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Decrease of serum immunoglobulin M levels in some diabetic patients. 部分糖尿病患者血清免疫球蛋白M水平降低。
Medecine interne Pub Date : 1989-07-01
D Cheţa, G Stoica, N Cheţa, C Dumitrescu, V Michiu, I Mincu
{"title":"Decrease of serum immunoglobulin M levels in some diabetic patients.","authors":"D Cheţa,&nbsp;G Stoica,&nbsp;N Cheţa,&nbsp;C Dumitrescu,&nbsp;V Michiu,&nbsp;I Mincu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Contradictory results have been published on serum immunoglobulin levels in diabetes. Our study population consisted of 26 \"juvenile\" IDDM patients (males/females 14/12, mean age 15.8 +/- 2.4 yrs), 42 \"adult-onset\" IDDM patients (25/17, 45.1 +/- 15.2 yrs), 62 NIDDM patients (27/35, 59.8 +/- 7.7 yrs), 128 controls. IgM has been measured by a highly standardized endpoint radial immunodiffusion. Since age and sex significantly influence serum IgM levels, we calculated Z values using the formula: log (Xobs:Xexp): SDexp, where Xobs is the measured IgM in any individual and Xexp and SDexp are the expected (geometric) mean and standard deviation of the log IgM values for each year of age in both sexes, as previously calculated by orthogonal polynomials from a large population of \"laboratory controls\" (n = 755; 10-70 yrs). These Z values (+/- SD) in juvenile IDDM (-0.442 +/- 0.988) and NIDDM (-0.559 +/- 1.215) were significantly lower (P = 0.035 and P less than 10(-3)) than in \"laboratory controls\" (0 +/- 1). Values in adult IDDM (-0.0225 +/- 1.213; P = 0.24) and in controls (-0.018 +/- 1.04) did not differ significantly from the \"laboratory controls\". The prevalence of diabetes within the four quartiles of the IgM distribution differed significantly from the one expected according to the null hypothesis (chi-square = 42.2; 3df; P less than 10(-4]. This is also applied to juvenile IDDM (P less than 0.05) and NIDDM (P less than 10(-4], but not to adult-onset IDDM. These results suggest that the low IgM levels may partly contribute to the poorly explained increase in susceptibility to infections in some diabetics.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 3","pages":"219-23"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13758680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The antiallergic action of some bioactive maize extracts and their possible effects on the immune response. 几种生物活性玉米提取物的抗过敏作用及其对免疫应答的可能影响。
Medecine interne Pub Date : 1989-07-01
D S Al-George
{"title":"The antiallergic action of some bioactive maize extracts and their possible effects on the immune response.","authors":"D S Al-George","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The paper brings into discussion the utility as a therapeutic agent of the active principle existing in the bioactive concentrated extracts from maize. The antiallergic action of these concentrated extracts was demonstrated both experimentally and clinically. Their therapeutic effect is characterized by a very good tolerance and a remarkable \"retard\" effect (protection for 2 to 8 months). The possibility of an effect on the immune response (immunomodulating effect) is also discussed. The data regarding this research and the discovery patented in 1977 have been discussed in several papers and reports published between 1974 and 1986.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 3","pages":"237-40"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13758536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of thick intimas and of obstructive lesions in the vessels supplying the conduction system of the heart. 心脏传导系统血管中厚内膜和梗阻性病变的患病率。
Medecine interne Pub Date : 1989-07-01
D Velican, G Serban-Pîrîu, C Petrescu, C Velican
{"title":"Prevalence of thick intimas and of obstructive lesions in the vessels supplying the conduction system of the heart.","authors":"D Velican,&nbsp;G Serban-Pîrîu,&nbsp;C Petrescu,&nbsp;C Velican","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study of the prevalence of thick intimas and of obstructive lesions in the vessels supplying the conduction system of the heart (first septal artery, sinus node artery, atrioventricular node artery, posterior descending artery) was carried out on both non-hospitalized and hospitalized subjects. A total of 932 cases aged 6 to 55 years were investigated. The age period of the onset of both intimal thickenings and atherosclerotic plaques, the percent of cases with intimal thickenings and atherosclerotic plaques in successive age groups and the highest value of the intima thickness/media thickness ratio, were recorded. Comparative data are presented between apparently healthy subjects who died of accidental causes and patients of similar age and sex, who died of coronary heart disease. Sudden cardiac death cases are presented showing as the most important lesion the obstruction of the sinus node and atrioventricular node arteries. The results point to a need for a more frequent routine examination of the vessels supplying the conduction tissue of the heart.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 3","pages":"197-208"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13758534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silent myocardial ischemia. II. Pathophysiology, relation to risk factors, treatment. 无症状心肌缺血。2病理生理学，与危险因素的关系，治疗。
