Nihon Rai Gakkai zasshi最新文献_第4页

[The 68th general meeting of the Japanese Leprosy Association. Yokohama, Japan. April 21-23, 1995. Abstracts]. [日本麻风病协会第68届大会]日本横滨。1995年4月21日至23日。摘要]。

Nihon Rai Gakkai zasshi Pub Date : 1995-03-01

引用次数: 0

[Effect of chloroform on the extracting efficiency of adenosine tri-phosphate (ATP) from the cells of Mycobacterium leprae]. 氯仿对麻风分枝杆菌细胞中三磷酸腺苷(ATP)提取效率的影响

Nihon Rai Gakkai zasshi Pub Date : 1994-11-01 DOI: 10.5025/hansen1977.63.99

M Nakamura

引用次数: 1

Paucibacillary leprosy patients treated with multidrug therapy four years experience (1988 to 1991) in Bangladesh. 孟加拉国采用多药治疗的少杆菌性麻风患者四年经验(1988年至1991年)。

Nihon Rai Gakkai zasshi Pub Date : 1994-11-01 DOI: 10.5025/hansen1977.63.95

E Faruque, A K Hoque, J Ahmed, R Ahmed, A Ali

引用次数: 1

[The dermal connective tissue of leprosy patients. Part 1. The elastic fibers and the skin appendages]. 麻风病患者的皮肤结缔组织。第1部分。弹性纤维和皮肤附属物]。

Nihon Rai Gakkai zasshi Pub Date : 1994-11-01 DOI: 10.5025/hansen1977.63.65

M Namisato, K Kameyama, M Yajima

{"title":"[The dermal connective tissue of leprosy patients. Part 1. The elastic fibers and the skin appendages].","authors":"M Namisato, K Kameyama, M Yajima","doi":"10.5025/hansen1977.63.65","DOIUrl":"https://doi.org/10.5025/hansen1977.63.65","url":null,"abstract":"Leprosy patients who are keeping long quiescent conditions show some characteristic changes clinically on their skins. The elastic fibers and skin appendages are important factors for the peculiar skin characters. We calculated the collagen and elastic fibers in the limbs and redundant facial skins of leprosy patients by automated computerized image analyser. Histopathological studies of these samples were also done. All cases were over sixty years old and many of them were in quiescent conditions. The control cases were taken from the same parts of age matched normal skins. We found the dermal thickness of lower legs of patients was significantly lower than that of controls. The amount of collagen fibers had tendensy of decrease accompanied with decreased dermal thickness, but the elastic fibers of leprosy patients did not show the same tendensy. In the patients' skin, the elastic fibers arranged irregularly, sometimes fragmented and focally coagressed. Skin appendages were greatly decreased and intraepidermal pores of sweat ducts were almost disappeared, but many sweat glands have survived. Of the facial skins, only 1 case showed a compatible feature with solar elastosis. We concluded that the dermal elastic fibers of leprosy patients had characteristic features. The types of leprosy, duration periods of active condition, destructed dermal structures, all these factors were suspected to have some relations with these phenomena.","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"63 3","pages":"65-74"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18732529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Down regulation of Ia expression in macrophages following incubation with mycobacteria. 分枝杆菌培养后巨噬细胞Ia表达的下调。

Nihon Rai Gakkai zasshi Pub Date : 1994-11-01 DOI: 10.5025/hansen1977.63.75

Y Fukutomi, S Inui, K Onozaki, Y Yogi, F Minagawa

{"title":"Down regulation of Ia expression in macrophages following incubation with mycobacteria.","authors":"Y Fukutomi, S Inui, K Onozaki, Y Yogi, F Minagawa","doi":"10.5025/hansen1977.63.75","DOIUrl":"https://doi.org/10.5025/hansen1977.63.75","url":null,"abstract":"Macrophages are known to release cytokines in response to various kinds of stimulators. In the present study, peritoneal macrophages from C3H/He or C3H/HeJ mice were incubated in vitro with heat-killed M. lepraemurium, M. intracellulare or M. gordonare for 3 days followed by harvest culture supernatant to analyze cytokine activities. It, therefore, seems that macrophages phagocytizing these mycobacteria, released interleukin-1 (IL-1) and tumor necrosis factor (TNF) in culture media. The amount of release was dose dependent on mycobacteria employed. In addition, macrophages, as already have reported elsewhere, treated with IFN for 2 to 3 days showed enhanced expression of surface Ia; although the expression was inhibited if the cells phagocytized mycobacteria. Similarly, the reduced expression of Ia was observed in peritoneal macrophages from MRL/lpr mice after 3 day-culture with mycobacteria in vitro. More importantly, in the presence of the supernatant obtained from macrophages incubated with mycobacteria, IFN gamma-treated normal macrophages exhibited suppressed expression of Ia. These results demonstrate that cytokine release and reduced expression of surface Ia in macrophages are simultaneous phenomena after phagocytosis of mycobacteria. Suppression of Ia may be in part induced by Ia suppressive factor(s) released from mycobacterium-phagocytized macrophages.","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"63 3","pages":"75-85"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18732530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clofazimine-mediated augmentation of LPS-induced tumor necrosis factor production in macrophages. 氯法齐明介导的lps诱导巨噬细胞肿瘤坏死因子生成的增强。

