American Journal of Otolaryngology最新文献

{"title":"Factors associated with new-onset of mental health disorders in Bell's palsy patients: A MarketScan database study","authors":"Shaun Edalati ,&nbsp;Sujay Ratna ,&nbsp;Parul Agarwal ,&nbsp;Ariel Harsinay ,&nbsp;Joshua D. Rosenberg ,&nbsp;Mingyang L. Gray","doi":"10.1016/j.amjoto.2024.104547","DOIUrl":"10.1016/j.amjoto.2024.104547","url":null,"abstract":"<div><h3>Objective</h3><div>Limited research exists on mental health disorders (MHDs) in Bell's palsy patients. This study investigates risk factors associated with the development of MHDs in these patients.</div></div><div><h3>Methods</h3><div>MarketScan commercial and Medicare outpatient and prescription drug claims data were utilized to conduct this study on adults with Bell's palsy. Patients were identified using International Classification of Diseases, Ninth or Tenth Revision, Clinical Modification diagnosis codes from 2014 to 2020 data. A one-year washout period was applied where patients did not have any diagnosis of MHD before Bell's palsy diagnosis. Patients were included if they were continuously enrolled for at least two years. The primary outcome was new-onset of any MHDs within one year of diagnosis of Bell's palsy. Descriptive statistics and logistic regression model explored risk factors associated with the development of any MHDs.</div></div><div><h3>Results</h3><div>Out of 37,166 Bell's palsy patients (mean age 49; 50.4 % female), 8.27 % experienced new-onset MHDs, with anxiety being the most prevalent (3.88 %). Female sex [Adjusted odds ratio (AOR) 1.40, 95 % CI 1.30–1.51, <em>p</em> &lt; 0.0001], increasing Charlson comorbidity index (AOR 1.11, 95 % CI 1.04–1.176, <em>p</em> = 0.001), and symptoms like headache (AOR 1.16, 95 % CI 1.34–1.81, <em>p</em> &lt; 0.0001) and facial pain (AOR 1.71, 95 % CI 1.15–2.52, <em>p</em> = 0.007) were associated with increased odds of new-onset of MHDs.</div></div><div><h3>Conclusion</h3><div>Bell's palsy patients can develop MHDs within first year of diagnosis, although the incidence of MHDs in this cohort is lower than that of the general population. Several factors are associated with the development of MHDs. These findings underscore the significance of addressing mental health in Bell's palsy patients, offering valuable considerations for clinical care and future research.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104547"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real prognostic role of laryngeal dysplasia in patients affected by invasive cancer","authors":"Francesco Chu ,&nbsp;Francesco Bandi ,&nbsp;Giacomo Pietrobon ,&nbsp;Marta Tagliabue ,&nbsp;Stefano Zorzi ,&nbsp;Rita De Berardinis ,&nbsp;Pietro Benzi ,&nbsp;Mohssen Ansarin","doi":"10.1016/j.amjoto.2024.104535","DOIUrl":"10.1016/j.amjoto.2024.104535","url":null,"abstract":"<div><h3>Purpose</h3><div>Transoral laser microsurgery is the mainstay in treating early-stage laryngeal squamous cell carcinoma. However, consensus is lacking in non-radical surgery for infiltrating cancer, and even doubts are cast for patients with laryngeal dysplasia at the resection margins. In this study we aim to assess the prognostic significance of laryngeal dysplasia at the surgical margins in patients radically treated for infiltrating cancer.</div></div><div><h3>Materials and methods</h3><div>Patients treated between 2000 and 2020 for infiltrating cancer were included. We selected patients whose final histopathological report confirmed radical excision for infiltrating cancer. The cohort was further divided into two subgroups according to the presence or the absence of dysplastic resection margins. All patients underwent follow up to assess oncological outcomes, and the results from the two subgroups were compared to assess the prognostic relevance of laryngeal dysplasia.</div></div><div><h3>Results</h3><div>A cohort of 281 patients was evaluated. From the statistical analysis, the supraglottic extension of infiltrating cancer and deep muscle infiltration were associated worse oncological outcomes. Conversely, the presence of critical dysplastic margins, dysplastic severity and the number of positive margins were not linked to worse outcomes.