AIP Advances最新文献_第4页

Ultrafast optical and passive acoustic mapping characterization of nanoscale cavitation nuclei based on gas vesicle proteins. 基于气体囊泡蛋白的纳米尺度空化核的超快光学和被动声学成像表征。

IF 1.4 4区物理与天体物理

AIP Advances Pub Date : 2025-02-07 eCollection Date: 2025-02-01 DOI: 10.1063/5.0239607

Cameron A B Smith, Avinoam Bar-Zion, Qiang Wu, Dina Malounda, Luca Bau, Eleanor Stride, Mikhail G Shapiro, Constantin C Coussios

{"title":"Ultrafast optical and passive acoustic mapping characterization of nanoscale cavitation nuclei based on gas vesicle proteins.","authors":"Cameron A B Smith, Avinoam Bar-Zion, Qiang Wu, Dina Malounda, Luca Bau, Eleanor Stride, Mikhail G Shapiro, Constantin C Coussios","doi":"10.1063/5.0239607","DOIUrl":"10.1063/5.0239607","url":null,"abstract":"Genetically encodable gas-filled particles, known as gas vesicles (GVs), have shown promise as a biomolecular contrast agent for ultrasound imaging and have the potential to be used as cavitation nuclei for ultrasound therapy. In this study, we used passive acoustic mapping techniques to characterize GV-seeded cavitation, utilizing 0.5 and 1.6 MHz ultrasound insonation over peak rarefactional pressures ranging from 100 to 2200 kPa. We found that GVs produce cavitation for the duration of the first applied pulse, up to at least 5000 cycles, but that bubble activity diminishes rapidly over subsequent pulses. At 0.5 MHz, the frequency content of cavitation emissions was predominantly broadband in nature, while at 1.6 MHz, narrowband content at harmonics of the main excitation frequency dominated. Simulations and high-speed camera imaging suggest that the received cavitation emissions come not from individual GVs but instead from the coalescence of GV-released gas into larger bubbles during the applied ultrasound pulse. These results will aid the future development of GVs as cavitation nuclei in ultrasound therapy.","PeriodicalId":7619,"journal":{"name":"AIP Advances","volume":"15 2","pages":"025016"},"PeriodicalIF":1.4,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of a methyl-PEG2000-DSPE-PVP-LDC nanomaterial: A novel lidocaine delivery system 甲基- peg2000 - dspe - pvp - ldc纳米材料的制备与评价：一种新型利多卡因递送系统

4区物理与天体物理

AIP Advances Pub Date : 2025-02-01 DOI: 10.1063/5.0250331

Wan-Yi Mo, Jinzhen Kong, Honghua Dai, De-Cheng Liu, Yimin Wang, Tuck Yun Cheang, Hui Yao, Hui Zhang

{"title":"Preparation and evaluation of a methyl-PEG2000-DSPE-PVP-LDC nanomaterial: A novel lidocaine delivery system","authors":"Wan-Yi Mo, Jinzhen Kong, Honghua Dai, De-Cheng Liu, Yimin Wang, Tuck Yun Cheang, Hui Yao, Hui Zhang","doi":"10.1063/5.0250331","DOIUrl":"https://doi.org/10.1063/5.0250331","url":null,"abstract":"This study investigates the potential of methyl-PEG2000-DSPE-PVP-LDC as a drug delivery nanocarrier and its impact on human immortalized keratinocytes, focusing on cytotoxicity, migration inhibition, and drug-loading efficiency. Synthesized nanoparticles were characterized using scanning electron microscopy, transmission electron microscopy, zeta potential analysis, and Fourier-transform infrared spectroscopy (FTIR). The cytotoxicity in human keratinocyte HaCaT cells and the inhibition of cell migration were analyzed using a scratch assay. Furthermore, the drug-loading efficiency of the nanoparticles was quantified. The synthesized nanoparticles exhibited dimensions under 50 nm, with an optimal size of ∼10 nm for efficient drug loading. The zeta potential was −24.33 ± 2.654 mV. The drug-loading capacity was 226.618 35 µg LDC/mg nanoparticle material. FTIR revealed an interaction between lidocaine and the nanospheres. Cytotoxicity assays indicated that the nanomaterial suppressed the cell cycle progression. In addition, the nanomaterial exhibited a notable inhibition of cell migration, resulting in reduced migration efficiency compared with the control group. Thus, the methyl-PEG2000-DSPE-PVP-LDC nanomaterial demonstrates considerable promise for drug delivery owing to its small particle size, efficient drug-loading capability, and potential to inhibit the proliferation and migration of human immortalized keratinocytes, suggesting its potential diverse biomedical applications, particularly in cancer therapy.","PeriodicalId":7619,"journal":{"name":"AIP Advances","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of active components from different ages of old Wuyi rock tea by gradient extraction 梯度提取法分析武夷老岩茶不同年代有效成分

