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Leprosy in India最新文献

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Prevalence survey of secondary dapsone resistance in leprosy in Kancheepuram and Tiruvannamalai control units of Tamil Nadu. 泰米尔纳德邦Kancheepuram和Tiruvannamalai控制单位麻风病继发性氨苯砜耐药性调查
Leprosy in India Pub Date : 1983-04-01
P N Neelan, S K Noordeen, S Balakrishnan, P R Pandian
{"title":"Prevalence survey of secondary dapsone resistance in leprosy in Kancheepuram and Tiruvannamalai control units of Tamil Nadu.","authors":"P N Neelan,&nbsp;S K Noordeen,&nbsp;S Balakrishnan,&nbsp;P R Pandian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A field survey was designed and carried out in parts of Kancheepuram and Tiruvannamalai Leprosy Control Units in Tamilnadu (population 418,000) with the objective of finding out the prevalence of secondary dapsone resistance among 790 lepromatous (LL and BL) cases, who formed the patient population at risk based on certain treatment criteria. Using the mouse footpad experiment, 3 resistant cases were identified in Kancheepuram Unit (prevalence rate of 1.0 per cent) and 11 cases in Tiruvannamalai Unit (prevalence rate of 2.2 per cent). The metabolic status of dapsone was found to be normal in more than 90% of the patients, showing no relationship to occurrence of resistance.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"222-30"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17416046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Borderline leprosy (BL) in an infant--report of a case and a brief review. 婴儿边缘性麻风病(BL)一例报告及简要回顾。
Leprosy in India Pub Date : 1983-04-01
B K Girdhar, A Girdhar, G Ramu, K V Desikan
{"title":"Borderline leprosy (BL) in an infant--report of a case and a brief review.","authors":"B K Girdhar,&nbsp;A Girdhar,&nbsp;G Ramu,&nbsp;K V Desikan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of Borderline Leprosy (BL) occurring in an infant of 1 year and 7 months, beginning at the age of 9 to 10 months is reported along with a brief review of literature on childhood leprosy.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"333-7"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17687576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of pyridine extraction on the acid fastness of mycobacteria. 吡啶萃取对分枝杆菌耐酸性的影响。
Leprosy in India Pub Date : 1983-04-01
A K Dutta, V M Katoch, V D Sharma
{"title":"Effect of pyridine extraction on the acid fastness of mycobacteria.","authors":"A K Dutta,&nbsp;V M Katoch,&nbsp;V D Sharma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of pyridine extraction on mycobacterial acid-fastness has been studied using M. leprae and some cultivable mycobacteria. The results revealed that not only M. leprae but some other mycobacteria, notably, M. vaccae and M. phlei also lose their acid-fastness when extracted with fresh pyridine for 2 hours at room temperature. The implication of these findings is discussed.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"299-304"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17260366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mouse foot pad growth of M. leprae in relation to bacteriological index. 小鼠足垫麻风分枝杆菌生长与细菌学指标的关系。
Leprosy in India Pub Date : 1983-04-01
V N Bhatia, S Balakrishnan, H N Venkataramaniah, S Harikrishnan
{"title":"Mouse foot pad growth of M. leprae in relation to bacteriological index.","authors":"V N Bhatia,&nbsp;S Balakrishnan,&nbsp;H N Venkataramaniah,&nbsp;S Harikrishnan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A retrospective analysis was made of the mouse foot-pad growth of M. leprae from 35 cases of lepromatous leprosy with B.I. ranging from 1.33 to 4.0 (Dharmendra scale). Of these 35 cases, 6 were found to be harbouring dapsone resistant bacilli and 18 cases sensitive bacilli. In 11 of them there was no growth in the control group of animals. The analysis showed that there was no difference in the mean B.I. between those showing no growth and those showing growth in the 1st, 2nd or 3rd harvest. A minimum B.I. around 1.5 is considered adequate for positive foot-pad takes. Another interesting observation made in the study was that the growth rate in the control group foot-pads was consistently higher in mice receiving dapsone resistant bacilli as compared to those inoculated with bacilli, sensitive to the drug.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"247-51"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17416047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of alpha one antitrypsin activity in lepra reaction. 麻风反应中α 1抗胰蛋白酶活性的研究。
Leprosy in India Pub Date : 1983-04-01
S R Sengupta, T N Dhole, V L Jahagirdar, V L Yemul, R N Chawhan
{"title":"Study of alpha one antitrypsin activity in lepra reaction.","authors":"S R Sengupta,&nbsp;T N Dhole,&nbsp;V L Jahagirdar,&nbsp;V L Yemul,&nbsp;R N Chawhan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In our earlier study (Yemul et, al, 1983) we have reported elevation of serum alpha one antitrypsin levels in patients of lepromatous leprosy and lepra reaction. In this study estimation of serum alpha one antitrypsin levels in fifty lepra reaction patients (8 of type 1 and 42 of type II) and fifty age and sex matched healthy controls is described. Alpha one antitrypsin levels were elevated in lepra reaction patients (type I--mean value of 332 mg% and S.D. +/- 118.8 and type II--mean value of 450 mg% and S.D. +/- 73.7) when compared with the healthy controls (mean value of 285 mg% and S.D. +/- 66.05). The increase in levels in type II lepra reaction patients was statistically significant. The results are discussed to correlate the increased levels of alpha one antitrypsin and the high bacterial load leading to the release of various proteases in type II lepra reaction.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"242-6"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17661332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrocardiographic changes in lepra reaction. 麻风反应的心电图改变。
Leprosy in India Pub Date : 1983-04-01
P B Zawar, R N Chawhan, R M Swami
