K Lindenau, F Kokot, K Vetter, R Schmicker, P T Fröhling
{"title":"Influence of keto acid (KA) treatment on renal osteodystrophy.","authors":"K Lindenau, F Kokot, K Vetter, R Schmicker, P T Fröhling","doi":"10.1159/000226328","DOIUrl":"https://doi.org/10.1159/000226328","url":null,"abstract":"<p><p>A marked improvement of renal osteodystrophy was achieved after a combined treatment with keto acids and vitamin D in patients with chronic renal failure. Results were checked by histological investigations. The biochemical background of the successful treatment was analysed. A regression of hyperparathyroidism and improvement in vitamin D status are the cause of this phenomenon.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"40-2"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14624316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Scheffler, F Jung, C Mrowietz, P Waldhausen, G Leipnitz, B Häuser
{"title":"[Hemorheologic, micro- and macrocirculatory effects of hypervolemic infusions of middle molecular weight hydroxyethyl starch (10%, 200,000/0.62) in healthy probands].","authors":"P Scheffler, F Jung, C Mrowietz, P Waldhausen, G Leipnitz, B Häuser","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During an open clinical trial the influence of hypervolemic hemodilution (Infusion of 500 cc Elohäst within 1 h) on macrocirculation, microcirculation and blood fluidity of healthy volunteers was investigated. Blood pressure and heart rate remained constant during the infusion period and later on. The decline in hematocrit after 6 h was four points, plasma viscosity and erythrocyte aggregation, however, increased significantly. Three hours after completion of the infusion a significantly elevated blood flow in the common carotid artery could be assessed with a return to approximately normal values after 6 h. The improvement of the microcirculatory flow took a longer period of time. After 6 h a significantly increased erythrocyte velocity in the nailfold capillaries along with a significant augmentation of transcutaneously measured partial oxygen pressure could be stated.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 5","pages":"233-8"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13593456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Palacios Rubio, T Sanz Gonzalo, J M Montón Dito, A García Jalón, M L Calvo Ruata
{"title":"Caloric supply in parenteral nutrition in the stress phase.","authors":"V Palacios Rubio, T Sanz Gonzalo, J M Montón Dito, A García Jalón, M L Calvo Ruata","doi":"10.1159/000222217","DOIUrl":"https://doi.org/10.1159/000222217","url":null,"abstract":"<p><p>Due to the metabolic alterations following surgery, glucose is not completely oxidized but is converted into glycogen and lipids. Therefore we analysed 2 groups of 15 patients following surgery. They received parenteral nutrition with identical nitrogen (N = 0.28 g/kg/d) and lipid (1.5 g/kg/d) intake, whereby only the composition of carbohydrates was varied. Group I received exclusively glucose = 0.22 g/kg/h, and group II the combination fructose-glucose-xylitol in a proportion of 2:1:1 at the same infusion rate. The study lasted approximately 10 days. We found decreased exogenous insulin requirements and an increase in the NEFA levels with a maximum on the 3rd and 4th day in group II. There were no significant differences in the levels of either albumin, prealbumin or retinol-binding protein, nor were any hepatic or renal alterations related to the xylitol infusion observed. Xylituria was 6.13 +/- 3% of the amount infused. In our opinion, the partial substitution of glucose in group II led to a better utilisation of the infused energy supply, and to less insulin stimulation, which facilitated the mobilization of endogenous energy sources such as fatty acids, although we did not succeed in increasing the protein synthesis.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 5","pages":"196-201"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000222217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14250669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Homeostasis of plasma amino acids in standardized parenteral nutritional therapy in acute necrotizing pancreatitis].","authors":"H Wiedeck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study investigates amino acid homeostasis and nitrogen balance in patients with acute necrotizing pancreatitis. 10 patients received a parenteral nutritional regimen containing 1 g of amino acids/kg B.W./day and 6.5 g of carbohydrates/kg B.W./day. Parameters to define homeostasis were measured to characterize the patients. In addition we determined the plasma amino acids and the nitrogen balance. All those biochemical parameters measured to define homeostasis remained within the physiological reference range. The description of the relative amino acid pattern only demonstrated changes of the postoperatively typically altered amino acids, e.g. phenylalanine.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 5","pages":"224-7"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14250671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperfiltration due to amino and keto acid supplements of low-protein diets: influence on proteinuria.","authors":"E Meisinger, N Gretz, M Strauch","doi":"10.1159/000226323","DOIUrl":"https://doi.org/10.1159/000226323","url":null,"abstract":"<p><p>In 12 male 5/6 nephrectomized Sprague-Dawley rats we analyzed the influence of commercially available amino/keto acid supplements on proteinuria. The addition of different supplements to an 8% protein diet resulted in an increase of preexisting proteinuria. Keto acids per se do not seem to cause a remarkable degree of proteinuria/hyperfiltration. Our data underline the importance of the protein content of a low-protein diet and the composition of amino/keto acid supplements, as these factors per se can cause hyperfiltration and might accelerate progression of chronic renal failure.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"26-9"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14561110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U Brenner, J M Müller, H W Keller, M Walter, P Thul