4区物理与天体物理

AIP Advances Pub Date : 2025-02-01 DOI: 10.1063/5.0252943

Yan Lang, Qianli Ma, R.R. Chen, Dongli Yang, HU Xiao-mei, C. Zhang, Chenxi Shi, Zhonglin Guo

{"title":"Analysis of active components from different ages of old Wuyi rock tea by gradient extraction","authors":"Yan Lang, Qianli Ma, R.R. Chen, Dongli Yang, HU Xiao-mei, C. Zhang, Chenxi Shi, Zhonglin Guo","doi":"10.1063/5.0252943","DOIUrl":"https://doi.org/10.1063/5.0252943","url":null,"abstract":"In this study, a comparative analysis of the extraction yields of flavonoids, polyphenols, and terpenes from aged Wuyi rock tea of different years in solvents such as petroleum ether, dichloromethane, ethyl acetate, n-butanol, and water was conducted, which provides a theoretical basis for the separation and purification of active components. A 75% ethanol reflux extraction method was employed to prepare the ethanol extract, followed by extraction of the aqueous suspension using different polar organic solvents and deep eutectic solvents. The contents were determined by UV spectrophotometry. The results showed that the total extraction yields of flavonoids and polyphenols varied with the solvents, in the order of n-butanol, ethyl acetate, water, dichloromethane, and petroleum ether; for triterpenoids, the order was n-butanol, water, petroleum ether, ethyl acetate, and dichloromethane. N-butanol was identified as the optimal solvent. This study also detected a flavonoid compound, presumably glycyrrhizic acid, based on comparisons with existing literature and information. Currently, research and development on flavonoids, polyphenols, and triterpenoids in aged tea are underway, aiming to further explore the value and application potential of tea and contribute to the development of the tea industry.","PeriodicalId":7619,"journal":{"name":"AIP Advances","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on conductive polymer microneedles with adjustable dissolution rate 可调溶出率导电聚合物微针的研究

4区物理与天体物理

AIP Advances Pub Date : 2025-02-01 DOI: 10.1063/5.0247733

Wenkai Wang, Yanhong Liang, Xiaoxiao Yan, G. C. Tang, Yuwen Li, Zhibiao Li

{"title":"Research on conductive polymer microneedles with adjustable dissolution rate","authors":"Wenkai Wang, Yanhong Liang, Xiaoxiao Yan, G. C. Tang, Yuwen Li, Zhibiao Li","doi":"10.1063/5.0247733","DOIUrl":"https://doi.org/10.1063/5.0247733","url":null,"abstract":"Dissolvable polymeric microneedles have gained significant attention in recent years as a promising transdermal drug delivery method due to their simple fabrication and lack of medical waste after use. However, traditional polymeric microneedles possess several notable drawbacks, including insufficient mechanical strength, difficulty in effectively penetrating the skin barrier, limited drug loading capacity affecting therapeutic outcomes, and uncontrollable drug release rates leading to unstable efficacy. In this paper, a conductive polymer microneedle with an adjustable dissolution rate is proposed. The dissolution rate of microneedles can be adjusted by controlling the current so as to control the drug release rate and realize the controlled drug release truly. The PVA-Ag and PVP-Ag lidocaine-loaded microneedles demonstrated good puncture performance and nearly complete dissolution within 10 min in a simulated body fluid environment. The dissolution rate was significantly accelerated under electrical stimulation. The microneedles showed good biocompatibility, and under the application of a 3 V voltage, the drug delivery efficiency of PVP-Ag lidocaine microneedles reached 85% within 5 min, while PVA-Ag lidocaine microneedles achieved up to 90%.","PeriodicalId":7619,"journal":{"name":"AIP Advances","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Combined effect of confinement and dielectric exclusion on ion adsorption in slits, pores, and cavities. 约束和介电排斥对离子在狭缝、孔隙和空腔中吸附的综合影响。