</div></div><div><h3>Conclusion</h3><div>In our experience, the presence of dysplasia at the resection margins does not affect patient survival. Thus, revision surgery for critical dysplastic margins, following radical excision of infiltrating carcinoma should not be performed. Instead, patients may undergo endoscopic monitoring, thereby avoiding unnecessary overtreatment and potential negative effects on voice outcomes.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104535"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric neck injuries associated with trampoline use","authors":"Deepthi S. Akella ,&nbsp;Jeremy Walsh ,&nbsp;Maya Raghavan ,&nbsp;Alexandra F. Corbin ,&nbsp;Julia E. Barkell ,&nbsp;Nicole M. Favre ,&nbsp;Michele M. Carr","doi":"10.1016/j.amjoto.2024.104564","DOIUrl":"10.1016/j.amjoto.2024.104564","url":null,"abstract":"<div><h3>Objective</h3><div>Trampolines are popular among children, but trampoline injuries constitute a large number of emergency department visits. The purpose of this study was to determine how often neck injuries occur among children with trampoline-related injuries and to identify the mechanism of injury.</div></div><div><h3>Methods</h3><div>We analyzed the National Electronic Injury Surveillance System (NEISS) database to characterize patient demographics, injury types, injury subsite, and emergency department disposition status associated with trampoline related neck injuries between 2012 and 2021 in the United States. We utilized NEISS code 89 (neck) and code 1233 (trampoline) for our query along and identified patients between 0 and 19 years.</div></div><div><h3>Results</h3><div>Of the 33,929 trampoline injuries, 1436 injuries involved the neck (4.2 %). The overall mean age was 8.0 ± 4.1 years and there were 17,728 (52 %) males and 16,201 (48 %) females in the group. Mean age of children with neck injuries was higher (9.2 ± 3.6 years) compared to children with other injuries (8.0 ± 4.1 years, <em>P</em> &lt; .001). Males had a higher proportion of neck injuries compared to all injuries 800 (56 %) versus females 636 (44 %, <em>P</em> = .007). The most common neck injury was neck strain/sprain with 993 (69 % of neck injuries). The next most common diagnoses included neck contusions at 34 (2 %) and fractures at 20 (1 %). Children with neck injuries were more likely to be discharged prior to admission compared to other trampoline-related injuries (96 % versus 93 %, <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Neck strains/sprains are the most common type of pediatric trampoline-related neck injuries. Older children and males are more likely to have neck injuries while using the trampoline.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104564"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor site morbidity of upper extremity flaps in head and neck reconstruction","authors":"Craig Hanna ,&nbsp;David Danis III ,&nbsp;Rotem Kimia ,&nbsp;Heather Merkouris ,&nbsp;Peter Steinwald ,&nbsp;Miriam O'Leary ,&nbsp;Jeremiah Tracy","doi":"10.1016/j.amjoto.2024.104548","DOIUrl":"10.1016/j.amjoto.2024.104548","url":null,"abstract":"<div><h3>Objective</h3><div>This retrospective cohort study aims to compare donor site morbidity of three commonly used upper extremity flaps used in head and neck reconstructive surgery: scapular tip free flap (STFF), radial forearm free flap (RFFF), and pectoralis major pedicled flap (PMPF).</div></div><div><h3>Methods</h3><div>The billing database of an urban, academic, tertiary otolaryngology practice was queried to identify patients who underwent STFF, RFFF, and PMPF from 2020 to 2023. The primary outcome was identification of donor site pain and need for physical therapy (PT) referral after undergoing reconstruction.</div></div><div><h3>Results</h3><div>Seventy-three patients (44M:29F) underwent surgery that utilized upper extremity free or pedicled flaps. Patients undergoing free tissue transfer (FTT) were 5.455 times more likely to require PT referral compared to patients undergoing pedicled tissue transfer (PTT). Patients undergoing FTT were 3.417 times more likely to report donor site pain compared to patients undergoing PTT. There were no differences in post-operative PT referrals or post-operative donor site pain when comparing STFF or RFFF groups. Importantly, RFFF were primarily all fasciocutaneous flaps (33/35).</div></div><div><h3>Conclusions</h3><div>These findings have important implications when counselling patients regarding reconstructive options for complex head and neck surgery defects.