{"title":"[Renal effects of dopamine in healthy adults with special reference to the excretion of phosphate and calcium].","authors":"U Finsterer, R Rötzer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intravenous application of 4 micrograms/kg/min dopamine (DA) over 3 h in 11 healthy volunteers resulted in an increase in inulin clearance and urine volume by about 10%, renal excretion of sodium and calcium being increased by DA by a factor of 5. We found a strong linear correlation between changes of renal excretion of sodium and calcium under DA (r = 0,90). The concentration of ionized calcium in whole blood was absolutely stable under DA in the range of 1.25 to 1.27 mmol/l. The application of the catecholamine also resulted in a significant reduction of plasma volume by a mean of about 10% and in a nonsignificant reduction of intravascular protein mass by 8%. The phosphaturic effect of DA was weak and unpredictable. We suppose that in the intact organism the pharmacologic effect of dopamine on the tubular handling of phosphate which seems to be experimentally proven, may be masked by other mechanisms with an antiphosphaturic action such as increased levels of growth hormone and/or insulin.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 5","pages":"222-30"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14922011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Intraoperative infusion therapy. Evaluation of the rate of administration and assessment of the effectiveness of infusion warmers].","authors":"J Nagler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A look at the efficiency of infusion warmers from the clinician's point of view must be based on the infusion rates usually necessary in the operating room. Therefore a retrospective evaluation of 1,510 anesthesia records was made in order to register the flow rate of every infusion. As a general rule the flow rate did not exceed 1.5 1/h. Our past warming apparatus was found not very effective in this range under the standard conditions of a cold operating room with laminar air flow. A new in-line warmer, fast and easy to handle, proved superior in daily use.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 5","pages":"216-9"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14922010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Therapy using blood components. Prerequisites, indications and clinical use].","authors":"D Glück, B Kubanek, F W Ahnefeld","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The therapeutic benefit of blood components for specific substitution and volume replacement has been recognized for more than ten years. The increasing demand for blood and blood products, especially for albumin in connection with an only moderate growth of the base of blood donors has promoted the idea of a more efficient utilization of blood by specific replacement with blood components. The component therapy has reduced the side effects and improved the efficacy of blood transfusion and last but not least has led to a positive cost-effectiveness. Our clinical management of blood transfusion with a nearly complete use of components in surgical patients is presented. Particularly, the therapeutic strategy for massive transfusions by component therapy is discussed. In face of the technical and logistic problems, a transfusion schedule was developed which outlines the nearly exclusive therapeutic use of components. It applies with modifications and adjustment to the critical parameters to all cases of rapid and massive blood loss. In addition, diagnostic and therapeutic strategies are considered to preserve hemostasis or correct occurring hemostatic defects and to prevent thrombo-embolic events.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 5","pages":"240-9"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14922013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U Brenner, J M Müller, M Walter, W Holzmüller, H W Keller
{"title":"[Anthropometric parameters].","authors":"U Brenner, J M Müller, M Walter, W Holzmüller, H W Keller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anthropometry is defined as the comparative measurement and study of the human body. Anthropometric measurements have been used for many years to assess the nutritional status of individuals and populations in the United States. More recently anthropometric measurements have become a routine part of the nutrition assessment of surgical patients. Upper arm anthropometry and handgrip dynamometry are rapid and inexpensive tests for detecting malnutrition, but they are not useful for preoperative screening to predict postoperative morbidity because appropriate standards are missing in Europe. In a prospective study none of these preoperatively measured variables were of predictive value to postoperative complications, relating the method to its specificity, sensitivity, and validity.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 5","pages":"232-7"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14922012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Sitges-Serra, J Figueras-Felip, A Alastrue-Vidal, E Jaurrieta-Mas, A Rafecas-Renau
