J M Culebras-Fernandez, M de la Hoz Riesco, C Villares Garcia, G Hurtado Fernandez-Llamazares, A Alonso Villalba
{"title":"Improvement of the nutritional condition with hypocaloric peripheral parenteral nutrition (HPPN) in the immediate postoperative period of elective abdominal surgery.","authors":"J M Culebras-Fernandez, M de la Hoz Riesco, C Villares Garcia, G Hurtado Fernandez-Llamazares, A Alonso Villalba","doi":"10.1159/000222218","DOIUrl":"https://doi.org/10.1159/000222218","url":null,"abstract":"<p><p>Thirty-one patients scheduled for elective surgery for non-malignant abdominal disease were randomized during the first five postoperative days to two different schedules. Group I received water, electrolytes and glucose. Group II received a standard solution containing crystalline amino acids (3.8 g/l), xylitol (25 g/l) and sorbitol (25 g/l), accounting for a total of 900 cal/day. Evaluation was made with clinical, anthropometric and biochemical parameters. Among others, the following significant differences were observed at the end of the study: retinol bound protein: in group I, 4.25 +/- 1.3 and in group II, 5.38 +/- 1.53 (p less than 0.05); prealbumin: in group I, 18.7 +/- 6.24 and in group II, 24.51 +/- 7 (p less than 0.05). The significantly higher values of short-life plasma proteins observed in group II indicate that with HPPN a higher synthesis of visceral protein is promoted. These data demonstrate that HPPN improves the nutritional state during the postoperative period.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 5","pages":"202-8"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000222218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14250670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The disease picture of hepatic encephalopathy].","authors":"H Schomerus","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatic encephalopathy implies disturbances of consciousness, intellectual function, behavior and neuromuscular function in the course of diseases of the liver. By employing psychometric and neurophysiologic methods, functional disturbances can be demonstrated well before clinical manifestation of encephalopathy. This latent form of encephalopathy is especially disturbing for patients doing manual work. Treatment should be started during this early phase of the disease.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"50-2"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14561113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Schmicker, K Vetter, K Lindenau, P T Fröhling, F Kokot
{"title":"Conservative long-term treatment of chronic renal failure with keto acid and amino acid supplementation.","authors":"R Schmicker, K Vetter, K Lindenau, P T Fröhling, F Kokot","doi":"10.1159/000226327","DOIUrl":"https://doi.org/10.1159/000226327","url":null,"abstract":"<p><p>In a group of 119 patients with advanced chronic renal failure (serum creatinine level 733 +/- 186 mumol/l) the effect of a low-protein diet supplemented with essential amino acids (EAA) or their keto analogues (KA) on uremic metabolism and rehabilitation status was investigated. The protein intake amounted to 0.4 g/kg B.W./day, the phosphorus intake 0.4-0.6 g/day and the energy supply 120-150 kJ/kg B. W./day. In 51 patients there was a substitution with EAA and in 68 patients with their KA. The mean duration of dietary treatment in this study was 19 months (6-64 months). During this time, the serum creatinine increased from 733 +/- 186 to 1,220 +/- 256 mumol/l, whereas the urea nitrogen values remained relatively constant at between 26 and 30 mmol/l. There were no signs of protein malnutrition (nitrogen balance, serum transferrin and serum protein were normal). The hemoglobin concentration remained at greater than 5 mmol/l with creatinine levels of 1,220 +/- 256 mumol/l. During the substitution with KA, there was a significantly greater decrease in serum phosphate (p less than 0.05) and parathyroid hormone (PTH) (p less than 0.01) as compared with the uremics given EAA. In addition, we found a significant increase in testosterone (p less than 0.01) in patients supplemented with KA. Despite advanced chronic renal failure there was a good degree of rehabilitation (full-time work: 21%; part-time work: 66.4%). It can be concluded that a low-protein diet supplemented with EAA or KA can improve the uremic metabolism, rehabilitation status and safely postpone the start of maintenance dialysis.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"34-8"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226327","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14255681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Significance of branched-chain keto acids for protein metabolism].","authors":"P Schauder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Branched chain keto acids may offer therapeutic benefits for clinical conditions associated with nitrogen accumulation or increased proteolysis. The effects of keto acids on protein metabolism are complex. Mechanisms such as (1) transamination to the respective amino acids, (2) inhibition of proteolysis, (3) stimulation of insulin secretion, and (4) augmentation in the activity of BCKA-decarboxylase need to be considered. Presently, therapy with branched chain keto acids is still experimental.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"62-4"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14452504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Changes in organic acids in plasma and cerebrospinal fluid in cerebral infarct].","authors":"W D Rausch, K Schnecker, J Bruck, P Riederer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seventeen patients with recent cerebral infarction were included in the study. The general condition of the patients was evaluated within 3 days after the incidence (rating 1) and 7-9 days after the incidence (rating 2) using a clinical rating scale for internal, psychiatric and neurological findings. The statistical evaluation showed a clinical improvement of the score of 32%. The extent of the brain lesions was determined by cranial computed tomography. Routine analysis of the cerebrospinal fluid included determination of protein, cell count, cell type, glucose, lactic acid, and hemoglobin. In addition, spinal fluid and serum concentration of pyruvic acid, citric acid, fumaric acid, alpha-ketoglutaric acid and alpha-keto-beta-methylvaleric acid (3-MKV) were determined at the two rating times. CSF and serum values of fumaric acid, 3-MKV and pyruvic acid correlated at rating 1, while at rating 2 a correlation existed only for fumaric acid. A trend analysis infarction - postinfarction period showed the concentration of all metabolites to decrease significantly. This is interpreted as a reconstitution of the initially disturbed blood brain barrier function.