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Controversies and certitudes on the upper digestive hemorrhage through rupture of esophageal varices. II. The therapy of portal hypertension and of variceal bleeding. 食管静脉曲张破裂致上消化道出血的争议与确定性。2门静脉高压及静脉曲张出血的治疗。
Medecine interne Pub Date : 1988-10-01
M Voiculescu
{"title":"Controversies and certitudes on the upper digestive hemorrhage through rupture of esophageal varices. II. The therapy of portal hypertension and of variceal bleeding.","authors":"M Voiculescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present-day therapy of portal hypertension and of variceal bleeding includes new drugs (propranolol, glypressin, somatostatin, a.o.) and methods of hemostasis (variceal sclerotherapy). This second part of a paper concerned with the upper digestive hemorrhage through rupture of the esophageal varices presents the main drug therapies and other various methods used to decrease the portal pressure, to achieve a direct hemostasis in case of active variceal bleeding and to prevent the rebleedings.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"251-65"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14204016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of the Romanian product Silimarina in the treatment of chronic liver diseases. 使用罗马尼亚产品Silimarina治疗慢性肝病。
Medecine interne Pub Date : 1988-10-01
C Tănăsescu, S Petrea, R Băldescu, E Macarie, C Chiriloiu, S Purice
{"title":"Use of the Romanian product Silimarina in the treatment of chronic liver diseases.","authors":"C Tănăsescu,&nbsp;S Petrea,&nbsp;R Băldescu,&nbsp;E Macarie,&nbsp;C Chiriloiu,&nbsp;S Purice","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Romanian product Silimarina (synonym Legalon) was administered in a randomized double-blind trial, to a group of 180 patients with chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and hepatic cirrhosis (HC). The trial lasted for 40 days. The results showed favourable effects similar with those obtained with other preparations produced by foreign drug industries. The Romanian product proved to have no toxic effect. The authors discuss the present possibilities of estimating the evolution of chronic liver disease.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"311-22"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14204831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasminogen and plasminogen proactivator in liver diseases. 肝疾病中的纤溶酶原和纤溶酶原促活化剂。
Medecine interne Pub Date : 1988-10-01
H P Boyadjian, R N Bakalova
{"title":"Plasminogen and plasminogen proactivator in liver diseases.","authors":"H P Boyadjian,&nbsp;R N Bakalova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The behaviour of plasminogen (PLg) and plasminogen proactivator (PPLg) and some currently employed enzyme parameters were prospectively studied in 1047 subjects, of whom: 748 patients with liver diseases and jaundice; 52 tumor patients and 247 healthy persons. The patients with parenchymal liver diseases showed significantly reduced PLg and PPLg activity in direct relation with the severity and the stage of diseases. In patients with obstructive jaundice the activity of the fibrinolytic enzymes was usually normal, rarely increased. Other parameters such as: ALAT, LAP, G--GT and bilirubin were elevated most often in patients with viral hepatitis as well as in patients with obstructive jaundice. Quick time was found less affected during acute viral hepatitis and acute liver failure. It seems possible to recommend PLg and PPLg as liver function tests in association with the other function tests.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"291-6"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14373477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Campylobacter pylori infection in gastric and duodenal ulcer. 胃和十二指肠溃疡幽门弯曲杆菌感染。
Medecine interne Pub Date : 1988-10-01
V Andreica, N Sască, D Dumitraşcu, A Drăghici, O Pascu, C Sască, V Gorgan, A Ban
