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Growth of Mycobacterium leprae in nude mice. 麻风分枝杆菌在裸鼠体内的生长。
Leprosy in India Pub Date : 1983-10-01
N M Samuel, J Loudon, K Kohsaka
{"title":"Growth of Mycobacterium leprae in nude mice.","authors":"N M Samuel,&nbsp;J Loudon,&nbsp;K Kohsaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Athymic nude mice were introduced in our laboratories in 1982. In this paper results over one year period of nude mice inoculated with small numbers of M. leprae are described. In this study we showed that 1 X 10(4) M. leprae with low numbers of viable bacilli inoculated into hind foot pads of nude mice housed both in vinyl plastic isolators and \"clean room\" conditions had the ability to grow and reach remarkable levels. There was dissemination of the infection to other uninoculated foot pads by six months.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"648-53"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17426601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxic epidermal necrolysis (Lyell syndrome) 中毒性表皮坏死松解(莱尔综合征)
Leprosy in India Pub Date : 1983-10-01
B M Bedi
{"title":"Toxic epidermal necrolysis (Lyell syndrome)","authors":"B M Bedi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"780-1"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17724416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional lymph node involvement in tuberculoid leprosy. 结核样麻风病的局部淋巴结累及。
Leprosy in India Pub Date : 1983-10-01
D C Apte, M Zawar, M C Mehta, P B Zawar, R N Chawhan
{"title":"Regional lymph node involvement in tuberculoid leprosy.","authors":"D C Apte,&nbsp;M Zawar,&nbsp;M C Mehta,&nbsp;P B Zawar,&nbsp;R N Chawhan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study of regional lymph nodes in 44 cases of proved tuberculoid leprosy (BT & TT) is presented. Out of 26 cases of tuberculoid polar (TT) leprosy, 76.92% showed presence of paracortical lymphocytes, 61.52% showed presence of granuloma and 11.54% showed presence of acid fast bacilli in lymph nodes. In the borderline tuberculoid (BT) group, 61.1% showed granuloma, 72.22% showed presence of paracortical infiltration by lymphocytes and 11.11% showed presence of A.F.B. in lymph nodes. Lesions of tuberculoid leprosy have been conclusively demonstrated in the low resistant tuberculoid (BT) leprosy and polar tuberculoid leprosy (TT). The presence of paracortical lymphocytes in large numbers in the lymph nodes could indicate high cell mediated immunity (CMI) and possibly a tuberculoid end of the spectrum. The skin lesions and lymph nodes had comparative histopathology.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"680-5"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17723506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community awareness about leprosy and participation in National Leprosy Control Programme. 社区对麻风的认识和参与国家麻风控制规划。
Leprosy in India Pub Date : 1983-10-01
A Kumar, N S Prasad, P Sirumban, M Anbalagan, K Durgambal
{"title":"Community awareness about leprosy and participation in National Leprosy Control Programme.","authors":"A Kumar,&nbsp;N S Prasad,&nbsp;P Sirumban,&nbsp;M Anbalagan,&nbsp;K Durgambal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To evaluate the health education component of our National Leprosy Control Programme (NLCP), 955 adult community members and 225 adult leprosy patients were interviewed with a view to assess their awareness about leprosy and participation in NLCP. The early signs/symptoms of leprosy were poorly perceived by the community. Majority of the community (81%) and patients (75%) were unaware or held superstitious ideas about causation of leprosy. The spread of disease through close contact with patient(s) was better known to the community (65%) than the patients (45%); but the role of open cases in spread was stressed by more patients (17%) than community (5.5%). About 31% community and 23% patients had no idea about the ways to prevent leprosy spread. As against 89% patients, only 62% community believed in curability of leprosy with early and regular treatment; but 20% of the community members did not know where to refer patients for treatment. The causation and prevention of deformities were poorly perceived by 71% patients, and likewise 62% of the patients did not take precaution(s) to prevent the deformities. About 32% respondents were unaware of the efforts being made to control leprosy; and their (79-84% respondents) participation in NLCP was very vague. About 44% community members showed prejudice towards leprosy. The NLCP infra-structure and mass media could not educate community effectively. The implications of the findings are discussed in this paper.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"701-11"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17723510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunological aspects of human leprosy. 人类麻风病的免疫学方面。
Leprosy in India Pub Date : 1983-10-01
I Nath
{"title":"Immunological aspects of human leprosy.","authors":"I Nath","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"752-62"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17294874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypopigmentation in leprosy. 麻风病中的色素沉着。
Leprosy in India Pub Date : 1983-10-01
K Singh, B Iyenger, R Singh
{"title":"Hypopigmentation in leprosy.","authors":"K Singh,&nbsp;B Iyenger,&nbsp;R Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypopigmentation of macular leprosy lesions was not found to correlate with cellular infiltrate and AFB load in tissues. It is felt that hypopigmentation is in some way related to neural involvement.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"675-9"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17723505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous healing in lepromatous leprosy? 麻风病的自发愈合?
