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Materia medica Polona. Polish journal of medicine and pharmacy最新文献

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Changes in liver biochemical tests at diagnosis and after propylthiouracil therapy for hyperthyroidism. 甲状腺机能亢进诊断时和丙硫脲嘧啶治疗后肝脏生化试验的变化。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-07-01
A Gürlek, V Cobankara, M Bayraktar
{"title":"Changes in liver biochemical tests at diagnosis and after propylthiouracil therapy for hyperthyroidism.","authors":"A Gürlek,&nbsp;V Cobankara,&nbsp;M Bayraktar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We investigated liver biochemical tests at diagnosis and after a 6-week treatment with propylthiouracil (PTU) in forty-three patients with hyperthyroidism. At diagnosis, 60.5% of the patients had at least one liver biochemical abnormality. Elevation of alkaline phosphatase (ALP), alanine (ALT) and aspartate (AST) aminotransferase, and gamma-glutamyl transpeptidase (GGT) levels were observed in 19 (44.2%). 10 (23.3%), 6 (14%) and 6 (14%) of the patients, respectively. After 6-week treatment with PTU, seven (16.3%) patients developed subclinical hepatotoxicity, as evidenced by elevation of ALT levels. Age, sex, type of goiter (either diffuse or multinodular) and presence or absence of abnormal liver biochemical tests at diagnosis were not significant in determining the possibility of the development of hepatotoxicity. These data suggest that liver biochemical test abnormalities are frequently observed in hyperthyroid. However, presence or absence of these abnormalities do not indicate to the development of subclinical hepatoxicity during 6-week PTU therapy.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 3","pages":"103-6"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20114941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effective palliation for advanced esophageal cancer using intralumenal irradiation. 腔内照射对晚期食管癌的有效缓解。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-07-01
R Makarewicz, W Czechowicz, R Kabacińska
{"title":"Effective palliation for advanced esophageal cancer using intralumenal irradiation.","authors":"R Makarewicz,&nbsp;W Czechowicz,&nbsp;R Kabacińska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Palliative treatment by intracavitary irradiation alone has been used in 15 patients with advanced carcinoma of the esophagus. Most of them had already failed other palliative modalities including external irradiation, chemoradiotherapy, laserotherapy and dilatation. Intracavitary irradiation was carried out with a microSelectron HDR afterloading device and usually 22.5 Gy was given in three fractions repeated weekly. Up to three month after treatment, complete endoscopic regression was seen in 1 patient, partial endoscopic regression in 8 patients, no response in one and progressive disease in 5 patients. The median survival time is 6.2 months. There were not severe complications. We conclude that high dose rate intracavitary irradiation is a useful palliative modality in patients with advanced or recurrent esophageal cancer.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 3","pages":"107-110"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20113666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integral curves and the variational principle of intermittent normal conduction in the tachycardia-dependent right bundle branch block. 心动过速依赖性右束支阻滞间歇正常传导的积分曲线和变分原理。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
K Izumi
{"title":"Integral curves and the variational principle of intermittent normal conduction in the tachycardia-dependent right bundle branch block.","authors":"K Izumi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electrocardiographic (ECG) tracings of atrial fibrillation with the tachycardia-dependent right bundle branch block (RBBB) in a patient under digitalis therapy are presented, in which supernormal phase of intraventricular conduction was well-documented. The development of long intervals terminated by a normally conducted beat was attributed to the occurrence of concealed atrio-ventricular (A-V) conduction of atrial fibrillation impulse during the supernormal phase. The ventricular interval caused by a normally conducted beat (x seconds) in the interval of 1.01-1.50 seconds (s) was transformable into from of In(x + a) + l, where parameter a = 0, 0.04, 8.08 and 0.16. The vector differential equation dy/dx = ln (x + a) + 1l which is piecewise continuous and integrable, was assumed to describe the process of optimal control. This is equivalent to the problem of finding Green's function of the region, i.e. to solving, the Dirichlet problem for the region. The solution curves given by y = (x + a) ln(x + a) + l can be interpreted as distributions. This is the first study to apply integral curves and the variational principle