M Neuhäuser-Berthold, S Böhler, D Berthold, K H Bässler
{"title":"[Infusion solution with a high concentration of branched-chain amino acids and a high-percentage amino acid solution in an experimental animal model].","authors":"M Neuhäuser-Berthold, S Böhler, D Berthold, K H Bässler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Young male rats are randomized into two groups and maintained by total parenteral nutrition with an isocaloric and isonitrogenous regimen for 6 days. Group I receives a 15% amino acid solution containing 17% branched chain amino acids while group II is given a 10% amino acid solution containing 26.6% branched chain amino acids. By this regimen group I receives 1.02 g and group II 1.77 g branched chain amino acids/kg B.W./day. No significant differences are observed in weight gain, nitrogen balance, amino acid excretion and amino acid concentrations in muscle. The higher supply with branched chain amino acids is simply reflected in significant augmented plasma concentrations of these amino acids. Simultaneously there is a significant increase of glycine and threonine in plasma. The infusion of the concentrated amino acid solution is well tolerated by the animals and results in a decreased urinary volume.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"262-6"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14256445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H J Gramm, H Baudisch, S Schlagenhaufer, J Goecke, U Frucht
{"title":"[Content of trace elements in solutions for parenteral nutrition and blood derivatives].","authors":"H J Gramm, H Baudisch, S Schlagenhaufer, J Goecke, U Frucht","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intravenous solutions contain both essential and nonessential trace elements. The manufacturer is not obliged to declare the concentration of trace elements contained therein. Therefore, a study was done to investigate the concentration of magnesium, copper, chromium, manganese and cobalt, as well as a possible contamination by aluminum and nickel, in 15 solutions used for parenteral nutrition and blood products applied in Germany. Measured against the daily parenteral requirements, negligible concentrations were found for all essential trace elements with the exception of chromium and cobalt. A marked contamination by the nonessential metal ions aluminum and nickel was detected in the 5% protein- and 20% albumin-solutions. Aluminum concentration was 16-49 mumol/l in the blood products and up to 4.9 mumol/l in the nutrient solutions. The concentration of nickel found in the protein- and hydroxyethyl starch solutions was 250 times higher than the normal serum level. It must be assumed that different manufacturing procedures lead to the different degrees of contamination of the solutions (up to 100%). In view of more recent publications, the aluminum contamination may be a potential hazard to patients with prolonged parenteral nutrition and certain risk groups among the critically ill.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"290-4"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14256448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effect of L-lysine-induced amino acid imbalance on nitrogen balance in patients treated by total parenteral nutrition].","authors":"W Heinrichs, U Fauth, W Seufert, M Halmágyi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cumulative nitrogen balances of 109 patients in 3 groups under total parenteral nutrition were studied with regard to their daily intake of l-lysin. Patients in group 1 who received a mean daily amount of 4.5 g l-lysin exclusively from the amino-acid solution showed a cumulative nitrogen balance of -51.9 g N 10 days into the study. Patients in groups 2 and 3 received, additionally, l-lysin HCl for prophylaxis or therapy of metabolic alkalosis. Thus patients in group 2 received 5.3 g l-lysin (nitrogen balance -101.4 g N/10 days) and in group 3, 8.5 g l-lysin (nitrogen balance -97.6 g N/10 days). The markedly higher negative nitrogen balance in these groups is interpreted as the effect of an amino acid imbalance due to inadequate l-lysin intake; therefore, l-lysin should no longer be used for treatment of metabolic alkalosis in patients under total parenteral nutrition.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"252-5"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14256498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Metzner, W Hartig, R Matkowitz, H J Graubaum, K Jung, C Wagenknecht, R Ritter
{"title":"[Value of various amino acid mixtures for the treatment of chronic liver damage].","authors":"C Metzner, W Hartig, R Matkowitz, H J Graubaum, K Jung, C Wagenknecht, R Ritter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A reproducible liver lesion was caused in 28 pigs by intermittent, intraperitoneal administration of thioacetamide. The morphological degree of the liver lesion was checked by histological investigations (material drawn from the liver by biopsy). During a 3-day infusion period a so-called liver solution (Aminofusin hepar) was given to one group of animals, a normal solution (Infesol) to a second group, and only an electrolyte infusion solution under oral nutrition ad libitum to a third one. The solutions were labelled with (15N) glycine. The amounts of total N, total 15N, 15N with single non-protein fractions, a number of enzymes of 15N incorporated into the liver protein were measured in urine, and the following points were established: 1. The catabolic situation of metabolism is eliminated both by the so-called normal solution and the specific amino acid solution. The two mixtures of L-amino acids thus have a nutritive effect. 2. The toxic liver lesion is an indication for parenteral nutrition. Oral nutrition alone is not sufficient. 3. The so-called liver solution influences the liver metabolism of the protracted liver lesion more than the so-called normal solution does, and considerably more than an electrolyte infusion solution under oral nutrition ad libitum.