{"title":"Campylobacter pylori infection in gastric and duodenal ulcer.","authors":"V Andreica,&nbsp;N Sască,&nbsp;D Dumitraşcu,&nbsp;A Drăghici,&nbsp;O Pascu,&nbsp;C Sască,&nbsp;V Gorgan,&nbsp;A Ban","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The incidence of infection with Campylobacter pylori (CP) in gastric ulcer (GU) and duodenal ulcer (DU) and its correlation with the gastritis lesions associated to the two diseases, was investigated. In GU the incidence of CP infection was 76.3%, close to that in DU (71.4), but different from controls (33.3%). Chronic gastritis associated to gastric or duodenal ulcer is of variable severity, CP infection being the more often encountered the higher the severity of gastritis. Presence of CP was also observed in 75% of the cases associated also with intestinal metaplasia from UG. The diameter of CP-positive GU was significantly increased as compared with that in CP-negative GU. Type I GU was associated with CP infection in 81.8% of the cases. The results obtained allowed the conclusion that in GU and DU the incidence of CP infection is significantly higher as compared with that in controls but the pathogenetic relationship ulcer-bacterium is not yet elucidated.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"297-303"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14373479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum level of parathyroid hormone in certain rheumatic diseases. 某些风湿病的甲状旁腺激素血清水平。
Medecine interne Pub Date : 1988-10-01
K Bernacka, S Sierakowski, B Lewandowski, J Polakow, K Tytman
{"title":"Serum level of parathyroid hormone in certain rheumatic diseases.","authors":"K Bernacka,&nbsp;S Sierakowski,&nbsp;B Lewandowski,&nbsp;J Polakow,&nbsp;K Tytman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mechanism of joint destruction in rheumatic diseases is a complex and not fully known phenomenon in which many factors probably take part. The hormones which regulate the bone metabolism may be engaged in this process. In this study the serum level of the parathyroid hormone was correlated with the degree of joint destruction observed in rheumatoid arthritis, ankylosing spondylitis and osteoarthritis. Besides the degree of joint changes (radiologic aspects) the extension of the pathological process and duration of disease were also considered and the serum and urine level of calcium and phosphorus was analyzed. Similar patterns of the parameter investigated were observed in the rheumatic diseases studied and in healthy persons.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"273-8"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14396371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma fibronectin level in patients with connective tissue diseases. 结缔组织疾病患者血浆纤维连接蛋白水平
Medecine interne Pub Date : 1988-10-01
V Ciobanu, D Popescu, R Bălună, I Belascu, D Barac, R Tarnavschi, M Caralicea
{"title":"Plasma fibronectin level in patients with connective tissue diseases.","authors":"V Ciobanu,&nbsp;D Popescu,&nbsp;R Bălună,&nbsp;I Belascu,&nbsp;D Barac,&nbsp;R Tarnavschi,&nbsp;M Caralicea","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The level of plasma fibronectin (Fn) was studied in 40 patients with connective tissue diseases. Fn concentration was found increased in patients with rheumatoid arthritis (mean +/- SE, 560 +/- 30 micrograms/ml, p less than 0.01) decreased in patients with mixed connective tissue disease (337 +/- 12 micrograms/ml, p less than 0.05) and was not significantly different from controls in systemic lupus erythematosus, scleroderma, polymyositis. The value of plasma Fn level was found increased in active diseases and decreased in the cases, with presence of cryoprecipitates. The factors which might influence the level of plasma Fn and the possibility of using the changes of Fn concentration in the estimation of the evolution of connective tissue diseases are discussed.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"267-71"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14280262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immediate and delayed results in complicated cancer of the colon. 即时和延迟的结果是复杂的结肠癌。
Medecine interne Pub Date : 1988-07-01
V Păunescu, S T Răgălie, P Simici
{"title":"Immediate and delayed results in complicated cancer of the colon.","authors":"V Păunescu,&nbsp;S T Răgălie,&nbsp;P Simici","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 34 patients operated on in emergency for complications of cancer of the colon (CC) it was found that complications prevailed in stage III of disease and were mainly represented by occlusions which were more frequent in left colon cancer. Radical surgery proved preferable to the palliative one. The mean survival time in months after emergency surgery for complications of CC was longer for right colon localizations and after radical surgery. The survival after 5 years was of 13%.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 3","pages":"221-5"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14317816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversies and certitudes on the upper digestive hemorrhage through rupture of esophageal varices. I. Pathophysiology of portal hypertension and mechanism of rupture of the esophageal varices. 食管静脉曲张破裂致上消化道出血的争议与确定性。门脉高压的病理生理及食管静脉曲张破裂的机制。