Medecine interne Pub Date : 1989-07-01
C Velican, D Sipciu
{"title":"Silent myocardial ischemia. II. Pathophysiology, relation to risk factors, treatment.","authors":"C Velican,&nbsp;D Sipciu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The second part of this selective review on silent myocardial ischemia summarizes major hypotheses, viewpoints, findings and conclusions concerning: (a) the pathophysiology of silent myocardial ischemia; (b) the influence exerted by some risk factors for coronary heart disease in the precipitation of silent myocardial ischemia, particularly smoking and psychosocial stresses; (c) the medical treatment of silent myocardial ischemia, which, in a monitored environment, can produce definite improvements in laboratory tests, evolution of coronary heart disease and survival rates.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 3","pages":"185-95"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13834673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The systemic vasculitides. 全身性血管。
Medecine interne Pub Date : 1989-07-01
S Tănăseanu, S Purice
{"title":"The systemic vasculitides.","authors":"S Tănăseanu,&nbsp;S Purice","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The systemic vasculitides include a heterogenous group of diseases, characterized by inflammatory and necrotic lesions of the vessel walls, with subsequent ischemic changes in different organs. Various factors are incriminated in the vasculitides etiology, despite the fact that, in most of the cases, the etiologic agents are unknown. The pathogenic mechanisms are generally mediated through circulant immune complexes, which induce the inflammatory reaction at the vessel wall site, accompanied by complex immune reactions. A classification of vasculitides should take into account the type of the injured vessel, the elements of the inflammatory infiltrate and the triggering pathogenic mechanisms. The definition and monitoring of the therapeutic regimen are difficult but, generally, the main elements of medication are represented by corticosteroid and cytotoxic drugs.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 3","pages":"167-83"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13834736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advantages of treatment with Reprimun in sarcoidosis. 复明治疗结节病的优点。
Medecine interne Pub Date : 1989-07-01
E Păunescu, C Didilescu, F Mihălţan, S Udrea, A Serbescu, M Dănălache-Dumitrescu, M Smărăndache, M Stoinescu, C Zaharescu, A Petre
{"title":"Advantages of treatment with Reprimun in sarcoidosis.","authors":"E Păunescu,&nbsp;C Didilescu,&nbsp;F Mihălţan,&nbsp;S Udrea,&nbsp;A Serbescu,&nbsp;M Dănălache-Dumitrescu,&nbsp;M Smărăndache,&nbsp;M Stoinescu,&nbsp;C Zaharescu,&nbsp;A Petre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Favourable results were obtained by treatment with Reprimun alone or in association with low doses of Prednisone in 112 patients with sarcoidosis (59% with active sarcoidosis and 33% failures of a previous corticotherapy). Treatments were applied during 3-6 series each one of 6 weeks at intervals of 2 weeks between series. In comparison with the classical corticotherapy, treatment with Reprimun has better results, namely: absence of any major adverse reactions; reduction of the treatment period to 6-12 months (3-6 series); 95% lasting remissions in the sarcoidoses with initial treatment and 78% remissions in the case of failures of a previous corticotherapy.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 3","pages":"225-8"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13758535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical analysis of the current interpretation of immune diseases. Arguments for a more pathological classification. 对当前免疫疾病解释的批判性分析。更病理分类的论据。
Medecine interne Pub Date : 1989-04-01
D Pereţianu, V Lotreanu