{"title":"A randomized trial on the effect of isotonic amino acid infusion on postoperative complications and short life plasma protein concentrations.","authors":"A Sitges-Serra, J Figueras-Felip, A Alastrue-Vidal, E Jaurrieta-Mas, A Rafecas-Renau","doi":"10.1159/000222147","DOIUrl":"https://doi.org/10.1159/000222147","url":null,"abstract":"<p><p>In a randomized clinical study 30 patients with high risk surgical procedures were distributed to receive either standard fluid-therapy (n = 14) or an isotonic amino acid solution (n = 16) during five days. The patients were evaluated pre- and postoperatively using: anthropometric parameters: body weight, biceps and triceps skinfold thickness, and mid arm circumference; biochemical parameters: albumin, prealbumin, transferrin, retinol-binding protein, total iron-binding capacity, and cholesterol; and delayed cutaneous hypersensitivity. Clinical outcome and complications were also recorded. Positive ketonuria was obtained soon in the treatment group after 24 h. Mean daily nitrogen balance was better in the protein sparing group (-3.8 g vs -9.3 g) p less than 0.02. No differences were observed between both groups in the postoperative plasma protein levels. There were no significant differences in delayed cutaneous reactivity nor anthropometric parameters between both groups; and mortality and morbidity were similar. The present study lends little support for substituting the routine D5W and saline postoperative fluid regime. No clinical advantage of amino acids over standard fluids could be appreciated indicating that the much less expensive conventional solutions should not be replaced by amino acids, at least in routine postoperative cases.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 5","pages":"210-4"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000222147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14665126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Experiences with L-carnitine in the post-stress phase].","authors":"D Balogh, J M Hackl, E Legenstein, H E Musil","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A prospective randomized double blind investigation was made in 24 multiple injured patients. All patients were treated with a combined parenteral-enteral nutrition during 7 days. A group of 11 patients received as a continuous infusion over 16 h 60 mg/kg BW carnitine daily. Beside carnitine and acetylcarnitine levels in plasma and urine the following parameters were determinated to evaluate the effect of carnitine: for the metabolism of fatty acids: triglycerides, free fatty acids (FFA), alpha-hydroxy-butyrate for the metabolism of carbohydrates: glucose, insulin and lactate in plasma. Finally for amino acid metabolism: urea, creatinine, cholinesterase and kolloid osmotic pressure in plasma as well as ureanitrogen and alpha-aminonitrogen excretion in urine. In the patients receiving carnitine especially acetyl-carnitine in plasma and acetyl-carnitine excretion in urine increased, proving that the administered carnitine can pass through the mitochondrial membrane. In these patients the plasma level of FFA was markedly lower than in the group without carnitine. Simultaneously the level of the alpha-hydroxybutyrate was elevated, equivalent to an increased oxydation of fatty acids. There was no difference between the two groups in the metabolism of carbohydrates. Administration of carnitine caused a slight increase of the production of urea (PU), catabolism could not be reduced. The excretion of alpha-aminonitrogen in urine augmented after carnitine infusion. Carnitine is an AA itself and so the amount of excreted alpha-amino nitrogen will increase; additionally the reabsorption of AA in the proximal renal tubulus may be inhibited by carnitine.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 5","pages":"204-8"},"PeriodicalIF":0.0,"publicationDate":"1986-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14232733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The interpretation of ribosome determinations to assess protein synthesis in human skeletal muscle.","authors":"J Wernerman, A von der Decken, E Vinnars","doi":"10.1159/000222133","DOIUrl":"https://doi.org/10.1159/000222133","url":null,"abstract":"<p><p>A survey is given on the determination and interpretation of ribosomal concentration and size distribution in animal and human muscle biopsy samples as a means to assess protein synthesis under various physiological and pathological conditions.