Marit J.B. van Stigt , Saskia Coenraad , Inge Stegeman , Robert J. Stokroos , Stefaan H.A.J. Tytgat , Maud Y.A. Lindeboom , Arnold J.N. Bittermann
{"title":"Indication and efficacy of injection laryngoplasty for laryngeal clefts - A retrospective cohort study","authors":"Marit J.B. van Stigt , Saskia Coenraad , Inge Stegeman , Robert J. Stokroos , Stefaan H.A.J. Tytgat , Maud Y.A. Lindeboom , Arnold J.N. Bittermann","doi":"10.1016/j.amjoto.2024.104425","DOIUrl":"10.1016/j.amjoto.2024.104425","url":null,"abstract":"<div><h3>Purpose</h3><p>Laryngeal cleft (LC) is an anatomical defect of the larynx, where there is a gap (or cleft) between the arytenoids. Milder types can be treated with injection laryngoplasty (IL), involving injection with a filler, resulting in a decreased depth of the cleft and thereby reducing tracheal penetration or aspiration. The effect, however, is temporary. The aim of this study was to investigate the possible indications and the efficacy of IL for LC.</p></div><div><h3>Methods</h3><p>Patients who underwent IL for LC between March 2018 and June 2023 were retrospectively evaluated. The following parameters were studied: incidence of LC symptoms and objective swallowing evaluations before and after IL, the duration of possible symptom improvement, complications, and the number of subsequent suture repairs.</p></div><div><h3>Results</h3><p>Eighty-five patients were included. Before IL, 81 (96 %) patients had symptoms of aspiration during feeding, compared to 41 (54 %) patients after IL (<em>p</em> ≤ 0.001). In 42 (49 %) patients, temporary symptom relief occurred, in 22 (26 %) patients symptoms persisted, in 16 (19 %) patients symptoms decreased permanently. Mild complications such as cough and desaturations in the direct postoperative period occurred.</p></div><div><h3>Conclusion</h3><p>This study shows a statistically significant decrease in the number of parents/caretakers reporting swallowing symptoms after injection laryngoplasty, and a decrease in the average percentage of parents/caretakers reporting various other symptoms. Based on our results, injection laryngoplasty can be recommended as a diagnostic tool in the treatment of laryngeal cleft. Furthermore, it can be used as bridge therapy (i.e. until patients outgrow their symptoms, or until suture repair).</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 6","pages":"Article 104425"},"PeriodicalIF":1.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pooja D. Reddy , Soukaina Eljamri , Amber D. Shaffer , Reema Padia
{"title":"Impact of ciprofloxacin/dexamethasone on pediatric tracheostomy outcomes","authors":"Pooja D. Reddy , Soukaina Eljamri , Amber D. Shaffer , Reema Padia","doi":"10.1016/j.amjoto.2024.104406","DOIUrl":"10.1016/j.amjoto.2024.104406","url":null,"abstract":"<div><h3>Objective(s)</h3><p>To investigate the effectiveness of ciprofloxacin/dexamethasone in reducing granulation tissue post-tracheostomy in pediatric patients.</p></div><div><h3>Methods</h3><p>This cohort study examined pediatric patients with a tracheostomy at a single academic institution from 2016 to 2020. Exclusion criteria included: deceased within 1 year (<em>n</em> = 38), >16 years of age (<em>n</em> = 21), decannulated within 1 year (<em>n</em> = 15), lost to follow-up within 1 year (<em>n</em> = 6), and revision tracheostomy (<em>n</em> = 2). Logistic regression or Wilcoxon rank-sum (α = 0.05) were used to compare demographic and clinical characteristics between patients who did and did not receive ciprofloxacin/dexamethasone within 1 year of their tracheostomy.</p></div><div><h3>Results</h3><p>In this cohort, (<em>n</em> = 126, median age 5.2 months, 54.0 % male), 62.7 % received ciprofloxacin/dexamethasone within 1 year, with 27.8 % taking the nebulized form. Granulation tissue occurred in 81.0 % of cases, predominantly peristomal (69.8 %) and suprastomal (34.9 %). Notable complications included accidental decannulation (13.6 %), suprastomal collapse (11.2 %), and bleeding (7.2 %). Although granulation tissue was more common in ciprofloxacin/dexamethasone users (92.4 %) versus non-users (61.7 %) (OR: 7.55, 95 % CI: 2.73–20.9, <em>p</em> < 0.001), patients exhibited less frequent granulation tissue events after initiation (z = 3.88, p < 0.001). No significant differences in antibiotic resistance (<em>p</em> = 1.0) or endocrinology complications (<em>p</em> = 0.1) were found between those with and without ciprofloxacin/dexamethasone.