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A study of serum fibrinolytic activity in erythema nodosum leprosum (ENL). 麻风结节性红斑(ENL)血清纤溶活性的研究。
Leprosy in India Pub Date : 1983-01-01
V K Jain, K C Verma, S S Aggarwal
{"title":"A study of serum fibrinolytic activity in erythema nodosum leprosum (ENL).","authors":"V K Jain,&nbsp;K C Verma,&nbsp;S S Aggarwal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fibrinolytic activity was studied in 31 patients of leprosy and 10 healthy controls. Fibrinolytic activity was found to be significantly decreased in patients with erythema nodosum leprosum, compared to those with uncomplicated lepromatous leprosy, who in turn showed lowered activity compared to patients with tuberculoid form of leprosy and controls. The severity of ENL correlated very well with decrease in fibrinolytic activity. Fibrinolytic activity was improved to levels obtained in uncomplicated lepromatous leprosy after the subsidence of reaction. So it would seem reasonable to suggest that estimation of fibrinolytic activity provides a reliable criteria to quantitate the severity of erythema nodosum leprosum.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"95-9"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17925951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protease inhibitors activity in lepromatous leprosy and lepra reaction. 蛋白酶抑制剂在麻风病和麻风反应中的活性。
Leprosy in India Pub Date : 1983-01-01
V L Yemul, S R Sengupta, T N Dhole
{"title":"Protease inhibitors activity in lepromatous leprosy and lepra reaction.","authors":"V L Yemul,&nbsp;S R Sengupta,&nbsp;T N Dhole","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum alpha one antitrypsin levels were measured in 50 healthy age and sex matched controls with 45 lepromatous leprosy cases and 5 cases of lepra reaction. It was noted that the mean level in healthy controls was 281.00 mg%, while the mean levels in LL patients was 421.00 mg% and in LR 570.00 mg%. The elevation of Alpha one antitrypsin was statistically significant in LL patients. It is possible that the rise is a reaction to release of proteases and or higher complement activity, which are the results of a high bacillary loading to formation of immune complexes.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"91-4"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17659508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nerve conduction in leprosy: in vivo and in vitro study. 麻风病的神经传导:体内和体外研究。
Leprosy in India Pub Date : 1983-01-01
S V Donde, A Shah, N H Antia
{"title":"Nerve conduction in leprosy: in vivo and in vitro study.","authors":"S V Donde,&nbsp;A Shah,&nbsp;N H Antia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sensory and mixed nerve conduction studies were performed on the distal segments of the radial, sural, median and ulnar nerves of leprosy patients from the entire spectrum of the disease. The values obtained were compared with those of age matched normal controls. All the clinically involved nerves, and about 30% of the clinically normal patient nerves showed a delayed conduction velocity. The conduction velocity difference was most significant (P less than 0.001) for the cutaneous branch of the radial, and sural nerves as compared to the ulnar and median. Five patients nerves that were clinically normal and showed a normal conduction velocity when tested in vivo, were biopsies and studied in vitro to determine the type of early nerve damage. C and A delta fibre involvement was found in all these nerves. It is concluded that leprosy is a diffuse neuropathy and there is early detectable nerve involvement even in clinically normal nerves of leprosy patients.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"12-21"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17926033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concentration of serum calcium in leprosy. 麻风病患者血钙浓度。
Leprosy in India Pub Date : 1983-01-01
R Pal, B Pal, S Ghosh
{"title":"Concentration of serum calcium in leprosy.","authors":"R Pal,&nbsp;B Pal,&nbsp;S Ghosh","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"76-9"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17925948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxic epidermal necrolysis (Lyell syndrome). A case report. 中毒性表皮坏死松解(莱尔综合征)。一份病例报告。
Leprosy in India Pub Date : 1983-01-01
K Katoch, G Ramu, U Ramanathan
{"title":"Toxic epidermal necrolysis (Lyell syndrome). A case report.","authors":"K Katoch,&nbsp;G Ramu,&nbsp;U Ramanathan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"133-5"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17257118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Dorsal incision" the treatment of complicated forefoot plantar ulcers in the anaesthetic foot. “背侧切口”治疗麻醉足复杂前足足底溃疡。
Leprosy in India Pub Date : 1983-01-01
D J Pring, N Casabianca