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104548"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of combination therapy with mometasone and montelukast versus mometasone alone in treatment of adenoid hypertrophy in children: A systematic review and meta-analysis","authors":"Meghna Joseph ,&nbsp;Mrinal Murali Krishna ,&nbsp;Ancy Jenil Franco ,&nbsp;Laura Jekov ,&nbsp;Renan Yuji Ura Sudo ,&nbsp;Thamiris Dias Delfino Cabral","doi":"10.1016/j.amjoto.2024.104566","DOIUrl":"10.1016/j.amjoto.2024.104566","url":null,"abstract":"<div><h3>Introduction</h3><div>Intranasal mometasone and oral montelukast have been found to be effective for adenoid hypertrophy in children. We aimed to compare the efficacy of combination therapy of mometasone and montelukast versus mometasone alone for adenoid hypertrophy in children.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, we systematically searched PubMed, Embase, Cochrane CENTRAL, and <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> databases for randomized controlled trials (RCTs) comparing combination therapy of mometasone and montelukast with mometasone alone for adenoid hypertrophy in children. The outcomes of interest were rhinorrhea, snoring, mouth breathing, and adenoid/nasopharynx ratio. Data were pooled using a random effects model to generate mean differences (MD).</div></div><div><h3>Results</h3><div>3 RCTs comprising a total of 207 patients were included; (combination therapy <em>n</em> = 104 (50.2 %). Rhinorrhea (MD -1.47; 95 % CI -1.85 to −1.09; <em>p</em> &lt; 0.01; I² = 0 %), snoring (MD -1.33; 95 % CI -1.65 to −1.00; p &lt; 0.01; I² = 0 %), and mouth breathing (MD -1.06; 95 % CI -1.40 to −0.71; p &lt; 0.01; I² = 0 %) were significantly lower in patients treated with combination therapy. No difference was observed in the adenoid/nasopharynx ratio between the groups. However, analysis excluding the study with a high risk of bias showed a significant reduction in the adenoid/nasopharynx ratio (MD −10.73; 95 % CI −13.56 to −7.90; <em>p</em> &lt; 0.01; I² = 0 %) in the combination therapy group. During the 3-month follow-up period after cessation of treatment, adenoid/nasopharynx ratio, rhinorrhea, snoring, and mouth breathing were significantly lower in the combination therapy group.</div></div><div><h3>Conclusion</h3><div>In children with adenoid hypertrophy, combination therapy reduced rhinorrhea, snoring, mouth breathing, and adenoid/nasopharynx ratio at the end of the treatment period and 3 months after treatment cessation.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104566"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved visualization of the inferior tympanic and mastoid canaliculi with photon counting detector CT","authors":"James P. McDonald ,&nbsp;Paul J. Farnsworth ,&nbsp;Norbert G. Campeau ,&nbsp;Shuai Leng ,&nbsp;Matthew L. Carlson ,&nbsp;John C. Benson ,&nbsp;Ian T. Mark ,&nbsp;John I. Lane","doi":"10.1016/j.amjoto.2024.104585","DOIUrl":"10.1016/j.amjoto.2024.104585","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the performance of the photon-counting detector (PCD)-CT versus a state-of-the-art energy-integrating detector (EID)-CT to identify segments of the inferior tympanic canaliculus (Jacobsons nerve) and the mastoid canaliculus (Arnolds nerve).</div></div><div><h3>Materials &amp; methods</h3><div>Patients were prospectively recruited to undergo temporal bone CT on both EID-CT (Siemens Somatom Force) and PCD-CT (Siemens NAEOTOM Alpha) scanners under an IRB-approved protocol. Three neuroradiologists reviewed cases by consensus comparing the ability to identify the proximal, mid, and distal segments of the inferior tympanic canaliculus/Jacobsons nerve and mastoid canaliculus/Arnolds nerve on each scanner using 5-point Likert scales (with 1 indicating EID is far superior to PCD, 3 indicating they are equivalent, and 5 indicating PCD is far superior to EID).