The effect of the association of calcium channel inhibitors with antagonists of H2 histamine receptors on the gastric secretion in duodenal ulcer patients.

The effect of the association of verapamil (isoptin), a calcium channel inhibitor, with a cimetidine-like inhibitor of histamine receptors, on stimulated basal gastric secretion was studied in a group of 8 patients with duodenal ulcer. It was observed that by associating verapamil the effect of cimetidine was enhanced in most of the patients. The association of cimetidine with verapamil or other calcium channel inhibitors should be used especially in coronary patients with concomitant duodenal ulcer.