{"title":"[Comparison of prognostic nutrition indices in preoperative detection of risk patients. A prospective trial].","authors":"U Brenner, J M Müller, H W Keller, M Walter, P Thul","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Malnutrition must be considered as a factor of risk in surgery and therefore it has to be taken into account in surgical planning. Many authors aggregated several measurements into an index or another mathematical model by stepwise regression or discriminant analysis. Hitherto none of these approaches has been subjected to a critical analysis designed to determine whether the information gained differentiates patients with increased operative risk from those without, to a degree that is clinically relevant. In a prospective study the predictive values of nutritional assessment techniques of various authors were examined in 246 surgical patients undergoing a major surgical procedure. The specificity, sensitivity, and validity of each assessment technique were determined. The statistical analysis showed that none of the assessment techniques separated patients who were at high risk from those who were at low risk in a statistically significant predictive power. Serum albumin level was a quite accurate prognostic indicator of postoperative morbidity and mortality. The mean complication rate in this study was 26.8%. Concerning the specificity, sensitivity, and validity the single measurement of the serum albumin had a predictive value as high as all other determined assessment techniques in this study. We contend that combining measurements into a statistically derived index is time-consuming and expensive and does not produce an assessment technique with sufficient predictive power to identity high risk patients in a clinically relevant fashion.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 5","pages":"215-21"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14799030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G Barsotti, R Navalesi, E Morelli, O Giampietro, F Ciardella, A Cupisti, S Giovannetti
{"title":"Effects of a low-phosphorus, low-protein diet supplemented with essential amino acids and keto analogues on 'overt' diabetic nephropathy.","authors":"G Barsotti, R Navalesi, E Morelli, O Giampietro, F Ciardella, A Cupisti, S Giovannetti","doi":"10.1159/000226320","DOIUrl":"https://doi.org/10.1159/000226320","url":null,"abstract":"<p><p>In this paper we studied the effects of a low-protein, low-phosphorus supplemented diet in 8 type I diabetics with 'overt' diabetic nephropathy and mild or severe renal insufficiency. We examined the following parameters: the rate of decline of creatinine clearance, the urinary protein loss, the total serum protein, the daily insulin requirement, the serum fasting glucose, the pattern of serum lipids (serum total cholesterol, HDL cholesterol and serum triglycerides), the mean blood pressure and body weight. The rate of decline of creatinine clearance decreased monthly from 1.48 +/- 0.20 ml/min during a previous 15.6-month period of unrestricted protein diet (UPD), to 0.13 +/- 0.3 ml/min during the 11.4 months on the supplemented diet (SD). The mean blood pressure did not differ during UPD (130.9 +/- 7.0 mmHg) and during SD (128.1 +/- 1.6 mmHg). Urinary protein loss significantly decreased on SD, and total serum protein increased. The daily insulin requirement and the serum fasting glucose levels significantly decreased on SD. Serum cholesterol was lower during SD than during UPD, while serum HDL cholesterol and serum triglycerides were not significantly modified. In some patients the body weight decreased on SD as a consequence of the disappearance of edema. In conclusion, on the basis of these preliminary observations, the SD slows the progression of renal failure and seems to exert several beneficial and no unwanted side-effects in renal failure of type I diabetics.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"12-6"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14561107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperfiltration due to amino and keto acid supplements of low-protein diets: influence on creatinine clearance.","authors":"N Gretz, E Meisinger, M Strauch","doi":"10.1159/000226325","DOIUrl":"https://doi.org/10.1159/000226325","url":null,"abstract":"<p><p>In 12 male 5/6 nephrectomized Sprague-Dawley rats we analyzed the influence of commercially available amino/keto acid supplements on creatinine clearance. The addition of different supplements to an 8% protein diet resulted in an increase of creatinine clearance. Keto acids per se do not seem to cause a remarkable increase in creatinine clearance/hyperfiltration. Our data underline the importance of the protein content of a low-protein diet and the composition of amino/keto acid supplements, as these factors per se can cause hyperfiltration and might accelerate progression of chronic renal failure.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"30-3"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14561111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Schwartz, M Farriol, R Rodriguez, E García, J B Padró, P E Vente
{"title":"Influence of the qualitative caloric composition of enteral diets on liver protein synthesis in normal and operated rats.","authors":"S Schwartz, M Farriol, R Rodriguez, E García, J B Padró, P E Vente","doi":"10.1159/000226332","DOIUrl":"https://doi.org/10.1159/000226332","url":null,"abstract":"<p><p>Protein synthesis L-(l-14C) leucine in liver was studied. Normal (n = 40) and operated (n = 40) Sprague-Dawley rats with an initial body weight of 161.18 +/- 12 g were divided into four groups (n = 10), respectively. Each group, subjected to the same conditions of temperature, light, noise and movement received a different commercial formula for human enteral nutrition and water for 8 days (normal rats) and six days (operated rats). All rats received the same caloric and protein intake per ml (l kcal; 6-7.10(-3) g protein), with no statistically significant differences among groups. The differences in diets were merely qualitative. The tolerance to all diets was similar, with rats attaining the expected weight. Losses of protein, alpha aminic nitrogen, total fat and non sterified fatty acid in faeces were negligible. In normal rats, different results in liver protein synthesis were obtained. No mass/synthesis rate correlation was found. Under these conditions it would appear that these results are due to the different diets used. In operated rats, a significantly different liver protein synthesis per gram of body weight was obtained, but not per gram of organ weight. These results suggest that the influence of the qualitative caloric intake, in the stress phase, is less than in the normal state.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"59-61"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000226332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14255682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Hepatic encephalopathies].","authors":"W Gerok","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The functional disturbances of the central nervous system in hepatic encephalopathy are due to several coexisting pathogenetic factors: Endogenous neurotoxins, imbalance of amino acids in blood plasma and alterations of the blood-brain barrier. These factors, in turn, effect alterations of neurotransmitters and their receptors. Therapeutic interventions are aimed at the inhibition of ammonia production by protein restriction, lactulose or antibiotics. A new therapeutic concept is the application of branched chain amino acids. Their effect is based on the stimulation of protein synthesis in muscle, enhanced urea synthesis in the liver and increased ammonia detoxification by glutamine synthesis in the brain.</p>","PeriodicalId":75931,"journal":{"name":"Infusionstherapie und klinische Ernahrung","volume":"14 Suppl 5 ","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14031274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}