IF 1.4 4区物理与天体物理

AIP Advances Pub Date : 2024-12-24 eCollection Date: 2024-12-01 DOI: 10.1063/5.0237169

János Szarvas, Mónika Valiskó, Dirk Gillespie, Dezső Boda

{"title":"Combined effect of confinement and dielectric exclusion on ion adsorption in slits, pores, and cavities.","authors":"János Szarvas, Mónika Valiskó, Dirk Gillespie, Dezső Boda","doi":"10.1063/5.0237169","DOIUrl":"10.1063/5.0237169","url":null,"abstract":"We present simulation results for the Donnan equilibrium between a homogeneous bulk reservoir and inhomogeneous confining geometries with varying number of restricted dimensions, d c. Planar slits (d c = 1), cylindrical pores (d c = 2), and spherical cavities (d c = 3) are considered. The walls have a negative surface charge density. Because different dielectric constants are used in the reservoir and confined system, we used the Donnan grand canonical Monte Carlo method [Boda and Gillespie, J. Mol. Liq. 391, 123372 (2023)] to simulate the equilibrium. The systems with larger confining dimensionality produce greater adsorption of counterions (cations) into the confinements, so cation selectivity increases with increasing dimensionality. The systems with smaller dielectric constants produce more effective coion (anion) exclusion, so cation selectivity increases with decreasing dielectric constant. The combined effect of a more confining space and solvation penalty produces even more efficient anion exclusion and cation selectivity than each separately.","PeriodicalId":7619,"journal":{"name":"AIP Advances","volume":"14 12","pages":"125323"},"PeriodicalIF":1.4,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance study on a new solar air heater for space heating: A numerical and experimental study 一种用于空间采暖的新型太阳能空气加热器的性能研究：数值与实验研究

4区物理与天体物理

AIP Advances Pub Date : 2024-12-01 DOI: 10.1063/5.0243594

Malika Amari, Amjad Ali, Harikumar Pallathadka, Omar H. AL‐Zoubi, Harpreet Kaur, Jatinder Kaur, Abhinav Kumar, Laith H. Alzubaidi, Ali Foladi

{"title":"Performance study on a new solar air heater for space heating: A numerical and experimental study","authors":"Malika Amari, Amjad Ali, Harikumar Pallathadka, Omar H. AL‐Zoubi, Harpreet Kaur, Jatinder Kaur, Abhinav Kumar, Laith H. Alzubaidi, Ali Foladi","doi":"10.1063/5.0243594","DOIUrl":"https://doi.org/10.1063/5.0243594","url":null,"abstract":"The need to address energy challenges and environmental pollution has led researchers to focus on utilizing solar energy. In this study, a new solar air heater collector system was developed that incorporates arc-shaped wire roughness and external airflow recycling. The system performance was evaluated under various conditions using energy conservation equations and a semi-analytical method for modeling. The results were validated, confirming the method’s accuracy. The findings revealed that the hybrid system significantly improved energy and exergy efficiencies at lower mass flow rates. Increasing the airflow recycle ratio up to 3 in conditions of constant roughness and low mass flow rates enhanced collector performance. However, at high flow rates and recycle ratios, exergy efficiency decreased due to increased pressure drop, despite a rise in energy efficiency, making it less effective than a simple collector system. The results show that the temperature increase is not so much from a mass flow rate of more than 0.05 kg/s. The existence of considered artificial roughness has caused an increase in temperature, especially in mass flow rates of less than 0.035 kg/s.","PeriodicalId":7619,"journal":{"name":"AIP Advances","volume":"14 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.aip.org/aip/adv/article-pdf/doi/10.1063/5.0243594/20287219/125314_1_5.0243594.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Dimensional analysis of diffusive association rate equations. 扩散关联速率方程的维度分析。