Nihon Rai Gakkai zasshi Pub Date : 1994-11-01 DOI: 10.5025/hansen1977.63.86

J G Xiong, F Minagawa, Y Fukutomi

引用次数: 0

On the beta-glucuronidase binding protein (BGBP) of microorganisms. Its purification, the antiserum preparation against that and its localization in leproma and the other infectious lesions shown by immunohistologic method. 微生物β -葡萄糖醛酸酶结合蛋白(BGBP)的研究。其纯化、抗血清制备及在麻风病及其他感染性病变中的定位。

Nihon Rai Gakkai zasshi Pub Date : 1994-07-01 DOI: 10.5025/hansen1977.63.35

E. Matsuo, A. Komatsu, S. Maekawa, Y. Furuno, A. Matsushita, A. Sumiishi, N. Sasaki, O. K. Skinsnes

{"title":"On the beta-glucuronidase binding protein (BGBP) of microorganisms. Its purification, the antiserum preparation against that and its localization in leproma and the other infectious lesions shown by immunohistologic method.","authors":"E. Matsuo, A. Komatsu, S. Maekawa, Y. Furuno, A. Matsushita, A. Sumiishi, N. Sasaki, O. K. Skinsnes","doi":"10.5025/hansen1977.63.35","DOIUrl":"https://doi.org/10.5025/hansen1977.63.35","url":null,"abstract":"Our previous studies suggested that M. leprae (ML) grow in peripheral nerves and lepra cells because ML metabolize hyaluronic acid (HA), and use its component for their growth by the aid of host enzyme combined to the bacilli derived beta-glucuronidase binding protein (BGBP). In this study, therefore, we examined the method to purify BGBP from a mycobacterium HI-75 originally separated from a leproma and cultured by modified Ogawa's medium containing split products of HA (glucuronic acid and N-acetylglucosamine). The distribution of BGBP in leproma and the other lesions consisting of hepatitis B virus infected liver and M. avium-intracellulare infected lung tissue were also immunohistologically examined. As the result, the best method to get BGBP was preparatory electrophoresis in the final step of the purification and not the molecular sieving. The BGBP was actually proven in leproma and the other infected tissues as described, indicating the abilities of these microorganisms to utilize the metabolic machinery of the host with the similar ways to that of ML.","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"35 1","pages":"35-46"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77968423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

[Is a false image of the senile plaque in elderly Japanese with leprosy?--pathological findings on the immunohistology]. 日本老年麻风病患者的老年斑是假的吗?-免疫组织学病理结果]。

Nihon Rai Gakkai zasshi Pub Date : 1994-07-01 DOI: 10.5025/hansen1977.63.51

G Koya, T Tabira

引用次数: 1

On the beta-glucuronidase binding protein (BGBP) of microorganisms. Its purification, the antiserum preparation against that and its localization in leproma and the other infectious lesions shown by immunohistologic method. 微生物β -葡萄糖醛酸酶结合蛋白(BGBP)的研究。其纯化、抗血清制备及在麻风病及其他感染性病变中的定位。

Nihon Rai Gakkai zasshi Pub Date : 1994-07-01

E Matsuo, A Komatsu, S Maekawa, Y Furuno, A Matsushita, A Sumiishi, N Sasaki, O K Skinsnes

{"title":"On the beta-glucuronidase binding protein (BGBP) of microorganisms. Its purification, the antiserum preparation against that and its localization in leproma and the other infectious lesions shown by immunohistologic method.","authors":"E Matsuo, A Komatsu, S Maekawa, Y Furuno, A Matsushita, A Sumiishi, N Sasaki, O K Skinsnes","doi":"","DOIUrl":"","url":null,"abstract":"Our previous studies suggested that M. leprae (ML) grow in peripheral nerves and lepra cells because ML metabolize hyaluronic acid (HA), and use its component for their growth by the aid of host enzyme combined to the bacilli derived beta-glucuronidase binding protein (BGBP). In this study, therefore, we examined the method to purify BGBP from a mycobacterium HI-75 originally separated from a leproma and cultured by modified Ogawa's medium containing split products of HA (glucuronic acid and N-acetylglucosamine). The distribution of BGBP in leproma and the other lesions consisting of hepatitis B virus infected liver and M. avium-intracellulare infected lung tissue were also immunohistologically examined. As the result, the best method to get BGBP was preparatory electrophoresis in the final step of the purification and not the molecular sieving. The BGBP was actually proven in leproma and the other infected tissues as described, indicating the abilities of these microorganisms to utilize the metabolic machinery of the host with the similar ways to that of ML.","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"63 2","pages":"35-46"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18843590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Elimination of contaminants in a homogenate of nude-mouse footpad experimentally infected with Mycobacterium leprae]. [去除实验感染麻风分枝杆菌的裸鼠足垫匀浆中的污染物]。

Nihon Rai Gakkai zasshi Pub Date : 1994-07-01 DOI: 10.5025/hansen1977.63.47

M Nakamura

引用次数: 12