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 4","pages":"162-5"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000222133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14653319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Ammonia and glutamine metabolism of the intestine. The effect of lactulose and neomycin].","authors":"P B Soeters, P A van Leeuwen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present work is directed to distinguish between ammonia production by the mucosa and by the intestinal flora, as well as to evaluate the influence of neomycin and lactulose. In vitro studies using rat intestine show that mucosa cells produce ammonia alanine and glutamic acid when incubated with glutamine, whose process can be impaired by neomycin or lactulose. Since the release of the above solutes is virtually the same in germ-free rats, the influence of the bacterial flora might be negligible under the experimental conditions used. Elimination of the aerobic microorganisms results in a minute decrease of ammonia concentration in portal blood in contrast to elimination of the anaerobic flora, which leads to an excessive reduction of ammonia formation. In germ-free rats colonisation with anaerobic microorganisms results in an increment in portal ammonia concentration, whose value, however, is still below levels observed in normal animals. Colonisation with aerobic bacteria has no effect on portal ammonia concentration. Neomycin and lactulose affect ammonia production in the gut by interfering with glutamine uptake in the mucosa cell, thus the influence upon ammonia formation apparently can not be exclusively explained by alterations of the intestinal flora. Possible reasons for the considerable increase in arterial glutamine levels in normal rats are discussed.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 4","pages":"186-90"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14876822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fat emulsions are more than energy suppliers.","authors":"Y A Carpentier, B E Bihain, R J Deckelbaum","doi":"10.1159/000222137","DOIUrl":"https://doi.org/10.1159/000222137","url":null,"abstract":"<p><p>The type of triglycerides in exogenous fat emulsions as well as the phospholipid: triglyceride ratio influences the plasma clearance. The plasma clearance cannot be used for indicating the utilization of fat emulsions as energy substrate. Introducing exogenous fat in replacement of part of the calories provided by glucose reduces a series of complications associated with large glucose intake. There are exchanges of triglycerides, esterified cholesterol, phospholipids and apoproteins between exogenous lipids and endogenous lipoproteins, depending on the composition of exogenous lipid emulsions. These interactions can significantly modify the composition of both, exogenous particles and endogenous lipoproteins. In future it will become essential to determine the removal site of 'exogenous remnants'. Future progress will allow a better understanding of the influence of these modifications on the metabolism of endogenous lipoproteins and the utilization of exogenous fat emulsions.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 4","pages":"182-4"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000222137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14653209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J A Vazquez, G A Paleos, H Lochs, K Langer, M Brandl, S A Adibi
{"title":"A concentrated mixture of amino acids and dipeptides for total parenteral nutrition.","authors":"J A Vazquez, G A Paleos, H Lochs, K Langer, M Brandl, S A Adibi","doi":"10.1159/000222140","DOIUrl":"https://doi.org/10.1159/000222140","url":null,"abstract":"<p><p>Using a subhuman primate (baboon) we have investigated the utility of a 20% mixture of amino acids and dipeptides as the nitrogen source for total parental nutrition. The mixture, besides containing all 8 essential amino acids and a number of non-essential amino acids (glutamate, aspartate, arginine, histidine, serine, ornithine and alanine), contained 6 dipeptides (Gly-Ile, Gly-Leu, Gly-Val, Gly-Tyr, Gly-Gln, and Ala-Gln) and acetyl-cysteine. A week of total parenteral nutrition was preceded by one week of oral feeding. The caloric intake and composition during the two periods was identical except for the nitrogen source, which was intact protein during the oral period, and the mixture of amino acids and dipeptides during the parenteral period. There was no significant difference between gain in body weight or nitrogen balance during the two periods. There were selective increases in plasma and muscle concentrations of amino acids during the parenteral period, which appeared to reflect the amino acid enrichment of the nitrogen source. The efficient utilization of dipeptides was evidenced by their small concentrations in plasma and urine. The urinary excretion of dipeptides was about 1% of the amount infused. This efficiency of dipeptide utilization persisted even when the infusion rate of the amino acid and dipeptide mixture was increased by 7-fold. There was no alteration in liver, kidney, and immune function during the parenteral period. The data indicate the efficacy and safety of the mixture of amino acids and dipeptides as the nitrogen source for parenteral nutrition.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"13 4","pages":"193-8"},"PeriodicalIF":0.0,"publicationDate":"1986-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000222140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14224887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}