to mathematical modelling of normal A-V conduction in tachycardia-dependent RBBB with atrial fibrillation. Furthermore, this is the first topological study to derive some definite properties of states of the phase space of a dynamical system. There are structurally stable vector field points so-called attractors on a differential manifold or surface. The optimal control is characterized by the fixed point property. In general, mathematical modelling may be applicable to the tachycardia-dependent RBBB when the cycle lengths caused by normally conducted beats range from 1.00 to 1.50 s as a feasible region. A solution of Dirichlet problem in the region was found. It was derived from this study that the normally conducted beats appeared as period doubling of 0.38-0.59 s, i.e. the interval of supernormal phase.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"57-63"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mysterious prion diseases--a historical perspective. 神秘的朊病毒疾病——一个历史的视角。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
H Urich
{"title":"The mysterious prion diseases--a historical perspective.","authors":"H Urich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The spongiform encephalopathies are a group of diseases sharing a common pathology and affecting both humans and animals. The human diseases include both sporadic and familiar disorders. Creutzefeld-Jakob disease and kuru are sporadic, familial Creutzfeld-Jakob, fatal familial insomnia and the Gerstmann-Sträussler-Scheinker syndrome are genetic and inherited as autosomal dominants. The hallmark of these diseases is the presence of abnormal forms of a membrane protein called prion, particularly abundant in the brain. Transmission of these diseases has been documented from humans to humans, from humans to animals and, more controversially, from animals to humans. Many questions in the aetiology and pathogenesis remain unanswered.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"39-41"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute alcoholic pancreatitis does not lead to complete recovery. 急性酒精性胰腺炎不能完全康复。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
E Małecka-Panas, A Juszyński, E Wilamski
{"title":"Acute alcoholic pancreatitis does not lead to complete recovery.","authors":"E Małecka-Panas,&nbsp;A Juszyński,&nbsp;E Wilamski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the study was to determine the late outcome of acute alcoholic pancreatitis (a.a.p.), as assessed by clinical examination, functional tests and imaging techniques. 47 patients, 4-7 years after a.a.p. of moderate clinical course underwent a secretin-cerulein test (SCT), glucose tolerance test (GTT), ultrasound (US) and computed tomography (CT) of the pancreas. Exocrine pancreatic function impairment was found in 63.8%, glucose impaired tolerance (GIT)-in 12.8% overt diabetes-in 17.0%. GIT and overt diabetes were found only in patients with severe exocrine function impairment requiring enzyme supplementation. Ultrasound revealed pancreatic structure abnormalities mostly pancreas enlargement, pseudocysts, structural heterogeneity, contour irregularity, Wirsung duct dilatation and calcifications in 36.21% patients and computed tomography in 44.7%. Out of 16 patients with concomittant pathology found in SCT, US and CT 14 (29.8%) suffered from attacks of abdominal pain. We conclude that, as reflected by clinical symptoms, exo- and endocrine pancreatic function tests and imaging techniques, in about one third of patients even a moderate attack of a.a.p may lead to chronic pancreatitis. We suggest that patients after acute alcoholic pancreatitis should undergo prospective evaluation including both the function and structure estimation in order to early recognize and treat the revealed changes.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"64-8"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infective endocarditis--changes in the microbiological profile. 感染性心内膜炎——微生物谱的变化。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
B Dudkiewicz, J Mikucki, S Ostrowski
{"title":"Infective endocarditis--changes in the microbiological profile.","authors":"B Dudkiewicz,&nbsp;J Mikucki,&nbsp;S Ostrowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The clinical material from 120 patients, with clinical diagnosis of infectious endocarditis (IE) (65 patients with IE on native valves and 55 patients with IE on artificial valves, i.e. mechanical or biological prosthesis) treated during the period of 1986-1994 was investigated. Sixty positive cultures were obtained from the valves and 40 positive cultures from the blood, which accounted for 76% and 60% of the confirmed IE cases, respectively. Bacteriological confirmation of IE was obtained in 91 (75.8%) patients, 80.2% of the isolated microorganisms being gram-positive bacteria, 17.6% gram-negative, and 2.2%-fungi. The most frequently isolated bacteriawere coagulase-negative staphylococci. They accounted for 40.5% of infections in the IE patients on native valves, and for 63.3% in those with artificial valves. Streptococci were isolated from 11.8% of the patients with IE on native valves and from only 2% of cases of IE on artificial valves. The multiresistant strains were most frequently isolated from the patients with IE on artificial valves.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of quinolinic acid administered during pregnancy on liver cells of rat offspring (ultrastructural investigation). 妊娠期间给予喹啉酸对大鼠子代肝细胞的影响(超微结构观察)。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
