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Anatomoclinical correlations in coronary heart disease: recent advances and unanswered questions. 冠心病的解剖临床相关性:最新进展和未解之谜
Medecine interne Pub Date : 1989-01-01
D Velican, M Iacob
{"title":"Anatomoclinical correlations in coronary heart disease: recent advances and unanswered questions.","authors":"D Velican,&nbsp;M Iacob","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An attempt is made to summarize the recent available information on anatomoclinical correlations in coronary heart disease. The paper focuses attention on: (a) the role in the pathogenesis of unstable angina pectoris, severe arrhythmias and sudden cardiac death, of repeated cycles of formation, disintegration and peripheral embolization of intramural thrombi or of thrombi developed on preexisting atherosclerotic plaques; (b) a still apparently unsolved problem: which comes first, coronary thrombosis or myocardial infarction? (c) the pathophysiological and clinical significance of the \"border zone\" of myocardial infarcts; (d) the importance, in the pathogenesis of coronary heart disease and particularly of sudden cardiac death, of obstructive lesions which occur in the vessels supplying the conduction system of the heart.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 1","pages":"3-14"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13805809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The therapy with cyclosporin A in rheumatoid arthritis. 环孢素A治疗类风湿性关节炎。
Medecine interne Pub Date : 1989-01-01
C Georgescu
{"title":"The therapy with cyclosporin A in rheumatoid arthritis.","authors":"C Georgescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cyclosporin A (CyA) was administered in 6 cases of classical or definite, seropositive rheumatoid arthritis (RA), stages II or III, resistant to the antiinflammatory or nonsteroid therapy, or dependent on high Prednisone doses. An intramuscular daily dose of 1.5 g CyA for a three-week period had good clinical and biologic results. The first signs of improvement, occurring after 14 days of therapy, were manifested by a reduction of the articular inflammation, increase in amplitude of the articular mobility, decrease of the morning stiffness and lowering of the ESR rate. The short-term application of this treatment permits the reintroduction of the nonsteroid drugs and a lowering of the daily dose of Prednisone.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 1","pages":"53-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13805725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The enzymatic deficiencies in lymphocytes of smokers. 吸烟者淋巴细胞酶的缺乏。
Medecine interne Pub Date : 1989-01-01
P Moszczyński, S Slowinski, J Lisiewicz
{"title":"The enzymatic deficiencies in lymphocytes of smokers.","authors":"P Moszczyński,&nbsp;S Slowinski,&nbsp;J Lisiewicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the peripheral blood lymphocytes of 85 men aged 18 to 42 years having smoked cigarettes for 2 to 25 years, the activity of various intracellular enzymes was determined using the semiquantitative histochemical methods. The lymphocytes of people having smoked for less than 10 years were characterized by increased acid phosphatase (AP), leucine aminopeptidase (LAP) and lactic dehydrogenase (LDH) activities whereas that of N-acetyl-beta-D-glucosaminidase (NAG) were lowered. In subjects having smoked for more than 10 years lower acid phosphatase, beta-glucuronidase, N-acetyl-beta-D-glucosaminidase and lactic dehydrogenase activities have been observed. According to the authors' suggestions, the functional lymphocyte abnormalities noted in smokers by numerous investigators may be associated with the intracellular enzymatic deficiencies.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 1","pages":"41-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13887839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful surgical treatment of polycystic liver disease. 多囊性肝病的成功手术治疗。
Medecine interne Pub Date : 1989-01-01
S Berliner, Y Shoenfeld, A Leisser, M Dinzman, I Russo, J Pinkhas