</div></div><div><h3>Results</h3><div>Forty temporal bones were analyzed. Average Likert scores for the ability to evaluate the proximal, mid, and distal aspects of inferior tympanic canaliculus/Jacobsons nerve on the PCD compared to EID scanner were 4.5 (SD = 0.6), 4.2 (0.4), and 4.1 (0.3). The scores for the mastoid canaliculus/Arnolds nerve were 4.0 (0.4), 4.1 (0.4), and 4.0 (0.4). Overall, the PCD scanner performed better than EID for image quality (Median = 4.2, 95 % CI = [4.1, 5.0], <em>p</em>-value &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>PCD-CT provides superior visualization of the proximal, mid, and distal aspects of the inferior tympanic canaliculus/Jacobsons nerve and mastoid canaliculus/Arnolds nerve compared to EID-CT examinations. The improved visualization of these nerves could be important for characterization of subtle pathology involving these structures, such as tympanic paraganglioma or nodular perineural spread.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104585"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the presence of rhinological surgery on social media: Factors influencing searches","authors":"Ogechukwu S. Anwaegbu ,&nbsp;Delayne M. Coleman ,&nbsp;Janisah Amirah I. Saripada ,&nbsp;Smiti Gandhi ,&nbsp;Cody D. Luong ,&nbsp;Michel M. Adeniran ,&nbsp;Brian J. McKinnon","doi":"10.1016/j.amjoto.2024.104595","DOIUrl":"10.1016/j.amjoto.2024.104595","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the quality and engagement of rhinology-related educational videos shared by healthcare providers on Instagram.</div></div><div><h3>Methods</h3><div>The top 150 videos on Instagram for <em>#SinusSurgeryEducation</em>, #<em>TurbinateReductionEducation</em>, and #<em>SeptoplastyEducation</em> were selected. Videos were categorized by provider's specialty and analyzed for engagement metrics (likes, comments, shares, views), video duration, and hashtags. The Patient Education Materials Assessment Tool Audio/Visual (PEMAT-A/V) was used to assess the understandability and actionability of the medical educational videos.</div></div><div><h3>Results</h3><div>Sixty-three videos were analyzed: septoplasty education (26 videos), turbinate reduction education (17 videos), and sinus surgery education (20 videos). Of these, 88 % were classified as medical education content, while 12% focused on before-and-after surgery visualizations.</div><div>Among the educational content, 38 % were by otolaryngologists, 32 % by plastic surgeons, and 30 % by other providers such as anesthesiologists and chiropractors. Content created by plastic surgeons received higher engagement metrics compared to otolaryngologists. The average PEMAT-A/V scores were 75 % for understandability and 37 % for actionability.</div></div><div><h3>Conclusion</h3><div>Our analysis reveals that plastic surgeons and otolaryngologists are using social media for medical education, with content demonstrating moderate engagement and quality understandability. As social media continues to evolve as a source for disseminating health-related information, providers should strive to understand its mechanisms and impacts.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104595"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENT specialists' knowledge and their skills in detecting maxillary sinusitis of odontogenic origin, a cross-sectional study","authors":"Ali Alaqla ,&nbsp;Meshal Alhasoun ,&nbsp;Mohammed Asseery ,&nbsp;Saud Altheyabi ,&nbsp;Fathima Fazrina Farook ,&nbsp;Hajar Albanyan ,&nbsp;Mohammad T. Al-Kadi","doi":"10.1016/j.amjoto.2024.104587","DOIUrl":"10.1016/j.amjoto.2024.104587","url":null,"abstract":"<div><h3>Background</h3><div>Odontogenic maxillary sinusitis (OMS) is recognized in literature, but diagnosing it is challenging due to its different and overlapping clinical presentations of it. Misdiagnosis can lead to persistent symptoms and clinical burden. Interestingly, recent guidelines from the American Academy of Otolaryngology-Head and Neck Surgery lack recommendations for dental evaluation in adult sinusitis cases.</div></div><div><h3>Aim</h3><div>To assess ENT physicians' knowledge and skills in diagnosing maxillary sinusitis of odontogenic origin. This study may emphasize the importance of raising awareness to help in proper diagnosis, timely referral, and efficient management of patients with maxillary sinusitis of odontogenic origin.</div></div><div><h3>Methods</h3><div>A cross-sectional analytical study on 210 ENT specialists in Riyadh, Saudi Arabia to evaluate their knowledge and ability in detecting OMS electronically.