IF 1.4 4区物理与天体物理

AIP Advances Pub Date : 2024-11-14 eCollection Date: 2024-11-01 DOI: 10.1063/5.0238119

Jixin Chen

引用次数: 0

Antibacterial activity of Ag+/MAF-7 nanocomposites against Enterococcus faecalis Ag+/MAF-7纳米复合材料对粪肠球菌的抑菌活性研究

4区物理与天体物理

AIP Advances Pub Date : 2024-11-01 DOI: 10.1063/5.0223464

Liu Xiao-bin, Xiaohua Dai, Li Li, Jing Shen, Wei Li, Changyi Li

引用次数: 2

Preparation of PDMS permeation membrane by emulsion dilution method and its separation performance for aromatics 乳液稀释法制备PDMS渗透膜及其对芳烃的分离性能

4区物理与天体物理

AIP Advances Pub Date : 2024-11-01 DOI: 10.1063/5.0230396

M. Wang, Fang Ni, Ziling Teng, Zixuan Ge, Qi Liu, Benwei Zhu, Huiyun Liao, Zhong Yao

{"title":"Preparation of PDMS permeation membrane by emulsion dilution method and its separation performance for aromatics","authors":"M. Wang, Fang Ni, Ziling Teng, Zixuan Ge, Qi Liu, Benwei Zhu, Huiyun Liao, Zhong Yao","doi":"10.1063/5.0230396","DOIUrl":"https://doi.org/10.1063/5.0230396","url":null,"abstract":"Natural aroma compounds are a kind of important food additive. Taking bis(2-ethylhexyl) sodium sulfosuccinate (AOT) as the surfactant, water-in-n-heptane emulsions were prepared. Then, the emulsions were adopted as the diluter to prepare polydimethylsiloxane (PDMS) pervaporation membranes using the emulsion templating method (ePDMS), of which the separation layer was controlled by the template action of emulsion drops. The ePDMS membranes were utilized to separate aroma compounds. Field-emission scanning electron microscope (FESEM) analysis revealed that the surface of the ePDMS membrane remained smooth, and white light interferometry confirmed the membrane’s surface smoothness. FESEM cross-sectional analysis exposed the voids left by the evaporation of the emulsion, rendering the separation layer of the ePDMS membrane more porous. Water contact angle measurements demonstrated the hydrophobicity of the ePDMS membrane, which is advantageous for the pervaporation of aromatic compounds. Fourier transform infrared spectrometry analysis confirmed the evaporation and separation of the emulsion, retaining the original chemical properties of the PDMS membrane. In an ethanol–water system, the permeation flux of ethanol in ePDMS membranes prepared with 1 emulsion (Vwater:Vn-heptane = 1:9; mass concentration of AOT of 1.0 mg/ml) is 90.6% higher than that in PDMS membranes, while the separation factor does not change obviously. The separation performance of ePDMS membranes for linalool in water was further studied. Results show that the permeation flux and separation factor of linalool in ePDMS composite membranes at 50 °C are 786 g m−2 h−1 and 17.69, which separately increase by 84.7% and 27.1% compared with those in PDMS membranes. This indicates that adding ethanol exerts a significant synergistic effect on the separation of linalool.","PeriodicalId":7619,"journal":{"name":"AIP Advances","volume":"14 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mesoporous La0.8Sr0.2CoO3/H-COK-12 catalyst synthesized by template method: Highly active for the complete oxidation of CO 模板法合成的介孔La0.8Sr0.2CoO3/H-COK-12催化剂：对CO的完全氧化具有高活性

4区物理与天体物理

AIP Advances Pub Date : 2024-10-01 DOI: 10.1063/5.0229589

Xuefang Wang, Jieming Chen, Chunhui Li, Pan Liu, Xiaoqin Zha

引用次数: 0