</p></div><div><h3>Conclusions</h3><p>We found a statistically significant reduction of granulation tissue incidence with ciprofloxacin/dexamethasone use and no significant differences in antibiotic resistance or endocrinology complications were noted. Future investigation is warranted to explore timing of ciprofloxacin/dexamethasone administration for granulation tissue and its role in managing and preventing tracheostomy complications.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 5","pages":"Article 104406"},"PeriodicalIF":1.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196070924001923/pdfft?md5=09bb0afeb3f963ea34b4b35e3d68c73a&pid=1-s2.0-S0196070924001923-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141764872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lawrance Lee , Thomas H. Fitzpatrick , Lindsay A. Irwin , Alyssa N. Calder , Nauman F. Manzoor
{"title":"Making a racket in America's fastest growing sport: Evaluation of noise exposure in pickleball","authors":"Lawrance Lee , Thomas H. Fitzpatrick , Lindsay A. Irwin , Alyssa N. Calder , Nauman F. Manzoor","doi":"10.1016/j.amjoto.2024.104409","DOIUrl":"10.1016/j.amjoto.2024.104409","url":null,"abstract":"<div><h3>Objective</h3><p>To measure noise exposure present on pickleball courts and assess the risk of noise-induced hearing loss (NIHL) per guidelines put forward by the National Institute of Occupational Safety and Health (NIOSH).</p></div><div><h3>Methods</h3><p>Observational study measuring noise levels at multiple recreational pickleball courts in the Richmond, VA area, documenting LAeq, LASmax, and LCpeak at courtside and waiting areas of pickleball courts. Measurements were completed using the NIOSH SLM application on an iPhone 13 with iMM-6 Calibrated Measurement Microphone (equivalent to IEC 61672-1 Class II) that was calibrated using ND-9 Sound Level Calibrator (IEC942 Class I).</p></div><div><h3>Results</h3><p>Average sound levels recorded at waiting areas adjacent to the courts, measured in LAeq, LASmax, and LCpeak, were 69.1 dBA, 92.0 dBA, and 112.1 dBC, respectively, while courtside measurements were 69.7 dBA, 92.2 dBA, and 115.6 dBC, respectively. These measurements were within NIOSH and OSHA recommendations.</p></div><div><h3>Conclusion</h3><p>The data demonstrates that randomly sampled pickleball courts have noise levels that do not increase risk for NIHL for participants or bystanders alike based on NIOSH guidelines. However, prolonged noise exposure and ambient noise pollution may have other health implications and warrant further investigations.</p></div><div><h3>Level of evidence</h3><p>Level 2.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 5","pages":"Article 104409"},"PeriodicalIF":1.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141764874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of ChatGPT generated educational material for head and neck surgery counseling","authors":"Lana Mnajjed , Rusha J. Patel","doi":"10.1016/j.amjoto.2024.104410","DOIUrl":"10.1016/j.amjoto.2024.104410","url":null,"abstract":"<div><h3>Background</h3><p>ChatGPT is becoming very popular as an information source for the public. The adequacy of ChatGPT generated patient counseling material has not yet been extensively assessed.</p></div><div><h3>Methods</h3><p>ChatGPT was presented with perioperative counseling and complication questions regarding five different procedure, and accuracy of responses was assessed. The chat was then asked to present an explanation of each procedure, and quality of the responses were compared to online educational material.