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Ocular leprosy - a new perspective. 眼麻风病——一个新的视角。
Leprosy in India Pub Date : 1983-07-01
P A Lamba, D Santoshkumar, R Arthanariswaran
{"title":"Ocular leprosy - a new perspective.","authors":"P A Lamba,&nbsp;D Santoshkumar,&nbsp;R Arthanariswaran","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The classification of ocular lesions in leprosy into academic and PST lesions clears away much of the confusion engendered by the wide disparity in the reported incidences. It also enables to project confidently the level of ocular morbidity in a given leprosy population with more precision. Based on the observation in the study approximately 1.5 million leprosy patients are expected to be affected with potentially sight threatening lesions. Measures to be undertaken to prevent this morbidity and visual impairment in this vulnerable group can be better worked up. The incidence of blindness on account of leprosy is reported to be 2.6 percent.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"490-4"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17740507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth of Mycobacterium leprae in a redox system. 麻风分枝杆菌在氧化还原系统中的生长。
Leprosy in India Pub Date : 1983-07-01
B R Chatterjee
{"title":"Growth of Mycobacterium leprae in a redox system.","authors":"B R Chatterjee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mycobacteria recovered from human lepromatous nodules and presumably M. leprae, have been grown in a medium that ensured a minimal oxygen tension at initiation of growth, and an increasing availability of oxygen as bacillary growth increased requiring marginal increments in oxygen tension. This physicochemical environment was achieved by the addition of strong biological reductants in the medium, and a combination of partial vacuum and alkaline pyrogallol in the culture vessel. In addition, n-tetradecane, a straight chain hydrocarbon, and lipids like Cholesterol and Lecithin, all three substances mixed in the aqueous medium as liposomes, were added and found to be useful. Menadione, or Vitamin K3, added to the medium considerably improved growth efficiency. Growth occurred initially as non-acid fast coccoids and bacilli that gradually changed to acid-fast bacilli and globi, and cell-wall deficient, spherical L-form elements. Appearance of growth in any form was perceptible within 1 to 2 weeks and optimal growth as acid fast bacilli took upto 3 months. Both the acid fast and non-acid fast bacilli could not be grown in conventional media, but the non-acid fast coccoids could be readily isolated from these cultures in a specially enriched liquid medium. The problem of harvesting of the growth free of lipid-hydrocarbon substances has still not been solved, as also an optimum oxidation-reduction potential. The growth is transferable.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"426-49"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17262079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriological study of trophic ulcers in leprosy patients (a preliminary study). 麻风病患者营养性溃疡的细菌学研究(初步研究)。
Leprosy in India Pub Date : 1983-07-01
C H Kumar, S Harikrishnan, V N Bhatia, R G Roy
{"title":"Bacteriological study of trophic ulcers in leprosy patients (a preliminary study).","authors":"C H Kumar,&nbsp;S Harikrishnan,&nbsp;V N Bhatia,&nbsp;R G Roy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Swabs from trophic ulcers from 108 cases were studied by culture. 37 cases yielded single organism (Ps. aeruginosa, 18, Proteus species 11, Staph. pyogenes 4, Others 4). 71 cases yielded mixed growth with two or more organisms. Ps. aeruginosa, Proteus species and Diphtheroids were the predominant organisms in these cultures. Ps. aeruginosa was sensitive to Gentamycin (96.6%), Streptomycin (62.7%) and Chloramphenicol (33.9%). Other organisms although comparatively more sensitive showed a similar pattern.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"504-11"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17478094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How much non-infectious are the "non-infectious" lepromatous leprosy patients? “非传染性”麻风病患者中有多少是非传染性的?
