{"title":"Tile test to monitor the self administration of dapsone by leprosy patients.","authors":"S S Naik","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The regularity of attendance of leprosy patients at clinic does not correlate well with regularity in drug consumption. This feature has been reported by several workers from different parts of the world. For monitoring self administration periodical check up of urine for drug content is necessary. The dapsone tile test described by Irudayaraj(1981) is performed in porcalein tile with drop of leprosy patient's urine. An appearance of pink colour and its intensity shows the drug content in urine. Instead of porcalein tile a cheap and readily available plastic blistered capsule card was used which is convenient to carry in the field and is disposable. 184 urine samples were collected in field and tested at field clinic by paramedical workers employing dapsone tile test. The same urine samples were later processed for dapsone/creatinine ratio at the laboratory by photoelectric colorimetric investigations. It was found that the results of dapsone tile test in the field correlated well upto 96% with dapsone/creatinine ratio estimations in the laboratory. The tile test in plastic card is simple to perform under field condition and it is reliable too.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 4","pages":"665-9"},"PeriodicalIF":0.0,"publicationDate":"1983-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17723678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eradication of leprosy in China today.","authors":"M Haide, Y Ganyun","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"512-20"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17711254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cultivation of M. leprae.","authors":"N H Antia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"420-3"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Field application of combined therapy for infectious leprosy cases. A feasibility study in Bombay.","authors":"R Ganapati, C R Revankar, S S Naik","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The practical problems related to dapsone monotherapy for a prolonged period to infectious leprosy patients are well known to the scientific community and combined treatment of dapsone with clofazimine, rifampicin or prothionamide has been successfully carried out by several workers in hospitalised leprosy patients. The application of polytherapy in field condition was hindered by the cost of the drugs and fear of side effects. 42 infectious leprosy patients attending 5 field leprosy clinics in the slums of Bombay city were put on combined drug schedule. The drug compliance of these patients was judged along with their regularity in attendance at clinics by the persons in charge and periodic and frequent check up of urines. 27 (65%) were regular in treatment from the beginning, 8(19%) who were initially irregular after motivation and 7(17%) remained irregular through out the period. The urine samples collected from leprosy patients on monotherapy and attending the same centres revealed 31% irregularity in drug consumption. The study indicates that advocating combined therapy in field conditions by paramedical workers is quite feasible. The patients on multiple drugs are more regular in drug consumption as compared to monotherapy group. The frequent check up of urine for drug content and advice to patients who are irregular in treatment improve their regularity in drug consumption.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"485-9"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17711252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Operational study to monitor the regularity of dapsone intake by leprosy out-patients.","authors":"A Kumar, S Balakrishnan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>319 leprosy patients, attending our Mobile Treatment Unit, were monitored for their regularity of dapsone intake by (1) Physical verification of DDS tablets; and (2) Spot test, in the field. The consistency in regularity of DDS intake by these patients, was monitored at two more occasions at the interval of about two months. Only 36% patients were regular in attending the clinics. On an average one patient would miss about one third of the clinics in a year. The number of patients taking regular treatment increased from 62% (I round) to 79% (in III round). Approximately 10% patients collected DDS tablets from clinic but never ingested them; and 3% to 7% patients removed Dapsone tablets regularly but ingested none of it, as indicated by negative spot tests. The spot test was found to be positive in about 86% patients, and had a very good correlation (98%) with DDS/Cr. ratio. Both the methods of monitoring were found to be operationally very feasible and reliable under field conditions, hence can be used together to monitor the dapsone intake by leprosy patients, in National Leprosy Control Programme.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"521-7"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17711255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral zinc in recurrent Erythema Nodosum Leprosum reaction.","authors":"N K Mathur, R A Bumb, H N Mangal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Oral zinc sulfate was tried in Eight cases of recurrent Erythema Nodosum Leprosum. To control ENL, they required high dosage of clofazimine and steroids for prolonged periods. After instituting oral zinc, the dose of clofazimine could be reduced to 100 mg twice a week and steroids could be withdrawn completely. Four out of five patients who were not tolerating dapsone earlier, started tolerating dapsone. Incidence and severity of subsequent ENL was also reduced.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"547-52"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17711258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of lysozyme on Mycobacterium leprae.","authors":"A M Dhople","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Because large amounts of lysozyme are present in phagocytes, it was selected, as one of the bactericidal substances, to study the in vitro effects on M. leprae. The results obtained led the author to conclude that M. leprae is not susceptible to lysozyme as many other atypical as well as attenuated pathogenic mycobacteria. This resistance of M. leprae to lysozyme was seen up to a level of 100-500 micrograms per ml, while levels of 1000 micrograms and more had very significant effect; the ATP content of such treated M. leprae declined to 30% of the original levels in 5 days of incubation at 37 degrees C, with optimum pH of 6.0, and these M. leprae after such exposure to lysozyme failed to multiply in the foot pads of mice. The interpretation of these results, though not definitive, have been discussed.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"455-64"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Examination of nasal mucous membrane biopsies.","authors":"S S Pandya","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"630"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Observations on the culture of M. leprae in Medium V. A preliminary report.","authors":"R Prabhakar, L Hari, D Herbert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper reports the preliminary findings of an investigation using Medium V for culture of M. leprae. The medium was prepared adhering to the procedures adopted by Veeraraghavan. Tissues from 7 cases of lepromatous leprosy (Bacteriological Index of 3 or more) were inoculated into Medium V and incubated at 8-10 degrees C for 72 hours. Quantitative estimation of leprosy bacilli were made employing the enumeration technique of Veeraraghavan. There was no evidence of multiplication in any of the cultures. The findings are in conformity with those of Kato (1983) and of Katoch and Desikan (1983).</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"450-4"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Splinting of the hand in leprosy.","authors":"V N Kulkarni, J M Mehta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clawing of the hand in Leprosy, which is caused due to paralysis of intrinsics can often be prevented and corrected to some extent if looked in properly. Splints can contribute a lot to this. This article emphasizes the use of variety of splints prepared from alumafoam, hexcelplast and such other materials, as an adjunct to other physiotherapy measures like wax-bath, massage and exercises.</p>","PeriodicalId":76113,"journal":{"name":"Leprosy in India","volume":"55 3","pages":"483-4"},"PeriodicalIF":0.0,"publicationDate":"1983-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17712416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}