</p></div><div><h3>Results</h3><p>ChatGPT responses were comprehensive when discussing counseling points commonly discussed by a provider prior to a procedure. Responses to questions on surgical complications were less accurate and comprehensive. In comparison to online educational material, ChatGPT scored at or above the median SAM and PEMAT scores for all procedures.</p></div><div><h3>Conclusions</h3><p>ChatGPT did well addressing basic counseling points during the perioperative period, although it did not perform as well when addressing surgical complications. Chat response quality was comparable to currently available online educational material.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 5","pages":"Article 104410"},"PeriodicalIF":1.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141764824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ying Wang , Qiaoli Lan , Endian Zheng , Xiaoxiao Lin , Yi Chen , Miaomiao Teng
{"title":"Efficacy analysis of the empathy-based attribution analysis-cognitive restructuring-pharmacological treatment model in the management of globus syndrome","authors":"Ying Wang , Qiaoli Lan , Endian Zheng , Xiaoxiao Lin , Yi Chen , Miaomiao Teng","doi":"10.1016/j.amjoto.2024.104421","DOIUrl":"10.1016/j.amjoto.2024.104421","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study is to investigate the clinical efficacy of the empathy-based attribution analysis-cognitive restructuring-pharmacological treatment model for the management of globus syndrome.</p></div><div><h3>Method</h3><p>Sixty-nine newly diagnosed patients with globus syndrome at the Wenzhou People's Hospital Department of Gastroenterology outpatient clinic were enrolled in this study. After obtaining informed consent, patients were randomly assigned to either the observation group (attribution analysis-cognitive restructuring-classical pharmacotherapy; <em>n</em> = 35) or the control group (pharmacotherapy alone; <em>n</em> = 34), with a treatment course of 4 weeks. Efficacy assessments were conducted before and during treatment using the 9-item Patient Health Questionnaire-9 (PHQ-9), the 7-item Generalized Anxiety Disorder-7 (GAD-7), and the Patient Health Questionnaire-15 (PHQ-15).</p></div><div><h3>Results</h3><p>After four weeks of treatment, the total efficacy rate was 100 % in the observation group and 27.6 % in the control group, with a statistically significant difference between the groups (<em>P</em> < 0.05). Scores on the PHQ-9, GAD-7, and PHQ-15 significantly improved in the observation group compared to before treatment and were better than those in the control group, with statistically significant differences (<em>P</em> < 0.05).</p></div><div><h3>Conclusion</h3><p>The empathy-based attribution analysis-cognitive restructuring-pharmacological treatment model for the management of globus syndrome demonstrated good clinical efficacy, providing strong evidence for further clinical promotion.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 5","pages":"Article 104421"},"PeriodicalIF":1.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phillip Q. Richards , Melissa Chavez , Aneesh A. Patel , Lucia S. Ryll , Jessica R. Levi
{"title":"Comparing the educational quality of YouTube and Facebook videos on tympanostomy tubes","authors":"Phillip Q. Richards , Melissa Chavez , Aneesh A. Patel , Lucia S. Ryll , Jessica R. Levi","doi":"10.1016/j.amjoto.2024.104396","DOIUrl":"10.1016/j.amjoto.2024.104396","url":null,"abstract":"<div><h3>Purpose</h3><p>Patients often refer to online materials when researching surgical procedures. This study compares the educational quality of online videos about tympanostomy tubes on two popular video platforms: YouTube and Facebook. This study provides clinicians with context about the content and quality of information patients may possess after watching online videos on tympanostomy tubes.</p></div><div><h3>Materials and methods</h3><p>YouTube and Facebook were searched using key terms related to tympanostomy tubes. Videos were screened and scored in triplicate. DISCERN quality, content, production, and alternative medicine scores were assigned. Statistical analysis was conducted using GraphPad Prism.