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Precipitation of type-I (upgrading) reaction in leprosy by skin testing with antigen and irritants. 通过抗原和刺激物皮肤试验测定麻风病i型(升级)反应。
Leprosy in India Pub Date : 1983-04-01
B Malhotra, K D Das, M A Tutakne, S K Aggarwal
{"title":"Precipitation of type-I (upgrading) reaction in leprosy by skin testing with antigen and irritants.","authors":"B Malhotra,&nbsp;K D Das,&nbsp;M A Tutakne,&nbsp;S K Aggarwal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty patients of various types of leprosy were skin tested with lepromin, PPD and DNCB to assess their immunological status. Two of the twenty (18 BT; 2 BB) patients belonging to BT type developed signs of acute neuritis of sudden onset about 4 weeks after the test with DNCB, lepromin and PPD. The patients were on DDS therapy already for the last 3-4 months. Presumably DNCB, PPD or lepromin testing had precipitated the reaction. A suggestion is made that lepromin a lower concentration could be used initially and if it gives negative reaction, a higher concentration may be used as in case of PPD testing, particularly in TT and BT cases already put on treatment.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"305-9"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17687790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tarsal disintegration (T.D.) in leprosy. 麻风病的跗骨解体。
Leprosy in India Pub Date : 1983-04-01
V N Kulkarni, J M Mehta
{"title":"Tarsal disintegration (T.D.) in leprosy.","authors":"V N Kulkarni,&nbsp;J M Mehta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tarsal Disintegration in leprosy has been a challenge as far as its prevention is concerned. It is, no doubt, a complex and less understood phenomenon influenced by many factors. In this study made at Dr. Bandorawalla Leprosy Hospital, Kondhawa, factors like insensitivity, loss of protective reflex, infection, lepromatous infiltration of bones etc. have been taken into consideration, but, more emphasis is laid on the biomechanical factors (i.e. altered muscle pulls due to muscular paralysis resulting in imbalance) and the resulting change in weight bearing areas and weight transmission lines. Sixteen cases of neuropathic feet were examined clinically and radiologically. All were burnt out cases of tuberculoid and borderline tuberculoid variety excepting one which was active being of lepromatous variety. Tracings made from actual radiographs of the patients were studied. It was found that apart from insensitivity, biomechanical factors play a lot of importance in accentuating the process of T.D. The changes are predominantly seen in Tuberculoid variety of Leprosy. Attempts have been made to understand this process more closely by drawing conclusions based on the kinetic and kinematic analysis of the normal human foot and comparing it with neuropathic feet.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"338-70"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17687577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinico-pathological study of primary neuritic leprosy. 原发性神经性麻风病的临床病理研究。
Leprosy in India Pub Date : 1983-04-01
V K Pannikar, S Arunthathi, C J Chacko, E P Fritschi
{"title":"A clinico-pathological study of primary neuritic leprosy.","authors":"V K Pannikar,&nbsp;S Arunthathi,&nbsp;C J Chacko,&nbsp;E P Fritschi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Normally neural involvement in leprosy is an ascending neuritis from the nerve involvement in the dermal lesions. However, in some cases neural involvement is seen in the absence of any dermal lesions. In some of these pure neuritic cases, dermal lesions appear sometime later. It is, therefore, more appropriate to designate such cases as 'primary neuritic' cases. This study is aimed at diagnosing primary neuritic leprosy among patients presenting with only neuritic symptoms. An attempt is also made to classify primary neuritic leprosy on a clinical and histopathological basis. During the period 1979-80, 30 patients reported to the out patient department of Schieffelin Leprosy Research and Training Centre, Karigiri with complaints of neuritic origin. In addition to clinical examination and routine skin smears, investigations such as skin, nerve and nasal biopsies, nerve conduction velocity and lepromin testing were carried out where feasible. 17 of these patients were diagnosed as primary neuritic leprosy and in 7 patients other neurological conditions were diagnosed. The remaining 6 patients were kept under observation and have not shown evidence of leprosy during a two year period of following-up. It is interesting that 4 of the 17 primary neuritic cases developed patches during follow-up period of two years. In the final analysis 7 patients (41.2%) were classified into the lepromatous group and 10 patients (58.8%) in the non-lepromatous group (Table-6). This classification will have a bearing on duration of treatment and for their subsequent release from control.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"212-21"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17687787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New developments in the chemotherapy of leprosy. 麻风病化疗的新进展。
