AJP Reports最新文献_第10页

Neonatal Atypical Hemolytic Uremic Syndrome in the Eculizumab Era. Eculizumab时代的新生儿非典型溶血性尿毒症综合征。

IF 0.9

AJP Reports Pub Date : 2021-04-01 Epub Date: 2021-06-23 DOI: 10.1055/s-0041-1731057

Sara Madureira Gomes, Rita Pissarra Teixeira, Gustavo Rocha, Paulo Soares, Hercilia Guimaraes, Paulo Santos, Joana Jardim, João Luís Barreira, Helena Pinto

{"title":"Neonatal Atypical Hemolytic Uremic Syndrome in the Eculizumab Era.","authors":"Sara Madureira Gomes, Rita Pissarra Teixeira, Gustavo Rocha, Paulo Soares, Hercilia Guimaraes, Paulo Santos, Joana Jardim, João Luís Barreira, Helena Pinto","doi":"10.1055/s-0041-1731057","DOIUrl":"https://doi.org/10.1055/s-0041-1731057","url":null,"abstract":"The atypical hemolytic uremic syndrome (aHUS) in the newborn is a rare disease, with high morbidity. Eculizumab, considered a first-line drug in older children, is not approved in neonates and in children weighing less than 5 kg. We present a 5-day-old female newborn, born at 36 weeks' twin gestation, by emergency cesarean section due to cord prolapse, with birth weight of 2,035 g and Apgar score of 7/7/7, who develops microangiopathic hemolytic anemia, thrombocytopenia, and progressive acute renal failure. In day 5, after diagnosis of aHUS, a daily infusion of fresh frozen plasma begins, with improvement of thrombocytopenia and very slight improvement in renal function. The etiologic study (congenital infection, Shiga toxin, ADAMTS13 activity, directed metabolic study) was normal. C3c was slightly decreased. On day 16 for maintenance of anemia and severe renal failure, she started 300 mg/dose eculizumab. Anemia resolves in 10 weeks and creatinine has normal values after 13 weeks of treatment. The genetic study was normal. In this case, eculizumab is effective in controlling microangiopathy and in the recovery of renal function. Diagnosis of neonatal aHUS can be challenging because of phenotypic heterogeneity and potential overlap with other manifestations that may confound it, such as perinatal asphyxia or sepsis/disseminated intravascular coagulation.","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e95-e98"},"PeriodicalIF":0.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1731057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39032471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Otitis Media in an Extremely Preterm Infant. 极早产儿急性中耳炎一例。

IF 0.9

AJP Reports Pub Date : 2021-04-01 Epub Date: 2021-06-23 DOI: 10.1055/s-0041-1731315

Aashika Janwadkar, Shirley Louis, Sheri L Nemerofsky

引用次数: 1

Report of a Confirmed SARS-CoV-2 Positive Newborn after Delivery Despite Negative SARS-CoV-2 Testing on Both Parents. 尽管父母双方的SARS-CoV-2检测均为阴性，但分娩后确诊新生儿SARS-CoV-2阳性的报告。

IF 0.9

AJP Reports Pub Date : 2021-04-01 Epub Date: 2021-06-16 DOI: 10.1055/s-0041-1728783

Benjamin R Harding, Farha Vora

{"title":"Report of a Confirmed SARS-CoV-2 Positive Newborn after Delivery Despite Negative SARS-CoV-2 Testing on Both Parents.","authors":"Benjamin R Harding, Farha Vora","doi":"10.1055/s-0041-1728783","DOIUrl":"https://doi.org/10.1055/s-0041-1728783","url":null,"abstract":"We present a case of a term infant born to an asymptomatic mother at a community hospital who required transfer to a local neonatal intensive care unit (NICU) immediately after birth for respiratory distress. The infant was tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at 24 hours of life by reverse transcription polymerase chain reaction (RT-PCR) testing due to the absence of prenatal maternal COVID-19 testing and was found to be positive for SARS-CoV-2 at that time. A second RT-PCR test was obtained on the infant on day of life (DOL) 4 and was also positive, confirming an accurate diagnosis of COVID-19 disease in the infant. Both the mother and father remained asymptomatic and concomitantly tested negative for SARS-CoV-2 on two separate occasions. The infant subsequently clinically improved and was discharged without any complications. This case raises the potential concern for two unreported newborn issues related to COVID-19. First, the potential unreliability of negative maternal COVID-19 testing surrounding the time of delivery as it relates to routine newborn testing and isolation needs, and second, if the negative material testing was accurate, this raises the concern for a potential case of nosocomial COVID-19 infection within the first 24 hours of life.","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e80-e83"},"PeriodicalIF":0.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1728783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39250273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case of an Extremely Low Birth Weight Infant with Morganella morganii Bacteremia and Peritonitis. 极低出生体重儿莫氏菌菌血症并发腹膜炎1例。

IF 0.9

AJP Reports Pub Date : 2021-04-01 Epub Date: 2021-08-19 DOI: 10.1055/s-0041-1732407