{"title":"Electrocardiographic changes in lepra reaction.","authors":"P B Zawar,&nbsp;R N Chawhan,&nbsp;R M Swami","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The electrocardiographic (E.C.G.) changes were evaluated in 54 patients of lepra reaction. Abnormalities of the E.C.G. observed were in the form of prolongation of QTc in 24 (44.44%), ST-T changes in a (16.66%), bundle branch block and ventricular extrasystoles in 2 each (3.70%). The mean QTc interval in 64 normal adults was 0.41 second (S.D. +/- 0.03, range 0.36 to 0.44 second). It was 0.44 second (S.D. +/- 0.05, range 0.38 to 0.52 second) in patients of lepra reaction. The difference in the QTc values in the two groups was statistically significant (P less than 0.01). The E.C.G. abnormalities in patients of lepra reaction appears to be due to myocardial involvement.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"197-9"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17687785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal abnormality in leprosy. 麻风病肾异常。
Leprosy in India Pub Date : 1983-04-01
S Grover, S K Bobhate, B S Chaubey
{"title":"Renal abnormality in leprosy.","authors":"S Grover,&nbsp;S K Bobhate,&nbsp;B S Chaubey","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Adequate kidney biopsy was studied in 54 cases of leprosy, of which 45 were of lepromatous leprosy, 4 of tuberculoid type and 5 belonged to borderline type of leprosy. Membranous glomerulonephritis (31.5%) was the commonest type of glomerular lesion followed by mesangioproliferative glomerulonephritis (11.1). It is concluded that renal lesions can occur in any type of leprosy. Reaction of renal tissues to M. leprae could be due to various local immunologic or physiological factors.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"286-91"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17687789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of drug regimen in lepromatous leprosy--II. 麻风性麻风药物治疗方案的评价——ⅱ。
Leprosy in India Pub Date : 1983-04-01
G Ramu, Sreevatsa
{"title":"Evaluation of drug regimen in lepromatous leprosy--II.","authors":"G Ramu,&nbsp;Sreevatsa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 2 year follow-up study of 4 drug regimen in 45 cases is reported; whereas the combination of Rifampicin and Dapsone had been found to effect clearance of bacteraemia within a week and effect negativity of nasal smears in a shorter period of time, at 2 years the clinical and bacteriological results in the DDS, DDS + Rifampicin, DDS + Thiacetazone + INH, and DDS + Clofazimine regimen were similar. However, on inoculating bacilli obtained from the dartos muscle into the foot-pads of mice, multiplication was found in 1 out of 11 cases on Rifampicin and DDS, whereas 2 out of 9 cases on DDS + Thiacetazone + INH; 2 out of 10 cases on DDS + Clofazimine and 4 out of 8 cases on DDS alone showed multiplication. Therefore at the end of 2 years there was no significant difference in the results of treatment with any of the drug combinations used in the trial. However, the drug combinations have been found to be better than monotherapy with dapsone alone.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"200-8"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17260365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphocyte transformation test in lepromatous leprosy patients and their healthy siblings. 麻风病患者及其健康兄弟姐妹的淋巴细胞转化试验。
Leprosy in India Pub Date : 1983-04-01
S R Sengupta, V L Yemul, T N Dhole
{"title":"Lymphocyte transformation test in lepromatous leprosy patients and their healthy siblings.","authors":"S R Sengupta,&nbsp;V L Yemul,&nbsp;T N Dhole","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphoproliferative response to M. leprae, PHA, PPD and mixed leucocyte culture (MLC) were measured in 20 cases of lepromatous leprosy, 17 of their normal healthy siblings and 15 healthy controls. 7 siblings of LL patients were HLA-D identical, which was identified by doing MLC reaction. All healthy siblings including HLA-D identical responded normal to all stimulating agents including M. leprae antigen. In contrast 20 cases of LL responded very poorly to M. leprae antigen and almost near normal to other stimulating agents. The specific unresponsiveness of LL patients to M. leprae antigen does not result from an HLA linked genetic defect and the defective CMI response to M. leprae antigen seems to be acquired and not genetically determined.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"261-4"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17635793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilization of medical agencies and treatment compliance by urban (Madras) leprosy patients. 城市(马德拉斯)麻风病患者对医疗机构的利用和治疗依从性。
Leprosy in India Pub Date : 1983-04-01
A Kumar, N Sivaprasad, M Anbalagan, N Thangavel, K Durgambal
{"title":"Utilization of medical agencies and treatment compliance by urban (Madras) leprosy patients.","authors":"A Kumar,&nbsp;N Sivaprasad,&nbsp;M Anbalagan,&nbsp;N Thangavel,&nbsp;K Durgambal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The utilization of medical agencies and treatment compliance by 3880 leprosy patients registered with Govt. Leprosy Control Unit, Saidapet, Madras were studied. It was observed that 39% patients waited for 1.32 (+/- 1.75) years before medical consultation, for their negligence and unawareness of disease. About 16% and 4% patients consulted Gen. Hospitals and Private Practitioners, respectively. The leprosy clinics were most popular, 35% patients changed medical agencies. On an average, one patient had consulted 1.47 (+/- 0.51) medical agencies and 1.23 (+/- 0.52) leprosy clinics, for treatment of leprosy. Only 45% patient attended clinic regularly, others attended irregularly (22.5%) or discontinued (32.4%). The unsuitable clinic timing (morning) was an important factor for defaulting the clinics. Of the 2625 (67.66%) patients who attended last clinic, one patient had missed an average of 5.5 (+/- 8.3) DDS tablets in a month. The implications of findings and suggestions to improve the service utilization with good compliance by patients, are discussed in this communication.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"322-32"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17687575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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