Leprosy in India Pub Date : 1983-07-01
M C Prabhakar, A V Appa Rao, D R Krishna, T V Ramanakar
{"title":"How much non-infectious are the \"non-infectious\" lepromatous leprosy patients?","authors":"M C Prabhakar,&nbsp;A V Appa Rao,&nbsp;D R Krishna,&nbsp;T V Ramanakar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nose forms an important site at which the M. leprae in lepromatous leprosy (LL) patients lodge and multiply. Nose forms an important reservoir for M. leprae, from where they may be transmitted to healthy contacts. Inspite of realizing the above fact, nose does not normally receive due importance during the chemotherapy of leprosy. LL patients, after regular treatment with dapsone or rifampin for about 20 wks and 3 wks respectively are normally considered non-infectious. From the present investigation it is clear that local treatment of the ones with a bactericidal agent should perhaps be necessary during chemotherapy of LL patients to make them non-infectious and to control the transmission of the disease.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"576-83"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status of T and B lymphocytes in peripheral blood. 外周血T淋巴细胞和B淋巴细胞的状态。
Leprosy in India Pub Date : 1983-07-01
P K Singh, Ratna, P K Jain, V P Mital
{"title":"Status of T and B lymphocytes in peripheral blood.","authors":"P K Singh,&nbsp;Ratna,&nbsp;P K Jain,&nbsp;V P Mital","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>T and B lymphocyte percentage was studied by Erythrocyte (E) and Erythrocyte antibody complement (EAC) rosette formation respectively in 90 cases including 65 cases of different types of leprosy and 25 healthy controls. The patient with different types of leprosy were classified according to Ridley and Jopling (1962). The mean percentage of T-lymphocyte was observed in gradually decreasing manner from tuberculoid pole to lepromatous pole. The fall in T-lymphocyte percentage was highly significant when control cases were compared with total cases of leprosy and different histological types of leprosy. This indicates that there is a gradually increasing loss of cell mediated immune response from tuberculoid to lepromatous pole.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"560-5"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17662776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological evidence of indeterminate leprosy in apparently uninvolved skin of entire spectrum of leprosy. 在整个麻风病谱系中明显未受累皮肤的不确定麻风病的组织病理学证据。
Leprosy in India Pub Date : 1983-07-01
K Singh, B Iyenger, R Singh
{"title":"Histopathological evidence of indeterminate leprosy in apparently uninvolved skin of entire spectrum of leprosy.","authors":"K Singh,&nbsp;B Iyenger,&nbsp;R Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Indeterminate histopathology with nerve involvement was seen in clinically uninvolved skin in 100% cases, irrespective of clinical type. This was an interesting observation for TT and BT cases: in such cases, it might be a reflection of the disease process which is generalised right from the beginning.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"500-3"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of screening tests for dapsone in urine. 尿中氨苯砜筛选试验的比较。
Leprosy in India Pub Date : 1983-07-01
P P Irudaya Raj, S Lourdumary, M Aschhoff, S Balakrishnan
{"title":"A comparison of screening tests for dapsone in urine.","authors":"P P Irudaya Raj,&nbsp;S Lourdumary,&nbsp;M Aschhoff,&nbsp;S Balakrishnan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The comparative merits and limitations of three qualitative tests for Dapsone screening in urine viz. the 'Spot-Test' using modified Ehrlich's reagent, 'Tile-Test' employing Bratton-Marshall reagents, and the 'Elisa-Test' were assessed with regard to their sensitivity and operational feasibility. Investigations were carried out on a total of 716 urine specimens of which 268 specimens were collected during surprise visits paid to the patients homes. The others were specimens collected from patients at different time intervals following the administration of 25, 50 and 100 mg of dapsone. The findings were evaluated against their corresponding ratios of the urinary concentrations of Dapsone and its diazotisable metabolites to creatinine. A good correlation was found between the three qualitative tests in general and also in relation to the DDS/C ratios. Operational feasibility under field conditions for spot and tile tests are discussed.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"528-38"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17711256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Side effects of rifampicin. 利福平的副作用。
Leprosy in India Pub Date : 1983-07-01
M Chaudhury
{"title":"Side effects of rifampicin.","authors":"M Chaudhury","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"631"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17711261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An attempt to influence nerve degeneration and regeneration by using macrophage cell homogenate. 巨噬细胞匀浆影响神经变性和再生的尝试。
Leprosy in India Pub Date : 1983-04-01
S S Pandya, S S Naik, S Gurnani
{"title":"An attempt to influence nerve degeneration and regeneration by using macrophage cell homogenate.","authors":"S S Pandya,&nbsp;S S Naik,&nbsp;S Gurnani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of the contents of activated macrophages on the degenerative/regenerative process in the mouse sciatic nerve was investigated as a possible model for leprosy. The whole cellular homogenate or saline was injected every week around physically impaired (to bypass the perineurial barrier) and normal nerves. Recovery of the nerve function was monitored clinically and electromyographically. After 14 weeks animals were sacrificed and nerves were processed for histology. The data obtained from 134 experimental and control nerves were rated and analysed statistically. The course of the nerve regeneration in the physically impaired nerve with and without homogenate was found to be similar. One of the reasons for this could be insufficient concentration of the homogenate in the endoneurial space.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"237-41"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17374862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of culture of M. leprae. 麻风分枝杆菌培养评价。
Leprosy in India Pub Date : 1983-04-01
K V Desikan
{"title":"Evaluation of culture of M. leprae.","authors":"K V Desikan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 2","pages":"188-92"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17416045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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