Betty Pham, Anne Denslow, Michel Mikhael, Jina Lim

{"title":"A Case of an Extremely Low Birth Weight Infant with Morganella morganii Bacteremia and Peritonitis.","authors":"Betty Pham, Anne Denslow, Michel Mikhael, Jina Lim","doi":"10.1055/s-0041-1732407","DOIUrl":"https://doi.org/10.1055/s-0041-1732407","url":null,"abstract":"We describe a case of late onset Morganella morganii sepsis in an extremely low birth weight male neonate born at 23 and 4/7 weeks gestational age to a 30-year-old primigravid mother due to preterm labor. The mother was otherwise healthy with an unremarkable prenatal course. She received steroids and ampicillin prior to delivery. While initial blood cultures were negative, at day of life 4, the neonate developed signs of sepsis with leukocytosis and bandemia, and subsequent blood culture demonstrated growth of M. morganii . The patient then had spontaneous intestinal perforation on day of life 8 with peritoneal cultures growing M. morganii . The infant responded to standard therapy and survived to discharge, with few mild developmental delays upon outpatient follow-up. While M. morganii has been demonstrated in the neonatal population, it generally causes early onset sepsis and is associated with high mortality in preterm neonates. Here, we present this case of late onset neonatal sepsis with M. morganii complicated by spontaneous intestinal perforation, with survival in a 23 weeks gestation infant.","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e113-e118"},"PeriodicalIF":0.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/fd/10-1055-s-0041-1732407.PMC8376401.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39348472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Profound Hypotonia and Respiratory Failure due to Suspected Nemaline Myopathy in a Preterm Infant. 疑为线状肌病的早产儿深度低张力和呼吸衰竭。

IF 0.9

AJP Reports Pub Date : 2021-04-01 Epub Date: 2021-06-23 DOI: 10.1055/s-0041-1728782

Gloria Akuamoah-Boateng, Raymond C Stetson, Bethany D Kaemingk, David A Bieber, Jane E Brumbaugh

引用次数: 1

The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report). 产前产后静脉注射免疫球蛋白对新生儿血色素沉着症严重程度的影响:两兄弟的故事(病例报告)。

IF 0.9

AJP Reports Pub Date : 2021-04-01 Epub Date: 2021-06-30 DOI: 10.1055/s-0041-1731311

Veronica Mugarab-Samedi, Michelle D Ryan, Essa Hamdan Al Awad, Adel Elsharkawy

引用次数: 2

Kagami-Ogata Syndrome: Case Series and Review of Literature. 神绪综合征:个案系列及文献回顾。

IF 0.9

AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727287

Rishika P Sakaria, Roya Mostafavi, Stephen Miller, Jewell C Ward, Eniko K Pivnick, Ajay J Talati

{"title":"Kagami-Ogata Syndrome: Case Series and Review of Literature.","authors":"Rishika P Sakaria, Roya Mostafavi, Stephen Miller, Jewell C Ward, Eniko K Pivnick, Ajay J Talati","doi":"10.1055/s-0041-1727287","DOIUrl":"https://doi.org/10.1055/s-0041-1727287","url":null,"abstract":"Kagami-Ogata syndrome (KOS) (OMIM #608149) is a genetic imprinting disorder affecting chromosome 14 that results in a characteristic phenotype consisting of typical facial features, skeletal abnormalities including rib abnormalities described as \"coat hanger ribs,\" respiratory distress, abdominal wall defects, polyhydramnios, and developmental delay. First identified by Wang et al in 1991, over 80 cases of KOS have been reported in the literature. KOS, however, continues to remain a rare and potentially underdiagnosed disorder. In this report, we describe two unrelated male infants with differing initial presentations who were both found to have the characteristic \"coat hanger\" rib appearance on chest X-ray, raising suspicion for KOS. Molecular testing confirmed KOS in each case. In addition to these new cases, we reviewed the existing cases reported in literature. Presence of polyhydramnios, small thorax, curved ribs, and abdominal wall defects must alert the perinatologist toward the possibility of KOS to facilitate appropriate molecular testing. The overall prognosis of KOS remains poor. Early diagnosis allows for counseling by a multidisciplinary team and enables parents to make informed decisions regarding both pregnancy management and postnatal care.","PeriodicalId":7645,"journal":{"name":"AJP Reports","volume":"11 2","pages":"e65-e75"},"PeriodicalIF":0.9,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1727287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38953807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Severe Consumptive Coagulopathy in an Extremely-Low-Birth-Weight Infant with Intra-Abdominal Umbilical Vein Varix: A Case Report. 严重消耗性凝血功能障碍的极低出生体重婴儿腹腔内脐静脉曲张:1例报告。

IF 0.9

AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727288

Mitsuhiro Haga, Kanako Itoh, Tsuguhiro Horikoshi, Fumihiko Namba, Kazuhiko Kabe

引用次数: 2

Neonatal Rupture of the Spleen: Successful Treatment with Splenic Artery Embolization. 新生儿脾破裂:脾动脉栓塞成功治疗。

IF 0.9

AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727257

Jelle W Raats, Lievay van Dam, Pieter J van Doormaal, Marjoleine van Hengel-Jacobs, Hester Langeveld-Benders

引用次数: 0

Refractory Pulmonary Interstitial Emphysema in Extreme Premature Newborn. 极早产儿难治性肺间质性肺气肿。

IF 0.9

AJP Reports Pub Date : 2021-03-01 Epub Date: 2021-05-27 DOI: 10.1055/s-0041-1727261

Mahmoud Ali, Lea Mallett, Greg Miller

引用次数: 1