Medecine interne Pub Date : 1988-07-01
M Voiculescu
{"title":"Controversies and certitudes on the upper digestive hemorrhage through rupture of esophageal varices. I. Pathophysiology of portal hypertension and mechanism of rupture of the esophageal varices.","authors":"M Voiculescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The frequency and severity of the upper digestive hemorrhage in patients with liver cirrhosis situate it among the main complications of this disease. Many studies have tried to explain the pathogenesis of portal hypertension and the mechanism of rupture of the esophageal varices, emphasizing the role of the venous flow in the rise of portal pressure and that of the local venous factors in the variceal rupture. Based on the recent data in the medical literature and on its own experience, the author presents--in this first part of a review of these problems--the methods of diagnosis and of evaluation of the response to therapy in patients with portal hypertension and with bleeding through rupture of the esophageal varices.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 3","pages":"179-90"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14187794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of the association of calcium channel inhibitors with antagonists of H2 histamine receptors on the gastric secretion in duodenal ulcer patients. 钙通道抑制剂联合H2组胺受体拮抗剂对十二指肠溃疡患者胃分泌的影响。
Medecine interne Pub Date : 1988-07-01
G H Gluhovschi, A Schiller, N Barbu
{"title":"The effect of the association of calcium channel inhibitors with antagonists of H2 histamine receptors on the gastric secretion in duodenal ulcer patients.","authors":"G H Gluhovschi,&nbsp;A Schiller,&nbsp;N Barbu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of the association of verapamil (isoptin), a calcium channel inhibitor, with a cimetidine-like inhibitor of histamine receptors, on stimulated basal gastric secretion was studied in a group of 8 patients with duodenal ulcer. It was observed that by associating verapamil the effect of cimetidine was enhanced in most of the patients. The association of cimetidine with verapamil or other calcium channel inhibitors should be used especially in coronary patients with concomitant duodenal ulcer.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 3","pages":"207-11"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14317815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical studies on plasma antithrombin III using an antiserum prepared in our laboratories. 使用实验室制备的抗血清血浆抗凝血酶III的临床研究。
Medecine interne Pub Date : 1988-07-01
M Cucuianu, A Cristea, A Vonica, I Lascu
{"title":"Clinical studies on plasma antithrombin III using an antiserum prepared in our laboratories.","authors":"M Cucuianu,&nbsp;A Cristea,&nbsp;A Vonica,&nbsp;I Lascu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using an antiserum obtained in rabbits injected with antithrombin III purified in our laboratories, the plasma level of this inhibitor of coagulation was found to be significantly (p less than 0.001) decreased in 8 patients with decompensated cirrhosis of the liver (15.66 mg/dl +/- 2.22) and in 18 nephrotic patients (21.74 mg/dl +/- 1.75). When compared to values noted in 22 normal-weight normolipidemic control subjects (31.54 mg/dl +/- 0.81), the plasma level of antithrombin III was slightly (p less than 0.05) higher in the 18 hyperlipidemic subjects (36.11 mg/dl +/- 1.9). Owing to an extremely wide dispersion of individual values, the mean level of antithrombin III noted in 16 critically ill postoperative patients (28.16 mg/dl +/- 2.98) did not significantly differ from control values, although this protease inhibitor was obviously decreased in those postoperative patients who developed multiple organ failure or disseminated intravascular-coagulation. Among the 11 patients with recurrent venous thrombosis, two subjects with familial deficiency in antithrombin III were detected. The results provide evidence that the antiserum prepared in our laboratories is a useful tool for detecting acquired and inherited antithrombin III deficiencies.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 3","pages":"191-7"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14317813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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