{"title":"Successful surgical treatment of polycystic liver disease.","authors":"S Berliner,&nbsp;Y Shoenfeld,&nbsp;A Leisser,&nbsp;M Dinzman,&nbsp;I Russo,&nbsp;J Pinkhas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A patient with multiple liver cysts, erroneously diagnosed as suffering from echinococcal infection, was treated with mebendazole for four months. When fever appeared, she was treated with antibiotics, but her condition further deteriorated. On laparotomy polycystic liver disease was diagnosed and four liters of pus (due to peptostreptococcal infection) was evacuated from one of the cysts, which was also deroofed. The other cysts were excised and the patient recovered. These unusual events are discussed in the light of the pertinent literature.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 1","pages":"65-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13889338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of thrombosis in the onset, progression and obstructive character of coronary atherosclerotic plaques. 血栓在冠状动脉粥样硬化斑块的发生、进展和梗阻性中的作用。
Medecine interne Pub Date : 1989-01-01
C Velican, D Velican, C Petrescu
{"title":"Role of thrombosis in the onset, progression and obstructive character of coronary atherosclerotic plaques.","authors":"C Velican,&nbsp;D Velican,&nbsp;C Petrescu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was carried out on the role of successive microthrombi incorporation and intramural thrombi formation in the onset, progression and obstructive character of coronary atherosclerotic plaques. The coronary arterial tree of 836 apparently healthy subjects 1 to 50 years old who died of accidental causes was investigated. The onset of coronary atherosclerotic plaques having as precursors thrombi could be detected in 10% of advanced lesions. The left anterior descending artery appeared as the vessel of the coronary arterial tree the most susceptible to plaque development induced by thrombi and to the occurrence of thrombi on preexisting plaques. This occurrence of thrombi on preexisting plaques was recorded in 48% of subjects aged 46 to 50 years and was followed by a severe luminal narrowing in the major coronary arteries.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 1","pages":"33-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13887837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical utility of plasma digoxin measurements. 血浆地高辛测定的临床应用。
Medecine interne Pub Date : 1989-01-01
R Cristodorescu, G Deutsch, S Drăgan
{"title":"Clinical utility of plasma digoxin measurements.","authors":"R Cristodorescu,&nbsp;G Deutsch,&nbsp;S Drăgan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of plasma digoxin concentration (PDC) measurements in 260 patients treated with digitalis lanata preparations (digoxin, lanatoside C, betamethyl-digoxin) allowed the following observations: 1. Owing to an important overlap between \"toxic\" and \"nontoxic\" PDC values, the method has a limited value in the diagnosis of digitalis toxicity. However, in patients with toxicity associated with PDC under 2 ng/ml, it allows identification digitalis sensitivity. 2. A dosage selection based on PDC assessment led to a decrease of digitalis toxicity under 4%. As the method is not widely available, it has to be used in patients with borderline renal function, in aged subjects and in patients with rapid atrial fibrillation who require higher digitalis doses for heart rate control.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"27 1","pages":"25-32"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13887838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of advances in radiologic biliary imaging on the diagnosis of obstructive jaundice. Comparative analysis of two groups of patients hospitalized at a 5-year interval. 胆道影像学进展对梗阻性黄疸诊断的影响。两组患者5年住院时间的比较分析。
Medecine interne Pub Date : 1988-10-01
M Acalovschi, D Dumitraşcu, G Badea, O Pascu, R Badea, M Hotoleanu, E Simo
{"title":"The impact of advances in radiologic biliary imaging on the diagnosis of obstructive jaundice. Comparative analysis of two groups of patients hospitalized at a 5-year interval.","authors":"M Acalovschi,&nbsp;D Dumitraşcu,&nbsp;G Badea,&nbsp;O Pascu,&nbsp;R Badea,&nbsp;M Hotoleanu,&nbsp;E Simo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study evaluates the impact of advances in biliary imaging techniques on the accuracy and rapidity of diagnosis in patients with obstructive jaundice. Two series of patients hospitalized at an interval of 5 years in the same clinic were prospectively analyzed. In both series, the results of ultrasonography (US) and percutaneous transhepatic cholangiography (PTC) were compared with the intraoperative findings. The performances of US in the assessment of ductal dilatation and choledocholithiasis significantly improved during this period. The fine-needle biopsies taken from the solid masses