</div></div><div><h3>Results</h3><div>Our sample included a total of 30 (14.29%) residents, 108 (51.43%) specialists, and 72 (34.28%) consultants. In cases of unilateral maxillary sinusitis, 61.43% of all participants reported that a dental examination was unnecessary. The regression analysis showed a significant interaction effect between the number of sinusitis cases per week and being a specialist (<em>p</em> = 0.0370). Conversely, there was no significant interaction effect between sinusitis cases per week and being a consultant (<em>p</em> = 0.1408).</div></div><div><h3>Conclusion</h3><div>ENT physicians underestimated the odontogenic etiology for unilateral OMS significantly. This study highlights the importance of targeted education to improve OMS detection and treatment and, ultimately, patient outcomes.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104587"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mepolizumab in chronic rhinosinusitis with nasal polyps: Real life data in a multicentric Sicilian experience","authors":"Cosimo Galletti ,&nbsp;Federico Sireci ,&nbsp;Giovanna Stilo ,&nbsp;Maria Antonietta Barbieri ,&nbsp;Giuliano Messina ,&nbsp;Riccardo Manzella ,&nbsp;Daniele Portelli ,&nbsp;Andrea Guglielmo Zappalà ,&nbsp;Mariut Diana ,&nbsp;Silvia Frangipane ,&nbsp;Angelo Immordino ,&nbsp;Francesco Lorusso ,&nbsp;Francesco Dispensa ,&nbsp;Francesco Ciodaro ,&nbsp;Francesco Freni ,&nbsp;Francesco Galletti ,&nbsp;Salvatore Gallina ,&nbsp;Ignazio La Mantia ,&nbsp;Bruno Galletti","doi":"10.1016/j.amjoto.2024.104597","DOIUrl":"10.1016/j.amjoto.2024.104597","url":null,"abstract":"<div><h3>Background</h3><div>Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation. Mepolizumab was approved for the treatment of CRSwNP in 2021. However, there is a lack of real-life studies.</div></div><div><h3>Aim</h3><div>This work aimed to evaluate the effectiveness and safety profile of Mepolizumab during the first year of treatment in a real-life setting.</div></div><div><h3>Methods</h3><div>A multicentric observational cohort study was carried out. A total of 67 patients were enrolled in the Otorhinolaryngology Unit of the three University Hospitals and considered for Mepolizumab therapy. All recorder characteristics were age (at the first Mepolizumab application visit), sex, smoke habits, previous local and systemic corticosteroid therapy, history of endoscopic sinus surgery, number of previous endoscopic sinus surgery, concomitant asthma, history of an allergic condition, immunoglobulin E (IgE), allergy to nonsteroidal anti-inflammatory drugs (NSAIDs), Aspirin Exacerbated Respiratory Disease (AERD), other comorbidities associated, blood eosinophils, nasal polyp score, sinonasal outcome test 22 (SNOT 22), sniffin' stick test, the start date of Mepolizumab therapy and number of doses of Mepolizumab and eventually, Mepolizumab's adverse events related to administration. The Wilcoxon test for dependent samples was performed to compare variables. Statistical significance was assumed for <em>p</em> values &lt; 0.05.</div></div><div><h3>Results</h3><div>A statistically significant reduction in SNOT-22 and NPS was shown in the 6th and 12th month compared to baseline values (p &lt; 0.001 for both comparisons). A statistically significant increase value at the Sniffin' sticks test was shown in the 6th and 12th month compared to baseline values (<em>p</em> &lt; 0.001 for both comparisons).</div><div>At the 12-month follow-up, according to EUFOREA indications, all patients were considered to remain in treatment with Mepolizumab and continued the treatment because of a reduced NPS, improved quality of life, and a reduced need for system corticosteroids.</div></div><div><h3>Conclusions</h3><div>This multi-centric real-life study supported the effectiveness of Mepolizumab in patients with severe uncontrolled CRSwNP in the improvement of quality of life, the severity of symptoms, polyp size reduction, and smell function. Our data also support the safety profile of monoclonal therapy with Mepolizumab.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104597"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational research for elucidating the relationship between chronic cough and laryngopharyngeal reflux disease","authors":"Mejdeddine Al Barajraji ,&nbsp;Jennifer Aoun ,&nbsp;Manon Louvrier ,&nbsp;Noémie Nemry ,&nbsp;Jerome R. Lechien","doi":"10.1016/j.amjoto.2024.104558","DOIUrl":"10.1016/j.amjoto.2024.104558","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104558"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}