</p></div><div><h3>Results</h3><p>76 YouTube and 86 Facebook videos were analyzed. DISCERN quality scores (mean = 1.8 vs. 1.4, <em>P</em> < .0001), content scores (mean = 1.7 vs. 1.0, <em>P</em> < .0001), and production scores (mean = 4.8 vs. 4.6, <em>P</em> = .0327) were significantly higher on YouTube compared to Facebook. 33 % of Facebook videos referenced alternative medicine, as compared with 0 % of YouTube videos (<em>P</em> < .0001). Physician/hospital-generated videos had significantly higher DISCERN and content scores than parent-, product-, and chiropractor-generated videos. Views did not correlate with DISCERN or content scores.</p></div><div><h3>Conclusion</h3><p>YouTube is a better platform than Facebook for educational videos about tympanostomy tubes. YouTube videos had higher educational quality, more comprehensive content, and less alternative medicine. One third of Facebook videos advocated for alternative treatments. Importantly, videos on both platforms were of limited educational quality as demonstrated through low DISCERN reliability scores and coverage of few important content areas.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 6","pages":"Article 104396"},"PeriodicalIF":1.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mihai A. Bentan, David Moffatt, Emaan Dawood, Ryan Nord
{"title":"Addressing the gaps: What social media tells us about patient experiences with hypoglossal nerve stimulation","authors":"Mihai A. Bentan, David Moffatt, Emaan Dawood, Ryan Nord","doi":"10.1016/j.amjoto.2024.104419","DOIUrl":"10.1016/j.amjoto.2024.104419","url":null,"abstract":"<div><h3>Purpose</h3><p>Hypoglossal nerve stimulation (HNS) can be an effective treatment for moderate to severe obstructive sleep apnea (OSA) in positive airway pressure (PAP) intolerant patients. To better understand patient perceptions of HNS therapy, we explored three Facebook groups pertaining to HNS therapy.</p></div><div><h3>Materials and methods</h3><p>A retrospective analysis of Facebook posts from three HNS-related Facebook groups, from October 1, 2022 to October 1, 2023, was performed. Posts were analyzed for author attitude, content (adverse events, inquiries, or sharing information), and the inclusion of media within the post.</p></div><div><h3>Results</h3><p>From 737 Facebook posts, 752 events were identified, predominantly authored by patients or family (99.5 %). Few posts included media attachments (7.3 %), primarily photos (85.5 %). Post tone was mainly neutral (79.4 %), rather than positive (12.9 %) or negative (7.7 %). Most posts (53.6 %) were queries to the Facebook group, as opposed to sharing information (28.9 %) or detailing adverse events (17.6 %). Notably queries posed by Facebook group members included those pertaining to the postoperative recovery course (10.17 %), physical activity restrictions (6.20 %), HNS therapy eligibility (4.71 %), financial considerations (4.22 %), and more.</p></div><div><h3>Conclusion</h3><p>Overall, Facebook group members reported a predominantly neutral tone, typically posting queries to the group rather than sharing information or detailing adverse events. These findings illustrate how diverse data sources, such as social media, can enhance our understanding of patient experiences and identify gaps in patient education with HNS therapy.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 5","pages":"Article 104419"},"PeriodicalIF":1.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert M. Conway , Hugh P. Mallany , Zaid Shareef , Nicholas Anthony , Caleb J. Fan , Jacob C. Lucas , Seilesh C. Babu
