Alexandria Journal of Medicine最新文献_第4页

Should we follow the guidelines on vitamin B12 deficiency and diabetes? A retrospective analysis of data from middle eastern population 我们应该遵循维生素B12缺乏和糖尿病的指南吗?中东人口资料的回顾性分析

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Alexandria Journal of Medicine Pub Date : 2023-05-22 DOI: 10.1080/20905068.2023.2209410

A. Swidan, M. Ahmed

引用次数: 0

Lidocaine 10% sprays versus oral diclofenac sodium for pain relief in women undergoing hysterosalpingography for infertility workup: A randomized clinical trial 10%利多卡因喷雾剂与口服双氯芬酸钠缓解不孕症子宫输卵管造影妇女的疼痛:一项随机临床试验

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Alexandria Journal of Medicine Pub Date : 2023-04-25 DOI: 10.1080/20905068.2023.2206715

A. Idowu, A. Fehintola, Mopelola c Ashaleye, O. Ayegbusi, A. D. Ajiboye, O. Badejoko, K. Ajenifuja, M. O. Loto

引用次数: 0

Assessment of the knowledge of basic first aid of acute poisoning among medical students at Imam Abdulrahman bin Faisal University, KSA 肯尼亚伊玛目阿卜杜勒拉赫曼·本·费萨尔大学医学生急性中毒基本急救知识评估

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Alexandria Journal of Medicine Pub Date : 2023-03-23 DOI: 10.1080/20905068.2023.2187538

Mohamed Gamaleldin Elsakkar, Rana Abdullah Alabdulhadi, Ghader Mohammed Alkazzaz, Zuhur Jafar Al-Qteeb, Md. Ashraful Islam

引用次数: 0

Assessment of feasibility of abdominal mesh vaginorectopexy in the repair of multiple pelvic organ prolapse 腹部网状阴道直肠固定术治疗盆腔多器官脱垂的可行性评价

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Alexandria Journal of Medicine Pub Date : 2023-03-15 DOI: 10.1080/20905068.2023.2183455

Mohamed Zakareya, W. Elshazly, Ahmed Moaz, B. Hegazy

引用次数: 0

Ocular abnormalities among patients with Down syndrome 唐氏综合征患者的眼部异常

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Alexandria Journal of Medicine Pub Date : 2022-12-31 DOI: 10.1080/20905068.2023.2212531

K. Awad, Y. El-Nahhal

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Identification of serum micro-RNAs of early knee osteoarthritis in a cohort of Egyptian patients 埃及患者队列中早期膝骨关节炎血清微小RNA的鉴定

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Alexandria Journal of Medicine Pub Date : 2022-12-09 DOI: 10.1080/20905068.2022.2140987

A. Abou-Raya, M. Rizk, E. Abdelghani, N. Abdelmegid

引用次数: 1

Nonalcoholic fatty liver disease is associated with early left ventricular diastolic dysfunction in patients with type 2 diabeteS 非酒精性脂肪肝与2型糖尿病患者早期左心室舒张功能障碍相关

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Alexandria Journal of Medicine Pub Date : 2022-10-25 DOI: 10.1080/20905068.2022.2132603

Walaa Sheba, E. Morsy, Salah Altahan, Mona W. Ayaad, S. A. Lashen

{"title":"Nonalcoholic fatty liver disease is associated with early left ventricular diastolic dysfunction in patients with type 2 diabeteS","authors":"Walaa Sheba, E. Morsy, Salah Altahan, Mona W. Ayaad, S. A. Lashen","doi":"10.1080/20905068.2022.2132603","DOIUrl":"https://doi.org/10.1080/20905068.2022.2132603","url":null,"abstract":"ABSTRACT Background Left ventricular diastolic dysfunction (LVDD) is the first preclinical sign of diabetic cardiomyopathy. Nonalcoholic fatty liver disease (NAFLD) is linked to morbidity and mortality in Type 2 diabetes mellitus (T2DM) and increases the chance of developing cardiovascular disease, the primary cause of death. Aim This work aimed to identify the association of LVDD and NAFLD in T2DM. Methods We recruited 40 patients with T2DM (20 with NAFLD and 20 without NAFLD). Laboratory investigations and abdominal ultrasonography were carried out. The degree of hepatic steatosis was measured by the hepatorenal index (HRI). The LVDD was assessed by echocardiography and tissue doppler imaging. Results The Left atrial volume, left ventricular volume index, and left ventricle filling pressure index (E/é) were higher in the NAFLD group (P < 0.05). The E/é index was correlated with HRI and gamma-glutamyl transpeptidase (P < 0.05). Hepatic steatosis by HRI was the only independent variable associated with LVDD. Conclusion NAFLD is associated and correlated with an increased risk of left ventricular diastolic dysfunction in patients with T2DM regardless of ventricular systolic function.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42891864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mechanistic role of epigallocatechin-3-gallate in regulation of the antioxidant markers in ethanol induced liver damage in mice 表没食子儿茶素-3-没食子酸盐在乙醇诱导的小鼠肝损伤中调节抗氧化标志物的机制作用

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Alexandria Journal of Medicine Pub Date : 2022-10-22 DOI: 10.1080/20905068.2022.2132604

Mujinya Pastori, Kembambazi Stella, Wandera Allan, Robert Siida, Jackie Rachael Mpumbya, Adomi Mbina Solomon, D. Okumu, Dominic Terkimbi Swase, Kyobe Ronald Kimanje, K. Eliah, Ondari Erick Nyakundi, Niwamanya Boaz