M Beskid, H Dybkowska-Klos, W Kocjasz, Z Rózycka
{"title":"The effect of quinolinic acid administered during pregnancy on liver cells of rat offspring (ultrastructural investigation).","authors":"M Beskid,&nbsp;H Dybkowska-Klos,&nbsp;W Kocjasz,&nbsp;Z Rózycka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Liver cells of rat's offspring were ultrastructurally examined after administering quinolinic acid to mothers intraperitoneally in a dose of 60 mmol or 100 mmol, once daily, throughout the entire gestation period. Liver tissue specimens were taken on day 5 after birth from experimental and control animals. Administration of quinolinic acid resulted in a marked proliferation of smooth elements of endoplasmic reticulum in liver cells of their offspring, which indicated microsomal enzymatic induction. Simultaneously, injuries of liver cells of varying intensity were observed, which were dose-dependent on quinolinic acid administration, the injured cells being more frequent at higher doses of the drug.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"42-8"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aneurysm of the posterior tibial vein. A case report. 胫骨后静脉的动脉瘤。一份病例报告。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
S Otto, G Religa, J A Polański
{"title":"Aneurysm of the posterior tibial vein. A case report.","authors":"S Otto,&nbsp;G Religa,&nbsp;J A Polański","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of venous aneurysm of the posterior tibial vein secondary to stab injury that resulted in A-V fistula in a 23 year male patient is presented. Popliteal venous aneurysm both of congenital as well as of acquired origin is a rare vascular entity that may be a potential source of thromboembolism. Thus surgery is usually required. In the presented case no history of pulmonary embolism was present. The aneurysm was treated surgically with good postoperative results.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"71-2"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum PSA levels at 6 month after surgery, TURP or Doxazosin therapy for BPH. 前列腺增生手术、TURP或Doxazosin治疗后6个月的血清PSA水平。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
S Dutkiewicz, K Stepień
{"title":"Serum PSA levels at 6 month after surgery, TURP or Doxazosin therapy for BPH.","authors":"S Dutkiewicz,&nbsp;K Stepień","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 180 men with BPH, aged 50-84 (mean 65) yrs. PSA levels were determined before and at 6 mo. after either transvesical removal of the adenoma (TRA, Group 1, n = 65), TURP (Group 2, n = 51) or after 6 mo. Doxazosin therapy (Group 3, n = 64). Fine-needle biopsy, performed when the baseline PSA exceeded 10 ng/ml, as well as pathologic examination of specimens taken during TRA and TURP confirmed BPH in all cases. After all modes of treatment the decrease in PSA values was largest in Group 1 and smallest in Group 3. This probably reflects the degree of completeness of adenoma removal. However, all therapeutic modalities including Doxazosin pharmacotherapy ensured PSA normalization, despite the persistence of the adenoma.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"69-70"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolapsed simple ureterocele in a ten-year-old girl. 10岁女童单纯性输尿管囊肿脱垂。
Materia medica Polona. Polish journal of medicine and pharmacy Pub Date : 1996-04-01
A S Ozdamar, E Y Gultekin, A Gokalp
{"title":"Prolapsed simple ureterocele in a ten-year-old girl.","authors":"A S Ozdamar,&nbsp;E Y Gultekin,&nbsp;A Gokalp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A ten-year-old girl with a prolapsing ureterocele during micturation has been presented. Even though it is rarely seen, prolapsed ureterocele should be taken into consideration in the differential diagnosis of the interlabial masses in girls.</p>","PeriodicalId":76124,"journal":{"name":"Materia medica Polona. Polish journal of medicine and pharmacy","volume":"28 2","pages":"73-4"},"PeriodicalIF":0.0,"publicationDate":"1996-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20039606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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