{"title":"\"Dorsal incision\" the treatment of complicated forefoot plantar ulcers in the anaesthetic foot.","authors":"D J Pring,&nbsp;N Casabianca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The in-patient treatment of 107 complicated forefoot plantar ulcers occurring in the anaesthetic foot by the operation of dorsal incision is presented. The operative technique of dorsal incision and subsequent wound dressing is described. 69 ulcers healed prior to discharge and all but 3 ulcers healed in an average of 27.2 days. In-patient stay averaged 31.4 days. The complications of the procedure are presented. Emphasis is placed on health education of the patient regarding care of the anaesthetic foot. Further follow up is suggested to see if dorsal incision reduces the recurrence of plantar ulceration.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"49-59"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17925945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary trial of intervention levamisole therapy in persistently bacteriologically positive lepromatous leprosy. 左旋咪唑干预治疗持续细菌学阳性麻风患者的初步试验。
Leprosy in India Pub Date : 1983-01-01
G Ramu, U Sengupta
{"title":"Preliminary trial of intervention levamisole therapy in persistently bacteriologically positive lepromatous leprosy.","authors":"G Ramu,&nbsp;U Sengupta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intervention treatment with the immuno-adjuvant levamisole was given in 14 persistently bacteriologically positive lepromatous cases who had had adequate chemotherapy for over 5 years. There was a temporary conversion of the early lepromin reaction in a majority of the patients with a corresponding improvement in clinical and bacteriological status. However, the lepromin response was short lived. Most patients had become bacteriologically negative at the end of 1 year. No adverse effects due to levamisole therapy were encountered.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"64-7"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17925947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Level of knowledge of leprosy patients towards their ailment. 麻风病患者对其疾病的了解程度。
Leprosy in India Pub Date : 1983-01-01
R K Kumar, T B Ramanaiah, F S Jessie, S Sabhesan
{"title":"Level of knowledge of leprosy patients towards their ailment.","authors":"R K Kumar,&nbsp;T B Ramanaiah,&nbsp;F S Jessie,&nbsp;S Sabhesan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"107-10"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17926029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of levamisole on clinical outcome and DNCB conversion in leprosy patients. A long term study. 左旋咪唑对麻风患者临床转归及DNCB转化的影响。一项长期研究。
Leprosy in India Pub Date : 1983-01-01
C S Yagnik, D G Jogaikar, J M Mehta
{"title":"Effect of levamisole on clinical outcome and DNCB conversion in leprosy patients. A long term study.","authors":"C S Yagnik,&nbsp;D G Jogaikar,&nbsp;J M Mehta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifteen patients of lepromatous leprosy within first 6 months of diagnosis were studied. 7 controls received standard DDS treatment and placebo while 8 patients received cyclical levamisole treatment (150 mg daily for 3 days repeated after a gap of 2 weeks), in addition to standard DDS treatment. Patients were followed up clinically for lepra reactions, serial B.I. and DNCB test for 2 years. We observed that ENL reactions were more common and more severe in levamisole treated group while an upgrading type reaction occurred only in one of the control patients. B I. remained same in both groups throughout, while DNCB score was higher in control rather than levamisole treated groups. Thus, levamisole treatment does not seem to have caused stimulation of CMI in our patients as judged by DNCB reaction while it may have caused stimulation of humoral immunity as seen by higher incidence of ENL reaction. This may be undesirable in lepromatous patients.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17735375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on sulphone resistant strains of M. leprae in field and institutionalized cases of leprosy. 麻风分枝杆菌抗磺胺酮菌株在田间和麻风机构病例中的研究。
Leprosy in India Pub Date : 1983-01-01
S Balakrishnan, P S Seshadri, P N Neelan, H N Venkataramaniah, S Harikrishnan, V N Bhatia
{"title":"Studies on sulphone resistant strains of M. leprae in field and institutionalized cases of leprosy.","authors":"S Balakrishnan,&nbsp;P S Seshadri,&nbsp;P N Neelan,&nbsp;H N Venkataramaniah,&nbsp;S Harikrishnan,&nbsp;V N Bhatia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The proportions of dapsone resistant strains of M. leprae in cases from the field and in patient institutionalized for treatment were compared. Identification of dapsone resistance was done by mouse-foot-pad experiments carried out in the Laboratory in Central Leprosy Teaching and Research Institute, Chengalpattu. A higher percentage of resistance was detected among institutional patients as compared to field cases. The distribution of M.I. ranges of M. leprae in dapsone resistant subjects was not different from that in dapsone sensitive cases.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 1","pages":"71-5"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17409135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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