in liver or pancreatic parenchyma under US guidance in the second series of patients contributed to the greater proportion of correct preoperative diagnoses in this group. The number of PTC investigations increased in the second group (p less than 0.001) given the clinicians' confidence in the safety and easy performance of this method. Using both methods, the etiology of biliary obstruction was correctly diagnosed preoperatively in 85.2 per cent of the second series of patients, significantly more frequently than in the first series of patients (62.7 per cent) (p less than 0.05). The mean period in hospital necessary for the diagnosis decreased during the period analyzed from 15.4 +/- 10.8 days to 10.2 +/- 7.8 days (p less than 0.05), a fact with direct impact on the course of disease, and also on the hospital costs.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"279-85"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14204830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pacemaker therapy in a group of 132 patients with sick sinus syndrome--indications and results. 132例病态窦性综合征患者的起搏器治疗——适应症和结果
Medecine interne Pub Date : 1988-10-01
M Vintilă, R Făgărăşanu, R Luca
{"title":"Pacemaker therapy in a group of 132 patients with sick sinus syndrome--indications and results.","authors":"M Vintilă,&nbsp;R Făgărăşanu,&nbsp;R Luca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Of the 132 patients with sick sinus syndrome (SSS) studied, 62 (47.8%) required pacemaker implantation thus showing the severity of the arrhythmic syndrome. The pacing requirement varied according to the SSS arrhythmic form with a maximum in the tachy-brady syndrome (53.5%) and in major sinus bradyarrhythmias--S--A block and sinus arrest (54.1%). The presence of syncopes (in 32.6% of the patients) represented the main indication for pacing. Very good results (100% efficiency) were obtained in the bradycardic forms. In the tachy-brady syndrome electrostimulation solved completely the bradycardic component and was able, alone, to suppress the tachyarrhythmic episodes in 18.4% of the patients. By associating pacing with antiarrhythmic drugs favourable results were obtained in an additional proportion of 65.8% of the patients. In the rest of 15.8% of the cases the results were partial.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"305-9"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14373480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chest-wall and transesophageal stimulation in the functional evaluation of patients with permanent pacemakers. 胸壁和经食管刺激在永久性起搏器患者功能评估中的应用。
Medecine interne Pub Date : 1988-10-01
S Cotoi, E Caraşca, A Incze
{"title":"Chest-wall and transesophageal stimulation in the functional evaluation of patients with permanent pacemakers.","authors":"S Cotoi,&nbsp;E Caraşca,&nbsp;A Incze","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For the functional estimation of artificial pacemakers, we have used two techniques: chest-wall stimulation and transesophageal stimulation. Transesophageal stimulation was always effective in inhibiting the generator, and it was used when chest-wall stimulation was ineffective. These two tests can be easily performed and are of remarkable usefulness in the follow-up of patients with permanent pacemaker.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"323-7"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14373482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver cirrhosis and hepatocellular carcinoma after prolonged exposure to TNT: causal relationship or mere coincidence? 长期暴露于TNT后肝硬化和肝细胞癌:因果关系还是巧合?
Medecine interne Pub Date : 1988-10-01
D Garfinkel, Y Sidi, M Steier, A Rothem, R Marilus, A Atsmon, J Pinkhas
{"title":"Liver cirrhosis and hepatocellular carcinoma after prolonged exposure to TNT: causal relationship or mere coincidence?","authors":"D Garfinkel,&nbsp;Y Sidi,&nbsp;M Steier,&nbsp;A Rothem,&nbsp;R Marilus,&nbsp;A Atsmon,&nbsp;J Pinkhas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Macronodular liver cirrhosis and hepatocellular carcinoma were found in a 61-year-old male who had been exposed for 35 years to Trinitrotoluene (TNT). The question whether TNT had induced these pathological processes is raised.</p>","PeriodicalId":76129,"journal":{"name":"Medecine interne","volume":"26 4","pages":"287-90"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13990060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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