Leprosy in India Pub Date : 1983-01-01
E Freerksen
{"title":"New developments in the chemotherapy of leprosy.","authors":"E Freerksen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"122-32"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17409131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Langerhans cell and leprosy. 朗格汉斯细胞和麻风病。
Leprosy in India Pub Date : 1983-01-01
N K Mathur, H N Mangal, D Mathur, R S Bedwal, R S Mathur
{"title":"Langerhans cell and leprosy.","authors":"N K Mathur,&nbsp;H N Mangal,&nbsp;D Mathur,&nbsp;R S Bedwal,&nbsp;R S Mathur","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Langerhans cell population was counted in 44 patients of different types of leprosy and compared with 12 normal volunteers. Significant reduction in LC count was observed in cases of LL (253.44 +/- 136.83/mm2) and BL (349.36 +/- 121.67/mm2). Whereas in TT (854.60 +/- 332.01/mm2) and BT (715.76 +/- 235.33/mm2) there was no significant difference, as compared to Normal (927.43 +/- 103.87/mm2). Treatment had no influence on LC population in both the polar types of leprosy. Role of these immunocompetent dendritic cells in the pathogenesis of leprosy is discussed.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"22-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17925943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal prosthesis. 鼻假体。
Leprosy in India Pub Date : 1983-01-01
R P Kumar
{"title":"Nasal prosthesis.","authors":"R P Kumar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"174-5"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17926034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grades of dapsone resistance to Mycobacterium leprae (burrowing terminology) 氨苯砜对麻风分枝杆菌的耐药等级(洞穴术语)
Leprosy in India Pub Date : 1983-01-01
R G Roy
{"title":"Grades of dapsone resistance to Mycobacterium leprae (burrowing terminology)","authors":"R G Roy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"179-80"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17409133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular changes in nerves in experimental leprosy--an ultrastructural study. 实验性麻风病神经血管的改变——一项超微结构研究。
Leprosy in India Pub Date : 1983-01-01
K R Bhat, M C Vaidya
{"title":"Vascular changes in nerves in experimental leprosy--an ultrastructural study.","authors":"K R Bhat,&nbsp;M C Vaidya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ultrastructural observations made on the blood vessels of nerves in CBA/J mice with experimentally produced M. leprae infection revealed cytoplasmic filamentous structures along with large sized vacuoles in the endothelial cells and reduplication of peripericytal basement membranes in the 6-9 months of infection. In animals with late infection of 9-15 months duration, the endothelial cells presented foamy appearance caused by an increase in the number of vacuoles. These findings are suggestive of degenerative changes in the endothelial cells probably due to circulation of noxious substance in the blood stream.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"60-3"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17925946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis-B-surface antigen (HBsAg) in leprosy patients. 麻风病患者乙型肝炎表面抗原(HBsAg)。
Leprosy in India Pub Date : 1983-01-01
S Balakrishnan, V N Bhatia, S Harikrishnan
{"title":"Hepatitis-B-surface antigen (HBsAg) in leprosy patients.","authors":"S Balakrishnan,&nbsp;V N Bhatia,&nbsp;S Harikrishnan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The detection of the presence of Hepatitis-B-Surface antigen (HBsAg) using Indirect Haemagglutination technique (IHA) was carried out in 134 Lepromatous Leprosy cases (LL), 22 Lepromatous Leprosy cases during ENL reaction (LL with ENL), 24 Borderline leprosy (BL) cases, 7 Borderline Tuberculoid cases (BT) and 31 control subjects. The maximum percentage positivity of 32% was seen in cases with LL as compared to 6.2% in controls. The difference was found to be statistically significant (P less than 0.01).</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"45-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17925944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New IAL classification of leprosy. 麻风病的新IAL分类。
Leprosy in India Pub Date : 1983-01-01
{"title":"New IAL classification of leprosy.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"147-52"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17926032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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