Leprosy in India Pub Date : 1983-10-01
V K Pannikar, K Jesudasan
{"title":"Spontaneous healing in lepromatous leprosy?","authors":"V K Pannikar,&nbsp;K Jesudasan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"712-3"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17723511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of lymph node biopsies in lepromatous leprosy patients under treatment. 麻风性麻风治疗患者淋巴结活检的研究。
Leprosy in India Pub Date : 1983-10-01
V R Lele, B S Raichur, S Grover
{"title":"Study of lymph node biopsies in lepromatous leprosy patients under treatment.","authors":"V R Lele,&nbsp;B S Raichur,&nbsp;S Grover","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study of lymph node biopsies from lepromatous leprosy patients undergoing treatment was carried out for one year in 1978-79 in the Department of Pathology, Government Medical College, Nagpur. Total 20 lymph node biopsies were studied, out of them, 12 were accompanied with skin biopsies. Typical lepromatous granulomas and presence of lepra bacilli were observed in 18 out of 20 lymph nodes, although this change was not constantly present in skin biopsies. Five out of twelve skin biopsies were bacteriologically negative. From this study, it is inferred that lymph node biopsies may be more helpful for follow up of patients after treatment.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"739-42"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17724414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Nose-blow" smears in multibacillary leprosy patients. 多菌性麻风病患者的“擤鼻”涂片。
Leprosy in India Pub Date : 1983-10-01
M N Padma, V N Bhatia
{"title":"\"Nose-blow\" smears in multibacillary leprosy patients.","authors":"M N Padma,&nbsp;V N Bhatia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>332 nose-blow specimens have been examined from 73 untreated multibacillary patients of leprosy before and periodically after they were put on a maximal, minimal or an intermediate multi-drug regimen. 80% of these specimens were found to be positive for acid fast bacilli initially. Bacillary positivity rate was more in samples containing pus or blood. Bacilli were seen in LL, LI as well as BL patients. Nearly half of the cases became negative for AFB in their nose-blow specimens within 3 months of initiation of treatment whereas none of these patients has become negative in skin smears. However, a few cases have continued to discharge bacilli in their nasal secretions even after 12 months of multi-drug regimen therapy.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"640-7"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17723676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study of systolic time intervals in lepra reaction. 麻风反应中收缩时间间隔的研究。
Leprosy in India Pub Date : 1983-10-01
P B Zawar, R N Chawhan, V V Mahajani
{"title":"A study of systolic time intervals in lepra reaction.","authors":"P B Zawar,&nbsp;R N Chawhan,&nbsp;V V Mahajani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Systolic time intervals (STI) were measured in 20 control subjects and 20 cases of lepromatous leprosy in lepra reaction. Significant differences in the pre-ejection period (PEP), PEP/LVET and isovolumic contraction (IVCT) were observed between the groups. The abnormalities of STI observed in patients of lepra reaction are characteristic of left ventricular dysfunction in patients of lepra reaction.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"697-700"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17723509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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