{"title":"Mechanistic role of epigallocatechin-3-gallate in regulation of the antioxidant markers in ethanol induced liver damage in mice","authors":"Mujinya Pastori, Kembambazi Stella, Wandera Allan, Robert Siida, Jackie Rachael Mpumbya, Adomi Mbina Solomon, D. Okumu, Dominic Terkimbi Swase, Kyobe Ronald Kimanje, K. Eliah, Ondari Erick Nyakundi, Niwamanya Boaz","doi":"10.1080/20905068.2022.2132604","DOIUrl":"https://doi.org/10.1080/20905068.2022.2132604","url":null,"abstract":"ABSTRACT Background: Failure of endogenous antioxidant system to eliminate high levels of ROS results to oxidative stress, consequently leading to liver damage. Excessive alcohol consumption leads to liver damage due to ROS generation, thus regarded as the leading causes of death worldwide, suggesting great need for use of exogenous antioxidants like epigallocatechin-3-gallate (EGCG), to avert liver damage. However, underlying EGCG mechanisms remains elusive.Aim of the work: This study focused on mechanistic role of EGCG in regulation of antioxidant marker activities during ethanol induced liver damage.Materials and Methods: 20 male Swiss Albino mice were divided into four groups and treated with different dosage. ALT, AST and total proteins were determined as indicators of liver damage. MDA and protein carbonyls were measured as oxidative stress markers. Activities of SOD and CAT were determined. SOD-2 and CAT differential gene expression were also determined. Liver histology analysis by H&E staining. All the experiments were run in duplicates. ANOVA was used to analyzes data using Tukey’s multiple comparison tests and results considered statistically significant if p ≤ 0.05 at 95% confidence level. Results: Findings revealed that chronic consumption of ethanol leads to liver damage through increased levels of serum ALT and AST, MDA, protein carbonyls and remarkable diffuse lipid droplets and decreased enzyme activity of SOD and CAT. EGCG increased activity of SOD and CAT and SOD-2 expression and did not affect CAT expression. Conclusion: In summary, ethanol induces liver damage, and administration of EGCG increases antioxidant system expression, suggesting its role in regulating their activities, defensive of oxidative stress through various pathways.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44608267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of anthropometric profile in obese children: risk factors & eating disorder 肥胖儿童的人体测量特征评估:危险因素与饮食失调

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Alexandria Journal of Medicine Pub Date : 2022-08-11 DOI: 10.1080/20905068.2022.2103884

R. Ben Othman, E. Talbi, R. Mizouri, N. Ben Amor, A. Gamoudi, Ines Lahmer, O. Berriche, F. Mahjoub, Henda Jamoussi

{"title":"Evaluation of anthropometric profile in obese children: risk factors & eating disorder","authors":"R. Ben Othman, E. Talbi, R. Mizouri, N. Ben Amor, A. Gamoudi, Ines Lahmer, O. Berriche, F. Mahjoub, Henda Jamoussi","doi":"10.1080/20905068.2022.2103884","DOIUrl":"https://doi.org/10.1080/20905068.2022.2103884","url":null,"abstract":"ABSTRACT Background Nutrition is the most important environmental factor in the development and progression of childhood obesity, which is very common in Arabic countries. Aim Study of associated factors and nutritional status of childhood obesity. Methods This was a comparative study of 50 obese children recruited from the outpatient department of the children’s hospital, as well as 35 controls. The two groups were matched for gender and age. Anthropometric measurements have been undertaken. A food history as well as a frequency of consumption of certain foods were performed. Results There were 32 girls in obese group. Breastfeeding was more common in the control group (p = 0.04) but gestational diabetes, pregnancy weight gain, and macrosomia were greater in obese people (p = 0.002; 0.0001 and 0.004) . Food diversification was early in the obese (p = 0.05). Mobile phone use was higher among obese people (p = 0.001) but time spent watching TV was not significant (p = 0.06). There was no significant difference between the two groups regarding: the number of hours of sleep, and the practice of sport. Sedentary lifestyle concerned 34% of obese versus 8.57% controls. Intense physical activity was practiced by 14.29% of the controls against any obese (p = 0.0001). The anthropometric parameters of the parents of the obese were more important than those of the controls. The average BMI of the obese was 25.63 Kg/m2.The frequency of consumption showed a more caloric and fat diet in obese group.The diet of the controls was richer in proteins and lipids but better distributed in MUFA and PUFA, but the energy intake of the obese was significantly higher (10,612 versus 4097 Kcal/d). The mineral and vitamin intakes of the obese were correct. Conclusions The fight against childhood obesity essentially involves prevention and promotion of a good lifestyle.","PeriodicalId":7611,"journal":{"name":"Alexandria Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46560488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical expression of CD8, CTLA4, and PD-L1 in NSCLC of smokers versus non smokers and its effect on prognosis CD8、CTLA4和PD-L1在吸烟者与非吸烟者非小细胞肺癌中的免疫组织化学表达及其对预后的影响

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Alexandria Journal of Medicine Pub Date : 2022-08-02 DOI: 10.1080/20905068.2022.2101083

R. Elsaka, S. Helal, A. Abdelhady, Nourhan. M. Kolaib, Manal. A. Soliman

引用次数: 0