2.0 vs. 0.8%, <i>p</i>  = 0.008). These differences persisted after controlling for potential confounders. <b>Conclusion</b>  Intrapartum magnesium sulfate administration to women with hypertensive disorders of pregnancy is associated with increased odds of postpartum hemorrhage, uterine atony, and red blood cell transfusion.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 1","pages":"e21-e25"},"PeriodicalIF":0.8,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/66/10-1055-s-0040-1721671.PMC7850913.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25335287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biallelic Variants in LAMB1 Causing Hydranencephaly: A Severe Phenotype of a Rare Malformative Encephalopathy. LAMB1双等位变异导致无水脑畸形:一种罕见的畸形脑病的严重表型。
IF 0.9
AJP Reports Pub Date : 2021-01-01 Epub Date: 2021-02-01 DOI: 10.1055/s-0040-1722728
Kuntal Sen, Shagun Kaur, David W Stockton, Mary Nyhuis, Jacquelyn Roberson
{"title":"Biallelic Variants in <i>LAMB1</i> Causing Hydranencephaly: A Severe Phenotype of a Rare Malformative Encephalopathy.","authors":"Kuntal Sen,&nbsp;Shagun Kaur,&nbsp;David W Stockton,&nbsp;Mary Nyhuis,&nbsp;Jacquelyn Roberson","doi":"10.1055/s-0040-1722728","DOIUrl":"https://doi.org/10.1055/s-0040-1722728","url":null,"abstract":"<p><p><b>Case Report</b>  A 32-year-old female with a history of three prior pregnancy losses presented for genetic testing following an ultrasonography diagnosis of fetal hydranencephaly. Baby was born via C-section and was noted to have a head circumference of 48 cm, in addition to ocular and cardiac anomalies and dysmorphic features. Whole genome sequencing revealed a homozygous variant in <i>LAMB1</i> gene. <b>Discussion</b>  The pathobiogenesis of hydranencephaly is incompletely understood and is attributed to vascular, infectious, or genetic etiology. Herein we present <i>LAMB1</i> as a monogenic cause of fetal hydranencephaly which was incompatible with life. Previously, <i>LAMB1</i> -associated phenotype consisted of cobblestone lissencephaly and hydrocephalus, developmental delay, and seizures. Our proband expands the phenotypic spectrum of this malformative encephalopathy.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 1","pages":"e26-e28"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1722728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25335289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Expectant Management of Severe COVID-19 Pneumonia in Late Preterm Pregnancy and Subsequent Cholecystitis: Lessons Learned. 早孕晚期重症 COVID-19 肺炎及其后胆囊炎的预期管理:经验教训。
IF 0.9
AJP Reports Pub Date : 2021-01-01 Epub Date: 2021-02-12 DOI: 10.1055/s-0040-1721672
Neggin B Mokhtari, Daphnie Drassinower, Lindsey A Orr, Nathan K Cobb, Oscar L Mims, Helain J Landy
{"title":"Expectant Management of Severe COVID-19 Pneumonia in Late Preterm Pregnancy and Subsequent Cholecystitis: Lessons Learned.","authors":"Neggin B Mokhtari, Daphnie Drassinower, Lindsey A Orr, Nathan K Cobb, Oscar L Mims, Helain J Landy","doi":"10.1055/s-0040-1721672","DOIUrl":"10.1055/s-0040-1721672","url":null,"abstract":"<p><p><b>Introduction</b>  Since the emergence of coronavirus disease 2019 (COVID-19) as a pandemic in March 2020, research and guidance have been published with regard to the management of infection and considerations in pregnancy, but much is still unknown. Pregnant women with COVID-19 infection are more likely to be hospitalized and are at increased risk for intensive care unit admissions and intubation than nonpregnant women with COVID-19 infection. The optimal timing of delivery among pregnant women with COVID-19 infection has not been established at this time, especially when the infection arises in late preterm and early term gestation. It is suggested that COVID-19 infection should not be considered a sole indication for delivery. The risks and benefits of prolonging pregnancy versus delivery should be taken into consideration at any given gestational age in a patient with COVID-19 infection. <b>Case Report</b>  We report a case of a patient in the late third trimester of pregnancy that presented with severe COVID-19 infection and was managed expectantly through her disease course with improvement of respiratory status without necessitating delivery. We also discuss the unique development of cholecystitis in her hospitalization that may represent another clinical association to COVID-19 infection. <b>Conclusion</b>  This case illustrates that delaying delivery is an option even in later gestational ages for maternal stabilization. A multidisciplinary approach and teamwork is needed to manage pregnant women with COVID-19 infection for optimal outcomes for both mother and fetus. <b>Key Points</b> Delaying delivery in severe coronavirus disease 2019 (COVID-19) infection is a reasonable option even in late gestation.A multidisciplinary team is of utmost importance when managing a pregnant woman with COVID-19.Other clinical sequalae such as cholecystitis may arise in the setting of COVID-19 infection.</p>","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 1","pages":"e29-e33"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/29/10-1055-s-0040-1721672.PMC7880816.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25377105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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