{"title":"Effect of pre-incident antiplatelet therapy on sudden sensorineural hearing loss","authors":"Robert M. Conway , Hugh P. Mallany , Zaid Shareef , Nicholas Anthony , Caleb J. Fan , Jacob C. Lucas , Seilesh C. Babu","doi":"10.1016/j.amjoto.2024.104431","DOIUrl":"10.1016/j.amjoto.2024.104431","url":null,"abstract":"<div><h3>Objective</h3><p>Identify if pre-incident aspirin influences severity and outcome of idiopathic sudden sensorineural hearing loss (SSNHL).</p></div><div><h3>Study design</h3><p>Retrospective review.</p></div><div><h3>Setting</h3><p>Tertiary care center.</p></div><div><h3>Methods</h3><p>Patients with idiopathic SSNHL were identified and separated into aspirin and non-aspirin groups. Variables, including demographics, comorbid conditions, audiologic outcomes were identified and compared between groups.</p></div><div><h3>Results</h3><p>One hundred forty-eight patients were included that met inclusion criteria. There were 38 patients who were on pre-incident aspirin therapy and 110 patients not on aspirin prior to the onset of SSNHL. Pre- and post-treatment audiologic status was worsened in the aspirin group. Other comorbid conditions, including hyperlipidemia, coronary artery disease (CAD), cerebrovascular accident (CVA), and vertigo symptoms had an effect as well. With multivariate analysis, CAD, CVA, and vertigo symptoms appeared to have an effect more than aspirin.</p></div><div><h3>Conclusions</h3><p>Patients on aspirin have a worsened pre- and post-treatment audiologic status. This appears to be more due to the underlying CAD or history of CVA rather than aspirin use itself.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 5","pages":"Article 104431"},"PeriodicalIF":1.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141764868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhongyan Chen, Qingling Bi, Yong Lv, Yan Li, Wenjing Yang, Xiaoyu Xu, Yuan Li
{"title":"Cochlear reimplantation outcomes over 20 years: Expertise in reimplantation surgery and auditory-speech rehabilitation","authors":"Zhongyan Chen, Qingling Bi, Yong Lv, Yan Li, Wenjing Yang, Xiaoyu Xu, Yuan Li","doi":"10.1016/j.amjoto.2024.104400","DOIUrl":"10.1016/j.amjoto.2024.104400","url":null,"abstract":"<div><h3>Objectives</h3><p>The aim of this study was to present an institution's experience with cochlear reimplantation (CRI), to assess surgical challenges and post-operative outcomes and to increase the success rate of CRI.</p></div><div><h3>Study design</h3><p>Retrospective single-institution study.</p></div><div><h3>Setting</h3><p>Tertiary medical center.</p></div><div><h3>Methods</h3><p>We retrospectively evaluated data from 76 reimplantation cases treated in a tertiary center between 2001 and 2022. Clinical features including etiology of hearing loss, type of failure, surgical issues, and auditory speech performance were analyzed. Categorical Auditory Performance (CAP) and Speech Intelligibility Rating (SIR) scores were used to evaluate pre- and post-CRI outcomes.</p></div><div><h3>Results</h3><p>The CRI population comprises of 7 patients from our institute,69 referred patients from other centers. Device failure was the most common reason (68/76, 89.5 %) for CRI; in addition, there were 7 medical failures and 1 had both soft device failure. Medical failures included flap rupture and device extrusion, magnet migration, auditory neuropathy, leukoencephalopathy, foreign-body residue and meningitis. In 21/76 patients, the electrode technology was upgraded. The mean time to failure was 0.58–13 years, with a mean of 4.97 years. The mean (± SD) CAP and SIR scores before and after CRI were 5.2 ± 1.2 versus 5.5 ± 1.1 and 3.4 ± 1.1 versus 3.5 ± 1.1, respectively. Performance was poor in six patients with severe cochlear malformation, auditory nerve dysplasia, leukoencephalopathy, and epilepsy.</p></div><div><h3>Conclusion</h3><p>CRI surgery is a challenging but relatively safe procedure, and most reimplanted patients experience favorable postoperative outcomes. Medical complications and intracochlear damage are the main causes of poor postoperative results. Therefore, adequate preoperative preparation and atraumatic CRI should be carried out for optimal results.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"45 5","pages":"Article 104400"},"PeriodicalIF":1.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196070924001868/pdfft?md5=eea80a22383f7da26b9273a5069884da&pid=1-s2.0-S0196070924001868-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}