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 5","pages":"209-13"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14799029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amino acid therapy for patients with chronic renal failure.","authors":"J Bergström, M Ahlberg, A Alvestrand, P Fürst","doi":"10.1159/000226319","DOIUrl":"https://doi.org/10.1159/000226319","url":null,"abstract":"<p><p>Conservative therapy in advanced chronic renal failure is based on low-protein diet. Precautions have to be taken so that the patient does not develop protein deficiency. By supplementing low-protein diets with essential amino acids orally (as tablets) this risk can be minimized. Uremic patients have specific requirements for some amino acids which can be fulfilled by modifying the composition of the amino acid preparation. By supplementing a low-protein diet (approximately 0.3 g protein/kg B.W./day) with an amino acid mixture which contains proportionally more valine and less leucine and isoleucine than prescribed by the Rose formula and, in addition, histidine and tyrosine, the amino acid abnormalities in plasma and muscle can be improved and nitrogen equilibrium maintained.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"8-11"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14560043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progression of chronic renal failure in patients given keto acids following amino acids.","authors":"M Walser, N LaFrance, L Ward, M A VanDuyn","doi":"10.1159/000226321","DOIUrl":"https://doi.org/10.1159/000226321","url":null,"abstract":"<p><p>Twelve patients with chronic renal failure who exhibited a progressive decline in 24-h creatinine clearance despite being given, for 2-10 months, a diet containing 0.3 g of protein/kg ideal weight and 7-9 mg of phosphorus/kg ideal weight supplemented with vitamins, CaCO3, and 10 g per day of essential amino acids, were changed to a supplement containing predominantly keto acids. In 6 patients whose serum creatinine levels were 7.5 mg/dl or greater at changeover, progression continued unabated. In 6 patients with serum creatinine levels at changeover of 6.5-7.4 mg/dl, one was non-compliant with the diet and progressed to dialysis. In the other 5, progression, measured as the rate of change of a bimonthly radioisotope clearance, has been undetectable during the ensuing 1-2 years.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14561108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Fatty liver in indirect calorimetry controlled total parenteral nutrition].","authors":"Z Aprili, R Hauser, T Norlindh, H Kahnemouyi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors have investigated the relationship between total parenteral nutrition (TPN) under indirect calorimetry and the development of fatty infiltrations of the liver in 21 surgical and traumatized patients. TPN was monitored by indirect calorimetry in order to balance lipid and amino acid intake. Glucose intake was adapted only when daily glucose utilization was higher than 150 g. Non protein respiratory quotient (npRQ) and respiratory quotient (RQ) remained below 0.9 during the whole study. The need for lipids was always significantly higher than the lipid intake up to the 5th day after operation or trauma. The need for carbohydrates was significantly lower than the intake of carbohydrates up to the 9th day after operation or trauma. In addition, the utilization of lipids was higher than the utilization of carbohydrates. After 2 weeks of TPN, no fatty infiltration of the liver could be detected by computer tomography and chemical analysis. The calorimetric monitoring of the TPN regimen and the individual adaptation of substrate intake might be responsible for the protection of the liver observed in this study.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 5","pages":"239-44"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14250672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The compliance with supplemented diet by chronic uremics and their nutritional status.","authors":"S Giovannetti","doi":"10.1159/000226318","DOIUrl":"https://doi.org/10.1159/000226318","url":null,"abstract":"<p><p>The compliance with the low-protein, supplemented diet is facilitated or hindered by psychological, social and toxic (severe uremia) factors; however, the most important factor which induces good compliance in patients is the fear of dialysis. The early effect of poor compliance is the appearance of intoxication related to renal failure and the consequent appearance of the uremic syndrome. The assessment of compliance with the low-protein intake is done quite easily by measuring urea appearance; however, regular clinical and laboratory controls are mandatory: anthropometric measurements, evaluation of the serum concentrations of proteins (especially those having a rapid turnover), and the evaluation of thyroid function--which is depressed in a state of malnutrition and improves following nutritional therapy--are adequate for detecting a state of malnutrition following poor compliance.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14561112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y A Carpentier, M Richelle, B E Bihain, W Dahlan, D Haumont, R J Deckelbaum
{"title":"Interactions between exogenous fat and plasma/lipoproteins.","authors":"Y A Carpentier, M Richelle, B E Bihain, W Dahlan, D Haumont, R J Deckelbaum","doi":"10.1159/000226178","DOIUrl":"https://doi.org/10.1159/000226178","url":null,"abstract":"<p><p>Fat emulsions are essentially composed of triglycerides and phospholipids. Their elimination from the plasma--which is generally rapid--is influenced by the amount and the composition of both these components. During their short stay in the vascular compartment, exogenous particles undergo major compositional changes. They acquire various apolipoproteins--namely C-II, C-III, E and A-IV--by transfer from HDL. They also acquire esterified cholesterol from HDL and LDL and transfer exogenous triglycerides and phospholipids to these endogenous lipoproteins. These exchanges are affected by the type of triglyceride fatty acids and the amount of phospholipids present in fat emulsions, as well as by the infusion rate. Some 10% of emulsions--with a high phospholipid: triglyceride ratio--contain a huge phospholipid excess which can be isolated as a separate fraction from the triglyceride-rich particles. These phospholipids markedly interfere with the metabolism of cholesterol and the plasma lipoprotein profile.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 3 ","pages":"29-32"},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14250675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}