{"title":"A critical analysis of the current interpretation of immune diseases. Arguments for a more pathological classification.","authors":"D Pereţianu,&nbsp;V Lotreanu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Based on the new acquisitions of knowledge on the immune network and on the regulating mechanisms of the immune system, the paper presents an original and at the same time a more pathophysiological classification of immune diseases according to: 1. the functionality stage (input--or antigen presentation, central--integrative, and output--effector), and 2. the immune ligand involved (immunoglobulin or Ti complex). From these new concepts it results that the main feature of the immune system reactivity is the antigen recognition. The authors bring arguments in favour of the assertion that immunity--characterized by recognition--is equal with autoimmunity--characterized by autorecognition, i.e., recognition of the self antigens. From this statement it ensues that: 1. an immune disease is a disease of internal regulation of the immune network, i.e., of the relationships between idiotypes and anti-idiotypes, and 2. any immune disease is an autoimmune disease, meaning that the pathogenetic significance of the so-called \"autoimmune diseases\" and of the \"hypersensitivity diseases\" is the same.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 2","pages":"149-62"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13825843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic pancreatitis. Anatomo-clinical and surgical treatment characteristics. 慢性胰腺炎。解剖临床及手术治疗特点。
Medecine interne Pub Date : 1989-04-01
V Grădinaru, T Seicaru, V Filon, L Grădinaru, C Filon
{"title":"Chronic pancreatitis. Anatomo-clinical and surgical treatment characteristics.","authors":"V Grădinaru,&nbsp;T Seicaru,&nbsp;V Filon,&nbsp;L Grădinaru,&nbsp;C Filon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic pancreatitis of biliary origin, often localized in the cephalic region of the gland and etiopathogenetically related to biliary lithiasis whose anatomoclinical evolution is thus complicated, has a good prognosis. Chronic pancreatitis proper, persistent, recurrent calcifying with pancreatic lithiasis and with pseudocysts, more rare in Romania, raises difficulties of diagnosis and of surgical treatment, the prognosis being doubtful. In a group of 321 patients (33.6% males and 66.4% females) with chronic pancreatitis of biliary origin (252 cases) and chronic pancreatitis proper unrelated to biliary diseases (69 cases), indirect surgery--to remove the biliary factor--(291 patients) and direct surgery on the gland for pancreatic decompression or even gland exeresis (30 patients) were performed. The results obtained in the 321 patients after indirect and direct surgery were very good in 52% of the cases, good in 34%, moderate in 8%, failure in 2.5%; the mortality was of 2.9%.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 2","pages":"115-26"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13951762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum calcium and salt restriction in the diet of patients with essential arterial hypertension. 原发性动脉性高血压患者饮食中的血钙盐限制。
Medecine interne Pub Date : 1989-04-01
G Uza, R Vlaicu
{"title":"Serum calcium and salt restriction in the diet of patients with essential arterial hypertension.","authors":"G Uza,&nbsp;R Vlaicu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum concentration of ionic calcium and the effect of dietary salt restriction on serum total calcium was studied in patients with essential arterial hypertension. The concentration of serum ionic calcium was significantly lower than in controls in all the evolutive stages of the disease (p less than 0.005; p less than 0.005; p less than 0.001). During salt restriction serum total calcium rises significantly (p less than 0.005) as compared with the values found under a salt containing diet. It was suggested that increased chronic ingestion of sodium or restriction of dietary salt produces alterations in Na-Ca exchanges across semipermeable membrane of the smooth muscle.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 2","pages":"93-7"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13951765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silent myocardial ischemia. 无症状心肌缺血。
Medecine interne Pub Date : 1989-04-01
C Velican, D Sipciu
{"title":"Silent myocardial ischemia.","authors":"C Velican,&nbsp;D Sipciu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Encouraging gains have been made during the last decade toward the identification of silent myocardial ischemia as a clinical form of coronary heart disease and also as its earliest and most common manifestation. Many efforts have also been made in elucidating the incidence, pathogenesis, pathophysiology, as well as the specificity of laboratory tests and the relation to risk factors and to symptomatic ischemic episodes. Once thought to be an unusual phenomenon, largely confined to anecdotal reports, silent myocardial ischemia is now recognized to be a common occurrence in the middle-aged and elderly people. The first part of this selective review summarizes major findings and conclusions concerning: (a) the identification of silent myocardial ischemia as the earliest form of coronary heart disease; (b) the selection of patients; (c) the particular feature of silent myocardial ischemia pathogenesis.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 2","pages":"79-91"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13825844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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