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"256-60"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14256444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Peculiarities of perioperative nutritional therapy in children].","authors":"K Zwiauer, K Widhalm","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is a well known correlation between postoperative morbidity and mortality and the preoperative nutritional status. Due to this fact perioperative nutritional therapy has gained growing importance. In newborns, children, and adolescents several metabolic facts have to be taken into account in the perioperative management which are the topics of this review. Differences in electrolyte, fluid, and nutrient requirements are discussed. The article presents a summary of possibilities in parenteral and enteral nutritional therapy, recommendations and practical guidelines for the treatment of children and adolescents.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"267-72"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14256446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Significance and assessment of the compatibility of mixed solutions with fat emulsion components for parenteral nutrition].","authors":"P Semler, K Sommermeyer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Combined solutions can greatly facilitate the carrying out of parenteral nutrition. The compatibility of their components as well as the stability of such solutions for the duration of clinical use are prerequisites for their application. The necessary and extensive tests of compatibility are illustrated on the basis of a combined solution that is easily produced in the clinic for peripheral and parenteral nutrition. The limits to the production of combined solutions are described.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"274-82"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14256447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U Brenner, L Herbertz, M Meibert, J M Müller, H Reinauer
{"title":"[The effect of the small intestine on 3-methylhistidine metabolism in the human].","authors":"U Brenner, L Herbertz, M Meibert, J M Müller, H Reinauer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>20 male adult Sprague-Dawley rats were fed exclusively parenterally. After achieving metabolic equilibrium they received a duodenoileostomy and subtotal resection leaving only 8-10% of the small gut. On the 1st postoperative day the urinary 3-MH excretion rose to 1.5-1.7 times the preoperative level, but on the 12th-14th postoperative day it fell again and was equal to the preoperative basal level. A control group of 10 rats undergoing a small gut anastomosis without resection yielded similar results. We conclude that the small gut source does not make a significant contribution to 24h-urinary 3-MH excretion in the adult rat. The transient postoperative increase in urinary 3-MH excretion is probably due to post-injury metabolism. In contrast to these are the measurements in two male patients with a short bowel syndrome because of an occlusion of the superior mesenteric artery. Both patients have a body weight of 60 kg, are aged 44 and 45 years respectively, and have a 24h-urinary 3-MH excretion of 120.7 +/- 28 mumol. More than 1 year after operation they are being nourished parenterally in metabolic equilibrium. The 24h-urinary 3-MH excretion in a similar control group of 8 healthy male volunteers is 229.4 +/- 25 mumol (measurements for 6 days after a 1-week meat-free diet). We conclude that the small gut source makes a significant contribution to 24h-urinary 3-MH excretion in the adult human. There is no evident correlation between the rat model and measurements in human.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"248-51"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14256496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Human albumin therapy and prognostic value of determining colloid osmotic pressure at the surgical intensive care station].","authors":"R Grundmann, D Tübergen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>367 patients treated on the intensive care unit were prospectively documented during a 1-year observation period. Plasma colloid osmotic pressure (COP) was daily measured. Human albumin therapy was required only in 10% of all patients. These mainly long-term (greater than 10 days) treated patients also showed the lowest levels of COP (minimum COP means: 21 cmH2O (= 15.4 mmHg]. In the majority of all cases an extreme decrease of COP (less than 20 cmH2O (= 14.7 mmHg] was due to sepsis associated with an unfavorable prognosis. 67% of all patients with at least a single decrease of COP less than 20 cmH2O died, as compared to 15% of the patients where the COP never fell below 25 cmH2O. When a low COP was secondary to sepsis, the therapeutic benefit of an albumin therapy could not be evaluated.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 6","pages":"284-8"},"PeriodicalIF":0.0,"publicationDate":"1987-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14565208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of diet and underlying renal disease on the rate of progression of chronic renal failure.","authors":"N Gretz, E Meisinger, M Strauch","doi":"10.1159/000226322","DOIUrl":"https://doi.org/10.1159/000226322","url":null,"abstract":"<p><p>The data presented demonstrate that the underlying renal disease and the type of diet used are considerably influencing the rate of progression of chronic renal failure. In relative terms the course of the renal disease is mostly changed in patients suffering from glomerulonephritis, while in absolute terms patients suffering from polycystic kidney disease exhibit the slowest rate of progression. The comparison suggests that a low-protein diet purely based on vegetarian food might considerably slow down the overall rate of progression of chronic renal failure. This finding is supported by results obtained in animal experiments.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"21-5"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14561109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Therapeutic studies with branched-chain amino acids in portasystemic encephalopathy].","authors":"E H Egberts","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Published controlled clinical trials with branched chain amino acids (BCAA) in patients with portosystemic encephalopathy (PSE) are described and their results discussed. A positive effect on PSE by BCAA seems probable but without altering mortality rate. Improvement of nutritional state cannot be finally evaluated.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"53-8"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14452503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}